Simulación prospectiva del crecimiento urbano en la Comunidad Autónoma de Madrid a partir de modelos basados en autómatas celulares y modelos basados en EMC

En el presente trabajo se analizan los resultados de varias simulaciones prospectivas de crecimiento urbano, entre los años 2000 y 2020, realizadas en la Comunidad de Madrid, aplicando dos modelos diferentes: uno basado en Autómatas Celulares (AC) y otro en técnicas de Evaluación MultiCriterio (EMC). El objetivo es comparar los resultados de las simulaciones de ambos modelos para detectar si se aproximan o están fuertemente influidos por la técnica empleada. Esto también permitiría, en cierta forma, evaluar los modelos desarrollados y su utilidad, pudiendo generar una cartografía de los resultados más robustos, es decir, de localizaciones que reiteradamente aparecen en las distintas simulaciones como las más apropiadas para desarrollar una futura ocupación urbana. En este caso concreto, se ha podido comprobar la escasa coincidencia entre resultados, evidenciando la necesidad, por un lado, de utilizar metodologías de comparación de mapas más flexibles, que permitan valorar mejor las semejanzas/diferencias encontradas, y, por otro, de detectar particularidades de los modelos que estén condicionando los resultados e, inclusive, deficiencias en su desarrollo.Proyecto SIMURBAN2: Instrumentos de Geosimulación y planificación ambiental en la ordenación territorial de ámbitos metropolitanos. Aplicación a escalas intermedias (Ref.: CSO2012-38158-C02-01)

Clasificador Catastral: complemento de QGIS para la clasificación de los usos del suelo urbano a nivel de parcela

El conocimiento apropiado de la distribución espacial de los distintos tipos de usos del suelo es fundamental para su planificación y gestión, y para ello se requiere de fuentes de información de alto detalle. En este contexto se ha desarrollado el complemento Clasificador Catastral (CC) para QGIS, que tiene como finalidad el análisis de la información catastral para dar como resultado clasificaciones de uso de suelo con distinto nivel de detalle. CC permite realizar tres tipos de clasificaciones, desde una básica con 6 usos y una intermedia con 14, que incluye usos mixtos, hasta una avanzada, con tantos usos como el usuario defina. Para validar su funcionamiento se ha analizado la correspondencia de la clasificación resultante de un municipio de la Comunidad de Madrid con información catastral y trabajo de campo. Se observa que hay un alto grado de fidelidad con la realidad, a excepción de las zonas verdes, que requieren de fuentes de información adicionales

Perception of and adaptability to the effects of climate change in a rural community of the State of Mexico

Objective: To analyze the population’s perception of recent changes in climate patterns and the actions they have taken to adapt to these changes in the El Saltillo community, Municipality of Jilotepec.Design/methodology/approach: A survey was carried out between September and October 2022, answered online. Social networking and WhatsApp groups were used to disseminate the invitation to participate in the Survey; 96 responses were received, of which 30 were answered on site together with the respondent. Aspects such as socioeconomic data, conceptualization and perception of climate change and adaptability actions were measured.Results: All the survey respondents mentioned that they perceive strong changes in droughts and frosts inthe last 10-15 years. Of them, 96% stated that they had heard the term climate change in different media; however, it is not a concept that is used to explain the changes that take place in the community. As a result of these changes, the population has chosen to build or enlarge rainwater container mounds for agricultural and livestock use, improve the physical condition of the stables, and begin to use precocious corn seed or more adapted varieties of improved corn.Limitations on study/implications: The application of surveys online is a feasible and economical option that implies the need to implement data validation, control and verification mechanisms, as well as sampling  of the results.Findings/conclusions: Adaptation strategies to climate change were identified, showing that they are not spontaneous actions and that they have emerged empirically through daily contact with the phenomenon

SHARDS: A global view of the star formation activity at z∼ 0.84 and z∼ 1.23

et al.In this paper, we present a comprehensive analysis of star-forming galaxies (SFGs) at intermediate redshifts (z ∼ 1). We combine the ultra-deep optical spectro-photometric data from the Survey for High-z Absorption Red and Dead Sources (SHARDS) with deep UV-to-FIR observations in the GOODS-N field. Exploiting two of the 25 SHARDS medium-band filters, F687W17 and F823W17, we select [O ii] emission line galaxies at z ∼ 0.84 and z ∼ 1.23 and characterize their physical properties. Their rest-frame equivalent widths (EW([O ii])), line fluxes, luminosities, star formation rates (SFRs), and dust attenuation properties are investigated. The evolution of EW([O ii]) closely follows the SFR density evolution of the universe, with a trend of EW([O ii]) (1 + z) up to redshift z ≃ 1, followed by a possible flattening. The SF properties of the galaxies selected on the basis of their [O ii] emission are compared with complementary samples of SFGs selected by their MIR and FIR emission, and also with a general mass-selected sample of galaxies at the same redshifts. We demonstrate observationally that the UVJ diagram (or, similarly, a cut in the specific SFR) is only partially able to distinguish the quiescent galaxies from the SFGs. The SFR-M relation is investigated for the different samples, yielding a logarithmic slope ∼1, in good agreement with previous results. The dust attenuations derived from different SFR indicators (UV(1600), UV(2800), [O ii], IR) are compared and show clear trends with respect to both the stellar mass and total SFR, with more massive and highly star-forming galaxies being affected by stronger dust attenuation.The work of A.C. is supported by the STARFORM Sinergia Project funded by the Swiss National Science Foundation, and also benefited from a MERAC Funding and Travel Award. P.G.P.-G. acknowledges support from the Spanish Programa Nacional de Astronomía y Astrofísica under grants AYA2012-31277. A.V.G. acknowledges support from the ERC via an Advanced Grant under grant agreement no. 321323-NEOGAL. N.C. acknowledges support from the Spanish Ministry of Economy and Competitiveness under grant AYA2013-46724-P. A.A.H. and A.H.C. acknowledge financial support from the Spanish Ministry of Economy and Competitiveness through grant AYA2012-31447, which is partly funded by the FEDER program. A.J.C. is a Ramón y Cajal Fellow of the Spanish Ministry of Science and Innovation and acknowledges financial support from the Spanish Ministry of Economy and Competitiveness through grant AYA2012-30789, partly funded by the FEDER program.Peer Reviewe

Zinc-Doped Iron Oxide Nanoparticles as a Proton-Activatable Agent for Dose Range Verification in Proton Therapy

Proton therapy allows the treatment of specific areas and avoids the surrounding tissues. However, this technique has uncertainties in terms of the distal dose fall-off. A promising approach to studying the proton range is the use of nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) with a hydrodynamic size of 10 nm and stability in serum. Cytotoxicity, defined as half of the surveillance, was 100 μg Zn/mL in the U251 cell line. The effect on clonogenic cell death was tested after X-ray irradiation, which suggested a radioprotective effect of these nanoparticles at low concentrations (1–10 μg Zn/mL). To evaluate the production of positron emitters and prompt-gamma signals, IONP@Zn-cit was irradiated with protons, obtaining prompt-gamma signals at the lowest measured concentration (10 mg Zn/mL). Finally, 67Ga-IONP@Zn-cit showed accumulation in the liver and spleen and an accumulation in the tumor tissue of 0.95% ID/g in a mouse model of U251 cells. These results suggest the possibility of using Zn nanoparticles as proton-activatable agents to verify the range by prompt gamma detection and face the challenges of prompt gamma detection in a specific biological situation, opening different avenues to go forward in this field

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe