Last Glacial Maximum CO2 and δ13C successfully reconciled

During the Last Glacial Maximum (LGM, ∼21,000 years ago) the cold climate was strongly tied to low atmospheric CO2 concentration (∼190 ppm). Although it is generally assumed that this low CO2 was due to an expansion of the oceanic carbon reservoir, simulating the glacial level has remained a challenge especially with the additional δ13C constraint. Indeed the LGM carbon cycle was also characterized by a modern-like δ13C in the atmosphere and a higher surface to deep Atlantic δ13C gradient indicating probable changes in the thermohaline circulation. Here we show with a model of intermediate complexity, that adding three oceanic mechanisms: brine induced stratification, stratification-dependant diffusion and iron fertilization to the standard glacial simulation (which includes sea level drop, temperature change, carbonate compensation and terrestrial carbon release) decreases CO2 down to the glacial value of ∼190 ppm and simultaneously matches glacial atmospheric and oceanic δ13C inferred from proxy data. LGM CO2 and δ13C can at last be successfully reconciled

An Embedded Gait Analysis System for CNS Injury Patients

Clinical evaluation of CNS injury patients before and after treatment is an essential step in gait rehabilitation. Medical care of gait disturbance for stroke patients is based on different treatments based on clinical and functional evaluations. Evaluation of gait aims at characterizing the motor performance to provide clinicians with information on the patient’s organizational or performance status and to allow them to consider the most appropriate treatment options. A 3D instrumented gait analysis system allows quantification of several parameters at each instant of walking but does not represent gait in daily life conditions. The absence of devices usable in daily life situation constitutes a lack pointed out by clinical practitioners and is at the origin of this work. In the following are described the design and implementation of a wireless embedded system for the collection of spatiotemporal parameters of pathological gait in everyday life. Algorithms estimate joint angles, step length, and gait events and automatically partition data into gait cycles. Experiments have been carried out to accurately evaluate the joint angles, the precision of sensor synchronization, the precision of gait event detection, and the robustness in the case of pathological walk. Comparisons with references given by the 3D instrumented gait analysis system are detailed

Electronic conduction in multi-walled carbon nanotubes: Role of intershell coupling and incommensurability

Geometry incommensurability between weakly coupled shells in multi-walled carbon nanotubes is shown to be the origin of unconventional electronic conduction mechanism, power-law scaling of the conductance, and remarkable magnetotransport and low temperature dependent conductivity when the dephasing mechanism is dominated by weak electron-electron coupling

Identités culturelles européennes et bibliothèques

Journée d\u27étude organisée le 9 juin 2011 à l\u27enssib portant sur les enjeux de la politique culturelle européenne, 20 ans après la signature du traité de Maastricht, et plus spécifiquement sur les actions menées par l\u27Union Européenne en direction des bibliothèques

Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia

Background: Plasmodium falciparum malaria is one of the most widespread parasitic infections in humans and remains a leading global health concern. Malaria elimination efforts are threatened by the emergence and spread of resistance to artemisinin-based combination therapy, the first-line treatment of malaria. Promising molecular markers and pathways associated with artemisinin drug resistance have been identified, but the underlying molecular mechanisms of resistance remains unknown. The genomic data from early period of emergence of artemisinin resistance (2008–2011) was evaluated, with aim to define k13 associated genetic background in Cambodia, the country identified as epicentre of anti-malarial drug resistance, through characterization of 167 parasite isolates using a panel of 21,257 SNPs. Results: Eight subpopulations were identified suggesting a process of acquisition of artemisinin resistance consistent with an emergence-selection-diffusion model, supported by the shifting balance theory. Identification of population specific mutations facilitated the characterization of a core set of 57 background genes associated with artemisinin resistance and associated pathways. The analysis indicates that the background of artemisinin resistance was not acquired after drug pressure, rather is the result of fixation followed by selection on the daughter subpopulations derived from the ancestral population. Conclusions: Functional analysis of artemisinin resistance subpopulations illustrates the strong interplay between ubiquitination and cell division or differentiation in artemisinin resistant parasites. The relationship of these pathways with the P. falciparum resistant subpopulation and presence of drug resistance markers in addition to k13, highlights the major role of admixed parasite population in the diffusion of artemisinin resistant background. The diffusion of resistant genes in the Cambodian admixed population after selection resulted from mating of gametocytes of sensitive and resistant parasite populations. (Résumé d'auteur

The evolution of deep-ocean flow speeds and δ¹³C under large changes in the Atlantic overturning circulation: Toward a more direct model-data comparison

To investigate the dynamics of the Atlantic meridional overturning circulation (AMOC) on timescales longer than the observational records, model-data comparisons of past AMOC variability are imperative. However, this remains challenging because of dissimilarities between different proxy-based AMOC tracers and the difficulty of comparing these to model output. We present an iLOVECLIM simulation with tuned AMOC evolution and focus on AMOC tracers that are directly comparable to reconstructions: flow speeds and δ¹³C. We deduce their driving factors and show that they yield different but complementary information about AMOC changes. Simulated flow speed changes are only linked to AMOC changes in regions bathed by North Atlantic Deep Water; however, in those regions they do provide details on vertical migration and thickness changes of the water masses. Simulated δ¹³C changes in the North Atlantic Deep Water region are again related to AMOC changes. Yet in regions bathed by Antarctic Bottom Water or Antarctic Intermediate Water, the δ¹³C evolution is driven by Southern Hemisphere source water δ¹³C changes, while in the Nordic Seas and the two major overflow regions it is driven by Northern Hemisphere source water δ¹³C changes. This shows that AMOC changes are not necessarily recorded by δ¹³C and stresses the need for combining both tracers in paleoclimate studies. A preliminary model-data comparison for Last Interglacial flow speeds and δ¹³C changes in the Deep Western Boundary Current shows that this integrated approach is far from straightforward and currently inconclusive on the Last Interglacial AMOC evolution. Nonetheless, the approach yields potential for more direct and in-depth model-data comparisons of past AMOC changes