Performing Under Uncertainty: Contextualized Engagement in Wildland Firefighting

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111802/1/jccm12076.pd

Progress in dark tourism and thanatourism research: An uneasy relationship with heritage tourism

This paper reviews academic research into dark tourism and thanatourism over the 1996–2016 period. The aims of this paper are threefold. First, it reviews the evolution of the concepts of dark tourism and thanatourism, highlighting similarities and differences between them. Second it evaluates progress in 6 key themes and debates. These are: issues of the definition and scope of the concepts; ethical issues associated with such forms of tourism; the political and ideological dimensions of dark tourism and thanatourism; the nature of demand for places of death and suffering; the management of such places; and the methods of research used for investigating such tourism. Third, research gaps and issues that demand fuller scrutiny are identified. The paper argues that two decades of research have not convincingly demonstrated that dark tourism and thanatourism are distinct forms of tourism, and in many ways they appear to be little different from heritage tourism

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Leadership Redundancy in a Multiteam System

Inspection, maintenance, and repair (IMR) operations of the subsea infrastructure off Norway’s coast are performed from specialized vessels by multiteam systems. A case study shows how leadership is organized and practiced to coordinate interdependencies, and to cope with the risks inherent in this type of complex and tightly coupled operation. Leadership redundancy is proposed as a mechanism that can contribute to the smooth and safe functioning of a multiteam system operating in a volatile environment

: L’exemple des sapeurs-pompiers de Paris

National audienceCet article rend compte d’une étude empirique approfondie de la gestion des incendies au sein d’une unité militaire d’élite : la brigade des sapeurs-pompiers de Paris. Il souligne l’intérêt d’une lecture croisant les littératures sur les situations extrêmes et sur les organisations à haute fiabilité pour mettre en évidence le rôle des règles dans la lutte contre le feu et la capacité de l’organisation à apprendre des situations imprévues vécues par les sapeurs-pompiers. Puis il montre le rôle de la discipline telle que l’appréhende Foucault pour comprendre comment fiabilité et flexibilité s’articulent