Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

Ana-Maria Rizzuto and the Psychoanalysis of Religion: The Road to the Living God

Ana-María Rizzuto’s groundbreaking explorations of the formation of God representations in early childhood and their elaboration throughout the life cycle have made their mark, enriching the practice of psychoanalysis and psychotherapy, as well as scholarship within the psychoanalytic study of religion. Accompanied by illuminating commentaries by Rizzuto, the authors of this edited collections essays in this volume underscore Rizzuto’s most important contribution to clinical practice: rather than assert that psychoanalysis is incompatible with religious beliefs and practices or with spiritual concerns that patients may bring to a therapeutic context, Rizzuto makes room for the coexistence of psychoanalysis and religion in the therapeutic setting. Demonstrating how Rizzuto’s work has enhanced connections within and among psychoanalytic theories of religion, established pathways for new developments in psychotherapy, and facilitated interdisciplinary conversations, this volume showcases the compelling power of Rizzuto’s work and its ongoing influence. -- Provided by publisherhttps://scholarworks.uni.edu/facbook/1427/thumbnail.jp

Fungal endophyte diversity in the leaves of the medicinal plant Myracrodruon urundeuva in a Brazilian dry tropical forest and their capacity to produce L-asparaginase

ABSTRACT We studied the fungal endophyte community of the leaves of Myracrodruon urundeuva in Brazil along with their potential to produce L-asparaginase. In total, 187 endophytes were isolated. The colonization rate of leaf fragments from caatinga (10.41 %) was lower than those from brejo de altitude (39.58 %). Sequences of ITS rDNA from all endophytes revealed relationships with Ascomycota (Botryosphaeriales, Chaetothyriales, Diaporthales, Eurotiales, Glomerellales, Hypocreales, and Pleosporales) and Basidiomycota (Polyporales). The most frequent endophytes were members of the genus Diaporthe. Talaromyces was an indicator genus for caatinga while Phyllosticta, Diaporthe, and Colletotrichum were for brejo de altitude. The composition of endophytic fungi in caatinga and brejo de altitude differed significantly, its richness and diversity (H' = 3.41) being significantly higher in brejo de altitude. Diaporthe sp. URM 7793 was the best producer of L-asparaginase (2.41 U/g), followed by Diaporthe sp. URM 7779 (2.00 U/g), Talaromyces sp. URM 7785 (1.91 U/g), and Diaporthe sp. URM 7792 (1.47 U/g). The composition of endophytic fungi assemblages is strongly influenced by the type of ecosystem. In its natural habitat, M. urundeuva harbors an important diversity of endophytes, which could be used to produce L-asparaginase