Contextualising the bycatch 'problem' in the Olifants Estuary Small-Scale Gillnet Fishery using an Ecosystem Approach to Fisheries

Conventional fisheries management approaches have been shown, in many instances, to have been ineffective in dealing with complex conservation concerns such as bycatch. Greater considerations for broader-scale and holistic approaches, as proposed by the 'Ecosystem Approach to Fisheries' (EAF) and the 'balanced harvesting approach', are beginning to challenge some of the negative misconceptions around bycatch, especially in small-scale fisheries. The need for a more holistic approach to fisheries management, particularly in small-scale fisheries, in South Africa is highlighted by its commitment to an EAF and the recent Small-Scale Fisheries Policy, for which the Marine living Resource Act of 1998 provides the legal framework to implement. The case study of the Olifants estuary small-scale traditional gillnet fishing community, located on the west coast of South Africa, provides a particularly relevant example of a complex fishery requiring a holistic approach. Current regulations prohibit the harvesting or retention of any bycatch species. Fisheries management worldwide and in South Africa, generally view gillnet fisheries as destructive, due to the occurrence of bycatch and the fact that many of these bycatch species are considered overexploited, which has led to numerous attempts over the years to phase out the Olifants gillnet fishery. The purpose of this study was to, firstly, use an EAF framework to contextualise the issue of bycatch in the Olifants gillnet fishery, and secondly, to identify the relative contributions of all fisheriy sectors to the four key selected linefish species caught as bycatch by the fishery. An extensive review and analysis of available secondary data, as well as primary data collected for this study, have estimated, with acknowledged limitations, the magnitude of the exploitation by all known fisheries of these species. Key information from small-scale fisher interviews and community-monitoring data highlight the capture rate of key linefish species by this fishery. This is echoed by recent landings for 2012 indicating the relative contribution of the national beache seine and gillnet fishery to the overall catch of (Elf [Pomatomus saltatrix] - 26.94%; Silver Kob [Argyrosomus inodorus] - 0.88%; White Stumpnose [Rhabdosargus globiceps] - 1.05% - excluding the recreational sector). A significant finding of this study is the substantial levels of cross-sectorial exploitation of Silver Kob and White Stumpnose, and to a somewhat lesser extent Elf and White Steenbras

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Change begets change: employing a change perspective to inform South Africa's coastal community conservation policy-praxis disjuncture

Contemporary biodiversity conservation is ‘wickedly complex'. This complexity stems from the need to address the diverse objectives of protecting biodiversity and enhancing social wellbeing. However, centralized and exclusionary conservation approaches are often ill-suited to tackling these coupled objectives. Consequently, increasingly calls have been made for the development of more holistic, participatory, nuanced and context-specific conservation governance approaches. Community-based conservation – which seeks to include local communities and their knowledge and priorities in conservation governance – offers a viable though context-specific alternative. However, thus far communitybased conservation initiatives have produced mixed results, largely due to a lack of understanding of how to effectively initiate, implement and manage such ‘wickedly complex' conservation initiatives. South Africa possesses enabling legislation for community-based conservation, but to date there has been no implementation of legally recognized communityconserved areas in the coastal zone. Accordingly, this research is guided by a desire to better understand this ‘policy-praxis disjuncture', and explores what factors, conditions and processes are required to enable South Africa to embrace a more community-orientated approach to conservation. It is proposed that greater understanding and potentially success can be gained by viewing communitybased conservation including, the initiation, implementation and governance of community-conserved areas, as a ‘change process'. Drawing on Commons Theory, Governance Theory, and the Theory of Change approach, a framework was developed to guide the exploration of the factors, conditions and processes that enable the shift to a community-based mode of conservation governance. Case study investigations were conducted in two established regional community coastal conservation cases, and one South African ‘case-in-progress'. Based on the findings of these cases, and the perceptions of South African conservation actors, this dissertation offers insights for tackling South Africa's policy-praxis disjuncture by developing a South African Empirical Community-Based Conservation Theory of Change Pathway. By exploring the initiation, implementation and governance of community-based conservation initiatives as a change process, this dissertation provides a framework for designing a process to facilitate and implement community-based conservation where contextually appropriate. More specifically, it emphasizes the need to develop a context-appropriate, strategic, systematic and iterative set of actions, with clearly articulated assumptions, which strive to address present or potential issues, to support the change to community-based governance. Consequently, this dissertation provides a framework for understanding how a shift to a community-based mode of conservation governance takes place, and offers a South African specific design pathway, with potential application by diverse conservation actors in other countries