Estudo da resposta subjetiva a vibrações em aeronaves

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2011Com a crescente demanda pelo transporte aéreo, os fabricantes de aeronaves buscam melhorar o conforto interno destas. A vibração em conjunto com o ruído são alguns dos fatores que mais influenciam a percepção do conforto pelos passageiros de aviões. Desse modo, o objetivo deste estudo foi relacionar como as pessoas percebem a vibração com os parâmetros físicos dos estímulos. Para isso, foram realizados ensaios subjetivos para a pesquisa da diferença de limiar de vibração, do limiar absoluto de vibração e da percepção do conforto por meio da reprodução de quatro estímulos vibracionais gravados em voos reais e reproduzidos em um simulador (mock-up) no Laboratório de Vibrações e Acústica da UFSC. Com a análise dos resultados desses ensaios, foi possível compreender como as pessoas percebem as vibrações e relacionar alguns parâmetros físicos dos estímulos, tais como amplitudes de vibração por bandas de frequência, com as respostas da percepção de conforto dos jurados, com o auxílio de métodos estatísticos, como análise de regressão e redes neurais artificiai

Análise de ferramentas e tecnologias de desenvolvimento de software para dispositivos móveis: estudo de caso aplicado à implementação de um sistema especialista na área de segurança do trabalho

Anais do V Encontro de Iniciação Científica e I Encontro Anual de Iniciação ao Desenvolvimento Tecnológico e Inovação – EICTI 2016 - 05 e 07 de outubro de 2016 – Sessão EngenhariasA geração atual de dispositivos móveis permite que os usuários realizem um conjunto de tarefas, antes realizadas em computadores, estando conectados ou não à Internet. Podem-se destacar como principais características da computação móvel a mobilidade e flexibilidade que engloba também portabilidade, usabilidade e conectividade desses dispositivos. Já um Sistema Especialista (SE) é uma ferramenta que representa uma forma automática de auxílio à tomada de decisão, baseando-se no conhecimento existente naquele assunto (REZENDE, 2001). Isto permite melhorar a eficiência e prevenir erros em análises realizadas por especialistas em diversas áreas do conhecimento. Considerando as vantagens da mobilidade de dispositivos móveis e o uso dos Sistemas Especialistas, objetivo geral neste trabalho é o desenvolvimento de funcionalidades adicionais para um sistema especialista móvel, denominado Sistema Especialista Em Segurança do Trabalho (SEST). Este aplicativo realiza o diagnóstico de salubridade do ruído em um ambiente de trabalho, conforme descrito em (NADAI, 2013) e pela Norma de Higiene Ocupacional 01 – NHO-01 (FUNDACENTRO, 2001

From proteomic analysis to potential therapeutic targets: functional profile of two lung cancer cell lines, A549 and SW900, widely studied in pre-clinical research

Lung cancer is a serious health problem and the leading cause of cancer death worldwide. The standard use of cell lines as in vitro pre-clinical models to study the molecular mechanisms that drive tumorigenesis and access drug sensitivity/effectiveness is of undisputable importance. Label-free mass spectrometry and bioinformatics were employed to study the proteomic profiles of two representative lung cancer cell lines and to unravel the specific biological processes. Adenocarcinoma A549 cells were enriched in proteins related to cellular respiration, ubiquitination, apoptosis and response to drug/hypoxia/oxidative stress. In turn, squamous carcinoma SW900 cells were enriched in proteins related to translation, apoptosis, response to inorganic/organic substances and cytoskeleton organization. Several proteins with differential expression were related to cancer transformation, tumor resistance, proliferation, migration, invasion and metastasis. Combined analysis of proteome and interactome data highlighted key proteins and suggested that adenocarcinoma might be more prone to PI3K/Akt/mTOR and topoisomerase IIα inhibitors, and squamous carcinoma to Ck2 inhibitors. Moreover, ILF3 overexpression in adenocarcinoma, and PCNA and NEDD8 in squamous carcinoma shows them as promising candidates for therapeutic purposes. This study highlights the functional proteomic differences of two main subtypes of lung cancer models and hints several targeted therapies that might assist in this type of cancer.publishe

Ruído gerado em refrigeradores skin condenser por pulsação de descarga

Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2021.A evolução das residências com novos conceitos arquitetônicos coloca equipamentos como refrigeradores mais próximos de ambientes de estar, aumentando a importância de produzir equipamentos cada vez mais silenciosos. O conceito de refrigeradores tipo skin condenser tem sido cada vez mais explorado pelo fato de proporcionar vantagens em relação aos condensadores convencionais. Entretanto, a pulsação da descarga do gás de refrigeração tem-se tornado uma fonte significativa do ruido pelo fato de excitar diretamente o gabinete. Este trabalho analisa os mecanismos de excitação de vibração do gabinete pela pulsação do gás nos tubos do condensador. Testes iniciais foram realizados com medição de vibração em gabinetes de refrigeradores com skin condenser. Os resultados mostraram que o gabinete vibra de modo forçado nas frequências de pulsação, com a forma dos modos naturais de flexão mais próximos. O mesmo comportamento foi encontrado quando segmentos da parede de refrigeradores skin condenser foram excitados somente por pulsação, demonstrando que os modos de flexão governam a deformação. A análise teórica mostrou que o momento fletor devido à pulsação é causado por assimetrias na seção transversal do tubo, que podem ser relativas à geometria, propriedades ou condições de contorno do tubo. Avaliações numéricas foram realizadas para validação da análise teórica e confirmaram este efeito em diversos tipos de assimetrias. Com estes resultados foi possível propor diferentes configurações de montagens de skin condenser visando a minimização da geração de vibração no gabinete, que foram testadas utilizando simulação numérica.Abstract: The evolution of homes with new architectural concepts places equipment such as refrigerators closer to living environments, increasing the importance of producing increasingly quiet equipment. The concept of skin condenser refrigerators has been increasingly explored for its advantages over conventional condensers. However, the pulsation of the cooling gas discharge has become a significant source of noise because it directly excites the enclosure. This work analyzes the mechanisms of cabinet vibration excitation by gas pulsation in the condenser tubes. Initial tests were performed with vibration measurements on refrigerator cabinets with skin condenser. The results showed that the cabinet vibrates in a forced mode at pulsation frequencies, with the shape of the closest natural bendings modes. The same behavior was found when segments of the skin condenser refrigerator wall were excited only by pulsation, demonstrating that the bending modes govern the deformation. Theoretical analysis showed that the bending moment due to pulsation is caused by asymmetries in the tube cross section, which may be relative to the tube geometry, properties, or boundary conditions. Numerical evaluations were performed to validate the theoretical analysis and confirmed this effect in several types of asymmetries. With these results it was possible to propose different configurations of skin condenser assemblies aiming at minimizing the vibration generation in the cabinet, which were tested using numerical simulation

Excitation of pipe bending modes by internal pressure: A phenomenon present in refrigerators with skin condenser

The concept of skin condenser refrigerators has been increasingly explored for its capacity to provide a larger internal cabinet volume. However, the discharge pulsation of the cooling gas has become a significant source of noise because it directly excites the cabinet. This paper analyzes the mechanisms of cabinet vibration excitation by gas pulsation in the condenser tubes. Initial tests were performed with vibration measurements on a refrigerator and on segments of the cabinet excited by pulsation only. The results showed that bending modes of cabinet segments were excited by the pulsation in the condenser tube. A theoretical analysis showed that asymmetry in the condenser tube cross section is responsible for bending moment generation and numerical evaluations confirmed this effect for different types of asymmetries

Diagnosis of the Energy Regulatory Scenario with Emphasis on Smart Energy

The energy management system has evolved into a digitized and autonomous environment, where consumers can manage their own generation, consumption and storage through virtual environments. Smart Energy (SE) understands this decentralized energy management by streamlining and helping in this matter, however, there is a need to regulate this scenario. Considering that the electric energy sector has a solid regulation, efforts need to be concentrated to adapt it to a model that emphasizes the SE and everything that it proposes. Therefore, the objective of this article is to propose a diagnosis of the current energy regulatory scenario directed to the SE. Through a focus group, experts from the energy sector contributed with opinions on the subject for the construction of a Current Reality Tree (CRT), which aimed to identify the root causes that affect and limit the energy regulation scenario SE-oriented. The current situation of this scenario was analyzed and what can be changed. 38 actions that contribute to the development and propagation of SE were suggested. These actions are guiding ways to regulate and enable the regulatory environment to support the insertion of technologies related to the theme

Competitiveness of Food Industry in the Era of Digital Transformation towards Agriculture 4.0

Industry 4.0 and its technologies can potentially increase business competitiveness in the age of digital transformation through the implementation of its technologies. These digital technologies are increasingly present in the food industry, characterizing the concept of Agriculture 4.0. This digital transformation is a reality; however, it is unclear which digital technologies are most useful for each industry sector. Therefore, this paper seeks to explore the current state of implementation of digital technologies in different industrial sectors and which digital technologies should be leveraged to increase the performance of the agribusiness system. To do so, we used secondary data from a large-scale survey of 28 industrial sectors, representing 2225 companies in the Brazilian industry. Analyzing the different industrial sectors allowed us to present a framework of digital transformation to boost food industry competitiveness towards Agriculture 4.0. The results show that the food industry usually uses only one digital technology, showing the need for simultaneous and joint investments in the other technologies presented in this research. Public policies must be directed to encourage the expansion of digital technologies in the food industry

Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry.

BACKGROUND AND OBJECTIVES COVID-19 related inflammation, endothelial dysfunction and coagulopathy may increase the bleeding risk and lower efficacy of revascularization treatments in patients with acute ischemic stroke. We aimed to evaluate the safety and outcomes of revascularization treatments in patients with acute ischemic stroke and COVID-19. METHODS Retrospective multicenter cohort study of consecutive patients with acute ischemic stroke receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021, tested for SARS-CoV-2 infection. With a doubly-robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). RESULTS Of a total of 15128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19. 5848 (38.7%) patients received IVT-only, and 9280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted odds ratio [OR] 1.53; 95% CI 1.16-2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20-2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23-1.99), 24-hour (OR 2.47; 95% CI 1.58-3.86) and 3-month mortality (OR 1.88; 95% CI 1.52-2.33).COVID-19 patients also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26-1.60). DISCUSSION Patients with acute ischemic stroke and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 treated patients. Current available data does not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in COVID-19 patients, or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring and establishing prognosis