Impact of Solid Waste Dumping Site on Environment and Public Health in Sargodha City

The waste generated from houses, industries and different commercial activities are considered as municipal solid waste. In most of the developing countries especially Pakistan municipal solid waste are not handled properly and are thrown on open places without using proper treatment. This research is conducted to identify the municipal solid waste disposal sites and to compare the health problems between the people residing near dumping sites and the people living 8km away from these sites. A sample size of 60 household was taken out of which 30household were selected from the surrounding of waste place and 30household far away from waste site at the distance of (8) km.  Data for health problem were collected through questionnaire, interview and also testing  the concentration of pH, EC, TDS, Ni, Cu, Cr, Cd in the ground water sample collected from the waste disposal place. The result showed that diseases like skin and eye irritation, continuous fever (malaria, Typhoid),/cough, diarrhea, Infant less weight, stomach problem, heart problem and hepatitis are common in those people who are residing close to waste site as compared to far away residents. The quality of water near waste disposal site is also not good for drinking because the  level of heavy metal selected for study like Cadmium, Chromium, Lead, Copper are high than WHO permissible value except copper and as a result source of many water borne diseases. The study concluded that these sites should be established away from the residing areas and should be managed properly

Impact of Solid Waste Dumping Site on Environment and Public Health in Sargodha City

The waste generated from houses, industries and different commercial activities are considered as municipal solid waste. In most of the developing countries especially Pakistan municipal solid waste are not handled properly and are thrown on open places without using proper treatment. This research is conducted to identify the municipal solid waste disposal sites and to compare the health problems between the people residing near dumping sites and the people living 8km away from these sites. A sample size of 60 household was taken out of which 30household were selected from the surrounding of waste place and 30household far away from waste site at the distance of (8) km.  Data for health problem were collected through questionnaire, interview and also testing  the concentration of pH, EC, TDS, Ni, Cu, Cr, Cd in the ground water sample collected from the waste disposal place. The result showed that diseases like skin and eye irritation, continuous fever (malaria, Typhoid),/cough, diarrhea, Infant less weight, stomach problem, heart problem and hepatitis are common in those people who are residing close to waste site as compared to far away residents. The quality of water near waste disposal site is also not good for drinking because the  level of heavy metal selected for study like Cadmium, Chromium, Lead, Copper are high than WHO permissible value except copper and as a result source of many water borne diseases. The study concluded that these sites should be established away from the residing areas and should be managed properly

Geographical Evaluation of Socio-economic Condition of Sargodha City to Measure Urban Poverty

The current study presents the socio economic conditions of people of Sargodha city to analyze the urban poverty level. Research was accomplished during the year of 2016-2018. Urban poverty is a burning social issue in world when a person do not succeeds to carry out his family needs and wants. A survey was conducted in eleven different colonies and 188 households were visited. Poverty level was scrutinized according to international poverty line less than 1 Dollar per day. During the field survey it was perceived that 17 percent of the households have income of less than 1 Dollar per day and they were real poor. Different parameters were examined like slums, dependency ratio, income, transportation, drinking water scheme, sewerage system and literacy rate. These parameters have compared with poverty to analyze the affordability and living condition of people. It was examined that there were several reasons for poverty in city like unemployment / low income, less education, high dependency ratio etc. Most of the people have large families but low income due to not as much of education and more dependent people in households. It was also suggested that Government should make better living conditions for people by providing technical skills to uneducated person to diminish unemployment and should advance the sanitation problems for better lifestyle

Geographical Evaluation of Socio-economic Condition of Sargodha City to Measure Urban Poverty

The current study presents the socio economic conditions of people of Sargodha city to analyze the urban poverty level. Research was accomplished during the year of 2016-2018. Urban poverty is a burning social issue in world when a person do not succeeds to carry out his family needs and wants. A survey was conducted in eleven different colonies and 188 households were visited. Poverty level was scrutinized according to international poverty line less than 1 Dollar per day. During the field survey it was perceived that 17 percent of the households have income of less than 1 Dollar per day and they were real poor. Different parameters were examined like slums, dependency ratio, income, transportation, drinking water scheme, sewerage system and literacy rate. These parameters have compared with poverty to analyze the affordability and living condition of people. It was examined that there were several reasons for poverty in city like unemployment / low income, less education, high dependency ratio etc. Most of the people have large families but low income due to not as much of education and more dependent people in households. It was also suggested that Government should make better living conditions for people by providing technical skills to uneducated person to diminish unemployment and should advance the sanitation problems for better lifestyle

On designing a sequential based EWMA structure for efficient process monitoring

Control chart is a popular technique that is widely used in statistical process control to identify any possible deviations from a stable state of a process. Shewhart charts are famous for identifying larger shifts, while cumulative sum and exponentially weighted moving average control charts are well known for identifying smaller shifts in process parameters. This study examines the performance of a sequential-based EWMA (namely (Formula presented.)) chart for observing the location of a normally distributed process. The performance of (Formula presented.) is oberved by using several overall run length properties (like average, median and standard deviation). The comparative study reveals that the overall performance of the proposed design is better than the existing counterparts. Moreover, the superiority depends on the choice of the design parameters of the proposed chart. A real-life data set from a steel rod manufacturing industry were considered to show the real-life illustration of the proposed design. 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.The authors are thankful to the anonymous reviewer for the constructive comments that helped in improving the initial version of the paper. The author Saddam Akber Abbasi would like to acknowledge Qatar University for providing excellent research facilities. The authors, M. Hafidz Omar and Muhammad Riaz, would also like to acknowledge the research facilities provided by the Deanship of Scientific Research (DSR) at King Fahd University of Petroleum & Minerals (KFUPM).Scopu

Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery

Abstract OBJECTIVES Many intraoperative decisions regarding the extent of thoracic aortic surgery are subjective and are based on the appearance of the aorta, perceived surgical risks and likelihood of early recurrent disease. Our objective in this work was to carry out a cross-sectional study to demonstrate that rapid evaporative ionization mass spectrometry (REIMS) of electrosurgical aerosol is able to empirically discriminate ex vivo aneurysmal human thoracic aorta from normal aorta, thus providing supportive evidence for the development of the technique as a point-of-care test guiding intraoperative surgical decision-making. METHODS Human aortic tissue was obtained from patients undergoing surgery for thoracic aortic aneurysms (n = 44). Normal aorta was obtained from a mixture of post-mortem and punch biopsies from patients undergoing coronary surgery (n = 13). Monopolar electrocautery was applied to samples and surgical aerosol aspirated and analysed by REIMS to produce mass spectral data. RESULTS Models generated from REIMS data can discriminate aneurysmal from normal aorta with accuracy and precision of 88.7% and 85.1%, respectively. In addition, further analysis investigating aneurysmal tissue from patients with bicuspid and tricuspid aortic valves was discriminated from normal tissue and each other with accuracies and precision of 93.5% and 91.4% for control, 83.8% and 76.7% for bicuspid aortic valve and 89.3% and 86.0% for tricuspid aortic valve, respectively. CONCLUSIONS Analysis of electrosurgical aerosol from ex vivo aortic tissue using REIMS allowed us to discriminate aneurysmal from normal aorta, supporting its development as a point-of-care test (Intelligent Knife) for guiding surgical intraoperative decision-making. </jats:sec

Time-dependent mechanical behaviour of the aortic chronic dissection flap.

ObjectivesThe transition of aortic dissection from acute to chronic is poorly understood. We examined time-dependent mechanical behaviour and biochemical properties of chronic dissection tissues.MethodsAorta samples were obtained from 14 patients with mixed aetiology who were undergoing elective surgery for chronic dissected aneurysms, ranging from 3 months to 15 years post-dissection. The tissue elastic modulus and tissue deformation following application of loading for 5 h were measured for the false lumen (FL), true lumen (TL) and flap (FP) tissues with a custom-indentation technique. Collagen, elastin and glycosaminoglycan levels were determined with established biochemical assays. Elastin fragmentation was graded from histological sections. The number of tissues characterized was as follows: FP (n = 10), TL (n = 5 for biomechanical testing, n = 8 for biochemical analysis, n = 8 for histological assessment) and FL (n = 4).ResultsTissues stiffness was highest in FP [59.8 (14.8) kPa] as compared with TL [50.7 (6.2) kPa] and FL [40.5 (4.7) kPa] (P = 0.023 and P = 0.006, respectively). FP [0.5 (0.08) mm] also exhibited reduced deformation relative to TL [0.7 (0.02) mm] and FL [0.9 (0.08) mm] (P = 0.003 and P = 0.006, respectively), lowest collagen concentration [FP: 40.1 (19.6) µg/mg, TL: 59.9 (19.5) µg/mg, P = 0.008; FL: 79.1 (32.0) µg/mg, P = 0.006] and the lowest collagen: elastin ratio [0.4 (0.1)] relative to the other tissues [TL; 0.6 (0.3), P = 0.006, FL; 1.5 (0.4); P = 0.003]. Significant elastin loss was evident in the FL-stained tissue sections whereas highly aligned, long fibres were visible in the FP and TL. A linear relationship was found between the stiffness, deformation and the time from the dissection event to surgical intervention for the FP. All data are presented as median (interquartile range).ConclusionsFP exhibited reduced time-dependent deformation and distinct biochemical properties relative to TL and FL irrespective of connective tissue disorder or the anatomical region of the dissection

GWAS study using DNA pooling strategy identifies association of variant rs4910623 in OR52B4 gene with anti-VEGF treatment response in age-related macular degeneration

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Pooled DNA based GWAS to determine genetic association of SNPs with visual acuity (VA) outcome in anti-vascular endothelial growth factor (anti-VEGF) treated neovascular age-related macular degeneration (nAMD) patients. We performed pooled DNA based GWAS on 285 anti-VEGF treated nAMD patients using high density Illumina 4.3 M array. Primary outcome was change in VA in Early Treatment Diabetic Retinopathy Study (ETDRS) letters after 6 months of anti-VEGF treatment (patients who lost ≥5 ETDRS letters classified as non-responders and all remaining classified as responders). GWAS analysis identified 44 SNPs of interest: 37 with strong evidence of association (p < 9 × 10−8), 2 in drug resistance genes (p < 5 × 10−6) and 5 nonsynonymous changes (p < 1 × 10−4). In the validation phase, individual genotyping of 44 variants showed three SNPs (rs4910623 p = 5.6 × 10−5, rs323085 p = 6.5 × 10−4 and rs10198937 p = 1.30 × 10−3) remained associated with VA response at 6 months. SNP rs4910623 also associated with treatment response at 3 months (p = 1.5 × 10−3). Replication of these three SNPs in 376 patients revealed association of rs4910623 with poor VA response after 3 and 6 months of treatment (p = 2.4 × 10−3 and p = 3.5 × 10−2, respectively). Meta-analysis of both cohorts (673 samples) confirmed association of rs4910623 with poor VA response after 3 months (p = 1.2 × 10−5) and 6 months (p = 9.3 × 10−6) of treatment in nAMD patients

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London