Hallelujahs From Portsmouth Campmeeting

https://place.asburyseminary.edu/firstfruitsheritagematerial/1126/thumbnail.jp

A comparison of wind observations of the upper thermosphere from the dynamics explorer satellite with the predictions of a global time-dependent model

Seven polar passes of the NASA Dynamics Explorer 2 (DE-2) satellite during October and early December 1981 have been used to examine the high-latitude circulation in the upper thermosphere. Vector winds along the satellite track are derived by appropriate merging of the data from the remote-sensing Fabry-Perot interferometer (meridional wind) and the in situ wind and temperature spectrometer (zonal wind) and are compared with the predictions of a three-dimensional, time-dependent, global model of the thermosphere. Major features of the experimental winds, such as the mean day to night circulation caused by solar u.v. and e.u.v. heating, augmented by magnetospheric processes at high latitude and the sharp boundaries and flow reversals imposed on thermospheric winds by momentum transfer (ion drag) from the magnetosphere, are qualitatively explained by a version of the global model using a semi-empirical global model of polar electric fields (Volland Model 2 or Heppner Model A) and a model of global electron density which excludes the effects of high-latitude geomagnetic processes. A second version of the global dynamic model includes a theoretical model of the high-latitude ionosphere which is self-consistent and reflects the enhancement of ionization due to magnetospheric phenomena acting in addition to solar e.u.v. photo-ionization, including the interactive processes which occur between ionization and high latitude ion convection and thermospheric winds. This second dynamical model shows an improved comparison with the structure and magnitude of polar cap and auroral oval winds at times of other than extremely low geomagnetic activity, when the first model appears a better match. An improved empirical description of the complex magnetospheric processes exciting the thermosphere in the vicinity of the dayside polar cusp and an empirical description of storm-time electric fields will be required for a quantitative explanation of the polar thermospheric winds during geomagnetic substorm events.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25079/1/0000510.pd

The westward thermospheric jet-stream of the evening auroral oval

One of the most consistent and often dramatic interactions between the high latitude ionosphere and the thermosphere occurs in the vicinity of the auroral oval in the afternoon and evening period. Ionospheric ions, convected sunward by the influence of the magnetospheric electric field, create a sunward jet-stream in the thermosphere, where wind speeds of up to 1 km s-1 can occur. This jet-stream is nearly always present in the middle and upper thermosphere (above 200 km altitude), even during periods of very low geomagnetic activity. However, the magnitude of the winds in the jet-stream, as well as its location and range in latitude, each depend on geomagnetic activity. On two occasions, jet-streams of extreme magnitude have been studied using simultaneous ground-based and satellite observations, probing both the latitudinal structure and the local time dependence. The observations have then been evaluated with the aid of simulations using a global, three-dimensional, time-dependent model of thermospheric dynamics including the effects of magnetospheric convection and particle precipitation. The extreme events, where sunward winds of above 800 ms-1 are generated at relatively low geomagnetic latitudes (60-70[deg]) require a greatly expanded auroral oval and large cross-polar cap electric field ( ~ 150 kV). These in turn are generated by a persistent strong Interplanetary Magnetic Field, with a large southward component. Global indices such as Kp are a relatively poor indicator of the magnitude and extent of the jet-stream winds.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25724/1/0000281.pd

A theoretical and empirical study of the response of the high latitude thermosphere to the sense of the "Y" component of the interplanetary magnetic field

The strength and direction of the Interplanetary Magnetic Field (IMF) controls the transfer of solar wind momentum and energy to the high latitude thermosphere in a direct fashion. The sense of " Y" component of the IMF (BY) creates a significant asymmetry of the magnetospheric convection pattern as mapped onto the high latitude thermosphere and ionosphere. The resulting response of the polar thermospheric winds during periods when BY is either positive or negative is quite distinct, with pronounced changes in the relative strength of thermospheric winds in the dusk-dawn parts of the polar cap and in the dawn part of the auroral oval. In a study of four periods when there was a clear signature of BY, observed by the ISEE-3 satellite, with observations of polar winds and electric fields from the Dynamics Explorer-2 satellite and with wind observations by a ground-based Fabry-Perot interferometer located in Kiruna, Northern Sweden, it is possible to explain features of the high latitude thermospheric circulation using three dimensional global models including BY dependent, asymmetric, polar convection fields. Ground-based Fabry-Perot interferometers often observe anomalously low zonal wind velocities in the (Northern) dawn auroral oval during periods of extremely high geomagnetic activity when BY is positive. Conversely, for BY negative, there is an early transition from westward to southward and eastward winds in the evening auroral oval (excluding the effects of auroral substorms), and extremely large eastward (sunward) winds may be driven in the auroral oval after magnetic midnight. These observations are matched by the observation of strong anti-sunward polar-cap wind jets from the DE-2 satellite, on the dusk side with BY negative, and on the dawn side with BY positive.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26311/1/0000396.pd

Susceptibility of adult cat fleas (Siphonaptera: Pulicidae) to insecticides and status of insecticide resistance mutations at the Rdl and knockdown resistance loci

This is an Open Access article. © 2015 The Author(s). Published by Springer Berlin Heidelberg.The susceptibility of 12 field-collected isolates and 4 laboratory strains of cat fleas, Ctenocephalides felis was determined by topical application of some of the insecticides used as on-animal therapies to control them. In the tested field-collected flea isolates the LD50 values for fipronil and imidacloprid ranged from 0.09 to 0.35 ng/flea and 0.02 to 0.19 ng/flea, respectively, and were consistent with baseline figures published previously. The extent of variation in response to four pyrethroid insecticides differed between compounds with the LD50 values for deltamethrin ranging from 2.3 to 28.2 ng/flea, etofenprox ranging from 26.7 to 86.7 ng/flea, permethrin ranging from 17.5 to 85.6 ng/flea, and d-phenothrin ranging from 14.5 to 130 ng/flea. A comparison with earlier data for permethrin and deltamethrin implied a level of pyrethroid resistance in all isolates and strains. LD50 values for tetrachlorvinphos ranged from 20.0 to 420.0 ng/flea. The rdl mutation (conferring target-site resistance to cyclodiene insecticides) was present in most field-collected and laboratory strains, but had no discernible effect on responses to fipronil, which acts on the same receptor protein as cyclodienes. The kdr and skdr mutations conferring target-site resistance to pyrethroids but segregated in opposition to one another, precluding the formation of genotypes homozygous for both mutations.Peer reviewedFinal Published versio

Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource

Objective: Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn’s disease (CD), including their impact on need for surgery. Design: Outcomes were assessed in 11 928 patients (4968 UC, 6960 CD) in the UK IBD BioResource initiated on thiopurine monotherapy with the intention of maintaining medically induced remission. Effectiveness was assessed retrospectively using patient-level data and a definition that required avoidance of escalation to biological therapy or surgery while on thiopurines. Analyses included overall effectiveness, time-to-event analysis for treatment escalation and comparison of surgery rates in patients tolerant or intolerant of thiopurines. Results: Using 68 132 patient-years of exposure, thiopurine monotherapy appeared effective for the duration of treatment in 2617/4968 (52.7%) patients with UC compared with 2378/6960 (34.2%) patients with CD (p<0.0001). This difference was corroborated in a multivariable analysis: after adjusting for variables including treatment era, thiopurine monotherapy was less effective in CD than UC (OR 0.47, 95% CI 0.43 to 0.51, p<0.0001). Thiopurine intolerance was associated with increased risk of surgery in UC (HR 2.44, p<0.0001); with a more modest impact on need for surgery in CD (HR=1.23, p=0.0015). Conclusion: Thiopurine monotherapy is an effective long-term treatment for UC but significantly less effective in CD

A communal catalogue reveals Earth's multiscale microbial diversity

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe

A communal catalogue reveals Earth’s multiscale microbial diversity

Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity

Thirty years of Biology & Philosophy: philosophy of which biology?

Which domains of biology do philosophers of biology primarily study? The fact that philosophy of biology has been dominated by an interest for evolutionary biology is widely admitted, but it has not been strictly demonstrated. Here I analyse the topics of all the papers published in Biology & Philosophy, just as the journal celebrates its thirtieth anniversary. I then compare the distribution of biological topics in Biology & Philosophy with that of the scientific journal Proceedings of the National Academy of Science of the USA, focusing on the recent period 2003-2015. This comparison reveals a significant mismatch between the distributions of these topics. I examine plausible explanations for that mismatch. Finally, I argue that many biological topics underrepresented in philosophy of biology raise important philosophical issues and should therefore play a more central role in future philosophy of biology