Mitochondrial membrane lipidome defines yeast longevity

Our studies revealed that lithocholic acid (LCA), a bile acid, is a potent anti‐aging natural compound that in yeast cultured under longevity‐extending caloric restriction (CR) conditions acts in synergy with CR to enable a significant further increase in chronological lifespan. Here, we investigate a mechanism underlying this robust longevity‐extending effect of LCA under CR. We found that exogenously added LCA enters yeast cells, is sorted to mitochondria, resides mainly in the inner mitochondrial membrane, and also associates with the outer mitochondrial membrane. LCA elicits an age‐related remodeling of glycerophospholipid synthesis and movement within both mitochondrial membranes, thereby causing substantial changes in mitochondrial membrane lipidome and triggering major changes in mitochondrial size, number and morphology. In synergy, these changes in the membrane lipidome and morphology of mitochondria alter the age‐related chronology of mitochondrial respiration, membrane potential, ATP synthesis and reactive oxygen species homeostasis. The LCA‐driven alterations in the age‐related dynamics of these vital mitochondrial processes extend yeast longevity. In sum, our findings suggest a mechanism underlying the ability of LCA to delay chronological aging in yeast by accumulating in both mitochondrial membranes and altering their glycerophospholipid compositions. We concluded that mitochondrial membrane lipidome plays an essential role in defining yeast longevity

The Many Manifestations of Downsizing: Hierarchical Galaxy Formation Models confront Observations

[abridged] It has been widely claimed that several lines of observational evidence point towards a "downsizing" (DS) of the process of galaxy formation over cosmic time. This behavior is sometimes termed "anti-hierarchical", and contrasted with the "bottom-up" assembly of the dark matter structures in Cold Dark Matter models. In this paper we address three different kinds of observational evidence that have been described as DS: the stellar mass assembly, star formation rate and the ages of the stellar populations in local galaxies. We compare a broad compilation of available data-sets with the predictions of three different semi-analytic models of galaxy formation within the Lambda-CDM framework. In the data, we see only weak evidence at best of DS in stellar mass and in star formation rate. We find that, when observational errors on stellar mass and SFR are taken into account, the models acceptably reproduce the evolution of massive galaxies, over the entire redshift range that we consider. However, lower mass galaxies are formed too early in the models and are too passive at late times. Thus, the models do not correctly reproduce the DS trend in stellar mass or the archaeological DS, while they qualitatively reproduce the mass-dependent evolution of the SFR. We demonstrate that these discrepancies are not solely due to a poor treatment of satellite galaxies but are mainly connected to the excessively efficient formation of central galaxies in high-redshift haloes with circular velocities ~100-200 km/s. [abridged]Comment: MNRAS accepted, 16 pages, 10 figure

DESI Survey Validation Spectra Reveal an Increasing Fraction of Recently Quenched Galaxies at z∼1z\sim1

We utilize $\sim17000$ bright Luminous Red Galaxies (LRGs) from the novel Dark Energy Spectroscopic Instrument Survey Validation spectroscopic sample, leveraging its deep ($\sim2.5$ hour/galaxy exposure time) spectra to characterize the contribution of recently quenched galaxies to the massive galaxy population at $0.4<z<1.3$. We use Prospector to infer non-parametric star formation histories and identify a significant population of post-starburst galaxies that have joined the quiescent population within the past $\sim1$ Gyr. The highest redshift subset (277 at $z>1$) of our sample of recently quenched galaxies represents the largest spectroscopic sample of post-starburst galaxies at that epoch. At $0.4<z<0.8$, we measure the number density of quiescent LRGs, finding that recently quenched galaxies constitute a growing fraction of the massive galaxy population with increasing lookback time. Finally, we quantify the importance of this population amongst massive ($\mathrm{log}(M_\star/M_\odot)>11.2$) LRGs by measuring the fraction of stellar mass each galaxy formed in the Gyr before observation, $f_{\mathrm{1 Gyr}}$. Although galaxies with $f_{\mathrm{1 Gyr}}>0.1$ are rare at $z\sim0.4$ ($\lesssim 0.5\%$ of the population), by $z\sim0.8$ they constitute $\sim3\%$ of massive galaxies. Relaxing this threshold, we find that galaxies with $f_\mathrm{1 Gyr}>5\%$ constitute $\sim10\%$ of the massive galaxy population at $z\sim0.8$. We also identify a small but significant sample of galaxies at $z=1.1-1.3$ that formed with $f_{\mathrm{1 Gyr}}>50\%$, implying that they may be analogues to high-redshift quiescent galaxies that formed on similar timescales. Future analysis of this unprecedented sample promises to illuminate the physical mechanisms that drive the quenching of massive galaxies after cosmic noon.Comment: Submitted to ApJ Letters after DESI Collaboration Review. 14 pages, 5 figures, comments welcome

DUALZ: Deep UNCOVER-ALMA Legacy High-Z Survey

We present the survey design and initial results of the ALMA Cycle 9 program of DUALZ, which aims to establish a joint ALMA and JWST public legacy field targeting the massive galaxy cluster Abell 2744. DUALZ features a contiguous $4'\times6'$ ALMA 30-GHz-wide mosaic in Band 6, covering areas of $\mu>2$ down to a sensitivity of $\sigma=32.7~\mu$Jy. Through a blind search, we identified 69 dust continuum sources at S/N $\gtrsim5.0$ with median redshift and intrinsic 1.2-mm flux of $z=2.30$ and $S_{\rm 1.2mm}^{\rm int}=0.24$~mJy. Of these, 27 have been spectroscopically confirmed, leveraged by the latest NIRSpec observations, while photometric redshift estimates are constrained by the comprehensive HST, NIRCam, and ALMA data for the remaining sources. With priors, we further identify a [CII]158 $\mu$m line emitter at $z=6.3254\pm0.0004$, confirmed by the latest NIRSpec spectroscopy. The NIRCam counterparts of the 1.2-mm continuum exhibit undisturbed morphologies, denoted either by disk or spheroid, implying the triggers for the faint mm emission are less catastrophic than mergers. We have identified 8 HST-dark galaxies (F150W$>$27mag, F150W$-$F444W$>$2.3) and 2 JWST-dark (F444W$>$30mag) galaxy candidates among the ALMA continuum sources. The former includes face-on disk galaxies, hinting that substantial dust obscuration does not always result from inclination. We also detect a marginal dust emission from an X-ray-detected galaxy at $z_{\rm spec}=10.07$, suggesting an active co-evolution of the central black hole and its host. We assess the infrared luminosity function up to $z\sim10$ and find it consistent with predictions from galaxy formation models. To foster diverse scientific outcomes from the community, we publicly release reduced ALMA mosaic maps, cubes, and the source catalog.Comment: 33 pages, 16 figures, and 5 tables. Submitted to ApJS. The ALMA products are fully available from here: https://jwst-uncover.github.io/DR2.html#DUAL

The JWST UNCOVER Treasury survey: Ultradeep NIRSpec and NIRCam ObserVations before the Epoch of Reionization

In this paper we describe the survey design for the Ultradeep NIRSpec and NIRCam ObserVations before the Epoch of Reionization (UNCOVER) Cycle 1 JWST Treasury program, which executed its early imaging component in November 2022. The UNCOVER survey includes ultradeep ($\sim29-30\mathrm{AB}$) imaging of $\sim$45 arcmin$^2$ on and around the well-studied Abell 2744 galaxy cluster at $z=0.308$ and will follow-up ${\sim}500$ galaxies with extremely deep low-resolution spectroscopy with the NIRSpec/PRISM during the summer of 2023. We describe the science goals, survey design, target selection, and planned data releases. We also present and characterize the depths of the first NIRCam imaging mosaic, highlighting previously unparalleled resolved and ultradeep 2-4 micron imaging of known objects in the field. The UNCOVER primary NIRCam mosaic spans 28.8 arcmin$^2$ in seven filters (F115W, F150W, F200W, F277W, F356W, F410M, F444W) and 16.8 arcmin$^2$ in our NIRISS parallel (F115W, F150W, F200W, F356W, and F444W). To maximize early community use of the Treasury data set, we publicly release full reduced mosaics of public JWST imaging including 45 arcmin$^2$ NIRCam and 17 arcmin$^2$ NIRISS mosaics on and around the Abell 2744 cluster, including the Hubble Frontier Field primary and parallel footprints.Comment: 17 pages, 8 figures, 4 tables, submitted to ApJ, comments welcome (v2 with full author list in metadata

The Physical Conditions of Emission-Line Galaxies at Cosmic Dawn from JWST/NIRSpec Spectroscopy in the SMACS 0723 Early Release Observations

We present rest-frame optical emission-line flux ratio measurements for five $z>5$ galaxies observed by the JWST Near-Infared Spectrograph (NIRSpec) in the SMACS 0723 Early Release Observations. We add several quality-control and post-processing steps to the NIRSpec pipeline reduction products in order to ensure reliable relative flux calibration of emission lines that are closely separated in wavelength, despite the uncertain \textit{absolute} spectrophotometry of the current version of the reductions. Compared to $z\sim3$ galaxies in the literature, the $z>5$ galaxies have similar [OIII]$\lambda$5008/H$\beta$ ratios, similar [OIII]$\lambda$4364/H$\gamma$ ratios, and higher ($\sim$0.5 dex) [NeIII]$\lambda$3870/[OII]$\lambda$3728 ratios. We compare the observations to MAPPINGS V photoionization models and find that the measured [NeIII]$\lambda$3870/[OII]$\lambda$3728, [OIII]$\lambda$4364/H$\gamma$, and [OIII]$\lambda$5008/H$\beta$ emission-line ratios are consistent with an interstellar medium that has very high ionization ($\log(Q) \simeq 8-9$, units of cm~s$^{-1}$), low metallicity ($Z/Z_\odot \lesssim 0.2$), and very high pressure ($\log(P/k) \simeq 8-9$, units of cm$^{-3}$). The combination of [OIII]$\lambda$4364/H$\gamma$ and [OIII]$\lambda$(4960+5008)/H$\beta$ line ratios indicate very high electron temperatures of $4.1<\log(T_e/{\rm K})<4.4$, further implying metallicities of $Z/Z_\odot \lesssim 0.2$ with the application of low-redshift calibrations for ``$T_e$-based'' metallicities. These observations represent a tantalizing new view of the physical conditions of the interstellar medium in galaxies at cosmic dawn.Comment: Accepted for publication in AAS Journals. 14 pages, 6 figures, 3 table

CANDELS: The Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey

The Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) is designed to document the first third of galactic evolution, over the approximate redshift (z) range 8--1.5. It will image >250,000 distant galaxies using three separate cameras on the Hubble Space Telescope, from the mid-ultraviolet to the near-infrared, and will find and measure Type Ia supernovae at z>1.5 to test their accuracy as standardizable candles for cosmology. Five premier multi-wavelength sky regions are selected, each with extensive ancillary data. The use of five widely separated fields mitigates cosmic variance and yields statistically robust and complete samples of galaxies down to a stellar mass of 10^9 M_\odot to z \approx 2, reaching the knee of the ultraviolet luminosity function (UVLF) of galaxies to z \approx 8. The survey covers approximately 800 arcmin^2 and is divided into two parts. The CANDELS/Deep survey (5\sigma\ point-source limit H=27.7 mag) covers \sim 125 arcmin^2 within GOODS-N and GOODS-S. The CANDELS/Wide survey includes GOODS and three additional fields (EGS, COSMOS, and UDS) and covers the full area to a 5\sigma\ point-source limit of H \gtrsim 27.0 mag. Together with the Hubble Ultra Deep Fields, the strategy creates a three-tiered "wedding cake" approach that has proven efficient for extragalactic surveys. Data from the survey are nonproprietary and are useful for a wide variety of science investigations. In this paper, we describe the basic motivations for the survey, the CANDELS team science goals and the resulting observational requirements, the field selection and geometry, and the observing design. The Hubble data processing and products are described in a companion paper.Comment: Submitted to Astrophysical Journal Supplement Series; Revised version, subsequent to referee repor

Patterns of leisure-time physical activity participation in a British birth cohort at early old age.

Using data from a nationally representative British birth cohort we characterized the type and diversity of leisure-time physical activity that 2,188 participants (age 60–64 years) engaged in throughout the year by gender and obesity. Participants most commonly reported walking (71%), swimming (33%), floor exercises (24%) and cycling (15%). Sixty-two percent of participants reported $2 activities in the past year and 40% reported diversity on a regular basis. Regular engagement in different types of activity (cardio-respiratory, balance/flexibility and strength) was reported by 67%, 19% and 11% of participants, respectively. We found gender differences, as well as differences by obesity status, in the activities reported, the levels of activity diversity and activity type. Non-obese participants had greater activity diversity, and more often reported activities beneficial for cardio-respiratory health and balance/flexibility than obese participants. These findings may be used to inform the development of trials of physical activity interventions targeting older adults, and those older adults with high body mass index

Childhood socioeconomic position and adult leisure-time physical activity: A systematic review

Regular leisure-time physical activity (LTPA) benefits health and is thought to be less prevalent in lower socioeconomic groups. Evidence suggests that childhood socioeconomic circumstances can impact on adult health and behaviour however, it is unclear if this includes an influence on adult LTPA. This review tested the hypothesis that a lower childhood socioeconomic position (SEP) is associated with less frequent LTPA during adulthood. Studies were located through a systematic search of MEDLINE, Embase, PsycINFO, CINAHL and SPORTDiscus and by searching reference lists. Eligible studies were English-language publications testing the association between any indicator of childhood SEP and an LTPA outcome measured during adulthood. Forty-five papers from 36 studies, most of which were European, were included. In most samples, childhood SEP and LTPA were self-reported in midlife. Twenty-two studies found evidence to support the review’s hypothesis and thirteen studies found no association. Accounting for own adult SEP partly attenuated associations. There was more evidence of an association in British compared with Scandinavian cohorts and in women compared with men. Results did not vary by childhood SEP indicator or age at assessment of LTPA. This review found evidence of an association between less advantaged childhood SEP and less frequent LTPA during adulthood. Understanding how associations vary by gender and place could provide insights into underlying pathways