106 research outputs found
Patients' Understanding of How Genotype Variation Affects Benefits of Tamoxifen Therapy for Breast Cancer
CYP2D6 is a critical enzyme in the metabolism of tamoxifen and potentially a key determinant in breast cancer outcomes. Our study examined patients' beliefs about how CYP2D6 genotype would affect their prognoses
Study of the lineshape of the chi(c1) (3872) state
A study of the lineshape of the chi(c1) (3872) state is made using a data sample corresponding to an integrated luminosity of 3 fb(-1) collected in pp collisions at center-of-mass energies of 7 and 8 TeV with the LHCb detector. Candidate chi(c1)(3872) and psi(2S) mesons from b-hadron decays are selected in the J/psi pi(+)pi(-) decay mode. Describing the lineshape with a Breit-Wigner function, the mass splitting between the chi(c1 )(3872) and psi(2S) states, Delta m, and the width of the chi(c1 )(3872) state, Gamma(Bw), are determined to be (Delta m=185.598 +/- 0.067 +/- 0.068 Mev,)(Gamma BW=1.39 +/- 0.24 +/- 0.10 Mev,) where the first uncertainty is statistical and the second systematic. Using a Flatte-inspired model, the mode and full width at half maximum of the lineshape are determined to be (mode=3871.69+0.00+0.05 MeV.)(FWHM=0.22-0.04+0.13+0.07+0.11-0.06-0.13 MeV, ) An investigation of the analytic structure of the Flatte amplitude reveals a pole structure, which is compatible with a quasibound D-0(D) over bar*(0) state but a quasivirtual state is still allowed at the level of 2 standard deviations
Measurement of the CKM angle in and decays with
A measurement of -violating observables is performed using the decays
and , where the meson is
reconstructed in one of the self-conjugate three-body final states and (commonly denoted ). The decays are analysed in bins of the -decay phase space, leading
to a measurement that is independent of the modelling of the -decay
amplitude. The observables are interpreted in terms of the CKM angle .
Using a data sample corresponding to an integrated luminosity of
collected in proton-proton collisions at centre-of-mass
energies of , , and with the LHCb experiment,
is measured to be . The hadronic
parameters , , , and ,
which are the ratios and strong-phase differences of the suppressed and
favoured decays, are also reported
THE RATE OF BINARY BLACK HOLE MERGERS INFERRED FROM ADVANCED LIGO OBSERVATIONS SURROUNDING GW150914
A transient gravitational-wave signal, GW150914, was identi
fi
ed in the twin Advanced LIGO detectors on 2015
September 2015 at 09:50:45 UTC. To asse
ss the implications of this discovery,
the detectors remained in operation with
unchanged con
fi
gurations over a period of 39 days around the time of t
he signal. At the detection statistic threshold
corresponding to that observed for GW150914, our search of the 16 days of simultaneous two-detector observational
data is estimated to have a false-alarm rate
(
FAR
)
of
<
́
--
4.9 10 yr
61
, yielding a
p
-value for GW150914 of
<
́
-
210
7
. Parameter estimation follo
w-up on this trigger identi
fi
es its source as a binary black hole
(
BBH
)
merger
with component masses
(
)(
)
=
-
+
-
+
mm
M
,36,29
12
4
5
4
4
at redshift
=
-
+
z
0.09
0.04
0.03
(
median and 90% credible range
)
.
Here, we report on the constraints these observations place on the rate of BBH coalescences. Considering only
GW150914, assuming that all BBHs in the universe have the same masses and spins as this event, imposing a search
FAR threshold of 1 per 100 years, and assuming that the BBH merger rate is constant in the comoving frame, we infer a
90% credible range of merger rates between
–
--
2
53 Gpc yr
31
(
comoving frame
)
. Incorporating all search triggers that
pass a much lower threshold while accounting for the uncerta
inty in the astrophysical origin of each trigger, we estimate
a higher rate, ranging from
–
--
13 600 Gpc yr
31
depending on assumptions about the BBH mass distribution. All
together, our various rate estimat
es fall in the conservative range
–
--
2
600 Gpc yr
31
Study of the doubly charmed tetraquark T+cc
Quantum chromodynamics, the theory of the strong force, describes interactions of coloured quarks and gluons and the formation of hadronic matter. Conventional hadronic matter consists of baryons and mesons made of three quarks and quark-antiquark pairs, respectively. Particles with an alternative quark content are known as exotic states. Here a study is reported of an exotic narrow state in the D0D0π+ mass spectrum just below the D*+D0 mass threshold produced in proton-proton collisions collected with the LHCb detector at the Large Hadron Collider. The state is consistent with the ground isoscalar T+cc tetraquark with a quark content of ccu⎯⎯⎯d⎯⎯⎯ and spin-parity quantum numbers JP = 1+. Study of the DD mass spectra disfavours interpretation of the resonance as the isovector state. The decay structure via intermediate off-shell D*+ mesons is consistent with the observed D0π+ mass distribution. To analyse the mass of the resonance and its coupling to the D*D system, a dedicated model is developed under the assumption of an isoscalar axial-vector T+cc state decaying to the D*D channel. Using this model, resonance parameters including the pole position, scattering length, effective range and compositeness are determined to reveal important information about the nature of the T+cc state. In addition, an unexpected dependence of the production rate on track multiplicity is observed
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