Effective transport properties of drug delivery systems: Porous granules and tablets

Solid dosage forms such as tablets, granules or capsules represent over 80% of all pharmaceutical products. Modern pharmaceutical formulations are designed so as to release the active pharmaceutical ingredient (API) at a well-defined and reproducible rate. Two main classes of dosage forms can be distinguished: rapid release formulations (which are designed to disintegrate rapidly and dissolve the API within the shortest possible time), and sustained release formulations (which are designed to release the API gradually over a prolonged period of time, typically 24 hours). In both cases, the effective transport properties of the drug carrier (granule, tablet) play a crucial role. Please download the full abstract below