131 research outputs found
Alien Registration- Profenno, Mary C. (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/25525/thumbnail.jp
The restorative role of annexin A1 at the blood–brain barrier
Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune
system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the
study of this molecule in the central nervous system (CNS), focusing particularly on the primary interface between the
peripheral body and CNS: the blood–brain barrier. In this review, we provide an overview of the role of this molecule
in the brain, with a particular emphasis on its functions in the endothelium of the blood–brain barrier, and the protective
actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease. We focus on the
possible new therapeutic avenues opened up by an increased understanding of the role of annexin A1 in the CNS
vasculature, and its potential for repairing blood–brain barrier damage in disease and aging
Glucose but not insulin or insulin resistance is associated with memory performance in middle-aged non-diabetic women: a cross sectional study
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration
Alzheimer’s disease (AD) is a complex, multifactorial disease with a number of leading mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to amyloid β peptide, tau protein hyperphosphorylation, relocalization and deposition. These mechanisms are propagated by obesity, the metabolic syndrome and type-2 diabetes mellitus. Stress, sedentariness, dietary overconsumption of saturated fat and refined sugars, and circadian derangements/disturbed sleep contribute to obesity and related metabolic diseases, but also accelerate age-related damage and senescence that all feed the risk of developing AD too. The complex and interacting mechanisms are not yet completely understood and will require further analysis. Instead of investigating AD as a mono- or oligocausal disease we should address the disease by understanding the multiple underlying mechanisms and how these interact. Future research therefore might concentrate on integrating these by systems biology approaches, but also to regard them from an evolutionary medicine point of view. The current review addresses several of these interacting mechanisms in animal models and compares them with clinical data giving an overview about our current knowledge and puts them into an integrated framework
Alien Registration- Profenno, Antonia (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/25524/thumbnail.jp
Alien Registration- Profenno, Mary C. (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/25525/thumbnail.jp
Alien Registration- Profenno, Antonia (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/25524/thumbnail.jp
Alien Registration- Profenno, Mary C. (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/25525/thumbnail.jp
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