Gestion optimisée d'un modèle d'agrégation de flexibilités diffuses

The desire to increase the share of renewable energies in the energy mix leads to an increase inshare of volatile and non-controllable energy and makes it difficult to meet the supply-demand balance. A solution to manage anyway theses energies in the current electrical grid is to deploy new energy storage and demand response systems across the country to counter balance under or over production. In order to integrate all these energies systems to the supply and demand balance process, there are gathered together within a virtual flexibility aggregation power plant which is then seen as a virtual power plant. As for any other power plant, it is necessary to compute its production plan. Firstly, we propose in this PhD thesis an architecture and management method for an aggregation power plant composed of any type of energies systems. Then, we propose algorithms to compute the production plan of any types of energy systems satisfying all theirs constraints. Finally, we propose an approach to compute the production plan of the aggregation power plant in order to maximize its financial profit while complying with all the constraints of the grid.Le souhait d’augmenter la part des énergies renouvelables dans le mix énergétique entraine une augmentation des parts des énergies volatiles et non pilotables, et rend donc l’équilibre offre-demande difficile à satisfaire. Une façon d’intégrer ces énergies dans le réseau électrique actuel est d’utiliser de petits moyens de production, de consommation et de stockage répartis sur tout le territoire pour compenser les sous ou sur productions. Afin que ces procédés puissent être intégrés dans le processus d’équilibre offre-demande, ils sont regroupés au sein d’une centrale virtuelle d’agrégation de flexibilité, qui est vue alors comme une centrale virtuelle. Comme pour tout autre moyen de production du réseau, il est nécessaire de déterminer son plan de production. Nous proposons dans un premier temps dans cette thèse une architecture et un mode de gestion pour une centrale d’agrégation composée de n’importe quel type de procédés. Dans un second temps, nous présentons des algorithmes permettant de calculer le plan de production des différents types de procédés respectant toutes leurs contraintes de fonctionnement. Et enfin, nous proposons des approches pour calculer le plan de production de la centrale d’agrégation dans le but de maximiser son gain financier en respectant les contraintes réseau

Programa intensivo ERASMUS: TOPCART. Documentación Geométrica del Patrimonio (memoria de actividades 2010-2011)

[EN] Data contained in this record come from the following accademic activity (from which it is possible to locate additional records related with the Monastery):● LDGP_inv_002: "Intensive Program ERASMUS: TOPCART. Geometric Documentation of the Heritage (administrative and academic documentation)", http://hdl.handle.net/10810/9906[ES] Los datos de este registro provienen de la una actividad académica que también aparece descrita en el repositorio y desde donde se puede acceder a otros trabajos relacionados con el Monasterio:● LDGP_inv_002: "Programa intensivo ERASMUS: TOPCART. Documentación Geométrica del Patrimonio (documentación administrativa y académica)", http://hdl.handle.net/10810/9906[EN] The main objective this project is looking for is the exchange of practical methodologies, in topics related with the measure and representation of heritage, between teachers and specially students from different countries. For the achievement of this aim we expect the participation of a group of about 30 students and 8 lecturers from Germany, Italy, Greece, Lithuania and Spain.Activities will be focused on the development of concrete projects in documentation of heritage, specifically in the San Prudencio Monastery (La Rioja, Spain). In this site, digital techniques for the acquisition of geometric information from GPS equipment, surveying total stations, laser scanner and photogrammetry systems, will be put into practice.Obtained data will be processed as follows: first of all, they will be documented by adding necessary metadata in order to ensure their use in the future, then, they will be treated to obtain cartographic representations and virtual models which can be distributed on the Internet.As results we expect: metric data of the monument, graphic models for difussion and collaboration partnertships.[ES] El objetivo principal que se persigue en este proyecto es el intercambio de metodológico práctico, en materias afines a la medida y la representación del patrimonio, entre profesores y fundamentalmente alumnos, de diferentes países. Para la consecución de este fin se espera la participación de un grupo de aproximadamente 25 alumnos y 8 profesores de (Alemania, Italia, Grecia, Lituania y España).Las actividades se centrarán en el desarrollo de proyectos concretos de documentación de elementos patrimoniales, en concreto el apartado práctico se desarrollará en el Monasterio de San Prudencio (La Rioja, España). En el se aplicarán técnicas digitales de registro de información geométrica, constituidas por receptores GPS, estaciones totales topográficas, escáneres láser y sistemas fotogramétricos.Los datos obtenidos serán tratados de la siguiente manera: en primer lugar serán documentados, mediante la adición de la metainformación necesaria para garantizar su utilidad a lo largo del tiempo, seguidamente serán procesados con el fin de obtener las representaciones cartográficas y modelos virtuales de representación que puedan ser difundidas por medio de Internet.Como resultados se pretenden: un conjunto de registros métricos del momento de la intervención, modelos gráficos de difusión y finalmente relaciones de colaboración interpersonal e interinstitucional.European Commission, DG Education and Culture (Erasmus 2009-1-ES1-ERAIP-0013, 2010-1-ES1-ERA10-0024); Organismo Autónomo Programas Educativos Europeos (OAPEE); Gobierno de La Rioja (Spain); Universidad de La Rioja; Clavijo City Council; Logroño City Council; Ilustre Colegio de Ingenieros Técnicos en Topografía (Delegación de La Rioja)[ES] Memoria de proyecto (PDF) [es el último fichero de la lista, el enlace directo es https://addi.ehu.es/bitstream/10810/7053/1053/ldgp_mem011-1_Clavijo_SanPrudencio.pdf] + 11 imágenes de la visita preliminar en abril de 2009, en formato JPEG + 19 nubes de puntos en formato txt (comprimido en ZIP junto a un fichero de metadatos y una imagen que sirve de croquis y que también se presenta suelta) + 27 fotografías tomadas desde un helicóptero radicontrolado en 2011 por el grupo H (JPEG) + 18 fotografías métricas del edificio en forma de -L- tomadas desde el Sur + 13 fotografías métricas del edificio en forma de -L- tomadas desde el Este + 95 fotografías métricas del interior del edificio en forma de -L- (JPEG) + 35 fotografías métricas tomadas desde el cerro que se encuentra al sur (JPEG) + 8 fotografías métricas que forman 4 pares estereoscópicos (2 del grupo B y 2 del grupo D) (JPEG) + 183 fotografías métricas que forman 91 tripletas (grupos B, C y D) (JPEG). [NOTA: este registro no está cerrado, se irán incorporando nuevos materiales de forma progresiva][EN] General report (PDF) [it is the last file of the list, the direct link is https://addi.ehu.es/bitstream/10810/7053/1053/ldgp_mem011-1_Clavijo_SanPrudencio.pdf] + 11 pictures taken during the preliminary visit in April 2009 (JPEG format) + 19 point clouds in plain text (compressed in a ZIP file together with a file with metadata and an image PNG as sketch, these image are also presented on their own) + 27 photographs taken from a remote-controlled helicopter for the group H in 2011(JPEG) + 18 metric pictures of the L-shaped building taken from the South (JPEG) + 13 metric pictures of the L-shaped building taken from the East (JPEG) + 95 metric pictures of the inside part of the L-shaped building (JPEG) + 35 metric photographs taken from the hill opposite in the Southern + 8 metric photographs in four stereopairs (2 from group B and 2 from group D) (JPEG) + 183 metric photographs arranged in 91 triplets from groups B, C and D (JPEG). [NOTE: this record is not closed, more data will be uploaded progressively

Present state and future perspectives of using pluripotent stem cells in toxicology research

The use of novel drugs and chemicals requires reliable data on their potential toxic effects on humans. Current test systems are mainly based on animals or in vitro–cultured animal-derived cells and do not or not sufficiently mirror the situation in humans. Therefore, in vitro models based on human pluripotent stem cells (hPSCs) have become an attractive alternative. The article summarizes the characteristics of pluripotent stem cells, including embryonic carcinoma and embryonic germ cells, and discusses the potential of pluripotent stem cells for safety pharmacology and toxicology. Special attention is directed to the potential application of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) for the assessment of developmental toxicology as well as cardio- and hepatotoxicology. With respect to embryotoxicology, recent achievements of the embryonic stem cell test (EST) are described and current limitations as well as prospects of embryotoxicity studies using pluripotent stem cells are discussed. Furthermore, recent efforts to establish hPSC-based cell models for testing cardio- and hepatotoxicity are presented. In this context, methods for differentiation and selection of cardiac and hepatic cells from hPSCs are summarized, requirements and implications with respect to the use of these cells in safety pharmacology and toxicology are presented, and future challenges and perspectives of using hPSCs are discussed

Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

Background and purpose: Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods: In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results: The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions: Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration: URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013

Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation. the GLORIA-AF registry

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007

Qualidade dos investimentos brasileiros: papel e limitações do BNDES

XX Encontro Nacional de Economia Política: desenvolvimento Latino-Americano, Integração e Inserção Internacional - UNILA, Foz do Iguaçu, 26 a 29 de maio de 2015O BNDES é a principal instituição de estímulo ao desenvolvimento nacional, responsável por realizar a alocação de uma parte signifi cativa da poupança para setores estratégicos. A hipótese testada é que a taxa de crescimento limitada do PIB não se deve apenas à baixa taxa de investimento, mas à baixa qualidade dos investimentos nacionais e dos recursos liberados pelo BNDES, destinados a setores que possuem baixos ganhos de produtividade. A análise da evolução histórica do BNDES mostra que ele não é imune a pressão política, a qual resulta em uma mudança frequente nos objetivos perseguidos, comprometendo os objetivos de longo prazo relacionados ao desenvolvimento nacional. Os fi nanciamentos do BNDES exercem uma pressão seletiva sobre a estrutura produtiva nacional, induzindo uma especialização regressiva, que benefi cia setores que geram menor crescimento no PIB e menor nível de rendaBanco Nacional de Desenvolvimento Econômico e Social (BNDES); Usina Hidrelétrica de Itaipu (ITAIPU); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Universidade Federal da Integração Latino-Americana (UNILA

Optimized management of a distributed demand response aggregation model

Le souhait d’augmenter la part des énergies renouvelables dans le mix énergétique entraine une augmentation des parts des énergies volatiles et non pilotables, et rend donc l’équilibre offre-demande difficile à satisfaire. Une façon d’intégrer ces énergies dans le réseau électrique actuel est d’utiliser de petits moyens de production, de consommation et de stockage répartis sur tout le territoire pour compenser les sous ou sur productions. Afin que ces procédés puissent être intégrés dans le processus d’équilibre offre-demande, ils sont regroupés au sein d’une centrale virtuelle d’agrégation de flexibilité, qui est vue alors comme une centrale virtuelle. Comme pour tout autre moyen de production du réseau, il est nécessaire de déterminer son plan de production. Nous proposons dans un premier temps dans cette thèse une architecture et un mode de gestion pour une centrale d’agrégation composée de n’importe quel type de procédés. Dans un second temps, nous présentons des algorithmes permettant de calculer le plan de production des différents types de procédés respectant toutes leurs contraintes de fonctionnement. Et enfin, nous proposons des approches pour calculer le plan de production de la centrale d’agrégation dans le but de maximiser son gain financier en respectant les contraintes réseau.The desire to increase the share of renewable energies in the energy mix leads to an increase inshare of volatile and non-controllable energy and makes it difficult to meet the supply-demand balance. A solution to manage anyway theses energies in the current electrical grid is to deploy new energy storage and demand response systems across the country to counter balance under or over production. In order to integrate all these energies systems to the supply and demand balance process, there are gathered together within a virtual flexibility aggregation power plant which is then seen as a virtual power plant. As for any other power plant, it is necessary to compute its production plan. Firstly, we propose in this PhD thesis an architecture and management method for an aggregation power plant composed of any type of energies systems. Then, we propose algorithms to compute the production plan of any types of energy systems satisfying all theirs constraints. Finally, we propose an approach to compute the production plan of the aggregation power plant in order to maximize its financial profit while complying with all the constraints of the grid

Approches génériques pour calculer le plan de production des procédés d'un smart grid

International audienceLe souhait d'augmenter la part des énergies renouvelables dans le mix énergétique entraine une augmentation des parts des énergies non pilotables. Une façon d'intégrer ces énergies dans le réseau électrique actuel est de moduler la courbe de charge en utilisant des procédés regroupés au sein d'un smart grid. Afin de piloter ce dernier comme une centrale classique il est nécessaire de déterminer son plan de production, ce qui implique de calculer très rapidement le plan de production de chacun de ses procédés. L'objectif principal de cette étude est donc de calculer le plan de production optimal de n'importe quel type de procédé en moins d'une minute, de façon à maximiser son gain en fonction d'un signal de prix reçu. Les procédés peuvent être classés en six groupes : les procédés de production pilotable, de consommation pilotable, de déplacement de production non pilotable, de consommation non pilotable, de stockage, et de déplacement de consommation pilotable. Suivant leur nature, ces procédés ont des caractéristiques différentes et peuvent être soumis à diverses contraintes.  Nous proposons un modèle générique de programmation par contraintes (PPC) et un modèle générique de programmation linéaire en nombres entiers (PLNE). Les résultats montrent que les premières solutions trouvées par le solveur de PLNE sont très éloignées de l'optimum, alors que la méthode de PPC fournit très rapidement de bonnes solutions. En utilisant la PPC afin de trouver une solution initiale pour le solveur de PLNE, les résultats sont nettement améliorés : le gap moyen pour la combinaison des deux méthodes est de 1,79 % contre 5,73 % pour la PPC et 6,03 % pour la PLNE, et 52 % des problèmes sont résolus en moins d'une minute.</p