Empirical Evidences on Foreign Tourist Demand Perception on Bucharest

Tourism is one of the most dynamic economic sectors, largely influenced by consumer’s perception and overall satisfaction. Tourism destinations are very complex being determined by many attributes. They are often perceived before the visit and confirmed or contradicted as attractive places by tourists’ experiences which determine their loyalty toward them. Our study depicts the incoming tourists’ perception upon Bucharest, the elements leading to it and the degree into which they are satisfied and would come back. Literature research, official statistics and a survey addressed to in-bound tourists were the main sources for collecting data, further on quantitatively and qualitatively analyzed using appropriate software solutions in order to detach a before and an after visit opinion on Bucharest. The research results show the fact that a dominantly negative perception on the tourist destination of Bucharest, formed before the visit, suffers an obvious post-consume change. As a consequence of their positive experiences during the visit most incoming tourists declare their intent to include Romania on their list of future holiday destinations. These results may be used by both academics and practitioners as a valid argument for further in-depth marketing studies and better oriented branding and promotional strategies aiming tourism development for Bucharest

An Optimization Model for the Temporary Locations of Mobile Charging Stations

A possible solution with which to alleviate the range anxiety of electric vehicle (EV) drivers could be a mobile charging station which moves in different places to charge EVs, having a charging time of even half an hour. A problem that arises is the impossibility of charging in any location due to heavy traffic or limited space constraints. This paper proposes a new operational mode for the mobile charging station through temporarily stationing it at different places for certain amounts of time. A mathematical model, in the form of an optimization problem, is built by modeling the mobile charging station as a queuing process, the goal of the problem being to place a minimum number of temporary service centers (which may have one or more mobile charging stations) to minimize operating costs and the charger capacity of the mobile charging station so that the service offered is efficient. The temporary locations obtained are in areas with no or few fixed charging stations, making the mobile station infrastructure complementary to the fixed charging station infrastructure. The temporary location operational mode, compared to current moving operational mode, is more efficient, having a small miss ratio, short mean response time and short mean queuing time

The importance of applying computational creativity to scientific and mathematical domains

Science and mathematics are currently underrepresented in the computational creativity (CC) community. We discuss why the CC community should apply their work to mathematical and scientific domains, and argue that this would be mutually beneficial for the domains in question. We identify a key challenge in Automated Reasoning – that it has not achieved widespread adoption by mathematicians; and one in Automated Scientific Discovery – the need for communicability of automatically generated scientific knowledge. We recommend that CC researchers help to address these two challenges by: (i) applying systems based on cognitive mechanisms to scientific and mathematical domains; (ii) employing experience in building and evaluating interactive systems to this context; and (iii) using expertise in automatically producing framing functionality to enhance the communicability of automatically generated scientific knowledge.EPSRC funded project EP/P017320/1 "Example-driven machine-human collaboration in mathematics

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

This work was supported by National Institute of Biomedical Imaging and Bioengineering Grant No. U54EB020403 (to the ENIGMA consortium)

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions

Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro Imaging genetics through meta analysis (ENIGMA) Consortium

BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. METHODS: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide. RESULTS: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. CONCLUSIONS: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder