Indivdualism in the Patriarchy: Ideology in Three Billboards

Using ideology theory to discuss how Three Billboards sets itself up as a traditional genre picture based upon specific film categories. And how it subverts the expectations to critique American ideology

La motivación y la productividad de los operadores de grúa pórtico en la empresa Dp World Callao, Callao 2019

La presente investigación fue realizada en la empresa Dp World Callao en el año 2019, el cual tuvo como objetivo establecer la relación de la motivación y productividad de los operadores de grúa pórtico en la empresa Dp World Callao, Callao 2019. Esta investigación se encuentra enfocada al tipo aplicada, con diseño no experimental, de nivel Correlacional y de corte transversal. La muestra estuvo conformada por 25 operadores de grua pórtico de la empresa Dp World Callao, a los que se les aplicaron dos cuestionarios con aplicación de Escala de Likert. Se emplearon estadísticos descriptivos y para la prueba de correlación se usó la prueba de Rho Spearman a un nivel de confianza del 95%. Los resultados demostraron que un 4% de los operadores de grua pórtico presentan un nivel de motivación insatisfecho, el 44% satisfecho y el 52% muy satisfecho, es decir, los operadores de grua sienten un nivel de motivación aceptable por parte de la empresa. Respecto a la productividad, el 32% de los operadores de grua pórtico perciben un nivel de productividad bueno y el 68% excelente; en tal sentido los operadores de grua sienten que el nivel de productividad de la empresa es la adecuada. Los resultados arrojaron que la motivación se relaciona significativamente con la productividad de los operadores de grua pórtico, al tener como resultado un coeficiente de correlación de Spearman (rho=0,443) y un p-valor igual a 0,000. Lo que demuestra que una mejora en la motivación de los operadores de grua pórtico, se alcanzaran una mayor productividad

PLUG-AND-PLAY TRANSCEIVER WITH HIGH GAIN AND ULTRA LOW NOISE FIGURE FOR IEEE 802.15.4 APPLICATION

This paper shows the design and performance simulation of a 2.4 GHz plug-and-play transceiver based on a high speed switch for IEEE 802.15.4 applications. The electrical design was optimized taking into account the scattering parameters, input-output impedance matching and minimum trace width. The simulation results show an important performance regarding the Noise Figure (0.38 dB) and gain (21 dB) at particular temperature for reception mode, transmission scattering parameters (S12 and S21) and reflection scattering parameters (all the rest parameters) for both mode operation (Power Amplifier and Low Noise Amplifier)

Plan de negocio para producir, comercializar y distribuir granola artesanal en distritos de San Borja y Miraflores

El objetivo principal de la tesis es determinar la viabilidad de nuestro plan de negocio para poder producir, distribuir y comercializar la granola artesanal, siendo nuestro mercado potencial j?venes deportistas y personas adultas que les gusta invertir en su alimentaci?n para mantenerse saludables. El m?todo de investigaci?n es de tipo experimental, de corte transversal y realizando un an?lisis descriptivo de toda la informaci?n recopilada

Planeamiento estratégico para la región Piura

El presente Plan Estratégico de la Región Piura se elaboró siguiendo el modelo secuencial del proceso estratégico de D’Alessio. Se identificaron como ejes de crecimiento hacia el 2028 la agroindustria de exportación, focalizada en productos no tradicionales y orgánicos; así como en el sector del turismo de playa de hoteles de lujo. La Región Piura es una región privilegiada en recursos naturales, situada en una zona estratégica para el comercio y con un nivel de crecimiento poblacional que brinda una gran esperanza de desarrollo a futuro y una ventaja competitiva a explotar. El Gobierno Regional de Piura, dirigido por el Presidente Regional, será el responsable de dirigir la ejecución de los planes y programas del Gobierno Regional, por lo tanto, la formulación de este plan estratégico se centra en acciones y estrategias a ser implementadas por dicha administración. Con ello, se busca incrementar el empleo e impulsar el crecimiento sostenido en la región, logrando un mayor beneficio económico y social de su población.The present Strategic Plan of the Piura Region was elaborated following the sequential model of D'Alessio's strategic process. The agro-industry for export, focused on non-traditional and organic products, was identified as growth axes by 2028; as well as in the beach tourism sector of luxury hotels. The Piura Region is a region privileged in natural resources, located in a strategic area for trade and with a level of population growth that provides great hope for future development and a competitive advantage to exploit. The Regional Government of Piura, headed by the Regional President, will be responsible for directing the execution of the plans and programs of the Regional Government, therefore, the formulation of this strategic plan focuses on actions and strategies to be implemented by said administration. With this, it seeks to increase employment and boost sustained growth in the region, achieving greater economic and social benefits for its population.Tesi

New record and range expansion of Masticophis lateralis (Hallowell, 1853) (Squamata, Colubridae) into western Baja California Sur, Mexico

A specimen of Masticophis lateralis (Hallowell, 1853) was found and photographed in the outskirts of San Juanico Bay, Baja California Sur, Mexico. This record fills in a gap of the distribution of this species along both coasts of Baja California Sur. &nbsp

Methodology to optimize fluid-dynamic design in a redox cell

[EN] The present work is aimed at the optimization of a redox cell design. The studied redox cell consists on a device designed to convert the energy of reactants into electrical energy when a liquid electrolyte reacts at the electrode in a conventional manner. In this particular sort of cells, the two electrolytes are present and separated by a proton exchange membrane. Therefore, the flow of the electrolyte and the interaction with the membrane takes a paramount importance for the general performance of the cell. A methodology for designing the inlet part of the cell based on optimizing the uniformity of the flow and the initial position of the membrane is presented in this study. This methodology, based on the definition and optimization of several parameters related to the electrolyte flow in different regions of the geometry, is depicted. The CFD (Computational Fluid Dynamics) model coupled with the statistical study pointed to several practical conclusions on how to improve the final geometry construction of the redox cell. A particular case study of redox cell is implemented in order to validate the proposed methodology[ES] El presente trabajo tiene como objetivo la optimización de un diseño de la batería redox. La pila redox estudiada consiste en un dispositivo diseñado para convertir la energía de los reactivos en energía eléctrica cuando un electrolito líquido reacciona en el electrodo de una manera convencional . En este tipo particular de células , los dos electrolitos están presentes y separados por una membrana de intercambio de protones . Por lo tanto , el flujo del electrolito y la interacción con la membrana tiene una importancia primordial para el rendimiento general de la célula . La metodología propuesta para el diseño de la parte de entrada de la celda en base a la optimización de la uniformidad del flujo y la inicial posición de la membrana se presenta en este estudio . Esta metodología, basada en la definición y optimización de varios parámetros relacionados con el flujo de electrolito en las diferentes regiones de la geometría , es representado . El modelo de CFD (Computational Fluid Dynamics ), junto con el estudio estadístico se refirió a varias conclusiones prácticas sobre la manera de mejorar la construcción geometría final de la pila redox . El estudio de caso particular de célula redox que se describe, se implementa con el fin de validar la metodología propuestaEscudero González, J.; López Jiménez, PA. (2014). Methodology to optimize fluid-dynamic design in a redox cell. Journal of Power Sources. 251(1):243-253. doi:10.1016/j.jpowsour.2013.11.058S243253251

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

Genome-wide association and fine-mapping studies in 14 autoimmune diseases (AID) have implicated more than 250 loci in one or more of these diseases. As more than 90% of AID-associated SNPs are intergenic or intronic, pinpointing the causal genes is challenging. We performed a systematic analysis to link 460 SNPs that are associated with 14 AID to causal genes using transcriptomic data from 629 blood samples. We were able to link 71 (39%) of the AID-SNPs to two or more nearby genes, providing evidence that for part of the AID loci multiple causal genes exist. While 54 of the AID loci are shared by one or more AID, 17% of them do not share candidate causal genes. In addition to finding novel genes such as ULK3, we also implicate novel disease mechanisms and pathways like autophagy in celiac disease pathogenesis. Furthermore, 42 of the AID SNPs specifically affected the expression of 53 non-coding RNA genes. To further understand how the non-coding genome contributes to AID, the SNPs were linked to functional regulatory elements, which suggest a model where AID genes are regulated by network of chromatin looping/non-coding RNAs interactions. The looping model also explains how a causal candidate gene is not necessarily the gene closest to the AID SNP, which was the case in nearly 50% of cases

Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Dual agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPARɑ/ɣ) have beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to potential adverse effects. Here we report the design and preclinical evaluation of a molecule that covalently links the PPARɑ/ɣ dual-agonist tesaglitazar to a GLP-1 receptor agonist (GLP-1RA) to allow for GLP-1R-dependent cellular delivery of tesaglitazar. GLP-1RA/tesaglitazar does not differ from the pharmacokinetically matched GLP-1RA in GLP-1R signalling, but shows GLP-1R-dependent PPARɣ-retinoic acid receptor heterodimerization and enhanced improvements of body weight, food intake and glucose metabolism relative to the GLP-1RA or tesaglitazar alone in obese male mice. The conjugate fails to affect body weight and glucose metabolism in GLP-1R knockout mice and shows preserved effects in obese mice at subthreshold doses for the GLP-1RA and tesaglitazar. Liquid chromatography–mass spectrometry-based proteomics identified PPAR regulated proteins in the hypothalamus that are acutely upregulated by GLP-1RA/tesaglitazar. Our data show that GLP-1RA/tesaglitazar improves glucose control with superior efficacy to the GLP-1RA or tesaglitazar alone and suggest that this conjugate might hold therapeutic value to acutely treat hyperglycaemia and insulin resistance