Tecnologias física e social: os novos paradigmas da propriedade intelectual frente ao sistema de inovação

The article discusses technological innovation in the physical and social technology as an important factor of economic development among the nations and their asymmetries in the global market. It analyzes the paradigms of the institute of intellectual property vis-à-vis the systems innovation, as well as the urgency of structural changes concerning the protective rules of the intangible knowledge of companies. It also takes into account the fact that economic development is intimately linked with the companies’ ability to produce and generate intellectual capital. This research is justified by the current transformations, leading companies to look for a new rhythm, more appropriate and compatible with the economic, technological and social development, as an emergency measure resulting from the advent of the new era of knowledge.Key words: innovation, economic development, intellectual property, physical and socialtechnology.O presente trabalho tem como objetivo discutir a inovação tecnológica no âmbito das tecnologias física e social, como fator de desenvolvimento econômico entre as nações, e suas assimetrias no mercado global. Após esta fase, discutem-se os paradigmas do instituto da propriedade intelectual frente aos sistemas inovativos, bem como a urgência de mudanças estruturais respeitantes às regras protetivas do conhecimento intangível das empresas. Leva-se ainda em consideração o fato de que o desenvolvimento econômico está intimamente ligado à capacidade das empresas produzirem e gerarem capital intelectual. Justifica-se a presente pesquisa pelas grandes transformações correntes na contemporaneidade, impelindo as empresas, como medida emergencial decorrentes do advento da nova era do conhecimento, a buscarem um ritmo mais adequado e compatível com o desenvolvimento econômico, tecnológico e social.Palavras-chave: inovação, desenvolvimento econômico, propriedade intelectual, tecnologias física e social

The sustainable transformation of business events: sociodemographic variables as determinants of attitudes towards sustainable academic conferences

PurposeThis study aimed to assess whether sociodemographic variables explain significant differences in attitudes towards transforming academic conferences into more sustainable events.Design/methodology/approachAn analytical model of participants' attitudes towards sustainable conferences based on literature review as well as the theories of reasoned action and planned behaviour was developed and applied to a sample of 532 surveyed individuals from 68 countries who regularly attended academic conferences in the last five years prior to 2020. The results were refined using statistical and computational techniques to achieve more empirically robust conclusions.FindingsResults reveal that sociodemographic variables such as attendees' gender and age explain differences in attitudes. Women and older adults have stronger pro-environmental attitudes regarding event sustainability. On the other hand, attitudes towards more sustainable academic conferences are quite strong and positive overall. More sustainable events' venues, catering, conference materials and accommodations strongly influence attendees' attitudes towards more sustainable conferences. The strength of attitudes was weaker towards transportation.Research limitations/implicationsFirst, the analyses focused on only aspects related to the attendees' attitudes. Assessing their real behaviour would complete this research. The geographical areas defined by the U.N. and used in this study have the limitation of combining highly developed countries and developing countries in the same geographical area, for example, the Americas and Asia and the Pacific.Practical implicationsSpecific socio-demographic variables' effects on attitudes towards sustainable academic conferences can indicate how organisers can best promote these events according to attendees' characteristics and develop differentiated marketing campaigns. For women and older adults, event sustainability should be emphasised as a competitive strategy to promote events and attract these audiences. Marketing strategies for younger attendees (under 30 years old) could focus on technology, networking or attractive social programmes. Sustainable venues, catering, conference materials and accommodations are easier to promote. Event organisers should encourage participants to make more environmentally friendly decisions regarding more sustainable event transport.Social implicationsA strategy based on promoting the event as contributing to sustainable development could educate attendees and put them on the path to developing stronger positive attitudes regarding sustainability and more sustainable behaviours. Sustainable academic conferences can educate students, organisers, service providers and delegates through their involvement in sustainable practices.Originality/valueTo our best knowledge, this research is the first to assess whether sociodemographic variables explain significant differences in attitudes towards the sustainable transformation of academic conferences.info:eu-repo/semantics/publishedVersio

Floppy closing door epiglottis treated successfully with an mhealth application based on myofunctional therapy: a case report

We introduce the first case reported to date of a floppy closing door epiglottis in an OSA (obstructive sleep apnea) patient treated successfully with an Mhealth smartphone application based on myofunctional therapy

Perspectivas da Inovação Tecnológica: análises comparativas da dinâmica tecnológica entre Brasil e Coréia

O presente artigo foi construído a partir da análise da importância das inovações tecnológicas e sua relação com o desenvolvimento econômico e social para os países. Neste contexto, enfatizamos de forma comparativa os sistemas inovativos do Brasil e da Coréia, traçando um paralelo entre ciências e inovações tecnológicas, suas políticas públicas e os processos históricos de cada qual, respeitando suas idiossincrasias sociais, culturais e econômicas, mas sem perder de vista a finalidade precípua desses dois países, qual seja, a competição em mercados globais

Integrating magnetic capabilities to intracellular chips for cell trapping

Current microtechnologies have shown plenty of room inside a living cell for silicon chips. Microchips as barcodes, biochemical sensors, mechanical sensors and even electrical devices have been internalized into living cells without interfering their cell viability. However, these technologies lack from the ability to trap and preconcentrate cells in a specific region, which are prerequisites for cell separation, purification and posterior studies with enhanced sensitivity. Magnetic manipulation of microobjects, which allows a non-contacting method, has become an attractive and promising technique at small scales. Here, we show intracellular Ni-based chips with magnetic capabilities to allow cell enrichment. As a proof of concept of the potential to integrate multiple functionalities on a single device of this technique, we combine coding and magnetic manipulation capabilities in a single device. Devices were found to be internalized by HeLa cells without interfering in their viability. We demonstrated the tagging of a subpopulation of cells and their subsequent magnetic trapping with internalized barcodes subjected to a force up to 2.57 pN (for magnet-cells distance of 4.9 mm). The work opens the venue for future intracellular chips that integrate multiple functionalities with the magnetic manipulation of cells

Wicked problems in a post-truth political economy: a dilemma for knowledge translation

The discipline of knowledge translation (KT) emerged as a way of systematically understanding and addressing the challenges of applying health and medical research in practice. In light of ongoing and emerging critique of KT from the medical humanities and social sciences disciplines, KT researchers have become increasingly aware of the complexity of the translational process, particularly the significance of culture, tradition and values in how scientific evidence is understood and received, and thus increasingly receptive to pluralistic notions of knowledge. Hence, there is now an emerging view of KT as a highly complex, dynamic, and integrated sociological phenomenon, which neither assumes nor creates knowledge hierarchies and neither prescribes nor privileges scientific evidence. Such a view, however, does not guarantee that scientific evidence will be applied in practice and thus poses a significant dilemma for KT regarding its status as a scientific and practice-oriented discipline, particularly within the current sociopolitical climate. Therefore, in response to the ongoing and emerging critique of KT, we argue that KT must provide scope for relevant scientific evidence to occupy an appropriate position of epistemic primacy in public discourse. Such a view is not intended to uphold the privileged status of science nor affirm the “scientific logos” per se. It is proffered as a counterbalance to powerful social, cultural, political and market forces that are able to challenge scientific evidence and promote disinformation to the detriment of democratic outcomes and the public good

Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study

Background: Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11 metals with metabolic patterns, and the interacting role of candidate genetic variants, in 1145 participants from the Hortega Study, a population-based sample from Spain. Methods: Urine antimony (Sb), arsenic, barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), molybdenum (Mo) and vanadium (V), and plasma copper (Cu), selenium (Se) and zinc (Zn) were measured by ICP-MS and AAS, respectively. We summarized 54 plasma metabolites, measured with targeted NMR, by estimating metabolic principal components (mPC). Redox-related SNPs (N = 291) were measured by oligo-ligation assay. Results: In our study, the association with metabolic principal component (mPC) 1 (reflecting non-essential and essential amino acids, including branched chain, and bacterial co-metabolism versus fatty acids and VLDL subclasses) was positive for Se and Zn, but inverse for Cu, arsenobetaine-corrected arsenic (As) and Sb. The association with mPC2 (reflecting essential amino acids, including aromatic, and bacterial co-metabolism) was inverse for Se, Zn and Cd. The association with mPC3 (reflecting LDL subclasses) was positive for Cu, Se and Zn, but inverse for Co. The association for mPC4 (reflecting HDL subclasses) was positive for Sb, but inverse for plasma Zn. These associations were mainly driven by Cu and Sb for mPC1; Se, Zn and Cd for mPC2; Co, Se and Zn for mPC3; and Zn for mPC4. The most SNP-metal interacting genes were NOX1, GSR, GCLC, AGT and REN. Co and Zn showed the highest number of interactions with genetic variants associated to enriched endocrine, cardiovascular and neurological pathways. Conclusions: Exposures to Co, Cu, Se, Zn, As, Cd and Sb were associated with several metabolic patterns involved in chronic disease. Carriers of redox-related variants may have differential susceptibility to metabolic alterations associated to excessive exposure to metals.This work was supported by the Strategic Action for Research in Health sciences [CP12/03080, PI15/00071, PI10/0082, PI13/01848, PI14/00874, PI16/01402, PI21/00506 and PI11/00726], CIBER Fisio patología Obesidad y Nutrición (CIBEROBN) (CIBER-02-08-2009, CB06/03 and CB12/03/30,016), the State Agency for Research (PID2019-108973RB- C21 and C22), the Valencia Government (GRUPOS 03/101; PROMETEO/2009/029 and ACOMP/2013/039, IDI FEDER/2021/072 and GRISOLIAP/2021/119), the Castilla-Leon Government (GRS/279/A/08) and European Network of Excellence Ingenious Hypercare (EPSS-037093) from the European Commission. The Strategic Action for Research in Health sciences, CIBERDEM and CIBEROBN are initiatives from Carlos III Health Institute Madrid and cofunded with European Funds for Regional Development (FEDER). The State Agency for Research and Carlos III Health Institute belong to the Spanish Ministry of Science and Innovation. ADR received the support of a fellowship from “la Caixa” Foundation (ID 100010434) (fellowship code “LCF/BQ/DR19/11740016”). MGP received the support of a fellowship from “la Caixa” Foundation (ID 100010434, fellowship code LCFLCF/BQ/DI18/11660001). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.S

Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes

Biofuels synthesized from renewable resources are of increasing interest because of global energy and environmental problems. We have previously demonstrated production of higher alcohols from Escherichia coli using a 2-keto acid-based pathway. Here, we have compared the effect of various alcohol dehydrogenases (ADH) for the last step of the isobutanol production. E. coli has the yqhD gene which encodes a broad-range ADH. Isobutanol production significantly decreased with the deletion of yqhD, suggesting that the yqhD gene on the genome contributed to isobutanol production. The adh genes of two bacteria and one yeast were also compared in E. coli harboring the isobutanol synthesis pathway. Overexpression of yqhD or adhA in E. coli showed better production than ADH2, a result confirmed by activity measurements with isobutyraldehyde

Amerindian Helicobacter pylori Strains Go Extinct, as European Strains Expand Their Host Range

We studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European (hpEurope) and all from Koreans were hspEAsia but that Amerindians and Mestizos carried mixed strains: hspAmerind and hpEurope strains had been cultured from Amerindians and hpEurope and hpAfrica1 were cultured from Mestizos. The least genetically diverse H. pylori strains were hspAmerind. Strains hpEurope were the most diverse and showed remarkable multilocus sequence mosaicism (indicating recombination). The lower genetic structure in hpEurope strains is consistent with colonization of a diversity of hosts. If diversity is important for the success of H. pylori, then the low diversity of Amerindian strains might be linked to their apparent tendency to disappear. This suggests that Amerindian strains may lack the needed diversity to survive the diversity brought by non-Amerindian hosts

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced reinstatement to different drugs of abuse, different stressors, and different behavioral procedures. We also discuss neuropharmacological mechanisms, and brain areas and circuits controlling stress-induced reinstatement of drug seeking. We conclude by discussing results from translational human laboratory studies and clinical trials that were inspired by results from rat studies on stress-induced reinstatement. Our main conclusions are (1) The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice. This phenomenon, however, is stressor specific and not all stressors induce reinstatement of drug seeking. (2) Neuropharmacological studies indicate the involvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphin, and several other peptide and neurotransmitter systems in stress-induced reinstatement. Neuropharmacology and circuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of stria terminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in other components of the mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal cortex, and nucleus accumbens). (3) Translational human laboratory studies and a recent clinical trial study show the efficacy of alpha-2 adrenoceptor agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse