Portable Intravenous Fluid Production Device for Ground Use

There are several medical conditions that require intravenous (IV) fluids. Limitations of mass, volume, storage space, shelf-life, transportation, and local resources can restrict the availability of such important fluids. These limitations are expected in long-duration space exploration missions and in remote or austere environments on Earth. Current IV fluid production requires large factory-based processes. Easy, portable, on-site production of IV fluids can eliminate these limitations. Based on experience gained in developing a device for spaceflight, a ground-use device was developed. This design uses regular drinking water that is pumped through two filters to produce, in minutes, sterile, ultrapure water that meets the stringent quality standards of the United States Pharmacopeia for Water for Injection (Total Bacteria, Conductivity, Endotoxins, Total Organic Carbon). The device weighs 2.2 lb (1 kg) and is 10 in. long, 5 in. wide, and 3 in. high (.25, 13, and 7.5 cm, respectively) in its storage configuration. This handheld device produces one liter of medical-grade water in 21 minutes. Total production capacity for this innovation is expected to be in the hundreds of liters

Precise ultra fast single qubit control using optimal control pulses

Ultra fast and accurate quantum operations are required in many modern scientific areas - for instance quantum information, quantum metrology and magnetometry. However the accuracy is limited if the Rabi frequency is comparable with the transition frequency due to the breakdown of the rotating wave approximation (RWA). Here we report the experimental implementation of a method based on optimal control theory, which does not suffer these restrictions. We realised the most commonly used quantum gates - the Hadamard (\pi/2 pulse) and NOT (\pi pulse) gates with fidelities ($F^{\mathrm{exp}}_{\pi/2}=0.9472\pm0.01$ and $F^{\mathrm{exp}}_{\pi}=0.993\pm0.016$), in an excellent agreement with the theoretical predictions ($F^{\mathrm{theory}}_{\pi/2}=0.9545$ and $F^{\mathrm{theory}}_{\pi}=0.9986$). Moreover, we demonstrate magnetic resonance experiments both in the rotating and lab frames and we can deliberately "switch" between these two frames. Since our technique is general, it could find a wide application in magnetic resonance, quantum computing, quantum optics and broadband magnetometry.Comment: New, updated version of the manuscript with supplementary informatio

A Fluctuation Analysis of the Bolocam 1.1mm Lockman Hole Survey

We perform a fluctuation analysis of the 1.1mm Bolocam Lockman Hole Survey, which covers 324 square arcmin to a very uniform point source-filtered RMS noise level of 1.4 mJy/beam. The fluctuation analysis has the significant advantage of utilizing all of the available data. We constrain the number counts in the 1-10 mJy range, and derive significantly tighter constraints than in previous work: the power-law index is 2.7 (+0.18, -0.15), while the amplitude is equal to 1595 (+85,-238) sources per mJy per square degree, or N(>1 mJy) = 940 (+50,-140) sources/square degree (95% confidence). Our results agree extremely well with those derived from the extracted source number counts by Laurent et al (2005). Our derived normalization is about 2.5 times smaller than determined by MAMBO at 1.2mm by Greve et al (2004). However, the uncertainty in the normalization for both data sets is dominated by the systematic (i.e., absolute flux calibration) rather than statistical errors; within these uncertainties, our results are in agreement. We estimate that about 7% of the 1.1mm background has been resolved at 1 mJy.Comment: To appear in the Astrophysical Journal; 22 pages, 9 figure

Lense-Thirring precession of accretion disks around compact objects

Misaligned accretion disks surrounding rotating compact objects experience a torque due to the Lense-Thirring effect, which leads to precession of the inner disk. It has been suggested that this effect could be responsible for some low frequency Quasi-Periodic Oscillations observed in the X-ray lightcurves of neutron star and galactic black hole systems. We investigate this possibility via time-dependent calculations of the response of the inner disk to impulsive perturbations for both Newtonian point mass and Paczynski-Wiita potentials, and compare the results to the predictions of the linearized twisted accretion disk equations. For most of a wide range of disk models that we have considered, the combination of differential precession and viscosity causes the warps to decay extremely rapidly. Moreover, at least for relatively slowly rotating objects, linear calculations in a Newtonian point mass potential provide a good measure of the damping rate, provided only that the timescale for precession is much shorter than the viscous time in the inner disk. The typically rapid decay rates suggest that coherent precession of a fluid disk would not be observable, though it remains possible that the damping rate of warp in the disk could be low enough to permit weakly coherent signals from Lense-Thirring precession.Comment: ApJ, in press. Minor revisions to match accepted version. Animations showing warp evolution are available at http://www.cita.utoronto.ca/~armitage/lense_thirring.htm

Submillimeter Number Counts From Statistical Analysis of BLAST Maps

We describe the application of a statistical method to estimate submillimeter galaxy number counts from confusion limited observations by the Balloon-borne Large Aperture Submillimeter Telescope (BLAST). Our method is based on a maximum likelihood fit to the pixel histogram, sometimes called 'P(D)', an approach which has been used before to probe faint counts, the difference being that here we advocate its use even for sources with relatively high signal-to-noise ratios. This method has an advantage over standard techniques of source extraction in providing an unbiased estimate of the counts from the bright end down to flux densities well below the confusion limit. We specifically analyse BLAST observations of a roughly 10 sq. deg. map centered on the Great Observatories Origins Deep Survey South (GOODS-S) field. We provide estimates of number counts at the three BLAST wavelengths, 250, 350, and 500 microns; instead of counting sources in flux bins we estimate the counts at several flux density nodes connected with power-laws. We observe a generally very steep slope for the counts of about -3.7 at 250 microns and -4.5 at 350 and 500 microns, over the range ~0.02-0.5 Jy, breaking to a shallower slope below about 0.015 Jy at all three wavelengths. We also describe how to estimate the uncertainties and correlations in this method so that the results can be used for model-fitting. This method should be well-suited for analysis of data from the Herschel satellite.Comment: Accepted for publication in the Astrophysical Journal; see associated data and other papers at http://blastexperiment.info

Quasars Are Not Light-Bulbs: Testing Models of Quasar Lifetimes with the Observed Eddington Ratio Distribution

We use the observed distribution of Eddington ratios as a function of supermassive black hole (BH) mass to constrain models of AGN lifetimes and lightcurves. Given the observed AGN luminosity function, a model for AGN lifetimes (time above a given luminosity) translates directly to a predicted Eddington ratio distribution. Models for self-regulated BH growth, in which feedback produces a 'blowout' decay phase after some peak luminosity (shutting down accretion) make specific predictions for the lifetimes distinct from those expected if AGN are simply gas starved (without feedback) and very different from simple phenomenological 'light bulb' models. Present observations of the Eddington ratio distribution, spanning 5 decades in Eddington ratio, 3 in BH mass, and redshifts z=0-1, agree with the predictions of self-regulated models, and rule out 'light-bulb', pure exponential, and gas starvation models at high significance. We compare the Eddington ratio distributions at fixed BH mass and fixed luminosity (both are consistent, but the latter are much less constraining). We present empirical fits to the lifetime distribution and show how the Eddington ratio distributions place tight limits on AGN lifetimes at various luminosities. We use this to constrain the shape of the typical AGN lightcurve, and provide simple analytic fits. Given independent constraints on episodic lifetimes, most local BHs must have gained their mass in no more than a couple of bright episodes, in agreement with merger-driven fueling models.Comment: 21 pages, 13 figures, accepted to ApJ (revised to match accepted version; modeling and tests of redshift evolution added

Active galactic nuclei and the minor merger hypothesis

We have investigated the dynamics of the merging process in the minor merger hypothesis for active galactic nuclei. We find that for a satellite galaxy to be able to merge directly with the nucleus of the host galaxy (for example, to give rise to the compact dust discs which are seen in early type active galaxies) requires the initial orbit of the satellite to be well aimed. For the case of the host galaxy being a disc galaxy, if the initial orbits of the satellites are randomly oriented with respect to the host galaxy, then the orbits of those which reach the host nuclear regions in a reasonable time, are also fairly randomly oriented once they reach the nucleus. We note that this result might be able to provide an explanation of why the jet directions in the nuclei of Seyfert galaxies are apparently unrelated to the plane of the galaxy discs.Comment: Accepted for publication by MNRA

Period and Cohort Changes in Americans’ Support for Marijuana Legalization: Convergence and Divergence across Social Groups

We cast fresh light on how and why Americans’ views on marijuana legalization shifted between 1973 and 2014. Results from age-period-cohort models show a strong negative effect of age and relatively high levels of support for legalization among baby boom cohorts. Despite the baby boom effect, the large increase in support for marijuana legalization is predominantly a broad, period-based change in the population. Additional analyses demonstrate that differences in support for legalization by education, region, and religion decline, that differences by political party increase, and that differences between whites and African Americans reverse direction. We conclude by discussing the implications of these findings and by identifying promising directions for future research on this topic

A Narrative Review of Motor Competence in Children and Adolescents: What We Know and What We Need to Find Out

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically active lifestyle is Motor Competence (MC). MC is a complex biocultural attribute and therefore, its study requires a multi-sectoral, multi-, inter- and transdisciplinary approach. MC is a growing area of research, especially in children and adolescents due to its positive association with a plethora of health and developmental outcomes. Many questions, however, remain to be answered in this field of research, with regard to: (i) Health and Developmental-related Associations of MC; (ii) Assessment of MC; (iii) Prevalence and Trends of MC; (iv) Correlates and Determinants of MC; (v) MC Interventions, and (vi) Translating MC Research into Practice and Policy. This paper presents a narrative review of the literature, summarizing current knowledge, identifying key research gaps and presenting questions for future investigation on MC in children and adolescents. This is a collaborative effort from the International Motor Competence Network (IMCNetwork) a network of academics and researchers aiming to promote international collaborative research and knowledge translation in the expansive field of MC. The knowledge and deliverables generated by addressing and answering the aforementioned research questions on MC presented in this review have the potential to shape the ways in which researchers and practitioners promote MC and physical activity in children and adolescents across the worl