Optical polarisation of the Crab pulsar: precision measurements and comparison to the radio emission

The linear polarisation of the Crab pulsar and its close environment was derived from observations with the high-speed photo-polarimeter OPTIMA at the 2.56-m Nordic Optical Telescope in the optical spectral range (400 - 750 nm). Time resolution as short as 11 microseconds, which corresponds to a phase interval of 1/3000 of the pulsar rotation, and high statistics allow the derivation of polarisation details never achieved before. The degree of optical polarisation and the position angle correlate in surprising details with the light curves at optical wavelengths and at radio frequencies of 610 and 1400 MHz. Our observations show that there exists a subtle connection between presumed non-coherent (optical) and coherent (radio) emissions. This finding supports previously detected correlations between the optical intensity of the Crab and the occurrence of giant radio pulses. Interpretation of our observations require more elaborate theoretical models than those currently available in the literature.Comment: 21 pages, 13 figures, uses AMS.sty, mn2e.cls, mn2e.bst and natbib.sty, submitted to MNRA

A biologically relevant rapid quantification of physical and biological stress profiles on rocky shores.

Different combinations and intensities of physical (e.g. thermal) and biological (e.g.competition or predation) stress operate on organisms in different locations. Variation in these stresses can occur over small to medium spatial scales (cm to 10s m) in heterogeneous environments such as rocky shores, due to differences in sun and wave exposure, shore topography and/or recruitment. In this study we demonstrate how simple measurements can be taken that represent physical and biological stresses (stress profiles)in a given location. Using a bootstrapped principal component analysis, we identified significantly different stress profiles at four sites separated by only 10s to 100s of metres on the Shek O peninsula in Hong Kong. We then measured response to thermal stress, as determined by detachment temperature, in the limpet Cellana grata (which is known to be a sensitive indicator species to thermal stress) from each location. Significant differences in stress profile between locations were also seen in thermal stress tolerance of limpets from those locations. At locations where the major stresses are likely to be more physical or less biological in nature (e.g. southerly facing aspect or lower density of grazers), the mean detachment temperature was higher, whereas detachment temperature was lower at sites with more biological or less physical stress. This method is, therefore, able to determine biologically meaningful differences in stress profiles over small to medium spatial scales, and demonstrates that localised adaptation (i.e. post planktonic settlement) or acclimation of species may occur in response to these different stress profiles. The technique can be adapted to different environments and smaller or larger spatial scales as long as the stress experienced by the study species is relevant to these scales

The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders.

Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system elicits excess/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evidence is mounting for the involvement of ER stress in exacerbating inflammasome-induced inflammatory cascades, which may provide a new axis for therapeutic targeting in a range of inflammatory disorders. Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress- and inflammasome-related inflammatory disorders

Crosstalk between the Circadian Clock and Innate Immunity in Arabidopsis

Plants are frequently challenged by various pathogens. The circadian clock, which is the internal time measuring machinery, has been implicated in regulating plant responses to biotic cues. To better understand the role of the circadian clock in defense control, we tested disease resistance with Arabidopsis mutants disrupted in CCA1 and LHY , two key components of the circadian clock. We found that consistent with their contributions to the circadian clock, cca1 and lhy mutants synergistically affect resistance to both bacterial and oomycete pathogens. Disrupting the circadian clock caused by overexpression of CCA1 or LHY also results in severe disease susceptibility. Thus, our data further demonstrate a direct role of the circadian clock mediated by CCA1 and LHY in defense regulation. We also found that CCA1 and LHY act independently of salicylic acid mediated defense but at least through the down- stream target gene GRP7 to regulate both stomata- dependent and -independent pathways. We further show that defense activation by bacterial infection and the treatment with the elicitor flg22 can also feed back to regulate clock activity. Together our study reveals for the first time reciprocal regulation of the circadian clock and plant innate immunity, significantly expanding our view of complex gene networks regulating plant defense responses and development

Crosstalk between the Circadian Clock and Innate Immunity in Arabidopsis

Plants are frequently challenged by various pathogens. The circadian clock, which is the internal time measuring machinery, has been implicated in regulating plant responses to biotic cues. To better understand the role of the circadian clock in defense control, we tested disease resistance with Arabidopsis mutants disrupted in CCA1 and LHY , two key components of the circadian clock. We found that consistent with their contributions to the circadian clock, cca1 and lhy mutants synergistically affect resistance to both bacterial and oomycete pathogens. Disrupting the circadian clock caused by overexpression of CCA1 or LHY also results in severe disease susceptibility. Thus, our data further demonstrate a direct role of the circadian clock mediated by CCA1 and LHY in defense regulation. We also found that CCA1 and LHY act independently of salicylic acid mediated defense but at least through the down- stream target gene GRP7 to regulate both stomata- dependent and -independent pathways. We further show that defense activation by bacterial infection and the treatment with the elicitor flg22 can also feed back to regulate clock activity. Together our study reveals for the first time reciprocal regulation of the circadian clock and plant innate immunity, significantly expanding our view of complex gene networks regulating plant defense responses and development

Vitamin D intake and survival and recurrence in head and neck cancer patients

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146556/1/lary27256.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146556/2/lary27256_am.pd

Neutrinos From Particle Decay in the Sun and Earth

Weakly interacting massive particles (WIMPs) may be indirectly detected by observation of upward muons induced by energetic neutrinos from annihilation of WIMPs that have accumulated in the Sun and/or Earth. Energetic muon neutrinos come from the decays of $\tau$ leptons, $c$, $b$, and $t$ quarks, gauge bosons, and Higgs bosons produced by WIMP annihilation. We provide analytic expressions, suitable for computing the flux of upward muons, for the neutrino energy spectra from decays of all these particles in the center of the Sun and Earth. These analytic expressions should obviate the need for Monte Carlo calculations of the upward-muon flux. We investigate the effects of polarization of the gauge bosons on the neutrino spectra and find that they are small. We also present simple expressions for the second moments of the neutrino distributions which can be used to estimate the rates for observation of neutrino-induced muons from WIMP annihilation.Comment: submitted as a complete encapsulated postscript file, archived with uufiles 32 pages, IASSNS-HEP-94/45, SU-HEP-4240-58

Collective-efficacy as a mediator of the relationship of leaders' personality traits and team performance: A cross-level analysis

The relationship between a leader&#39;s personality and his team&#39;s performance has been established in organisational research, but the underlying process and mechanism responsible for this effect have not been fully explored. Both the traditional multiple linear regression and the multilevel structural equation model approaches were used in this study to test a proposed mediating model of subordinates&#39; perception of collective efficacy between leader personality and team performance. The results show that the team leader&#39;s extraversion and conscientiousness personality traits were related positively to both the team-average (individual) perception of collective efficacy and team performance, and the collective efficacy mediated the relationship of the leader&#39;s personality traits and team performance. This study also discusses how Chinese cultural elements play a role in such a mediating model.</p

Development of a Grp94 inhibitor

This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/ja303477g.Heat shock protein 90 (Hsp90) represents a promising therapeutic target for the treatment of cancer and other diseases. Unfortunately, results from clinical trials have been disappointing as off-target effects and toxicities have been observed. These detriments may be a consequence of pan-Hsp90 inhibition, as all clinically evaluated Hsp90 inhibitors simultaneously disrupt all four human Hsp90 isoforms. Using a structure-based approach, we designed an inhibitor of Grp94, the ER-resident Hsp90. The effect manifested by compound 2 on several Grp94 and Hsp90α/β (cytosolic isoforms) clients were investigated. Compound 2 prevented intracellular trafficking of the Toll receptor, inhibited the secretion of IGF-II, affected the conformation of Grp94, and suppressed Drosophila larval growth, all Grp94-dependent processes. In contrast, compound 2 had no effect on cell viability or cytosolic Hsp90α/β client proteins at similar concentrations. The design, synthesis, and evaluation of 2 are described herein