Ciclos de crecimiento en Argentina: comportamiento reciente

This article presents a characterization of Argentina’s gross domestic product (GDP) cycles of the last four decades. The extraction strategy follows two well-known approaches: the classic and the growth cycle. Both approaches show related results in terms of the number of cycles; cycles’ duration; the prevalence of expansions to contractions’ duration; cycles’ dating; and, the intensity of the different phases. The selection criteria used in the literature allowed the Christiano and Fitzgerald (CF) filter to stand out with desirable characteristics for Argentina’s GDP series over the rest of the alternatives considered in the growth cycle analysis.Este artículo presenta una caracterización de los ciclos de crecimiento de Argentina de las últimas cuatro décadas. La estrategia de extracción reposó en dos métodos ampliamente conocidos: el enfoque clásico y el enfoque del ciclo de crecimiento. Ambos enfoques muestran resultados similares en términos de: el número de ciclos, la duración de los mismos, la prevalencia de duración de las expansiones por sobre las contracciones, la datación de los ciclos, y la intensidad de las diferentes fases. En el enfoque del ciclo de crecimiento, el filtro de Christiano y Fitzgerald (CF), en su aplicación empírica sobre el producto interno bruto (PIB) de Argentina, exhibió ciertas características deseables en comparación con otros filtros también contemplados en el análisis.Facultad de Ciencias Económica

China and Latin America and the Caribbean: Exports competition in the United States market

This paper uses an augmented gravity trade model to examine the impact of Chinese exports to the United States on Latin America and the Caribbean (LAC) exports to the same market over the last two decades. The analysis relies on a sample of 33 LAC countries and trade data disaggregated to the 10- digit Harmonized Tariff Schedule (HTS) level. The results show that the impact of Chinese exports on US imports from LAC is negative and statistically significant across model specifications and levels of aggregation in the trade data. In addition, the model suggests that after accounting for such export competition, Free Trade Agreements with the United States, on average, increased imports from LAC countries by up to 1.5 percent. That is, countries with a trade agreement with the US have an advantage over those without, particularly in the manufacturing sector.Abstract. -- Introduction. I. Export competition between China and Latin America and the Caribbean .-- II. Similarity of Latin American and Chinese export structures. -- III. Gravity models of trade. -- IV. Augmented gravity models and export competition. -- V. Estimation approach. -- VI. Data .-- VII. Results. A. Baseline gravity model. B. Specification tests. C. Instrumental variable results. D. Industry results .-- VIII. Conclusions

Desarrollo económico y desempeño logístico : un enfoque probabilístico

There is not a consensus about a complete set of explanatory variables that could ultimately explain the linkages behind achieving economic development. In spite of this, determinants of economic development and especially the linkages between economic development and logistics performance are topics of growing interest within the recent literature, both in economic growth theory and maritime studies. In this paper our attention is focused on the importance of logistics performance as one of the explanatory variables for economic development. To this end, we have estimated different econometric models in an attempt to explain the probability of a country being economically developed, based on a number of traditional explanatory variables (including natural endowments, economic openness, and institutional framework, among others) along with logistics performance as the major theoretical innovation. The applied methodology follows the binary choice framework described in probit models. In the next step the research is concentrated on the determination of possible endogenous causalities of the economic development. In the last section we estimate the logistics gap, measured as a probability of reaching economic development that varies due to differences in the levels of logistics performance. Our main finding shows that logistics performance is closely related to the probability of a country being developed. Specifically, the probability of being a developed country increases when logistics performance is improved.En la literatura económica, no existe un pleno consenso acerca del conjunto de variables explicativas que inciden sobre el desarrollo económico. Por otra parte, la vinculación entre el crecimiento y desarrollo económico y el desempeño logístico son tópicos de creciente interés en la literatura especializada. En este documento prestamos especial atención al papel del desempeño logístico como una de las variables explicativas del desarrollo económico. Para este fin, hemos estimado diferentes modelos econométricos que buscan explicar cómo se afecta la probabilidad de un país de ser desarrollado al considerar algunas variables explicativas tradicionales (la dotación de recursos naturales, la apertura económica, y variables institucionales, entre otras), junto con el desempeño logístico. La metodología aplicada se basó en la utilización de modelos probit. El principal hallazgo del trabajo ha sido el de encontrar una incidencia positiva entre el desempeño logístico y la probabilidad de un país de ser desarrollado. Particularmente, la probabilidad de un país de ser desarrollado se incrementa cuando mejora el desempeño logístico

Numerical simulation of the filling and curing stages in reaction injection moulding, using CFX

Mestrado em Engenharia MecânicaOs métodos habitualmente utilizados para a simulação de injecção em moldes envolvem um número considerável de simplificações, originando reduções significativas do esforço computacional mas, nalguns casos também limitações. Neste trabalho são efectuadas simulações de Reaction Injection Moulding (RIM) com o mínimo de simplificações, através da utilização do software de CFD multi-objectivos CFX, concebido para a simulação numérica de escoamentos e transferência de calor e massa. Verifica-se que o modelo homogéneo para escoamentos multifásicos do CFX, geralmente considerado o apropriado para a modelação de escoamentos de superfície livre em que as fases estão completamente estratificadas, é incapaz de modelar correctamente o processo de enchimento. Este problema é ultrapassado através da implementação do modelo não homogéneo juntamente com a condição de fronteira de escorregamento livre para o ar. A reacção de cura é implementada no código como uma equação de transporte para uma variável escalar adicional, com um termo fonte. São testados vários esquemas transitórios e advectivos, com vista ao reconhecimentos de quais os que produzem os resultados mais precisos. Finalmente, as equações de conservação de massa, quantidade de movimento, cura e energia são implementadas conjuntamente para simular os processos simultâneos de enchimento e cura presentes no processo RIM. Os resultados numéricos obtidos reproduzem com boa fidelidade outros resultados numéricos e experimentais disponíveis, sendo necessários no entanto tempos de computação consideravelmente longos para efectuar as simulações. ABSTRACT: Commonly used methods for injection moulding simulation involve considerable number of simplifications, leading to a significant reduction of the computational effort but, in some cases also to limitations. In this work, Reaction Injection Moulding (RIM) simulations are performed with minimum of simplifications, by using the general purpose CFD software package CFX, designed for numerical simulation of fluid flow and heat and mass transfer. The CFX’s homogeneous multiphase flow model, which is generally considered to be the appropriate choice for modelling free surface flows where the phases are completely stratified and the interface is well defined, is shown to be unable to model the filling process correctly. This problem is overcome through the implementation of the inhomogeneous model in combination with the free-slip boundary condition for the air phase. The cure reaction is implemented in the code as a transport equation for an additional scalar variable, with a source term. Various transient and advection schemes are tested to determine which ones produce the most accurate results. Finally, the mass conservation, momentum, cure and energy equations are implemented all together to simulate the simultaneous filling and curing processes present in the RIM process. The obtained numerical results show a good global accuracy when compared with other available numerical and experimental results, though considerably long computation times are required to perform the simulations

A Novel murine model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

The introduction of highly selective ABL-tyrosine kinase inhibitors (TKIs) has revolutionized therapy for chronic myeloid leukemia (CML). However, TKIs are only efficacious in the chronic phase of the disease and effective therapies for TKI-refractory CML, or after progression to blast crisis (BC), are lacking. Whereas the chronic phase of CML is dependent on BCR-ABL, additional mutations are required for progression to BC. However, the identity of these mutations and the pathways they affect are poorly understood, hampering our ability to identify therapeutic targets and improve outcomes. Here, we describe a novel mouse model that allows identification of mechanisms of BC progression in an unbiased and tractable manner, using transposon-based insertional mutagenesis on the background of chronic phase CML. Our BC model is the first to faithfully recapitulate the phenotype, cellular and molecular biology of human CML progression. We report a heterogeneous and unique pattern of insertions identifying known and novel candidate genes and demonstrate that these pathways drive disease progression and provide potential targets for novel therapeutic strategies. Our model greatly informs the biology of CML progression and provides a potent resource for the development of candidate therapies to improve the dismal outcomes in this highly aggressive disease.Work in the Huntly laboratory is funded by CRUK, The European Research Council (ERC), Leukaemia Lymphoma Research, the Kay Kendall Leukaemia Fund, Wellcome Trust, the Medical Research Council (UK), the Leukemia Lymphoma Society America and the Cambridge NIHR Biomedical Research centre. David Adams is funded by Cancer Research UK and Wellcome Trust. Steffen Koschmieder has received funding from Deutsche José Carreras Leukämie-Stiftung (DJCLS; grant 10/23).This is the final published version. It first appeared at http://dx.doi.org/10.1084/jem.2014166

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs have not been investigated for their ability to promote and modulate tumorigenesis. Here, we established that the miR-191/425 cluster is transcriptionally dependent on the host gene, DALRD3, and that the hormone 17β-estradiol (estrogen or E2) controls expression of both miR-191/425 and DALRD3. MiR-191/425 locus characterization revealed that the recruitment of estrogen receptor α (ERα) to the regulatory region of the miR-191/425-DALRD3 unit resulted in the accumulation of miR-191 and miR-425 and subsequent decrease in DALRD3 expression levels. We demonstrated that miR-191 protects ERα positive breast cancer cells from hormone starvation-induced apoptosis through the suppression of tumor-suppressor EGR1. Furthermore, enforced expression of the miR-191/425 cluster in aggressive breast cancer cells altered global gene expression profiles and enabled us to identify important tumor promoting genes, including SATB1, CCND2, and FSCN1, as targets of miR-191 and miR-425. Finally, in vitro and in vivo experiments demonstrated that miR-191 and miR-425 reduced proliferation, impaired tumorigenesis and metastasis, and increased expression of epithelial markers in aggressive breast cancer cells. Our data provide compelling evidence for the transcriptional regulation of the miR-191/425 cluster and for its context-specific biological determinants in breast cancers. Importantly, we demonstrated that the miR-191/425 cluster, by reducing the expression of an extensive network of genes, has a fundamental impact on cancer initiation and progression of breast cancer cells

VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad

Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades. En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

The economic infrastructure gap in Latin America and the Caribbean

This edition of the FAL Bulletin analyzes the impact of economic infrastructure on development in Latin America and the Caribbean and looks at future investment needs for 2006-2020. It reviews the specialized literature and updates the statistical information available on public and private investment in developing economic infrastructure in some countries in the region

The People’s Republic of China and Latin America: the impact of Chinese economic growth on Latin American exports

The role of the People’s Republic of China in the world economy has grown substantially in recent decades, turning it into a strategic foreign trading partner for much of Latin America. Bilateral trade between the region and China totalled US$ 120 billion in 2009. This study analyses the income elasticity of the region’s exports to the country. The findings show that, assuming real gross domestic product (gdp) growth in China of about 7% a year, the value of Latin American exports to China (at 2005 prices) can be expected to increase by an average of about 10% a year between 2014 and 2019. In a more conservative scenario of 4.5% average annual growth in the Chinese economy over the period, exports would rise by about 7% a year