Comparación de los hábitos de consumo de carne de conejo entre consumidores jóvenes y compradores tradicionales de Sevilla

Se estudiaron los hábitos de consumo de carne de conejo de 499 estudiantes universitarios y de 399 compradores en mercados tradicionales de Sevilla (España). Los estudiantes universitarios afirmaron haber probado (67,9%) y consumir actualmente (38,6%) la carne de conejo en menor proporción que los compradores tradicionales (prueban: 84,5%; consumen: 46,6%). Ambos grupos afirman que les gusta esta carne en la misma proporción (78%).Las mujeres, sobre todo jóvenes, afirmaron haber probado y que les gusta en menor proporción esta carne que en el caso de los hombres. Se reveló además un mayor hábito de consumo y preferencia por la carne de conejo de monte en comparación con la del de granja, siendo la carne de conejo de monte preferida a la del de granja por un 88,2% de los consumidores sin distinción de grupo. Se dedujo una disminución del consumo de la carne de conejo entre los jóvenes en comparación con los compradores en mercados tradicionales

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND: Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVE: We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS: We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited from 29 international centers. RESULTS: At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% ± 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of ≤35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS: MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Comparison of opinions on the rabbit meat composition and properties between traditional purchasers and young consumers

Se estudiaron las opiniones sobre la composición y propiedades de la carne de conejo de 339 estudiantes universitarios y de 337 compradores en mercados tradicionales de Sevilla (España) que la habían consumido en alguna ocasión. El 28,4% de los encuestados opinaba que el contenido de proteína de esta carne es alto, sin diferencia entre jóvenes y consumidores tradicionales. El 60,7% de los sujetos afirmó que el contenido de grasa es bajo, el 39,6% consideró que el contenido de colesterol es bajo y el 25,7% afirmó que el aporte calórico es bajo, con mayor proporción de consumidores tradicionales que de jóvenes teniendo opiniones atinadas al respecto. La terneza y jugosidad fueron consideradas medias por el 83,2% y 52,1% de los sujetos, respectivamente, con mayor proporción de consumidores jóvenes que de compradores tradicionales otorgando puntuaciones altas a ambas propiedades organolépticas. El contenido de hueso de la carne de conejo se consideró alto por el 47,6% de los encuestados, con más proporción de jóvenes que de compradores manteniendo esta opinión. El 69,1% de los encuestados opinaban que la carne de conejo de granja tiene sabor medio, con mayor proporción de jóvenes opinando que el sabor es fuerte y de compradores tradicionales considerando que es débil. El 53,6% de los sujetos afirmaban que la carne de conejo de monte tiene sabor fuerte, con mayor proporción de jóvenes opinando que el sabor es medio y de compradores tradicionales considerando que es fuerte. El sexo sólo influyó en la opinión de los jóvenes sobre la jugosidad de la carne, siendo considerada alta por mayor proporción de hombres y nula por mayor proporción de mujeres, y en la opinión de los compradores tradicionales sobre el aporte calórico de la carne, que se consideró alto por mayor proporción de hombres y bajo por mayor proporción de mujeres. Se concluyó que existe cierto desconocimiento de la composición de la carne de conejo y que esta carne es percibida de diferente forma por consumidores jóvenes y compradores tradicionales.Opinions on the rabbit meat composition and properties from 339 students and 337 traditional purchasers from Seville (Spain), who had ever eaten this meat, were studied. 28.4% of respondents believed that the protein content of the meat is high, with no difference between young consumers and traditional purchasers. 60.7% of subjects said that the fat content is low, 39.6% felt that the cholesterol content is low and 25.7% said that calories are low, with higher proportion of traditional purchasers than young people having accurate views on the matter. Tenderness and juiciness were considered intermediate by 83.2% and 52.1% of subjects, respectively, with the highest proportion of young consumers against traditional purchasers giving high ratings to both organoleptic properties. The bone content in the rabbit meat was considered high by 47.6% of respondents, with more proportion of young consumers than traditional purchasers holding this opinion. 69.1% of respondents felt that the domestic rabbit meat taste is intermediate, with the highest proportion of young people believing that the taste is strong and traditional purchasers who thought that was weak. 53.6% of subjects claimed that the wild rabbit meat has a strong taste, with the highest proportion of young consumers believing that the taste is intermediate and traditional buyers believing it is strong. Sex influenced only the opinions of young people on the meat juiciness, being considered high by high proportion of men and low by more proportion of women; also influenced the opinion of the traditional purchasers about calories from meat, which was considered high by higher proportion of men and low by higher proportion of women. It was concluded that there is a certain ignorance of the composition of rabbit meat and that it is perceived differently by young consumers and traditional purchasers

Improvement of liquid absorption properties of nonwoven polypropylene substrates by low pressure plasma treatment with CH4-O2 mixture gas

“The final publication is available at Springer via http://dx.doi.org/10.1007/s12221-012-1139-z."The use of nonwoven textile substrates for filtration and absorption purposes is generalized due to the high surface area they can provide. Many of these applications require good wetting properties to increase efficiency. In this work, low pressure plasma treatment with a CH4-O-2 mixture gas has been used to increase surface wettability and subsequent absorption properties on nonwoven polypropylene substrates. CH4 plasma treatment leads to a plasma polymerization process which results in hydrophobic surface finishing, but in combination with O-2, it is possible to form a functionalized plasmapolymerized layer thus improving wetting properties. Changes in wetting properties have been studied by contact angle measurements showing that optimum wetting properties are obtained with exposure times to plasma treatment of about 10 min, and no significant changes are obtained for longer exposure times. Absorption efficiency has been followed by determining three different parameters by the guidelines of the UNE-EN-ISO 9073-6 standard: wetting time, liquid absorption capacity (LAC) and liquid propagation rate or absorption speed. All these properties are remarkably improved as the exposure time to CH4-O-2 plasma increases; this improvement is remarkably high for relatively short exposure times (5-10 min) and no significant changes are obtained for long exposure times so that, it is possible to conclude that previous plasma treatment with exposure times in the 5-10 min range is an efficient method to improve overall absorption properties of nonwoven polypropylene substrates.This work is a part of the project IPT-310000-2010-037, "ECOTEXCOMP: Research and development of textile structures useful as reinforcement of composite materials with marked ecological character" funded by the "Ministerio de Ciencia e Innovacion", with an aid of 189540.20 euros, within the "Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica 2008-2011" and funded by the European Union through FEDER funds, Technology Fund 2007-2013, Operational Programme on R+D+i for and on behalf of the companies.López, R.; Pascual Payá, M.; García Sanoguera, D.; Sánchez Nacher, L.; Balart Gimeno, RA. 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Transcriptional regulation of chemokine network by biologic monotherapy in ileum of patients with Crohn's disease

[Background]: Crohn’s disease (CD) exacerbation is marked by an intense cellular trafficking. We set out to determine the specific impact of biologic therapies on regulating chemokine network gene expression in healthy, mildly and severely inflamed tissue of CD patients.[Methods]: Twenty CD patients on biologics (adalimumab, ustekinumab, vedolizumab) or untreated undergoing colonoscopy due to clinical symptoms of flare. Healthy, mildly and severely inflamed ileum biopsies from each patient were collected. Chemokines and receptors gene expression was analyzed and a STRING analysis for functional enrichment was performed.[Results]: The chemokine network exhibited wide transcriptional differences among tissues in active untreated patients, whereas all biologic treatments reduced these differences and homogenized their transcriptional activity. In mildly inflamed tissue, all treatments showed gene upregulation while ustekinumab additionally maintained the downregulation of genes such as CCL2, CCL3, CCL17 or CCL23, involved in T cell chemotaxis, inflammatory monocyte and NK trafficking. In severely inflamed tissue, all treatments shared a downregulatory effect on chemokines controlling T cell response (i.e. CXCL16, CXCR3). Adalimumab and vedolizumab significantly reduced the expression of genes promoting antigen presentation by DCs and the initiation of leukocyte extravasation (i.e. CXCL12, CCL25, CCR7). Ustekinumab significantly reduced genes positively regulating Th1 cytokine production and IL-8 mediated signaling (i.e. IL1B, XCL1, CXCR1, CXCR2).[Conclusion]: Biologic therapies differentially target the chemokine network gene expression profile in the ileal tissue of active CD patients. These results may contribute to better understanding cell homing and to defining future personalized therapeutic strategies for CD patients.This study was partially funded by grants from Asociación Española de Gastroenterología (AEG), Madrid, Spain, to R.F.; from Instituto de Salud Carlos III (PI21/01702), Madrid, Spain., to A.G.; from the Spanish State Research Agency (AEI), cofinanced by ERDF (RYC-2015-18056 and RTI2018-102260-B-I00) to J.P.L.-A. The Instituto de Neurociencias (UMH-CSIC) is a “Centre of Excellence Severo Ochoa” (SEV-2017-0723).Peer reviewe