The Physics of the B Factories

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C

Ways to Reduce Risks When Building the Digital Economy in Russia. Educational Aspect

А group of authors of Peter the Great St. Petersburg Polytechnic University, working within the framework of the activity of Coordination Council for the Federal Educational and Methodical Associations on education in the field of “Engineering, Technology and Technical Sciences” have undertaken a comprehensive study dedicated to the processes of the digital economy formation. More than two hundred primary sources of reference have been analyzed. Several main groups of risks associated with the transition to global digitalization have been defined and classified. Further research results described in this article allow to characterize the specific features of the occurrence of risks in the Russian Federation and to determine the ways of reducing these risks.In addition to the six groups of risks which are currently possible to arise and which are characteristic of the entire world space, the authors have revealed a number of several additional risks typical only of Russia. One of the key areas in Russia that poses a whole range of various risks is the education system. The authors have analyzed and classified the policies and moves suggested by the researchers and politicians to reduce the likelihood of these specific risks occurrence.The qualitative leap of the educational process in Russia is possible only by means of the formation of some new competence profiles of educational institutions graduates with reference to the digital economy development conditions. The authors have defined seven types of competencies that are relevant for the transition of Russia to the digital economy and developed twelve pilot educational modules necessary for their formation

Toxicity management of angiogenesis inhibitors: resolution of expert panel

On 22 June 2017 in St. Petersburg the expert panel was held on the topic Management of toxicity of angiogenesis inhibitors, which discussed current issues of systemic therapy of advanced differentiated thyroid cancer resistant to radioactive iodine therapy, advanced kidney cancer and questions of efficacy and safety of new target drugs in the treatment of these diseases. The reports and discussions of experts raised the following questions: 1. Own experience of using lenvatinib in patients with differentiated thyroid cancer refractory to therapy with radioactive iodine and kidney cancer. 2. Profile of efficacy and safety of modern targeted therapy with multikinase inhibitors. 3. Prophylaxis and management of predictable toxicity

Late Neoproterozoic evolution of the southwestern margin of the Siberian Craton: evidence from sedimentology, geochronology and detrital zircon analysis

Sedimentary successions and igneous rocks exposed in Eastern Sayan provide an important geological record on the tectonic evolution of the southwestern margin of the Siberian Craton during the Neoproterozoic. Here we present sedimentological and detrital zircon provenance data from key stratigraphic units, complemented by a new U-Pb zircon age of 718 ± 6 Ma from the mafic Nersa magmatic complex. Sedimentological and provenance data from the lower part of the stratigraphic succession (Karagasy Group) show that these rocks were deposited in a passive margin setting after 750 Ma and before the emplacement of the Nersa magmatic complex. The upper part of the stratigraphic succession (Oselok Group) consists of Cryogenian and Ediacaran glaciogenic deposits and associated cap carbonates, overlain by mid to late Ediacaran sequences of dominantly shallow-marine and fluvial siliciclastic rocks. Provenance data indicate that rocks from the Tuva-Mongolia and Zavkhan terranes provided a significant input of detrital material into the sedimentary basin that was the source of the glacial deposits. Orogenic processes during the late Ediacaran (ca 570–540 Ma) in Eastern Sayan were likely associated with the accretion of the Tuva-Mongolia terrane, as indicated by the detrital zircon data

Hybridization of the RT-CR probes on chromosomes of <i>D</i>. <i>villosum</i>, <i>P</i>. <i>spicata</i>, <i>Th</i>. <i>bessarabicum</i>, and <i>Th</i>. <i>intermedium</i>.

<p><b>a-c</b> FISH analysis using RT-CR probes on the root-tip cells at mitotic metaphase in a) <i>D</i>. <i>villosum</i>, b) <i>P</i>. <i>spicata</i>, c) <i>Th</i>. <i>bessarabicum</i>; the metaphase plates are probed with <i>Davi</i> (a, green), <i>Pssp</i> (b, pink) and <i>Thbe</i> (c, pink). Bar = 5 μm. <b>d-f</b> Sequential multicolor FISH and multicolor GISH on the root-tip cells at mitotic metaphase in <i>Th</i>. <i>intermedium</i>: d) the mcFISH results using the <i>Thbe</i> probe (red); e) the same cell in (d) with <i>Pssp</i> probe (green); f) GISH analysis for the same cell in (d) and (e) with the labeled genomic DNA of <i>P</i>. <i>spicata</i> (green) and <i>D</i>. <i>villosum</i> (pink) as probes and <i>T</i>. <i>aestivum</i> genomic DNA (ABD genome) as a block. Bar = 10 μm. <b>g-i</b> Karyotype of chromosomes of <i>Th</i>. <i>intermedium</i> from (d-f) with the results of sequential multicolor FISH and multicolor GISH. Chromosomes organized into genomes J^r, J^vs and St according to St- and V-genome DNA labeling and FISH signal intensity in centromeric region. The J^vs chromosomes grouped into J^v chromosomes (in frame) and J^s chromosomes. The translocated chromosome marked with asterisk. g) Chromosomes with <i>Thbe</i> probe (red); h) The same chromosomes with <i>Pssp</i> probe (green); i) The same chromosomes labeled with genomic DNA of <i>P</i>. <i>spicata</i> (St genome, green) and <i>D</i>. <i>villosum</i> (V genome, pink) as probes and <i>T</i>. <i>aestivum</i> genomic DNA (ABD genome) as a block. Chromosomes counterstained with DAPI (blue).</p

Variation in Copy Number of Ty3/Gypsy Centromeric Retrotransposons in the Genomes of <i>Thinopyrum intermedium</i> and Its Diploid Progenitors

<div><p>Speciation and allopolyploidization in cereals may be accompanied by dramatic changes in abundance of centromeric repeated transposable elements. Here we demonstrate that the reverse transcriptase part of Ty3/gypsy centromeric retrotransposon (RT-CR) is highly conservative in the segmental hexaploid <i>Thinopyrum intermedium</i> (J^rJ^vsSt) and its possible diploid progenitors <i>Th</i>. <i>bessarabicum</i> (J^b), <i>Pseudoroegneria spicata</i> (St) and <i>Dasypyrum villosum</i> (V) but the abundance of the repeats varied to a large extent. Fluorescence <i>in situ</i> hybridization (FISH) showed hybridization signals in centromeric region of all chromosomes in the studied species, although the intensity of the signals drastically differed. In <i>Th</i>. <i>intermedium</i>, the strongest signal of RT-CR probe was detected on the chromosomes of J^v, intermediate on J^r and faint on J^s and St subgenome suggesting different abundance of RT-CR on the individual chromosomes rather than the sequence specificity of RT-CRs of the subgenomes. RT-CR quantification using real-time PCR revealed that its content per genome in <i>Th</i>. <i>bessarabicum</i> is ~ 2 times and <i>P</i>. <i>spicata</i> is ~ 1,5 times higher than in genome of <i>D</i>. <i>villosum</i>. The possible burst of Ty3/gypsy centromeric retrotransposon in <i>Th</i>. <i>intermedium</i> during allopolyploidization and its role in proper mitotic and meiotic chromosome behavior in a nascent allopolyploid is discussed.</p></div

The dendrogram of the deduced RT-CR amino acid sequences and their homologs from the NCBI Nucleotide collection search database.

<p>The dendrogram was constructed using the Maximum Likelihood method based on the JTT matrix-based model. The bootstrap consensus tree inferred from 1000 replicates. The colored bullets indicate the RT-CRs obtained in the present study.</p