25 research outputs found

    Détecter les manipulations financiÚres en France : Le cas d'une PME cotée sur Alternext

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    Cette recherche propose d'illustrer Ă  partir d'un cas rĂ©el la mise en oeuvre d'une dĂ©marche de dĂ©tection exante de diffĂ©rentes opĂ©rations de gestion des donnĂ©es comptables. S'appuyant sur les travaux de Schilitt, nous rappelons la typologie des manipulations comptables et donnons diffĂ©rents exemples de leur application par de grands groupes. La lecture attentive et l'analyse des documents financiers d'une jeune PME rĂ©cemment introduite en bourse nous permettent de prĂ©supposer et d'identifier certaines opĂ©rations de gestion des donnĂ©es comptables. Mauvaise reconnaissance des produits, transferts de charges actuelles vers des pĂ©riodes futures, prĂ©sentation d'actifs surĂ©valuĂ©s et de passifs sous-Ă©valuĂ©s sont les principales opĂ©rations identifiĂ©es. Ces opĂ©rations modifient considĂ©rablement les indicateurs financiers de la firme. Les contextes mouvants favorisent le recours Ă  la gestion des donnĂ©es comptables par les firmes. La multiplication des normes et rĂšgles ne peut Ă  elle seule suffire Ă  endiguer de telles pratiques, la dĂ©tection ex-ante doit aussi ĂȘtre privilĂ©giĂ©e tant par les praticiens que par les chercheurs et formateurs en sciences de gestion.analyse financiĂšre ; sociĂ©tĂ© cotĂ©e ; PME ; manipulations financiĂšres

    New genetic loci link adipose and insulin biology to body fat distribution.

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    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

    The genomics of heart failure: design and rationale of the HERMES consortium

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    Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targets) consortium aims to identify the genomic and molecular basis of heart failure.Methods and results The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of >1.10 for common variants (allele frequency > 0.05) and >1.20 for low-frequency variants (allele frequency 0.01-0.05) at P Conclusions HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.</p

    The genomics of heart failure: design and rationale of the HERMES consortium

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    Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≄1.10 for common variants (allele frequency ≄ 0.05) and ≄1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P &lt; 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction

    Quel enseignement de la finance entrepreneuriale ?

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    Les besoins et modalitĂ©s de financement des firmes innovantes ou Ă  forte croissance ont donnĂ© naissance ces derniĂšres annĂ©es Ă  un champ thĂ©orique et professionnel nouveau : la finance entrepreneuriale. Cet article propose, d’une part, de relever les particularitĂ©s de ce champ relativement aux autres champs de la finance et, d’autre part, de prĂ©senter l’ancrage thĂ©orique et pratique et les enjeux pĂ©dagogiques permettant de bĂątir une formation en finance entrepreneuriale. La concrĂ©tisation de ces rĂ©flexions a conduit Ă  l’élaboration d’un programme mastĂšre spĂ©cialisĂ© qui illustre, en derniĂšre partie, le propos. Nous espĂ©rons que cet article contribuera au dĂ©veloppement des formations en finance entrepreneuriale qui, par les exigences Ă©conomiques actuelles, devraient ĂȘtre amenĂ©es Ă  se rĂ©pandre tant en France qu’à l’international.Needs and modes for financing innovative or high-growth firms have given rise in recent years to a new professional and theoretical field : entrepreneurial finance. First, this article identifies and compares the characteristics of this field with those of other fields of finance. Second, we present the theoretical and practical foundations and the educational challenges of building a training program dedicated to entrepreneurial finance. The implementation of these ideas led to the development of a Specialized Masters program that encompasses this proposition. We hope that this article will contribute to the development of training programs in entrepreneurial finance, which should proliferate in France and abroad because of the current economic pressures and requirements.En los Ășltimos años, las necesidades y modalidades de financiamiento de las firmas innovantes o que tienen un crecimiento fuerte han dado nacimiento a un nuevo campo teĂłrico y profesional : Las finanzas del emprendimiento. Este artĂ­culo propone, por una parte, identificar las particularidades de este campo con respecto a las otras ĂĄreas de las finanzas y, por otra parte, presentar las implicaciones teĂłricas y prĂĄcticas y lo que estĂĄ en juego en el momento de concebir una formaciĂłn dedicada a las finanzas del emprendimiento. La concreciĂłn de estas reflexiones ha conducido a la creaciĂłn de un programa de Master especializado que ilustra, al final, nuestro propĂłsito. Esperamos que el artĂ­culo contribuirĂĄ al desarrollo de las formaciones en torno a las finanzas del emprendimiento que, tomando en cuenta las exigencias econĂłmicas actuales, deberĂ­an difundirse tanto en Francia como en el extranjero.Die steigende Bedeutung der BedĂŒrfnisse und die ModalitĂ€ten fĂŒr die Finanzierung innovativer und wachstumsorientierter Unternehmen hat in den letzten Jahren ein neues, theoretisches wie praktisches, BetĂ€tigungsfeld hervorgebracht : « Entrepreneurial Finance ». Einerseits grenzt die vorliegende Veröffentlichung die Eigenheiten von « Entrepreneurial Finance » zu anderen Finanzbereichen ab. Andererseits werden die theoretische und praktische Verankerung sowie die pĂ€dagogischen Herausforderungen bei der Entwicklung einer Lerneinheit zur Thematik dargestellt. Letzteres hat zur Bildung eines Masterprogrammes mit Schwerpunkt « Entrepreneurial Finance » gefĂŒhrt. Mit unserem Artikel leisten wir einen Beitrag zu Entwicklung der DomĂ€ne, in Frankreich wie international

    Quel enseignement de la finance entrepreneuriale ? Une proposition pragmatique

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    Les besoins et modalitĂ©s de financement des firmes innovantes ou Ă  forte croissance ont donnĂ© naissance ces derniĂšres annĂ©es Ă  un champ thĂ©orique et professionnel nouveau : la finance entrepreneuriale. Cet article propose, d’une part, de relever les particularitĂ©s de ce champ relativement aux autres champs de la finance et, d’autre part, de prĂ©senter l’ancrage thĂ©orique et pratique et les enjeux pĂ©dagogiques permettant de bĂątir une formation en finance entrepreneuriale. La concrĂ©tisation de ces rĂ©flexions a conduit Ă  l’élaboration d’un programme mastĂšre spĂ©cialisĂ© qui illustre, en derniĂšre partie, le propos. Nous espĂ©rons que cet article contribuera au dĂ©veloppement des formations en finance entrepreneuriale qui, par les exigences Ă©conomiques actuelles, devraient ĂȘtre amenĂ©es Ă  se rĂ©pandre tant en France qu’à l’international.Needs and modes for financing innovative or high-growth firms have given rise in recent years to a new professional and theoretical field : entrepreneurial finance. First, this article identifies and compares the characteristics of this field with those of other fields of finance. Second, we present the theoretical and practical foundations and the educational challenges of building a training program dedicated to entrepreneurial finance. The implementation of these ideas led to the development of a Specialized Masters program that encompasses this proposition. We hope that this article will contribute to the development of training programs in entrepreneurial finance, which should proliferate in France and abroad because of the current economic pressures and requirements.En los Ășltimos años, las necesidades y modalidades de financiamiento de las firmas innovantes o que tienen un crecimiento fuerte han dado nacimiento a un nuevo campo teĂłrico y profesional : Las finanzas del emprendimiento. Este artĂ­culo propone, por una parte, identificar las particularidades de este campo con respecto a las otras ĂĄreas de las finanzas y, por otra parte, presentar las implicaciones teĂłricas y prĂĄcticas y lo que estĂĄ en juego en el momento de concebir una formaciĂłn dedicada a las finanzas del emprendimiento. La concreciĂłn de estas reflexiones ha conducido a la creaciĂłn de un programa de Master especializado que ilustra, al final, nuestro propĂłsito. Esperamos que el artĂ­culo contribuirĂĄ al desarrollo de las formaciones en torno a las finanzas del emprendimiento que, tomando en cuenta las exigencias econĂłmicas actuales, deberĂ­an difundirse tanto en Francia como en el extranjero.Die steigende Bedeutung der BedĂŒrfnisse und die ModalitĂ€ten fĂŒr die Finanzierung innovativer und wachstumsorientierter Unternehmen hat in den letzten Jahren ein neues, theoretisches wie praktisches, BetĂ€tigungsfeld hervorgebracht : « Entrepreneurial Finance ». Einerseits grenzt die vorliegende Veröffentlichung die Eigenheiten von « Entrepreneurial Finance » zu anderen Finanzbereichen ab. Andererseits werden die theoretische und praktische Verankerung sowie die pĂ€dagogischen Herausforderungen bei der Entwicklung einer Lerneinheit zur Thematik dargestellt. Letzteres hat zur Bildung eines Masterprogrammes mit Schwerpunkt « Entrepreneurial Finance » gefĂŒhrt. Mit unserem Artikel leisten wir einen Beitrag zu Entwicklung der DomĂ€ne, in Frankreich wie international

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