102 research outputs found

    On the economic nature of consumers\u2019 willingness to pay for a selective and sustainable fishery: A comparative empirical study

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    Special issue on Discards regulation vs Mediterranean fisheries sustainability.-- 6 pages, 2 tables[EN] The EU Landing Obligation (LO) bans discards to incentivize a more selective and sustainable fishery. This regulation may induce a cost to the fishing industry that could be transferred to final fish consumers. We aim to assess the consumers’ reservation price for a sustainable and selective fishery. The methodology follows two steps: We first assess the value of the reservation price (willingness to pay, WTP) for a sustainable and selective fishery by using contingent valuation methods from a comparative perspective in Spain and Italy. We then attempt to empirically assess the components of WTP by using an original model specification that, unlike those presented in the literature, exogenizes socio-economic variables and uses ideological indicators to explain WTP in a two-line simultaneous model estimated by instrumental variable regression. The results show a positive, though low, WTP across the two samples, and very different impacts of estimated coefficients on the WTP for the two samples. A preliminary interpretation of this divergence highlights that Italian consumers consider LO-incentivized sustainable fishery a pure public good linked to issues of legality, and Spanish consumers consider it an impure public good linked to environmental issues. These differences may indicate how strongly the institutions and the policies in each region are perceived by a different human capital structure. They may also indicate that the problem, the perceptions of it and the solutions to it differ according to the context[ES] La obligación de desembarque de la Unión Europea (LO) prohíbe los descartes para incentivar una pesquería más selectiva y sostenible. Esta regulación puede inducir costes a la industria pesquera que a su vez pueden ser transferidos al consumidor final. Nuestro objetivo es evaluar el precio de reserva del consumidor para una pesquería más sostenible y selectiva. La metodología se basa en dos fases: primero, evaluamos el precio de reserva (disposición a pagar, WTP) para una pesquería sostenible y selectiva mediante métodos de valoración contingente (CV) en un estudio comparativo entre España e Italia. En una segunda fase intentamos estimar empíricamente los componentes de esta WTP mediante la especificación original de un modelo que, a diferencia de la literatura existente, exogeniza las variables socioeconómicas y usa indicadores ideológicos para explicar la WTP, en una regresión bi-funcional con variables instrumentales (IV). Los resultados muestran una WTP positiva, aunque reducida, en ambas muestras, y permiten deducir un impacto distinto de los coeficientes estimados en la WTP. La interpretación preliminar de esta divergencia hace destacar que los consumidores italianos consideran como un bien público puro a una pesquería sostenible incentivada mediante LO, relacionado con aspectos de legalidad, mientras que los consumidores españoles consideran ese modelo de pesquería como un bien público impuro, relacionado con conservación ambiental. Estas diferencias pueden indicar la fortaleza con la que dos estructuras distintas de capital humano perciben las instituciones y las políticas de cada región. También sugieren una distinta percepción, existencia y solución del problema en un contexto distintoThis research was funded by EU H2020 Research and Innovation Action “MINOUW” (contract nº 634495)Peer reviewe

    A deep phenotyping experience: up to date in management and diagnosis of Malan syndrome in a single center surveillance report

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    Background Malan syndrome (MALNS) is a recently described ultrarare syndrome lacking guidelines for diagnosis, management and monitoring of evolutive complications. Less than 90 patients are reported in the literature and limited clinical information are available to assure a proper health surveillance. Results A multidisciplinary team with high expertise in MALNS has been launched at the "Ospedale Pediatrico Bambino Gesu", Rome, Italy. Sixteen Italian MALNS individuals with molecular confirmed clinical diagnosis of MALNS were enrolled in the program. For all patients, 1-year surveillance in a dedicated outpatient Clinic was attained. The expert panel group enrolled 16 patients and performed a deep phenotyping analysis directed to clinically profiling the disorder and performing critical revision of previously reported individuals. Some evolutive complications were also assessed. Previously unappreciated features (e.g., high risk of bone fractures in childhood, neurological/neurovegetative symptoms, noise sensitivity and Chiari malformation type 1) requiring active surveillance were identified. A second case of neoplasm was recorded. No major cardiovascular anomalies were noticed. An accurate clinical description of 9 new MALNS cases was provided. Conclusions Deep phenotyping has provided a more accurate characterization of the main clinical features of MALNS and allows broadening the spectrum of disease. A minimal dataset of clinical evaluations and follow-up timeline has been proposed for proper management of patients affected by this ultrarare disorder

    DNA methylation episignature testing improves molecular diagnosis of Mendelian chromatinopathies

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    Purpose: Chromatinopathies include more than 50 disorders caused by disease-causing variants of various components of chromatin structure and function. Many of these disorders exhibit unique genome-wide DNA methylation profiles, known as episignatures. In this study, the methylation profile of a large cohort of individuals with chromatinopathies was analyzed for episignature detection. Methods: DNA methylation data was generated on extracted blood samples from 129 affected individuals with the Illumina Infinium EPIC arrays and analyzed using an established bioinformatic pipeline. Results: The DNA methylation profiles matched and confirmed the sequence findings in both the discovery and validation cohorts. Twenty-five affected individuals carrying a variant of uncertain significance, did not show a methylation profile matching any of the known episignatures. Three additional variant of uncertain significance cases with an identified KDM6A variant were re-classified as likely pathogenic (n = 2) or re-assigned as Wolf-Hirschhorn syndrome (n = 1). Thirty of the 33 Next Generation Sequencing negative cases did not match a defined episignature while three matched Kabuki syndrome, Rubinstein-Taybi syndrome and BAFopathy respectively. Conclusion: With the expanding clinical utility of the EpiSign assay, DNA methylation analysis should be considered part of the testing cascade for individuals presenting with clinical features of Mendelian chromatinopathy disorders

    Simulating the Effects of Alternative Management Measures of Trawl Fisheries in the Central Mediterranean Sea: Application of a Multi-Species Bio-economic Modeling Approach

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    In the last decades, the Mediterranean Sea experienced an increasing trend of fish stocks in overfishing status. Therefore, management actions to achieve a more sustainable exploitation of fishery resources are required and compelling. In this study, a spatially explicit multi-species bio-economic modeling approach, namely, SMART, was applied to the case study of central Mediterranean Sea to assess the potential effects of different trawl fisheries management scenarios on the demersal resources. The approach combines multiple modeling components, integrating the best available sets of spatial data about catches and stocks, fishing footprint from vessel monitoring systems (VMS) and economic parameters in order to describe the relationships between fishing effort pattern and impacts on resources and socio-economic consequences. Moreover, SMART takes into account the bi-directional connectivity between spawning and nurseries areas of target species, embedding the outcomes of a larvae transport Lagrangian model and of an empirical model of fish migration. Finally, population dynamics and trophic relationships are considered using a MICE (Models of Intermediate Complexity) approach. SMART simulates the fishing effort reallocation resulting from the introduction of different management scenarios. Specifically, SMART was applied to evaluate the potential benefits of different management approaches of the trawl fisheries targeting demersal stocks (deepwater rose shrimp Parapenaeus longirostris, the giant red shrimp Aristaeomorpha foliacea, the European hake Merluccius merluccius, and the red mullet Mullus barbatus) in the Strait of Sicily. The simulated management scenarios included a reduction of both fishing capacity and effort, two different sets of temporal fishing closures, and two sets of spatial fishing closures, defined involving fishers. Results showed that both temporal and spatial closures are expected to determine a significant improvement in the exploitation pattern for all the species, ultimately leading to the substantial recovery of spawning stock biomass for the stocks. Overall, one of the management scenarios suggested by fishers scored better and confirms the usefulness of participatory approaches, suggesting the need for more public consultation when dealing with resource management at sea

    Virgo calibration and reconstruction of the gravitational wave strain during VSR1

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    Virgo is a kilometer-length interferometer for gravitational waves detection located near Pisa. Its first science run, VSR1, occured from May to October 2007. The aims of the calibration are to measure the detector sensitivity and to reconstruct the time series of the gravitational wave strain h(t). The absolute length calibration is based on an original non-linear reconstruction of the differential arm length variations in free swinging Michelson configurations. It uses the laser wavelength as length standard. This method is used to calibrate the frequency dependent response of the Virgo mirror actuators and derive the detector in-loop response and sensitivity within ~5%. The principle of the strain reconstruction is highlighted and the h(t) systematic errors are estimated. A photon calibrator is used to check the sign of h(t). The reconstructed h(t) during VSR1 is valid from 10 Hz up to 10 kHz with systematic errors estimated to 6% in amplitude. The phase error is estimated to be 70 mrad below 1.9 kHz and 6 micro-seconds above.Comment: 8 pages, 8 figures, proceedings of Amaldi 8 conference, to be published in Journal of Physics Conference Series (JPCS). Second release: correct typo

    Calibration and sensitivity of the Virgo detector during its second science run

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    The Virgo detector is a kilometer-length interferometer for gravitational wave detection located near Pisa (Italy). During its second science run (VSR2) in 2009, six months of data were accumulated with a sensitivity close to its design. In this paper, the methods used to determine the parameters for sensitivity estimation and gravitational wave reconstruction are described. The main quantities to be calibrated are the frequency response of the mirror actuation and the sensing of the output power. Focus is also put on their absolute timing. The monitoring of the calibration data as well as the parameter estimation with independent techniques are discussed to provide an estimation of the calibration uncertainties. Finally, the estimation of the Virgo sensitivity in the frequency-domain is described and typical sensitivities measured during VSR2 are shown.Comment: 30 pages, 23 figures, 1 table. Published in Classical and Quantum Gravity (CQG), Corrigendum include

    Implementation and testing of the first prompt search for gravitational wave transients with electromagnetic counterparts

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    Aims. A transient astrophysical event observed in both gravitational wave (GW) and electromagnetic (EM) channels would yield rich scientific rewards. A first program initiating EM follow-ups to possible transient GW events has been developed and exercised by the LIGO and Virgo community in association with several partners. In this paper, we describe and evaluate the methods used to promptly identify and localize GW event candidates and to request images of targeted sky locations. Methods. During two observing periods (Dec 17 2009 to Jan 8 2010 and Sep 2 to Oct 20 2010), a low-latency analysis pipeline was used to identify GW event candidates and to reconstruct maps of possible sky locations. A catalog of nearby galaxies and Milky Way globular clusters was used to select the most promising sky positions to be imaged, and this directional information was delivered to EM observatories with time lags of about thirty minutes. A Monte Carlo simulation has been used to evaluate the low-latency GW pipeline's ability to reconstruct source positions correctly. Results. For signals near the detection threshold, our low-latency algorithms often localized simulated GW burst signals to tens of square degrees, while neutron star/neutron star inspirals and neutron star/black hole inspirals were localized to a few hundred square degrees. Localization precision improves for moderately stronger signals. The correct sky location of signals well above threshold and originating from nearby galaxies may be observed with ~50% or better probability with a few pointings of wide-field telescopes.Comment: 17 pages. This version (v2) includes two tables and 1 section not included in v1. Accepted for publication in Astronomy & Astrophysic
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