Anteproyecto arquitectónico de un complejo deportivo para la comarca de villa Chagüitillo, ubicado en el municipio de Sébaco, Departamento de Matagalpa

El deporte debe convertirse en un derecho fundamental que ha de basarse en la igualdad de oportunidades para todos; ya que fomenta el desarrollo físico, mental y social del individuo y es considerado una de las actividades que los seres humanos realizan desde temprana edad. Es por esto que el presente trabajo está dirigido al diseño de un Complejo Deportivo, ubicado en la comarca de Villa Chagüitillo, uno de los sectores rurales del municipio de Sébaco del departamento de Matagalpa, en donde las instalaciones para prácticas recreativas y deportivas han sido tradicionalmente descuidadas y en algunos casos abandonadas, por causa de los efectos negativos del crecimiento rural y urbano y el deterioro de las condiciones de vida de la población del sector. Debido a esto se pretende dar solución al déficit de zonas deportivas y recreativas, realizando el diseño de un Complejo Deportivo que permita el desarrollo de la población de todas las edades y que ayude al enriquecimiento de equipamiento del municipio

La influencia de las redes sociales en el rendimiento académico, de los estudiantes de 9° grado del Centro Escolar Cantón el Pajal, Municipio de San Juan Nonualco, Departamento de la Paz 2020.

Mediante dicha investigación se aplicó el Método Cualitativo con un diseño de Teoría Fundamentada (Proceso inductivo). Explico con más cautela la problemática y aprobación de la misma, resumiendo la inadecuada administración de las redes sociales, perjudicando el rendimiento académico de los estudiantes de noveno grado del centro escolar “Cantón el Pajal”. Descubriendo efectos en las áreas: Académica, familiar, social y económica tales como: Falta de concentración en los estudios, bajo rendimiento escolar, distanciamiento en la familia, alteraciones en el comportamiento, adicción, personalidad encubierta etc. Un porcentaje mínimo de participantes replico el aporte constructivo de las plataformas virtuales y el internet en general. Estableciendo como objetivo general: Conocer la influencia de las redes sociales en el rendimiento escolar, seguidamente los objetivos específicos ayudaron a culminar con el propósito. Finalmente dejar un aporte mediante un programa que permitirá orientar al alumnado respecto al área tecnológica con el fin de enfatizar en la temática

Acute or chronic effects of cannabinoids on spontaneous or pharmacologically induced yawning in rats

Abstract Yawning is a reflex or event that is not fully understood. It is controlled by many neurotransmitters and neuropeptides and can be induced pharmacologically by cholinergic or dopaminergic agonists. Amongst their many actions, cannabinoids acting on cannabinoid (CB 1 or CB 2 ) receptors can alter cholinergic and/or dopaminergic activity. This study examined the effects of D -THC. However, a high frequency of spontaneous yawning was observed 7 days after D 8 -THC discontinuation. These results suggest that cannabinoid agonists inhibited yawning induced by cholinergic or dopaminergic agonists. In addition, the increased frequency of spontaneous yawning following cessation of chronic administration of a cannabinoid agonist may be of importance as a withdrawal sign for these drugs.

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Fator de crescimento do endotélio vascular e do transportador de glicose 1 em cães com ceratose actínica e carcinoma de células escamosas

The skin exposed to UV light undergoes changes in morphology and function, this influences the local production of cytokines and impairs the antigen recognition and processing. The chronic sun exposure on the skin of dogs with ages of eight to ten years, short hair coat and clear, with little pigmentation and glabra, usually progresses to actinic keratosis (AK) and culminates in cutaneous squamous cell carcinoma (SCC). Essential part of the malignant phenotype is angiogenesis, which is the promoter Vascular Endothelial Growth Factor (VEGF) that plays on endothelial cells. Additionally angiogenesis, the growth of neoplastic cells requires increasing cell membrane proteins involved in nutrition, as the Glucose Transporter 1 (GLUT 1), which is essential for survival and proliferation of tumor cells. Thus, we proposed to investigate the value of VEGF and GLUT 1 in tumor progression employing for this skin of dogs concomitantly presented the AK (AK group), SCC (SCC Group) absent from skin diseases and skin (Lesions distant Group), comparing them with the skin of healthy dogs without histopathological changes (Control Group); also evaluate whether treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) may interfere with markings of antibodies, as well as evaluating the intensity of these markings differed in the skin of dogs with tumor recurrence of which did not. For this, 15 dogs were selected with AK and SCC lesions and with lesions distant skin and 15 dogs with normal skin. The intensity of expression of GLUT 1 and VEGF was investigated by use of immunohistochemistry and the results were evaluated statistically. The AK and Lesions distant Groups showed similar behavior as the intensity staining of VEGF; while the intensity of GLUT 1 was similar in AK and SCC Groups. Samples from the AK Group who did not receive NSAIDs, VEGF showed higher intensity staining than the AK group receiving NSAID; already in dogs with tumor recurrence ...A pele exposta à luz UV sofre alteração nas funções e características morfológicas, isto influencia a produção local de citocinas e prejudica o reconhecimento e processamento de antígenos. A cronicidade a exposição solar na pele de cães com idades de oito a dez anos, de pelame curto e claro, com pouca pigmentação e glabra, usualmente evolui para ceratose actínica (CA) e culmina em carcinoma de células escamosas (CCE) cutâneo. Parte essencial do fenótipo maligno é a angiogênese, que tem como promotor o Fator de Crescimento do Endotélio Vascular (VEGF) que atua nas células endoteliais. Adicionalmente a angiogênese, o crescimento das células neoplásicas requer o aumento de proteínas da membrana celular envolvidas na nutrição, como o Transportador de Glicose 1 (GLUT 1), que é essencial para a sobrevivência e proliferação das células tumorais. Assim, se propôs investigar o valor do VEGF e do GLUT 1 na progressão tumoral empregando-se para isso pele de cães que apresentavam concomitantemente a CA (Grupo CA), CCE (Grupo CCE) e pele ausente de dermatopatias (Grupo Distante de lesões), comparando-as com a pele de cães sadios sem alterações histopatológicas (Grupo Controle); também avaliar se o tratamento com anti-inflamatórios não esteroidais (AINEs) poderia interferir nas marcações dos anticorpos, bem como avaliar se a intensidade dessas marcações diferia na pele de cães que apresentaram recidiva tumoral dos que não apresentaram. Para isso, foram selecionados 15 cães com lesões de CA e CCE e pele distante de lesões e outros 15 cães com peles normais. A intensidade da expressão do VEGF e do GLUT 1 foi investigada pelo uso da imuno-histoquímica e os resultados avaliados estatisticamente. Os Grupos CA e Distante das lesões apresentaram comportamento semelhante quanto à intensidade de marcação do VEGF; enquanto a intensidade do GLUT 1 foi semelhante nos Grupos CA e CCE. Nas amostras do grupo CA ..

Caracterización morfológica de películas biodegradables a partir de almidón modificado de yuca, agente antimicrobiano y plastificante

Se ha evaluado la morfología superficial de almidones termoplásticos (TPS)obtenidos de tres variedades de almidón modificado de yuca, plastificante y unagente antimicrobiano. Las películas fueron obtenidas por extrusión soplado, seacondicionaron a una temperatura de 25 °C y humedad relativa de 50 % durante 48 horas y se extendieron sobre un portaobjetos; se procedió a tomar las fotomicrografías con los objetivos de 4x y 10x. Se usó la técnica microscopia óptica de alta resolución (MOAR) para caracterizar las imágenes. La técnica mostró que la adición del plastificante afecta la microestructura de películas de almidón de yuca demostrando una falta de homogeneidad, sin embargo se presentaron regiones lisas relacionadas con el tamaño y forma del gránulo de almidón, la concentración del plastificante y las condiciones del proceso de extrusión como la velocidad del tornillo y el perfil de temperatura. Esta investigación contribuyó a caracterizar las propiedades microestructurales de los almidones termoplásticos, que son imprescindibles para la continuidad en el estudio de películas biodegradables

Estudio y diseño de un sistema de vigilancia y monitoreo de video en tiempo real, sobre una red ip, para un terminal de despacho y bombeo de combustible de la gerencia regional sur de petrocomercial

EL PRESENTE PROYECTO ES ESTABLECER LAS BASE DEL FUNCIONAMIENTO DE UN SISTEMA DE VIDEO VIGILANCIA SOBRE UNA RED IP COMO UN SERVICIO DE SEGURIDAD Y DETECCION DE INTRUSOS QUESE IMPLEMENTAN EN UN TERMINAL DE DESPACHO Y BOMBEO DE COMBUSTISBLE DE LA REGIOANL SUR DE PETROCOMERCIAL SE ENCUENTRA DIVIDO EN CINCO CAPITULOS:1.REDES CONMUTADAS TRANSPORTE ARQUITECTURA FUNCIONAMIENTO.2.SISTEMA DE VIGILANCIA DESPACHO BOMBEO DE COMBUSTIBLE3.DISEÑO COBERTURA ARQUITECTURA4.ADMINISTRACION CONFIGURACION RED IP 5. ASPECTO ECONOMICO VALORES DE LA INVERSIO

CARACTERIZACIÓN MORFOLÓGICA DE PELÍCULAS BIODEGRADABLES A PARTIR DE ALMIDÓN MODIFICADO DE YUCA, AGENTE ANTIMICROBIANO Y PLASTIFICANTE CARACTERIZAÇÃO MORFOLÓGICA DE FILMES BIODEGRADÁVEIS A PARTIR DE AMIDO MODIFICADO DE MANDIOCA, AGENTE ANTIMICROBIANO E PLASTIFICANTE MORPHOLOGICAL CHARACTERIZATION OF BIODEGRADABLE FILMS MADE FROM MODIFIED CASSAVA STARCH, ANTIMICROBIAL AGENT AND PLASTICIZER

Se ha evaluado la morfología superficial de almidones termoplásticos (TPS) obtenidos de tres variedades de almidón modificado de yuca, plastificante y un agente antimicrobiano. Las películas fueron obtenidas por extrusión soplado, se acondicionaron a una temperatura de 25°C y humedad relativa de 50% durante 48 horas y se extendieron sobre un portaobjetos; se procedió a tomar las fotomicrografías con los objetivos de 4x y 10x. Se usó la técnica microscopia óptica de alta resolución (MOAR) para caracterizar las imágenes. La técnica mostró que la adición del plastificante afecta la microestructura de películas de almidón de yuca demostrando una falta de homogeneidad, sin embargo se presentaron regiones lisas relacionadas con el tamaño y forma del gránulo de almidón, la concentración del plastificante y las condiciones del proceso de extrusión como la velocidad del tornillo y el perfil de temperatura. Esta investigación contribuyó a caracterizar las propiedades microestructurales de los almidones termoplásticos, que son imprescindibles para la continuidad en el estudio de películas biodegradables.Avaliou-se a morfologia superficial dos amidos termoplásticos (TPS) obtidos de três variedades de amido modificado da mandioca, plastificante e um agente antimicrobiano. Os filmes foram obtidos por extrusão soprada e espalhados sobre uma lâmina; passou - se a tomar as fotomicrografias com os objetivos de 4x e 10x. Foi usada a técnica da microscopia óptica de alta resolução (MOAR) para caracterizar as imagens. A técnica mostrou que a adição do plastificante afeta a microestrutura dos filmes de amido de mandioca mostrando uma falta de homogeneidade, no entanto presentearam - se regiões lisas relacionadas com o tamanho y forma do granulo do amido, a concentração de plastificante e as condições do processo de extrusão como a velocidade do parafuso e o perfil de temperatura. Esta pesquisa contribuiu a caracterizar as propriedades microestruturais e mecânicas dos amidos termoplásticos, que são essenciais para a continuidade no estudo de filmes biodegradáveisIt was evaluated the morphological surface of thermoplastic starch (TPS) obtained from three modified cassava starch varieties, plasticizer and an antimicrobial agent. The films was made by blown extrusion and extended over a slide and then was taken photomicrographs with 4x and 10x objectives. It was used High Resolution Optical Microscopy to image characterization. The technique showed the effect of plasticizer addition over the starch films microstructure, it was found some inhomogeneity; however was identified some smooth regions related to form and size of starch granule, plasticizer concentration and extrusion variables process like velocity screw and temperature profile. This research contributed to characterize microstructural properties and gave some insights about the mechanical behaviour of TPS films, needed to study and make biodegradable films