City in Transition: Urban Open Innovation Environments as a Radical Innovation

In this paper we apply the transition prespective to the field of urban development. As many sectors of our society the field of urban development is undergoing major changes. Commom ways of working and traditional business models fail under the present economic circomstances and are not able to answer to the challenges that climate change, peak oil and the shortage of rare earth minirals present. We view new approaches to the process of urban area development and the introduction of the Smart City concept as prominent examples of potential transitional change in urban development and explore their possible synergies. In order to do so, we use the key concept of radical innovation and find that Urban Open Innovation Environments, such as Fab Labs, have most transitional potential. We conclude with some examples of these environments in the city of Rotterdam and preliminary success factors

The influence of volume and intensive care unit organization on hospital mortality in patients admitted with severe sepsis: a retrospective multicentre cohort study

Contains fulltext : 52407.pdf ( ) (Open Access)INTRODUCTION: The aim of the study was to assess the influence of annual volume and factors related to intensive care unit (ICU) organization on in-hospital mortality among patients admitted to the ICU with severe sepsis. METHODS: A retrospective cohort study was conducted using the database of the Dutch National Intensive Care Evaluation (NICE) registry. Analyses were based on consecutive patients admitted between 1 January 2003 and 30 June 2005 who fulfilled criteria for severe sepsis within the first 24 hours of admission. A 13-item questionnaire was sent to all 32 ICUs across The Netherlands that participated in the NICE registry within this period in order to obtain information on ICU organization and staffing. The association between in-hospital mortality and factors related to ICU organization was investigated using logistic regression analysis, combined with generalized estimation equations to account for potential correlations of outcomes within ICUs. Correction for patient-related factors took place by including Simplified Acute Physiology Score II, age, sex and number of dysfunctioning organ systems in the analyses. RESULTS: Analyses based on 4,605 patients from 28 ICUs (questionnaire response rate 90.6%) revealed that a higher annual volume of severe sepsis patients is associated with a lower in-hospital mortality (P = 0.029). The presence of a medium care unit (MCU) as a step-down facility with intermediate care is associated with a higher in-hospital mortality (P = 0.013). For other items regarding ICU organization, no independent significant relationships with in-hospital mortality were found. CONCLUSION: A larger annual volume of patients with severe sepsis admitted to Dutch ICUs is associated with lower in-hospital mortality in this patient group. The presence of a MCU as a step-down facility is associated with greater in-hospital mortality. No other significant associations between in-hospital mortality and factors related to ICU organization were found

Five planets and an independent confirmation of HD 196885Ab from Lick Observatory

We present time series Doppler data from Lick Observatory that reveal the presence of long-period planetary companions orbiting nearby stars. The typical eccentricity of these massive planets are greater than the mean eccentricity of known exoplanets. HD30562b has Msini = 1.29 Mjup, with semi-major axis of 2.3 AU and eccentricity 0.76. The host star has a spectral type F8V and is metal rich. HD86264b has Msini = 7.0 Mjup, arel = 2.86 AU, an eccentricity, e = 0.7 and orbits a metal-rich, F7V star. HD87883b has Msini = 1.78 Mjup, arel = 3.6 AU, e = 0.53 and orbits a metal-rich K0V star. HD89307b has Msini = 1.78 Mjup, arel = 3.3 AU, e = 0.24 and orbits a G0V star with slightly subsolar metallicity. HD148427b has Msini = 0.96 Mjup, arel = 0.93 AU, eccentricity of 0.16 and orbits a metal rich K0 subgiant. We also present velocities for a planet orbiting the F8V metal-rich binary star, HD196885A. The planet has Msini = 2.58 Mjup, arel = 2.37 AU, and orbital eccentricity of 0.48, in agreement with the independent discovery by Correia et al. 2008.Comment: 12 figures, 8 tables, accepted Ap

Retired A Stars and Their Companions II: Jovian planets orbiting kappa Coronae Borealis and HD167042

We report precise Doppler measurements of two evolved stars, kappa CrB (HD142091) and HD 167042, obtained at Lick Observatory as part of our search for planets orbiting intermediate-mass subgiants. Periodic variations in the radial velocities of both stars reveal the presence of substellar orbital companions. These two stars are notably massive with stellar masses of 1.80 Msun and 1.64 Msun, indicating that they are former A-type dwarfs that have evolved off of the main sequence and are now K-type subgiants. The planet orbiting kappa CrB has a minimum mass Msini = 1.8 Mjup, eccentricity e = 0.146 and a 1208 day period, corresponding to a semimajor axis of 2.7 AU. The planet around HD167042 has a minimum mass Msini = 1.7 Mjup and a 412.6 day orbit, corresponding to a semimajor axis of 1.3 AU. The eccentricity of HD167042b is consistent with circular (e = 0.027+/-0.04), adding to the rare class of known exoplanets in long-period, circular orbits similar to the Solar System gas giants. Like all of the planets previously discovered around evolved A stars, kappa CrBb and HD167042b orbit beyond 0.8 AU.Comment: 8 pages, 3 figures, 4 tables, ApJ Accepte

p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2.

Proper gene regulation is critical for both neuronal development and maintenance as the brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that interacts with transcription factors and chromatin remodeling complexes, is required for the embryonic formation of the cerebral cortex. Here we show that Akirin2 plays a mechanistically distinct role in maintaining healthy neurons during cortical maturation. Restricting Akirin2 loss to excitatory cortical neurons resulted in progressive neurodegeneration via necroptosis and severe cortical atrophy with age. Comparing transcriptomes from Akirin2-null postnatal neurons and cortical progenitors revealed that targets of the tumor suppressor p53, a regulator of both proliferation and cell death encoded b

Variable Sodium Absorption in a Low-Extinction Type Ia Supernova

Recent observations have revealed that some Type Ia supernovae exhibit narrow, time-variable Na I D absorption features. The origin of the absorbing material is controversial, but it may suggest the presence of circumstellar gas in the progenitor system prior to the explosion, with significant implications for the nature of the supernova progenitors. We present the third detection of such variable absorption, based on six epochs of high-resolution spectroscopy of the Type Ia supernova SN 2007le from Keck and the HET. The data span ~3 months, from 5 days before maximum light to 90 days after maximum. We find that one component of the Na D absorption lines strengthened significantly with time, indicating a total column density increase of ~2.5 x 10^12 cm^-2. The changes are most prominent after maximum light rather than at earlier times when the UV flux from the SN peaks. As with SN 2006X, we detect no change in the Ca II H&K lines over the same time period, rendering line-of-sight effects improbable and suggesting a circumstellar origin for the absorbing material. Unlike the previous two SNe exhibiting variable absorption, SN 2007le is not highly reddened (E_B-V = 0.27 mag), also pointing toward circumstellar rather than interstellar absorption. Photoionization models show that the data are consistent with a dense (10^7 cm^-3) cloud or clouds of gas located ~0.1 pc from the explosion. These results broadly support the single-degenerate scenario previously proposed to explain the variable absorption, with mass loss from a nondegenerate companion star responsible for providing the circumstellar gas. We also present tentative evidence for narrow Halpha emission associated with the SN, which will require followup observations at late times to confirm. [abridged]Comment: 16 pages, 10 figures (8 in color), 5 tables. Accepted for publication in Ap

Infall Times for Milky Way Satellites From Their Present-Day Kinematics

We analyze subhalos in the Via Lactea II (VL2) cosmological simulation to look for correlations among their infall times and z = 0 dynamical properties. We find that the present day orbital energy is tightly correlated with the time at which subhalos last crossed into the virial radius. This energy-infall correlation provides a means to infer infall times for Milky Way satellite galaxies. Assuming that the Milky Way's assembly can be modeled by VL2, we show that the infall times of some satellites are well constrained given only their Galactocentric positions and line-of-sight velocities. The constraints sharpen for satellites with proper motion measurements. We find that Carina, Ursa Minor, and Sculptor were all accreted early, more than 8 Gyr ago. Five other dwarfs, including Sextans and Segue 1, are also probable early accreters, though with larger uncertainties. On the other extreme, Leo T is just falling into the Milky Way for the first time while Leo I fell in \sim 2 Gyr ago and is now climbing out of the Milky Way's potential after its first perigalacticon. The energies of several other dwarfs, including Fornax and Hercules, point to intermediate infall times, 2 - 8 Gyr ago. We compare our infall time estimates to published star formation histories and find hints of a dichotomy between ultrafaint and classical dwarfs. The classical dwarfs appear to have quenched star formation after infall but the ultrafaint dwarfs tend to be quenched long before infall, at least for the cases in which our uncertainties allow us to discern differences. Our analysis suggests that the Large Magellanic Cloud crossed inside the Milky Way virial radius recently, within the last \sim 4 billion years.Comment: 15 pages, 7 figures, all figures include colors, submitted for publication in MNRA