The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population

WOS: 000393291900012OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. in this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. the patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). the patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: the levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population

Faunistic Composition, Ecological Properties and Zoogeographical Composition of the Family Elateridae (Coleoptera) of the Central Anatolian Region of Turkey

The focus of this study was to understand the faunistic composition, ecological properties and zoogeographical composition of Elateridae (Coleoptera) of the Central Anatolian region. 72 species belonging to seven subfamilies and 25 genera were identified. The major part of the Elateridae fauna of the Central Anatolian region is formed by the subfamilies Elaterinae and Cardiophorinae. The genus Cardiophorus was the most species-rich genus. The species composition of the Elateridae fauna of the Central Anatolian region is partially consistent with known Elateridae fauna of Turkey. The Central Anatolian region shares most species with the European part of the Western Palaearctic as does the Elateridae fauna of Turkey. Detailed localities of nine species are given for the first time for Turkey, with emphasis on the Central Anatolian region

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Retrospective evaluation of patients with meningocell and meningomyelocell surgery

Amaç: Nöral tüp defektleri (NTD) santral sinir sisteminin doğumsal orta hat gelişim anomalileri olarak adlandırılır. Klinikte bu hastalık grubunda en sık görülenler spinaldisrafizm grubunda yer alan meningomiyelosel ve meningoseldir. Meningomiyeloselspinal kordu hafif formundan çok şiddetli formuna kadar değişik derecelerde etkileyebilir. Bu çalışmada kliniğimizemeningomiyelosel ve meningosel tanısı ile cerrahi tedavi uygulanan hastalar retrospektif olarak değerlendirildi. Yaptığımız bu çalışmayla meningomiyelosel ve meningoselin tedavisi ve komplikasyonları ile mücadelede yeni stratejilerin geliştirilmesine yardımcı olmakamaçlanmıştır. Yöntem: Bu çalışma Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Beyin ve Sinir Cerrahisi Kliniğinde gerçekleştirildi. Çalışmaya;2018-kasım 2020 tarihleri arasında meningosel ve miyelomeningosel tanıları ile opere edilmiş hastalar dahil edildi. Bulgular: Retrospektif olarak yapılan bu çalışmaya, %51,2'si (n=42) erkek, %48,8'i (n=40) kız olmak üzere toplam 82 meningosel ve miyelomeningosel tanısı ile opere edilmiş hastalar dahil edilmiştir. Hastaların % 9,80'inde (n=8) meningosel, %90,20 'sinde (n=74) miyelomeningosel mevcuttu. Araştırmaya alınan bebeklerin gestasyonel yaş ortalaması 36,04±2,08 (30,00-39,00) , annelerin yaş ortalaması 27,55±5,56 (18,00-44,00) bulundu. Bebeklerin operasyon öncesindeki nörolojik muayene durumları incelendiğinde; %64,6 'sında (n=53) parapleji, %25,6'sında (n=21) parezi olduğu tespit edildi. Bebeklerin %9,8 'inde (n=8) kas gücü kaybı yoktu. Çalışmaya dahil edilen bebeklerin kese lezyon seviyelerine göre ayrıldığında; %62,2 'si (n=51) lomber, %23,2'si (n=19) lumbosakral, %8,5'i (n=7) torakolomber , % 6,1'i (n=5) torakal bölgede olduğu gözlendi. Hastalar ortalama 4,00±7,87 (1,00-36,00) günlük iken opere edildiği gözlendi. Opere edilen bebeklerin % 45,10'sinde (n=37) primer kapatma, % 54,90'ına (n=45) flep çevrilerek kapatma tekniği uygulandığı izlendi. . Operasyon sırasında bebeklerin % 22,00'ında (n=18) sentetik dura kullanıldığı tespit edildi. Opere edildikten sonra gerek görülen hastalara ortalama 20,00±16,99 (1,00-73,00) günlük iken şant takıldığı belirlendi. Operasyon sonrası hastaların % 24,40'ında (n=20) BOS fistülü geliştiği gözlendi. Sonuç:Meningosel ve meningomiyelosel hastalarının tedavilerinde multidisipliner yaklaşılması ve komplikasyonların ve eşlik eden anomalilerin de göz önünde bulundulması önemlidir. Kese cerrahisinde de mümkün oldukça hastanın kendi durası ve primer cilt kapatmanın tercih edilmesi önerilmektedir.Aim: Neural tube defects (NTDs) are called congenital midline developmental anomalies of the central nervous system. Meningomyelocele and meningocele, which are in the spinal dysraphism group, are the most common in this disease group. Meningomyelocele can affect the spinal cord in varying degrees from mild to very severe forms. In this study, patients who underwent surgery for meningomyelocele and meningocele in our clinic were evaluated retrospectively. With this study, we aimed to help develop new strategies in the treatment of meningomyelocele and meningocele and their complications. Methods: This study was carried out in Necmettin Erbakan University Meram Medical Faculty Brain and Nerve Surgery Clinic. Patients who were operated with the diagnosis of meningocele and myelomeningocele between 2018 and November 2020 were included in the study. Results: This retrospective study included 82 meningocele and myelomeningocele patients, 51.2% (n = 42) male and 48.8% (n = 40) female. 9.80% (n = 8) of the patients had meningocele and 90.20% (n = 74) had myelomeningocele. The mean gestational age of the babies included in the study was 36.04 ± 2.08 (30.00-39.00), and the mean age of the mothers was 27.55 ± 5.56 (18.00-44.00). When the pre-operative neurological examination status of babies is examined; It was found that 64.6% (n = 53) had paraplegia and 25.6% (n = 21) had paresis. There was no loss of muscle strength in 9.8% (n = 8) of the babies. When the bladder is separated according to the lesion levels of the babies included in the study; 62.2% (n = 51) lumbar, 23.2% (n = 19) lumbosacral, 8.5% (n = 7) thoracolumbar, 6.1% (n = 5) It was observed to be in the thoracic region. It was observed that the patients were operated when they were 4.00 ± 7.87 (1.00-36.00) days on average. It was observed that primary closure technique was applied in 45.10% (n = 37) of the operated babies, and closure technique was applied by turning flap to 54.90% (n = 45). . It was found that synthetic dura was used in 22.00% (n = 18) of the babies during the operation. It was determined that shunt was applied to patients who were deemed necessary after the operation when they were 20.00 ± 16.99 (1.00-73.00) days. It was observed that CSF fistula developed in 24.40% (n = 20) of the patients after the operation. Conclusion: In the treatment of meningocele and meningomyelocele patients, it is important to have a multidisciplinary approach and to consider complications and accompanying anomalies. In pouch surgery, it is recommended to prefer the patient's own dura and primary skin closure whenever possible

SEÇİMLERİN TÜRKİYE EKONOMİSİ ÜZERİNDE YARATTIGI ETKİLER: HENDRY YAKLASIMI

Seçimler siyasi iktidarın el degistirdigi veya iktidarını uzattıgı politik bir olay olmaktan çıkmıs, ekonomileri -siyasi aktörlerin fırsatçı davranıslarından dolayı- etkileyen, ekonometristlerin ve iktisatçıların ilgisini çeken bir konu baslıgı olmustur. Bu çalısmada; Politik Konjonktür Hareketleri Teorisi ısıgında, politika ile ekonomi arasındaki iliskide yer alan aktörler, bu aktörlerin davranısları ve bu davranısların seçimlere etkileri, Politik Konjonktür Hareketleri Teorisi'nin genel çerçevesi ve siyasi iktidarın seçimleri etkileyebilecegi popülist araçlar ele alınmıstır. Yapılan ampirik analizde ise; Türkiye'de 1988-2008 yılları arasındaki genel seçimlerin kamu harcamaları ve fiyatlar üzerine etkileri arastırılmıstır. Çalısma 3 aylık veriler ile Hendry'nin Genelden Özele Yaklasımıyla analiz edilmis, çalısmada seçimlerin fiyatlar üzerinde bir etkisinin bulunmadıgı fakat kamu harcamalarını etkiledigi sonucuna ulasılmıstır.Elections, which affect the economies due to the opportunist behaviors of politicians, are no longer phenomena of just a switch or an approval of political competence but have become a subject matter of interest for economists and econometrists. In this study, actors in the relationship between the politics and economy, their acts and effects of these acts on the elections, and populist policies which can be utilized by the government competence in order to affect the elections are analyzed in the light of the Political Conjuncture Actions Theory. An overview of the Political Conjuncture Actions Theory is also given in this thesis study. The effects of the general elections between years 1988-2008 on the government payment and prices in Turkey is researched by the help of an empirical analysis carried out. The analysis performed by using Hendry's deductive approach on 3 month period data showed no correlation between the prices and elections; but some effects of elections on government payment are observed

Tek parti (1923-1950) ve Demokrat Parti (1950-1960) dönemlerinde yerel siyaset ve yerel demokrasi : Ankara özelinde karşılaştırmalı bir analiz

Bu çalışma Ankara’nın Tek Parti dönemi (1923-1950) ve Demokrat Partidönemi (1950-1960) yerel siyaseti üzerine odaklanmaktadır. Ankara’daki yerel siyasetianaliz etme amacına yönelik olarak dönemin ulusal siyasetini, siyasal gelişmeleri, yerelseçimleri, kentleşmeyi ve sosyal yapıyı incelemektedir. Çalışma, Ankara’yımodernleşme projesi olarak gören Cumhuriyet Halk Partisi ile daha sonra iktidara gelenDemokrat Parti’nin Ankara’sı arasındaki yerel siyaset ve demokrasi bağlamındakianlayış farklarını, yerel iktidar mücadelesi pratiklerini ve dönemin yerel yönetimlerininulusal siyaset ile bağını karşılaştırmayı amaçlamaktadır.Türkiye’de yapılan kent tarihi araştırmalarında en fazla araştırmaya konu olankent İstanbul’dur. Oysa neredeyse bir yüzyıla yakın Türkiye Cumhuriyeti’ninbaşkentliği vazifesini üstlenen Ankara hakkında çalışılan alan sınırları içinde çok zenginbir kaynak arşivi mevcut değildir. Özellikle Demokrat Parti dönemi Ankara’sına aitçalışma yok denecek kadar azdır. Bu kapsamda araştırma, bu dönemin daha iyianlaşılmasına yönelik bir çabayı içermektedir.Araştırmanın sınırları, kapsamı ile doğrudan ilgilidir. Çalışmada Ankara’nın1923’den itibaren yayıldığı merkez alan yani şehrin merkezi coğrafi olarak dikkatealınmıştır. Ankara’nın ilçeleri çalışmanın kapsamında değildir. Çalışmanın zaman sınırıCumhuriyet Halk Partisi dönemi ile Demokrat Parti dönemini kapsamaktadır (1923-1960). Araştırmada mevcut veriler, alan yazın incelemesi, gazete ve dergikoleksiyonlarının taranması, Meclis tutanakları ve dönemin belge arşivi taranarak eldeedilmiştir. Çalışmada izlenen yöntem nitel veri analizidir. Nitel verilerin analizi için;tematik bir çerçeve oluşturma, tematik çerçeveye göre verilerin kodlanması, bulgularıntanımlanması, bulguların yorumlanması aşamalarını kapsayan betimsel analiz tekniğikullanılmıştır. Veri analiz yöntemi içerik analizidir. Araştırma ‘da kapsam içindekidöneme ait önemli görülen gazete, dergi ve belge toplanarak bunların içerik analizleriyapılmıştır.Çalışmada Ankara'nın Demokrat Parti ile geçirdiği dönemin bir öncekidönemden yerel siyaset açısından çok farklı olmadığı ve Tek Parti iktidarı dönemindeyerel siyasete yön veren iktidar kesiminin güç aldığı toplumsal sınıfın değiştiği ancakyerel demokrasi adına şehrin bir gelişme yaşayamadığı değerlendirilmektedir.--------------------This study focuses on the local politics of Ankara's Single Party period (1923-1950) and Democrat Party period (1950-1960). It examines the national politics,political developments, local elections, urbanization and social structure of the periodfor the purpose of analysing local politics in Ankara. The aim of the study is to show thedifferences in understanding in the context of local politics and democracy between theRepublican People's Party, which saw Ankara as a modernization project, and theDemocratic Party Ankara, which came to power later, the practices of local powerstruggle and the connection of local governments of the period with national politics.Istanbul is the city that is the subject of the most research in urban historyresearch conducted in Turkey. However, there is no very rich resource archive withinthe boundaries of the area studied about Ankara, which has served as the capital of the Republic of Turkey for almost a century. There is almost no work in Ankara during theDemocratic Party period. In this context, the research includes a effort aimed at betterunderstanding this period.The boundaries of the research are directly related to its scope. In the study, thecentral area in which Ankara has spread since 1923, that is, the center of the city istaken into account geographically. Ankara's districts are not covered by the study. Thetime limit of the study covers the period of the Republican People's Party and theDemocrat Party (1923-1960). The data available in the study were obtained byexamining the field type, scanning the collections of newspapers and magazines, theminutes of the Assembly and the archive of documents of the period. The methodfollowed in the study is qualitative data analysis. For the analysis of qualitative data;descriptive analysis technique covering the stages of creating a thematic framework,encoding data according to the thematic framework, identification of findings,interpretation of findings was used. The data analysis method is content analysis. In theresearch, newspapers, magazines and documents deemed important for the periodwithin the scope were collected and their content analyses were made.In the study, it is estimated that Ankara's period with the Democratic Partybetween was not very different from the previous period in terms of local politics, andthat the social class in which the ruling segment that led local politics during the periodof one-party power changed, but the city could not experience development in the nameof local democracy