28 research outputs found
Unidad 9 y 10: Fase 6 - Socializar el plan de RSE.
- Author
- Publication venue
- Universidad Nacional Abierta y a Distancia UNAD
- Publication date
- 22/07/2019
- Field of study
Unidad 9 y 10: Fase 6 - Socializar el plan de RSE.Desarrollar el plan de responsabilidad social empresarial de la empresa templado s.aDevelop the corporate social responsibility plan of the temperate company s.
Common variants in Alzheimerâs disease and risk stratification by polygenic risk scores
- Author
- Aarsland Dag
- Abdelnour Carla
- AlarcĂłn-MartĂn Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Antonell Anna
- AntĂșnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belezhanska Diyana
- Bellenguez CĂ©line
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal SĂĄnchez-Arjona MarĂa
- Besse CĂ©line
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Bizzarro Alessandra
- Blesa Rafael
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- BossĂč Paola
- Botne Sando Sigrid
- Buerger Katharina
- Buiza-Rueda Dolores
- Caffarra Paolo
- Calero Miguel
- Castaño Eduardo M.
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chillotti Caterina
- Chipi Elena
- ChĂȘne GeneviĂšve
- Ciccone Simona
- Clark Christopher
- Conti Elisa
- contributors EADB
- CorbatĂłn-Anchuelo Arturo
- Corma-GĂłmez AnaĂŻs
- Costantini Emanuele
- Craig David
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daniele Antonio
- Dardiotis Efthimios
- de Mendonça Alexandre
- De Roeck Ellen
- de Rojas Itziar
- Deckert JĂŒrgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen MĂłnica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Dufouil Carole
- Duron Emmanuelle
- DĂŒzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- FernĂĄndez-Fuertes Marta
- Ferrarese Carlo
- Ferrari Camilla
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- FlieĂbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-MacĂas Emilio
- Frank-GarcĂa Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- GarcĂa-GonzĂĄlez Pablo
- GarcĂa-Madrona SebastiĂĄn
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- GonzĂĄlez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Greco Antonio
- Grenier-Boley Benjamin
- Grimmer Timo
- GrĂŒnblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- HernĂĄndez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- HĂ€gg Sara
- Ikram M. Arfan
- Ingelsson Martin
- Ingino Carlos
- Janowitz Daniel
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Joachim Catharine
- Johansson Charlotte
- JĂŒrgen Deckert
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kern Silke
- Kilander Lena
- Kinhult StÄhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Kohler Eduardo
- Koivisto Anne
- Kok Almar A. L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Koutsouraki Effrosyni
- Kunkle Brian W.
- Kuulasmaa Teemu
- KĂŒĂ§ĂŒkali Fahri
- Lage Carmen
- Laske Christoph
- Lauria Alessandra
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Löwenmark Malin
- MacLeod Catherine
- MacĂas Juan
- Maier Wolfgang
- Mangialasche Francesca
- Mangone Carlos
- Mann David M.
- Marianthi Arnaoutoglou
- Marshall Rachel
- MartĂn Montes Angel
- MartĂnez RodrĂguez Carmen
- MartĂnez Carmen
- MartĂnez-Larrad MarĂa Teresa
- Masullo Carlo
- Mayeux Richard
- McGuinness Bernadette
- Mead Simon
- Meggy Alun
- Mendoza Silvia
- Menéndez-Gonzålez Manuel
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Muchnik Carolina
- Muñoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Neary David
- Ngandu Tiia
- Nicolas Gaël
- Nordestgaard BĂžrge G.
- Nöthen Markus M.
- Ortega Gemma
- Ortiz Cecilia
- Padovani Alessandro
- Palacio Dana Lis
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Ana Belén
- Pedersen Nancy L.
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pisanu Claudia
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- PĂ©rez-CordĂłn Alba
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Reyes Toso Carlos
- Reynolds Chandra A.
- Richardson Anna
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitée
- Rossi Giacomina
- Royo Jose LuĂs
- Rubino Elisa
- Rujescu Dan
- RĂĄbano Alberto
- Saenz Aldo
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ăngela
- Sanchez-Garcia Florentino
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- SelbĂŠk Geir
- Seripa Davide
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Solomon Alina
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- TybjĂŠrg-Hansen Anne
- Ullgren Abbe
- Vacca Alessandro
- Valero Sergi
- Van Broeckhoven Christine
- Van Dongen Jasper
- van Schoor Natasja M.
- Vandenberghe Rik
- Vardy Emma R. L. C.
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zoia Chiara Paola
- Zulaica Miren
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Funder: Funder: FundaciĂłn bancaria âLa Caixaâ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery nâ=â409,435 and validation size nâ=â58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE É4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- AbellĂĄn Javier
- Acosta-isaac René
- Aguado Jose MarĂa
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- AlcalĂĄ-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso MarĂa R.
- Andreu-bernabeu Ălvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich FernĂĄndez Francisco
- Arranz MarĂa J.
- Arribas López José Ramón
- Artiga Maria-jesĂșs
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana MarĂa
- Ballina MartĂn BelĂ©n
- Baptista-rosas RaĂșl C.
- Barranco-dĂaz Andrea
- Barreda-sĂĄnchez MarĂa
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lĂłpez Natalia
- Blancas Rafael
- Boix-palop LucĂa
- Borobia Alberto
- Bravo Elsa
- Brion MarĂa
- Brochado-kith Ăscar
- Brugada RamĂłn
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- CalderĂłn Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ăngel
- Carratto ThĂĄssia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo MarĂa A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gĂłmez Sylena
- Cid-lĂłpez Marco A.
- Cienfuegos-jimĂ©nez Ăscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sånchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- CĂĄceres Alejandro
- CĂĄceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De AraĂșjo JĂ©ssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodrĂguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- DomĂnguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- DĂaz-caneja Covadonga M.
- DĂaz-pĂ©rez Anderson
- Echave-sustaeta Jose
- Eiros RocĂo
- Enciso-olivera CĂ©sar O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas MarĂa Carmen
- Fernandes Marianne R.
- Fernandez-nestosa MarĂa J.
- FernĂĄndez MartĂnez Yolanda
- FernĂĄndez RamĂłn
- FernĂĄndez Ruth
- FernĂĄndez-caballero Lidia
- FernĂĄndez-capitĂĄn Carmen
- FernĂĄndez-cruz Ana
- FernĂĄndez-ferrero Silvia
- FernĂĄndez-robelo UxĂa
- FernĂĄndez-rodrĂguez Amanda
- FernĂĄndez-sampedro Marta
- FernĂĄndez-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernĂĄndez LĂĄcides
- Fuertes-nĂșñez Marta
- FumadĂł Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domĂnguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcĂa Josefina
- GarcĂa TorrejĂłn MarĂa Carmen
- GarcĂa InĂ©s
- GarcĂa Leticia
- GarcĂa Mercedes
- GarcĂa-cerrada Carlos
- GarcĂa-de-vicuña Aitor
- GarcĂa-garcĂa Irene
- GarcĂa-ibarbia Carmen
- GarcĂa-montero AndrĂ©s C.
- GarcĂa-soidĂĄn Ana
- GarcĂa-vĂĄzquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- GonzĂĄlez Bernaldo De QuirĂłs FernĂĄn
- GonzĂĄlez Ălvarez Beatriz
- GonzĂĄlez Juan R.
- GonzĂĄlez Juan R.
- GonzĂĄlez-montelongo Rafaela
- GonzĂĄlez-neira Anna
- Gonzålez-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- GuillĂ©n-guĂo Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- GĂłmez Carrera Luis
- GĂłmez GarcĂa MarĂa
- GĂłmez SacristĂĄn Ăngela
- GĂłmez-arrue Javier
- GĂłmez-duque Mario
- GĂłrgolas Miguel
- Heili-frades Sara
- HernĂĄndez Estefania
- HernĂĄndez-moro Cristina
- HernĂĄndez-ortega Luis D.
- Hernåndez-pérez Guillermo
- HernĂĄndez-vaquero Rebeca
- Herranz M. Teresa
- Herrera MarĂa
- Herrero MarĂa JosĂ©
- Herrero-gonzĂĄlez Antonio
- Herråez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- JimĂ©nez Ăngel
- Jiménez-alfaro Ignacio
- JimĂ©nez-sousa MarĂa A.
- Jordan Iolanda
- Laguna-goya RocĂo
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lĂĄzaro MarĂa
- Lattig MarĂa Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos LucĂa
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa MarĂa
- Luchessi Andre D.
- LĂłpez De Heredia Miguel
- LĂłpez De Heredia Miguel
- LĂłpez-bernĂșs Amparo
- LĂłpez-granados Eduardo
- LĂłpez-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- MartĂn MarĂa Dolores
- MartĂn MarĂa M.
- MartĂn Vicente
- MartĂn-lĂłpez Caridad
- MartĂn-oterino JosĂ©-Ăngel
- MartĂn-vicente MarĂa
- MartĂnez Juan JosĂ©
- MartĂnez Ricardo
- MartĂnez Silvia
- MartĂnez-aquino Eleno
- MartĂnez-gonzĂĄlez Ăscar
- MartĂnez-lĂłpez Iciar
- MartĂnez-nieto Ăscar
- MartĂnez-pĂ©rez Ăngel
- MartĂnez-ramas Andrea
- MartĂnez-resĂ©ndez Michel F.
- MartĂnez-robles Violeta
- Marzal Laura
- MarĂn-candĂłn Alicia
- Maya BelĂ©n RodrĂguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo MacĂas Eleuterio
- Mercadillo FĂĄtima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldĂĄn Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda VĂctor
- Moreno FernĂĄndez Alberto
- Moreno RocĂo
- Moreno-docĂłn Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz GarcĂa Patricia
- MĂ©ndez-echevarrĂa Ana
- MĂnguez Pablo
- Neira Pablo
- Nevado JuliĂĄn
- Nieto-gañån Israel
- Nunes Joana F. R.
- Nuñez-torres RocĂo
- Obrador-hevia AntĂČnia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera MarĂa Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lĂłpez RocĂo
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodrĂguez Roberto
- Paz-artal Estela
- Peces-barba GermĂĄn
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- PinzĂłn Luz Adriana
- Pita Guillermo
- Pla-juncĂ Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- PĂ©rez Alexandra
- PĂ©rez CĂ©sar
- PĂ©rez MarĂa JazmĂn
- PĂ©rez Patricia
- PĂ©rez-de-nanclares Gustavo
- PĂ©rez-garcĂa Felipe
- PĂ©rez-jurado Luis A.
- PĂ©rez-matute Patricia
- PĂ©rez-tomĂĄs M. Elena
- Quevedo-chĂĄvez MarĂa Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-leĂłn Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernĂĄndez Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero AgustĂ
- Rodriguez-urrego Paula A.
- RodrĂguez-artalejo Fernando
- RodrĂguez-ferrer Marena
- RodrĂguez-gallego Carlos
- RodrĂguez-garcĂa JosĂ© A.
- RodrĂguez-hernĂĄndez MarĂa A.
- RodrĂguez-novoa German Ezequiel
- RodrĂguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- RondĂłn-garcĂa Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcĂa Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- SchlĂŒter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- SilvĂĄn-fuentes Cristina
- Solé-violån Jordi
- Soria José Manuel
- SorlĂ Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suårez-rama José Javier
- SuĂĄrez-zamora David A.
- SĂĄnchez LĂłpez Antonio J.
- SĂĄnchez Pedro-luis
- SĂĄnchez-carpintero Abad MarĂa
- SĂĄnchez-pablo Clara
- SĂĄnchez-pernaute Olga
- SĂĄnchez-prados MarĂa ConcepciĂłn
- SĂĄnchez-real Javier
- SĂĄnchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernĂĄndez Juan Carlos
- Tavares Nathali A. C.
- TellerĂa Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya JesĂșs
- Urioste Miguel
- Valencia-ramos Juan
- Valido AgustĂn
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidån-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- VĂ©lez-santamarĂa Valentina
- VĂctor Virginia
- Yåñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Ălvarez Nuria
- Ălvarez-benĂtez Yady
- Ălvarez-navia Felipe
- Ălvarez-sala Walther Rodolfo
- Ăñigo-campos Antonio
- Ăñiguez MarĂa
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC .
- Ahmad Shahzad
- AlarcĂłn-MartĂn Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- AntĂșnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez CĂ©line
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse CĂ©line
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada MercĂš
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- BossĂč Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- BrÄthen Geir
- Buiza-Rueda Dolores
- Bullido MarĂa J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ăngel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE .
- Chen Hung-Hsin
- Chene GeneviĂšve
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert JĂŒrgen
- DEGESCO .
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene .
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen MĂłnica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- DĂŒzel Emrah
- EADB .
- EADI .
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- FernĂĄndez-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen .
- Fischer Peter
- Fladby Tormod
- FlieĂbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-MacĂas Emlio
- Frank-GarcĂa Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- GarcĂa-Alberca Jose Maria
- GarcĂa-GonzĂĄlez Pablo
- GERAD .
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- GonzĂĄlez-PĂ©rez Antonio
- GR@ACE .
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- GrĂŒnblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- HernĂĄndez Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual SĂĄnchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- KĂŒĂ§ĂŒkali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- LleĂł Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- MacĂas Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-Gonzålez Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel MartĂn
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard BĂžrge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- PĂ©rez-CordĂłn Alba
- PĂ©rez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- RodrĂguez Carmen MartĂnez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz AgustĂn
- Rujescu Dan
- RĂĄbano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ăngela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- SelbĂŠk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- StÄhlbom Anne Kinhult
- SĂĄez MarĂa Eugenia
- SĂĄnchez-Arjona MarĂa Bernal
- SĂĄnchez-Valle Raquel
- Tartan Juan Pablo
- TesĂ Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- TybjĂŠrg-Hansen Anne
- TĂĄrraga LluĂs
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-SĂ©bastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Ălvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Global disparities in surgeonsâ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study
- Author
- Abdelkhalek Mohamed
- AbellaÌn Antonio Melero
- AbelloÌ David
- Abu-Arish Hamdoon
- Acevedo Ana Karen Radilla
- Adamina Michel
- Adamovich Dmitry Mikhailovich
- Addeo Pietro
- Adewunmi Olayinka Lukman
- Aeschbacher Pauline
- Afolabi Akinwale Ibrahim
- Agastra Ervis
- Agresta Ferdinando
- Aguilar Juan Carlos Cardozo
- Ahmed Bensaad
- Ahmed Nauman
- Aimal Aimal Khan
- Aiolfi Alberto
- Akay Omer
- al-Najami Issam
- Al-Shehari Mohammed
- Alconchel Felipe
- Alesina Pier Francesco
- Alhazmi Ahmad
- Ali Mahmoud Ibrahim
- Aliyev Vusal
- Alonso Patricia
- Aloun Ali
- Altinel Yuksel
- Altomare Michele
- Alvarez-Gallego Mario
- Ammendola Michele
- Ammerata Giorgio
- Anania Marco
- Anas Abdelhmed
- Andreuccetti Jacopo
- Andriola Valeria
- Andriola Valeria
- Anelli Ferdinando M.
- Anestiadou Elissavet
- Angrisani Marco
- Antonacci Nicola
- Antonacci Nicola
- Antonelli Amedeo
- Antropoli Carmine
- Aparicio Antonio Carlos Maya
- Apostolou Konstantinos
- Arcudi Claudio
- Aregawi Alazar Berhe
- Argenio Giulio
- Ascari Francesca
- Asfaw Fitsum Terefe
- Athar Rahmatullah
- Atici Semra Demirli
- Au Stephanie
- Augustin Goran
- Avella Pasquale
- Avellaneda Nicolas
- Awad Ahmed K.
- Awad Selmy S.
- Awad Selmy S.
- Ayalew Alem Mekete
- Aytac Erman
- Aytac Erman
- Azevedo JoseÌ
- Baba Arshad Ahmed
- Bacchiocchi Giulia
- Bagaglini Giulia
- Bagaria Dinesh
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bala Miklosh
- Balaphas Alexandre
- Balassone Valerio
- Baldi Caterina
- Baldini Edoardo
- Balla Andrea
- Ballester Cristina
- Bandaru Kalyan Vijay Kumar
- Bandyopadhyay Samik K.
- Bannone Elisa
- Barba Leonardo A.
- Barberis Andrea
- Barone Mirko
- Barranquero Alberto G.
- Barugola Giuliano
- Barzola Ernesto J.
- Batıkan OgÌuzkagÌan
- Bavikatte Akshay Prasannakumar
- Bayileyegn Nebiyou Simegnew
- Bedros Nicole Mary
- Beisani Marc
- Bejiga Gosa Hundie
- Bekana Bekana L.
- Belay Tatek
- Belia Francesco
- Belkacem Acidi
- Bellanova Giovanni
- Bellato Vittoria
- Bellido-luque Juan
- Bellini Maria Irene
- Bellver Pedro PalazoÌn
- Benzoni Enrico
- Benzoni Ilaria
- Bergna Alessandro
- Bhat Pawan Singh
- Bhattacharya Kaushik
- Bhattacharya Neela
- Bhatti Hamza Waqar
- Bianchi Valentina
- Bianco Giuseppe
- Biloslavo Alan
- Biniam Ewnte
- Blanco-Antona Francisco
- Bocchino Antonio
- Bointas Georgios
- Bollino Ruggero
- Bonavina Luigi
- Bondurri Andrea
- Bonilla Fernando
- Bonito Alba Correa
- Bono Dario
- Borges Nuno
- Botelho Pedro
- Bottari Andrea
- Bottcher Sofia Maria Jaume
- Bourguiba Mohamed Aboulkacem
- Bourmpouteli Eirini
- Bouzid Chafik
- Braccio Bartolomeo
- Brady Richard R. W.
- Braholli Eriol
- Brasset Camille
- Brillantino Antonio
- Brillantino Antonio
- Briones Cristhian Gonzalo Aspiazu
- Brisinda Giuseppe
- Brito Ismael
- Brookes Charlotte Elisabeth
- Brucchi Francesco
- Bulte Joris P.
- Buonomo Oreste Claudio
- Butler Rebecca Jayne
- Cacciaguerra Andrea Benedetti
- Caldeira Beatriz
- Calini Giacomo
- Calu Valentin
- Calussi Marco
- Calussi Marco
- Cammarat Roberto
- Cammarata Roberto
- Campagnaro Tommaso
- Campanelli Michela
- Campisi Andrea
- Campus Federica
- Candilio Giuseppe
- Cannavo Maurizio
- Cannistra Marco
- Cannistra Marco
- Cano-Valderrama Oscar
- Canonico Giuseppe
- Cantarino Frederico
- Capitano Sante
- Capolupo Gabriella Teresa
- Cappuccio Micaela
- Capuano Marianna
- Capuano Marianna
- Caputo Damiano
- Carannante Filippo
- Carbone Ludovico
- Cardinali Luca
- Carneros Virginia JimeÌnez
- Carrabetta Salvatore
- Caruso Riccardo
- Carvas JoaÌo M.
- Carvas JoaÌo M. B.
- Casagranda Biagio
- Casas Maria Agustina
- Cascales-Sanchez Pedro
- Cassese Gianluca
- Castaldi Antonio
- Castaldi Antonio
- Castellano Javier Rivera
- Castro Ernest
- Castro Maria J.
- CC Tommaso
- Celentano Valerio
- Celotti Andrea
- CerdaÌn-Santacruz Carlos
- Cereda Marco Angelo
- Ceresoli Marco
- Cero Mariagiulia Dal
- Cestaro Giovanni
- Cestino Luca
- Chai Feng Yih
- Chalkoo Mushtaq A.
- Charalabopoulos Alexandros
- Charalabopoulos Alexandros
- Charitaki Evgenia
- Chessa Antonella
- Chessa Antonella
- Chevallay Mickael
- Chia Chi Fung
- Chillarge Gauri
- Chimenti Federica
- Chitul Andrei
- Chiu Jennifer H. F.
- Chooklin Serge
- Choudhry Asad
- Chouliaras Christos
- Chowdhury Ashim
- Christodoulou Prokopis
- Chrysikos Michael
- Chukwu Isaac Sunday
- Cianci Pasquale
- Ciarleglio Francesco A.
- Cicerchia Pierfranco Maria
- Ciesielski Wojciech J.
- Cigognini Maria
- Cillara Nicola
- Cioffi Stefano Piero Bernardo
- Ciro Mauricio Pedraza
- Clementi Marco
- Clocchiatti Lucrezia
- Colak Elif
- ColaÌs-Ruiz Enrique
- Coletta Diego
- Colombari Renan C.
- Colombo Francesco
- Colucci Gianluca
- Conte Luigi E.
- Conti Luigi
- Coppola Alessandro
- Corallino Diletta
- Corronca Federico
- Corrons Laia Codina
- Corvasce Arianna
- Costantini Giulia
- Costanzo Antonio
- Costea Radu V.
- Cotsoglou Christian
- Cozza Valerio
- Creavin Ben
- Cremona Simone
- CricriÌ Michele
- Crosbie Gonzalo Gabriel
- Cuccomarino Salvatore
- Cuk Vladica
- Cunha Miguel
- Curcio Silvia
- Curro Giuseppe
- Dajti Irida
- Daniel Clerc
- Dardanov Dragomir
- Davey Matthew G.
- Davies Justin
- Davis Daniel G.
- De AndreÌs-Asenjo Beatriz
- De Campos Tercio
- De Carlis Riccardo
- de las Casas Sara GortaÌzar
- De Luca Alessandro
- De Luca Raffaele
- De Lucia Chiara
- De Nobili Giovanni
- de Oliveira Gabriel Paiva
- De Padua Cristina
- De Rosa Michele
- de Sa Tiago Correia
- de Santos Iglesias Francisco Juan
- De Simone Belinda
- de Vries Hilbert S.
- Debela Bizuneh Sime
- Debena Dawit Gebregiorgis
- Deerenberg Eva B.
- Del Monte Simone Rossi
- del Olmo Juan Carlos MartiÌn
- Delaune Vaihere
- Delgado Ander Timoteo
- Delis Spiros
- Delogu Daniele
- Delvecchio Antonella
- Demir Anıl
- Devriendt Stefanie
- Di Bella Annamaria
- Di Carlo Isidoro
- Di Filippo Giacomo
- Di Franco Gregorio
- Di Lascio Pierpaolo
- Di Marco Federica
- Di Marco Federica
- Di Marco Federica
- Di Martino Marcello
- Di Martino Marcello
- Di Meo Giovanna
- di Mola Fabio F.
- Di Santo Albini Andrea G.
- Di Saverio Salomone
- Di Saverio Salomone
- Di Venere Beatrice
- Diaz-Elizondo Jose Antonio
- Diaz-Elizondo Jose Antonio
- Digne-Malcolm Holly Jane
- Dimitrov Evgeni
- Dinagde Tesfaye Aga
- DiÌaz Carlos JGoÌmez
- Don Cristine Brooke Pathirannehalage
- Dorovinis Panagiotis
- Douka Eleftheria
- Drogouti Maria
- Dudi-Venkata Nagendra N.
- Dulskas Audrius
- Dulskas Audrius
- Dziakova Jana
- DâAcapito Fabrizio
- DâAmbrosio Marco
- DâAmbrosio Marco
- DâUgo Stefano
- Efetov Sergey
- Efetov Sergey
- Elfeki Hossam
- Elghadban Hosam Mohamed
- Emile Sameh
- Ercolani Giorgio
- ErdogÌan Emre
- Ermias Nebiyou
- Escalante Karol S.
- Espino Eduardo Morales
- Esposito Francesco
- Esposito Giuseppe
- Estaire-GoÌmez Mercedes
- Fabbri NicoloÌ
- Fabbrizio Tiziana
- Farazi-Chongouki Christos
- Faro Carmelo Lo
- Faro Carmelo Lo
- Farolfi Tommaso
- Farooqui Marryam Riaz
- Farrarons Sara SentiÌ
- FarreÌ Silvia PeÌrez
- Farrukh Maira
- Fazio Federico
- Feituri Nura
- Feleke Tsega Terefe
- Felsenreich Daniel M.
- Fernandez Carmen Cagigas
- FernaÌndez FernaÌndez June
- Fernicola Agostino
- Ferrara Francesco
- Ferrari Davide
- Ferrario Luca
- Ferreira Rodrigo Vaz
- Ferretti Carlotta
- Ferronetti Antonio
- Festa Federico
- Fichera Alessandro
- Fiore Felicia
- Fleming Andrew Martin
- Fleres Francesco
- Florio Gaetano
- Folliero Cristina
- Fonseca Vinicius Cordeiro
- ForcignanoÌ Edoardo
- Foreman Michaael L.
- Formisano Giampaolo
- Fortuna Laura
- Franchi Eloisa
- Francis Fayez Maged
- Francone Elisa
- Francone Elisa
- Fransvea Pietro
- Frazzetta Giuseppe
- Freixa Celia Caula
- Frontali Alice
- Frountzas Maximos
- Funk Geoffrey A.
- Fuschillo Giacomo
- Gachabayov Mahir
- Galeev Shamil I.
- Galiffa Giampaolo
- Gall Malina ECaraiman
- Gallardo Cristian
- Gallo Gaetano
- Garoufalia Zoe
- Garzali Ibrahim Umar
- Gauci Chahaya M.
- Gazia Carlo
- Gerogiannis Ioannis
- Gervasi Maria Clelia
- Gessa Emanuela
- Ghannam Wagih
- Gherardi Dario
- Ghignone Federico
- Gialamas Eleftherios
- Giambusso Mauro
- Gica Nicolae
- Giordano Alessio
- Giordano Marco
- Giovine Gennaro
- Giuffrida Maria Carmela
- Giuffrida Mario
- Giuliani Antonio
- Giuliani Giuseppe
- Glasbey James
- Gomes Carlos Augusto
- Gonfa Kebebe Bekele
- Gonsaga Ricardo Alessandro Teixeira
- Gonzalez Ana
- GonzaÌlez Lluis GarciÌa
- GonzaÌlez Tomas Elosua
- Gourgiotis Stavros
- GoÌmez Marta JimeÌnez
- GoÌmez Marta JimeÌnez
- GoÌktepe Berk
- Grama Florin A.
- Granata Roberta
- Gravante Gianpiero
- Greco Antonio
- Grimaldi Luciano
- Grossi Ugo
- Guerci Claudio
- Guerrero MariÌa Alejandra
- Guevara Jenny
- Guitart Marc PeÌrez
- Gulcu Baris
- Guler Mert
- Gulmez Mehmet
- Gunay Emre
- Gupta Amit
- Gupta Ashish
- Gussago Stefano
- GuÌlcuÌ Barış
- GuÌngoÌr Mert
- Hailemariam Dagnachew H.
- Halder Subhadip
- Hale Lyman Lansing
- Harvitkar Rafique Umer
- Hassen Khalid Arebo
- Hernandez-Garcia Miguel
- HernaÌndez Edgard EfreÌn Lozada
- Horesh Nir
- Iacobone Maurizio
- Iannone Immacolata
- IbaÌnÌez Noelia
- Ibrahim Aini Fahriza
- Idiz Ufuk Oguz
- Ielpo Benedetto
- Ielpo Benedetto
- Imana Ruhama Yoseph
- Inama Marco
- Ingallinella Sara
- Ingallinella Sara
- Ioannidis Argyrios
- Ioannidis Orestis
- Iodice Alessandra
- Ioia Giovanna
- Iordache-Petrescu Madalina Ionela
- Iossa Angelo
- Iqbal Muhammad Rafaih
- Iranzo Marina AlarcoÌn
- Isik Arda
- Izzo Giuliano
- Jamiri Al-Radjid
- Jansson Hannes
- Johnson Benjamin E.
- JordaÌo Daniel Filipe Martins
- Juloski Jovan
- Junior Marcelo A. F. Ribeiro
- Kampouroglou Georgios
- Kapsampelis Panagiotis
- Kara Yasin
- Karamarkovic Aleksandar
- Karamarkovic Aleksandar
- Karamarkovic Aleksandar
- Kaur Mandeep
- Kchaou Ali
- Kebede Kirubel Abebe
- Keci Laura
- Keller Deborah S.
- Kelly Michael E.
- Khan Huma Ahmed
- Khan Jan Sher
- Khan Mansoor
- Khobragade Krunal H.
- Kiros Samuel
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- Klimczak Tomasz Jerzy
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- Kobe Yoshiro
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- Koh Peng Soon
- Komaei Iman
- Koneti Akshadhar J.
- Konstantoudakis Georgios
- Koppel Darren
- Korkoman Mohammed J.
- Kosir Jurij A.
- Kovacevic Bojan
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- Lasarte Mateusz PJeÌšckowski Aingeru Sarriuga
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- Lee Lee Yeong Sing
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- Leo Cosimo Alex
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- Levi Sandri Giovanni Battista
- Lianos Georgios D.
- Licardie Eugenio
- Lichliter Warren E.
- Linares Neiling Massiel Oviedo
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- Mambrilla Sara
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- Merlini David A.
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- Montuori Mauro
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- Morales Emilio J.
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- Nacion Aeris Jane D.
- Naeem Awais
- Nagarajan Prasanth
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- Natalia Savvala N.
- Nava Andrea Kazemi
- Navarro-SaÌnchez Antonio
- Nazir Fozia
- Nazir Fozia
- Neary Peter M.
- Negasa Tolera A.
- Negoi Ionut
- Neri Ignacio
- Neves Fernanda V. S.
- Newton Carla Joyce
- Nicolaescu Diana C.
- Nicolazzi Marco
- Nidaw Melkamu Kibret
- Nigri Giuseppe
- Nigri Giuseppe
- NL Harish
- Ntomi Vasileia
- null null
- Nunziante Marco
- Obiagwu Ndubuisi K.
- Oddis Lidia
- Oddis Lidia
- Oliva Alba
- Olivier James B.
- Olivieri Laura
- Olmi Stefano
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- Pach Radoslaw
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- Panaccio Paolo
- Pandanaboyana Sanjay
- Pangeni Anang
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- Panyko ArpaÌd
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- Papadopoulos Aristeidis
- Papatheodorou Panayiotis
- Paradiso Giulia
- Paramasvaran Ganendra
- Paranyak Mykola
- ParrenÌo-Manchado Felipe Carlos
- Pascale Marco Maria
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- Pattacini Gianmaria Casoni
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- Piccoli Micaela
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- Pierobon Elisa Sefora
- Pilia Tiziana
- Pinotti Enrico
- Pio Luca
- Piozzi Guglielmo N.
- Piras Carla
- Pisaniello Donatella
- Pisano Marcello
- Pisano Michele
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- Podda Mauro
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- Reiti Andrian
- Richards Chris B.
- Rico Douglas
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- Rizzuto Antonia
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- Roesel Raffaello
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- Scaringi Stefano
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- Scotti Mauro Alessandro
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- Siagian Dumaria Ketty
- Sibaja-Matamoros Dauber A.
- Sica Giuseppe S.
- Sidiropoulou Zacharoula
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- Siragusa Leandro
- Slesser Alistair A. P.
- Sliwinski Svenja Christin
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- Smerieri Nazareno
- Soares Antonio S.
- Soldini Gabriele
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- Stringfield Sarah Beth
- Stubbs Benjamin M.
- Subramaniam Ravichandran
- Supit Tommy
- Syed Syed Muhammad Ali
- Syn Nicholas L.
- Synekidou Eirini
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- Tamini NicoloÌ
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Jessica J.
- Tan Jih Huei
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- Tasselli Francesco Menegon
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- Tayeh Salim
- Taylor John Vincent
- Ted Tedla Gebretsadik
- Teddy Tewodros Abule Bilata
- Tegegn Ayenachew Getachew
- Tejedor Patricia
- Tekin Oguzhan
- Tellez Clara
- Tenconi Silvia Maria
- Tense Tadesse H.
- Tepelenis Kostas
- Teran Alfonso Ivan Sanchez
- TereÌs Lara Blanco
- Terwes Natasha Loria
- Tesfay Goytom Knfe
- Thambi Prem
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- Tolla Ashenafi Negash
- Tolonen Matti
- Tomada Elisa Paoluzzi
- Tomasicchio Giovanni
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- Toti Johannes M. A.
- Travers Lawrence Albert Salter
- Tropeano Francesca Paola
- Tryliskyy Yegor
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- Tur-Martinez Jaume
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- Uggeri Fabio
- Uzunoglu Mustafa Yener
- Uzzau Alessandro
- Uzzau Alessandro
- Vailas Michail
- Vailas Michail
- Valadez Michel Hernandez
- Valdivieso Xavier HGarciÌa
- Valinoti AgustiÌn
- Van Doorn Berend
- van Ramshorst Gabrielle
- Vanerio Patricio
- Vannelli Alberto
- Vanni Gianluca
- Vanni Gianluca
- Varela Cristopher
- Varela Cristopher L.
- Vargas Luis Felipe Cabrera
- Vellei Samantha
- Verdi Daunia
- Veroux Massimiliano
- Veroux Massimiliano
- Vescio Francesca
- Vigorita Vincenzo
- Vilallonga Ramon
- Vincenzi Paolo
- Vinci Danilo
- Vinci Danilo
- Violante Tommaso
- Visag-Castillo Victor
- Voon Kelvin
- WaleÌšdziak Maciej
- Wani Ajaz
- Wani Ishfaq Ahmad
- Wani Rauf
- Wassie Chekol
- Wilkins Alex
- Wyroslak-Najs Justyna
- Yallew Gebeyaw Mengist
- Yang Wah
- Yildirim Ali Cihat
- Yildiz Ishak
- Yiu Andrew
- Yiu Andrew
- Younis Muhammad Umar
- Yusoff Ahmad Ramzi
- Zacharis Georgios
- Zafra David Ambrona
- Zaghloul Tarek M.
- Zambon Martina
- Zanus Giacomo
- Zarnescu Narcis Octavian
- Zeb Muhammad
- Zena Alemayehu Shanko
- Zerbo Domenico
- Zuchini AndreÌs Mendoza
- Zullo Alessia
- Publication venue
- Publication date
- 29/04/2024
- Field of study
: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSSŸ v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950â2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- AbeldanÌo ZunÌiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas GuimaraÌes
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Ala Moein
- Aladelusi Timothy Olukunle
- Alalalmeh Samer O
- Alam Khurshid
- Alam Manjurul
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldridge Robert W
- Alemi Sharifullah
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
- Alimi Rasoul
- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
- Almahmeed Wael
- Almazan Joseph Uy
- Almidani Omar
- Alomari Mahmoud A
- Alonso Nivaldo
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Altaf Awais
- Altirkawi Khalid A
- Alvi Farrukh Jawad
- Alwafi Hassan
- Aly Hany
- Alzoubi Karem H
- Amare Azmeraw T
- Ameyaw Edward Kwabena
- Amhare Abebe Feyissa
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Aminian Dehkordi Javad
- Amiri Sohrab
- Amu Hubert
- Amugsi Dickson A
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angappan Dhanalakshmi
- Anil Abhishek
- Anjum Afifa
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Iyadunni Adesola
- Anwar Sumadi Lukman
- Anyasodor Anayochukwu Edward
- Appiah Seth Christopher Yaw
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- ArauÌjo Ana Margarida
- Aravkin Aleksandr Y
- Aremu Abdulfatai
- Ariffin Hany
- Aripov Timur
- Armocida Benedetta
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Arulappan Judie
- Aruleba Idowu Thomas
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asgary Saeed
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayele Getnet Melaku
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azhar Gulrez Shah
- Aziz Shahkaar
- Azzam Ahmed Y
- Babashahi Mina
- Babu Abraham Samuel
- Badar Muhammad
- Badawi Alaa
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bah Sulaiman
- Bahadorikhalili Saeed
- Bai Jianjun
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balogun Saliu A
- Baltatu Ovidiu Constantin
- Bam Kiran
- Banach Maciej
- Bandyopadhyay Soham
- Banik Biswajit
- Banik Palash Chandra
- Bansal Hansi
- Barati Shirin
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barr Ronald D
- Barrero Lope H
- Basharat Zarrin
- Bashir Asma'u I J
- Bashiru Hameed Akande
- Baskaran Pritish
- Basnyat Buddha
- Bassat Quique
- Basso JoaÌo Diogo
- Basu Saurav
- Batra Kavita
- Batra Ravi
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Beaney Thomas
- Bedi Neeraj
- Begum Tahmina
- Behboudi Emad
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Belgaumi Uzma Iqbal
- Bell Michelle L
- Bello Aminu K
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bendak Salaheddine
- Bennett Derrick A
- Bensenor Isabela M
- Benzian Habib
- Berezvai Zombor
- Berman Adam E
- Bermudez Amiel Nazer C
- Bettencourt Paulo J G
- Beyene Habtamu B
- Beyene Kebede A
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhalla Ashish
- Bhandari Dinesh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhardwaj Prarthna V
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Binmadi Nada
- Bintoro Bagas Suryo
- Biondi Antonio
- Bisignano Catherine
- Bisulli Francesca
- Biswas Atanu
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- Emeto Theophilus I
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- Erkhembayar Ryenchindorj
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- Fauk Nelsensius Klau
- Fazeli Pooria
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- Fekadu Ginenus
- Fereshtehnejad Seyed-Mohammad
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- Filip Irina
- Fischer Florian
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- Norouzian Baghani Abbas
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- Yang Lin
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- Yesera Gesila Endashaw
- Yesodharan Renjulal
- Yesuf Subah Abderehim
- YigÌit Arzu
- YigÌit Vahit
- Yip Paul
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
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- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
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- Zandieh Ghazal G Z
- ZanghiÌ Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- ZielinÌska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020â21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5â65·1] decline), and increased during the COVID-19 pandemic period (2020â21; 5·1% [0·9â9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98â5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50â6·01) in 2019. An estimated 131 million (126â137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7â17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8â24·8), from 49·0 years (46·7â51·3) to 71·7 years (70·9â72·5). Global life expectancy at birth declined by 1·6 years (1·0â2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67â8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4â52·7]) and south Asia (26·3% [9·0â44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gomez A.D.
- Alarcon-Martin Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Alvarez Victoria
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antonell Anna
- Antunez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belen Pastor Ana
- Bellenguez Celine
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sanchez-Arjona Maria
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Blennow Kaj
- Blesa Rafael
- Boada Merce
- Boerwinkle Eric
- Borroni Barbara
- Boschi Silvia
- Bossu Paola
- Buerger Katharina
- Buiza-Rueda Dolores
- Bullido Maria J.
- Caffarra Paolo
- Calero Miguel
- Carolina Dalmasso Maria
- Carracedo Angel
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chene Genevieve
- Chillotti Caterina
- Ciccone Simona
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corbaton-Anchuelo Arturo
- Corma-Gomez Anais
- Dardiotis Efthimios
- de Mendonca Alexandre
- de Rojas Itziar
- Deckert Juergen
- Deckert Jurgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Djurovic Srdjan
- Duezel Emrah
- Dufouil Carole
- Duron Emmanuelle
- Duzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Fuertes Marta
- Ferreira Catarina B.
- Ferri Evelyn
- Fischer Peter
- Fliessbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macias Emilio
- Frank-Garcia Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- Gonzalez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Grenier-Boley Benjamin
- Grimmer Timo
- Gruenblatt Edna
- Grunblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haegg Sara
- Hagg Sara
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernandez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- K\ufc\ue7\ufckali Fahri
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Lage Carmen
- Lambert Jean-Charles
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Lleo Alberto
- Loewenmark Malin
- Lopez de Munain Adolfo
- Lowenmark Malin
- Macias Juan
- Macleod C.
- Maier Wolfgang
- Mangialasche Francesca
- Maria Garcia-Alberca Jose
- Marquie Marta
- Marshall Rachel
- Martin Montes Angel
- Martinez Rodriguez Carmen
- Masullo Carlo
- Mather Karen A.
- Mayeux Richard
- Mead Simon
- Medina Miguel
- Meggy Alun
- Mendoza Silvia
- Menendez-Gonzalez Manuel
- Mir Pablo
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Munoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Noethen Markus M.
- Nordestgaard Borge G.
- Nothen Markus M.
- Orellana Adelina
- Ortega Gemma
- Padovani Alessandro
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Pau
- Pedersen Nancy L.
- Perez-Cordon Alba
- Perez-Tur Jordi
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pinol-Ripoll Gerard
- Pisanu Claudia
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Quenez Olivier
- Quintela Ines
- Rabano Alberto
- Rainero Innocenzo
- Ramirez Alfredo
- Real Luis M.
- Reynolds Chandra A.
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitee
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustin
- Rujescu Dan
- Saez Maria Eugenia
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Angela
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sanchez-Valle Raquel
- Sando Sigrid Botne
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbaek Geir
- Seripa Davide
- Serrano-Rios Manuel
- Seshadri Sudha
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stahlbom Anne Kinhult
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tarraga Lluis
- Teresa Martinez-Larrad Maria
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjaerg-Hansen Anne
- Tybjorg-Hansen Anne
- Ullgren Abbe
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zulaica Miren
- Publication venue
- Nat Commun
- Publication date
- 01/01/2021
- Field of study
Funder: Funder: FundaciĂłn bancaria âLa Caixaâ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery nâ=â409,435 and validation size nâ=â58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE É4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease
Multiancestry analysis of the HLA locus in Alzheimerâs and Parkinsonâs diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-GĂłmez A.D.
- Adarmes-GĂłmez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- AlarcĂłn-MartĂn E.
- AlarcĂłn-MartĂn Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- AntĂșnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez CĂ©line
- Bellenguez CĂ©line
- Bellenguez CĂ©line
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse CĂ©line
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada MercĂš
- Boada MercĂš
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- BossĂč Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- BrÄthen Geir
- BrÄthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido MarĂa J.
- Bullido MarĂa J.
- Burguera J.A.
- Burholt Vanessa
- BĂrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ăngel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- CarriĂłn-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene GeneviĂšve
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- ClarimĂłn J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- CorbatĂłn-Anchuelo A.
- Cores Valeria
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert JĂŒrgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen MĂłnica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso MarĂa
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- DĂŒzel Emrah
- DĂŒzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia SĂĄez MarĂa
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- FernĂĄndez-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
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- FlieĂbach Klaus
- Foo Jia Nee
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- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
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- Franco E.
- Franco-MacĂas Emlio
- Frank-GarcĂa A.
- Frank-GarcĂa Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
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- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- GarcĂa-Alberca J.M.
- GarcĂa-Alberca JosĂ© MarĂa
- GarcĂa-GonzĂĄlez P.
- GarcĂa-GonzĂĄlez Pablo
- GarcĂa-GonzĂĄlez Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- GonzĂĄlez-PĂ©erez A.
- GonzĂĄlez-PĂ©rez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- GrĂŒnblatt Edna
- GrĂŒnblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- GĂłmez-Garre P.
- GĂłmez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- HernĂĄndez Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- HĂŒll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- JesĂșs S.
- JesĂșs S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- JĂŒrgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult StÄhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- KĂŒĂ§ĂŒkali Fahri
- KĂŒĂ§ĂŒkali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente AsunciĂłn
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- LleĂł Alberto
- LleĂło A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- LuĂs Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- LĂłopez de MunĂĄin A.
- LĂłpez-GarcĂa S.
- LĂłpez-GarcĂa Sara
- Löwemark Malin
- Macias J.
- Macias-GarcĂa D.
- Macias-GarcĂa D.
- MacLeod Catherine A.
- MacĂas Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
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- Mann David
- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria GarcĂa-Alberca Jose
- Maroñas O.
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- Marshall Rachel
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- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
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- Mecocci Patrizia
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- Medina M.
- Medina Miguel
- Meggy Alun
- Meggy Alun
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- Menéndez-Gonzålez Manuel
- Mignot Emmanuel
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- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
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- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
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- Morgan Kevin
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- Muchnik Carolina
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- Naito Tatsuhiko
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- Natunen Teemu
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- Nicolas Gael
- Niida Shumpei
- Nordestgaard BĂžrge G.
- Nordestgaard BĂžrge G.
- Novack Gisela
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- Paola Zoia Chiara
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- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
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- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- PelejĂ E.
- PelejĂ Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
- Periñån Mt
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- Perneczky Robert
- Peters Oliver
- Peters Oliver
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- Pijnenburg Yolande A. L.
- Pijnenburg Yolande A.L.
- Pinchler Sabrina
- Pineda J.A.
- Pineda Juan A.
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- Piras Fabrizio
- Piras Federica
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- Piñol-Ripoll Gerard
- Piñol-Ripoll Gerard
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- Popp Julius
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- Posthuma Danielle
- Powell John
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- Priller Josef
- Proitsi Petra
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- PĂ©rez-Cordon A.
- PĂ©rez-CordĂłn Alba
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- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
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- Ramakers Inez
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- Ramirez Alfredo
- Ramirez Alfredo
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- Real de AsĂșa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- RodrĂguez-RodrĂguez E.
- Rojo Matias
- Rong Zhang Bao
- Rongve Arvid
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- Rosende-Roca M.
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- Ross Owen A.
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- Rubino Elisa
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- Ryan Nathalie
- RĂĄabano A.
- RĂĄbano Alberto
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- Saenz Aldo
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- Saltvedt Ingvild
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- Sanabria A.
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- Sando Sigrid B.
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- Sastre MerlĂn Isabel
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- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- SchĂŒrmann Britta
- SelbĂŠk Geir
- SelbĂŠk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- SĂĄez M.E.
- SĂĄnchez Juan Pascual
- SĂĄnchez-Arjona MarĂa Bernal
- SĂĄnchez-Juan P.
- SĂĄnchez-Juan Pascual
- SĂĄnchez-Valle Raquel
- SĂĄnchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa MartĂnez-Larrad MarĂa
- TesĂ Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg HĂ„kan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- TybjĂŠrg-Hansen Anne
- Tzourio Christophe
- TĂĄarraga L.
- TĂĄrraga LluĂs
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-SĂ©bastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Ălvarez I.
- Ălvarez V.
- Ălvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinsonâs disease (PD) and Alzheimerâs disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased AÎČ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado HĂ©ctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso JesĂșs AarĂłn MartĂnez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
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- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
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- Arshad Muhammad
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- Asla Amir
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- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
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- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
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- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
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- Baia Marco
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- Bailey Karen
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- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
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- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
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- Banerjee Sumit
- Banipal Gurpreet Singh
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- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
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- Bergkvist David JuliĂ
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- Bissacco Daniele
- BÄ°ĆGÄ°N TAYFUN
- Blair James
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- Blencowe Natalie
- Bloemers Frank
- Board Timothy
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- Bonavina Luigi
- Bonci Eduard-Alexandru
- Bondurri Andrea
- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel FrĂłis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- BrzeszczyĆski Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
- BĂ mbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
- Cabeza Leticia
- Cabrera Marino
- Cais Simon
- Cakmak Guldeniz Karadeniz
- Calabretto Francesca
- CalabrĂČ Marcello
- Calavia Pablo
- Calculli Federica
- Calini Giacomo
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- Callcut Rachael
- Calu Valentin
- Calvache Jose Andres
- Calvache Nieto
- Calvo Francisco Javier Redondo
- Cama Jitoko
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- Camarena Ana Isabel Avellaneda
- Camargo-Parra Katherin
- Cammarata Emanuele
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- Cammarata Roberto
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- CampennĂŹ Paola
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- Capella Stefano
- Capitan-Morales Luis-Cristobal
- Capobianco Mattia
- Capolupo Gabriella Teresa
- Capozzi Enrico
- Cappuccio Micaela
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- Carreras-Castañer Anna
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- Carvello Michele
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- Cullinane Carolyn
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- Cunningham Brian
- CurrĂČ Giuseppe
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- Cutmore Carina
- Czako Ladislav
- CĂĄceres Freud
- D'Acapito Fabrizio
- D'Addino José Luis
- D'Amico Alessia
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- D'Archi Sabatino
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- Daddi Niccolo'
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- Davidescu Mihnea
- Davies Jessica
- Davies Mark
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- Davis Amelia
- Dawson Amanda Caroline
- Dawson Jonathon
- Dbouk Samer
- De AlarcĂłn Jaime RodrĂguez
- De Andrés-Asenjo Beatriz
- De Bacco Marangon Gustavo
- De Campos Prado Caio Antonio
- De Cillia Michael
- De Haro Jorge Irene
- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
- De La Infiesta GarcĂa Carlos
- De La Medina Antonio Ramos
- De La Rosa-Estadella Marta
- De Nardi Paola
- De Oliveira Gabriel Paiva
- De Pastena Matteo
- De Simone Veronica
- De Sousa Ălvaro Francisco Lopes
- De Vega SĂĄnchez Blanca
- De Virgilio Armando
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- Dean Yomna
- Degarege Dawit
- Degener Stephan
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- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K
- Demetriou Charis
- Demir Sebahattin
- Dennis Rory
- Deputy Mohammed
- Derilo Habtamu
- Des DĂ©serts Marc Danguy
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- Di Nuzzo Maria Michela
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- Diehl Thomas
- Dif Elmes Saoussene
- Dimas Angelos
- Dimitrokallis Nikolaos
- Dincer MĂŒserref Beril
- Dindyal Shiva
- Djama Zakarya
- Djedovic Gabriel
- Doerner Johannes
- Doherty Daniel
- Dolci Giampiero
- Domanin Maurizio
- Domingo Marta MarĂa Arroyo
- Dominguez-Rosado Ismael
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- Donkin Ian
- Donmez Emin Erhan
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- Dural Ahmet Cem
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- Duro Agustin
- Durrani Abdullah
- Dyas Adam
- Dzhumabaev Khasan
- Dziakova Jana
- Dzogbefia Mawutor
- DĂaz Jeancarlos Trujillo
- Dölker Theresa
- Eardley Nicola
- Ebrahim Abdulla
- Echieh Chidiebere Peter
- Edwards John
- Efetov Sergey
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- Ekwen Gerald
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- El-Hussuna Alaa
- El-Kassas Mohamed
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- Pejkova Sofija
- Pekcici Mevlut Recep
- Pellacani Arrigo
- Pellini Raul
- Pellino Gianluca
- Peltrini Roberto
- Peral Ana
- Perez-Chrzanowska Hanna
- Perfecto Arkaitz
- Peristeri Dimitra
- Perivoliotis Konstantinos
- Peros Georgios
- Perra Teresa
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- Persad Amit
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- Pessaux Patrick
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- Petrone Patrizio
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- Petruzzi Gerardo
- Pettigrove K.L.
- Phillips Jonathan
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- Pires Robinson Esteves
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- Pockney Peter
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- Potamianos Spyridon
- Potten Stephanie
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- Power Nicholas
- Prada Carlos
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- Pramesh C.S.
- Prats Milagros Carrasco
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- Prodromidou Anastasia
- Proud David
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- Soljic Martina
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- Sue-Chue-Lam Colin
- Suer Muhammed Salih
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- Sundarraju Shalini
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- SzabĂłmihĂĄlyovĂĄ KatarĂna
- Szakmany Tamas
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- Sånchez-Guillén Luis
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- Valanci Sofia
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- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
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- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- VelĂĄzquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- VilarĂł Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Våsquez Javier Alberto Gutiérrez
- VĂĄzquez Gil
- VĂĄzquez Irene Ortega
- VÇcÇraĆu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Ăzge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- ZarĂĄnd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha HorĂĄcio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ăvila Clara Castro
- ĂlgĂ„ Andreas
- Ăakici Mehmet Ăaǧlar
- Ăelik Enes
- Ăelik Meryem Nur
- Ăzçay Necdet
- Ćevik HĂŒsnĂŒ
- Ć antak Goran
- Ć imko KristiĂĄn
- ĆœateckĂœ Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study
- Author
- Adam Orengia
- Aditya Chowdary
- Aditya Kulkarni
- Adnan Kuvvetli
- Adolfo Navarro
- Adolfo Pisanu
- Adrian Smith
- Adriana Cavero Ibiricu
- Aeris Jane D Nacion
- Ahmad Alhazmi
- Ahmad Alsaleh
- Ahmad Elmabri
- Ahmet Rencuzogullari
- Aingeru Sarriugarte Lasarte
- Ainhoa Valle Rubio
- Ajaz Wani
- Akshay Bavikatte
- Akshay Kumar
- Al-Radjid Jamiri
- Alain Michel Alvarado Padilla
- Alban Cacurri
- Alberto de San Ildefonso
- Alberto Porcu
- Alberto Sartori
- Aldo Rocca
- Alejandro Becaria
- Alejandro Paz Yåñez
- Alejandro SolĂs-Peña
- Aleksandar SretenoviÄ
- Alessandro De Luca
- Alex Boddy
- Alex Urbistondo
- Alexandros Charalabopoulos
- Alexios Tzivanakis
- Alfonso Amendola
- Alfonso Bandin
- Alfonso Najar
- Alfredo Ramirez-Gutierrez de Velasco
- Ali Cihat Yildirim
- Alice Frontali
- Alpha Oumar Toure
- Alvaro GarcĂa-Granero
- Amaia MartĂnez Roldan
- Amaia Sanz Larrainzar
- Amila Sanjiva Ratnayake
- Ana Gonzales-Ganso
- Ana M Minaya-Bravo
- Ana MarĂa Gonzalez-Ganso
- Andre Das
- Andrea Bondurri
- Andrea Costanzi
- Andrea Lucchi
- Andrea Mazzari
- Andrea Musig
- Andrea Peloso
- Andrea Piano
- Andrea Police
- Andrei Mihailescu
- Andrés Pouy
- Angela Romano
- Angelo Iossa
- Anna Carmen Leonetti
- Anna Guariniello
- Anna Isaac
- Anna Pia Delli Bovi
- Antonella Chessa
- Antonella Tromba
- Antonino TornambĂš
- Antonio Brillantino
- Antonio Caira
- Antonio Castaldi
- Antonio Ferronetti
- Antonio Giuliani
- Antonio Prestera
- Antonio Ramos-De la Medina
- Antonio Tarasconi
- Antonio Ălvarez MartĂnez
- Arcangelo Picciariello
- Argyrios Ioannidis
- Ari LeppÀniemi
- Arshad Khan
- Arshad Rashid
- Arteaga Luis Eduardo PĂ©rez-SĂĄnchez
- Ashok Mittal
- Ashrarur Rahman Mitul
- Asif Mehraj
- Asim Laharwal
- Asnel Dorismé
- Athanasios Marinis
- Atif Iqbal
- Augusto Moncada
- Bartolomeo Braccio
- Basim Alkhafaji
- Beatriz de Andrés Asenjo
- Beatriz Martin-Perez
- Belinda SĂĄnchez PĂ©rez
- Ben Creavin
- Benedetto CalĂŹ
- Benedetto Ielpo
- Beniamino Pascotto
- Benjamin Stubbs
- Benjamin Zavala Retes
- Branislav Jovanovic
- Brian K P Goh
- Brian Kp Goh
- Bruno Sensi
- Carlo Biddau
- Carlo Gazia
- Carlo Vallicelli
- Carlos Alberto Fagundes
- Carlos CerdĂĄn Santacruz
- Carlos Chirico
- Carlos Javier GĂłmez
- Carlos Petrola
- Carlos SĂĄnchez Rodriguez
- Carlos YĂĄnez BenĂtez
- Carmelisa Dammaro
- Carmelo Lo Faro
- Caroline Reinke
- Casandra Dominguez Paez
- Catalina Oliva
- Charlotte Thomas
- Charudutt Paranjape
- Chi Fung Chia
- Chi Kwan Kong
- Chiara De Lucia
- Christian Ovalle Chao
- Claudio Arcudi
- Claudio Guerci
- Clement Chia
- Cristiano Parise
- Cristina Folliero
- Cristopher Varela
- Dalya M Ferguson
- Daniel Camacho
- Daniel Popowich
- Daniel Souza Lima
- Daniela Rega
- Daniele Delogu
- Daniele Zigiotto
- Danilo Vinci
- Dario D'Antonio
- Dario Parini
- David Alessio Merlini
- David DE Zimmerman
- David Moro-Valdezate
- Davide Pertile
- Deborah Maria Giusti
- Deborah S Keller
- Delko Tarik
- Denis Kalivaçi
- Dennis Mazingi
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- Sheikh Junaid
- Sidney Rojas
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- Silvia GarcĂa
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- Sonja Chiappetta
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- Tariq Rawashdeh
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- Tercio De Campos
- Teresa Calderon Duque
- Teresa Perra
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- Theodoros Daskalakis
- Theodoros Liakakos
- Thomas Barnes
- Tijmen Koëter
- Tiku Zalla
- Tommaso Campagnaro
- Tommy Brown
- TomĂĄs E GonzĂĄlez
- TomĂĄs Elosua
- Topi Luoto
- Touré Alpha Oumar
- Ugo Giustizieri
- Ugo Grossi
- Umberto Bracale
- Uriel Rivas
- Valentina Ferri
- Valentina Sosa
- Valentina Testa
- Valeria Andriola
- Valeria Tonini
- Valeria Tonini
- Valerio Balassone
- Valerio Celentano
- Valerio Progno
- Vanessa Carroni
- Varun Raju
- Venera Cavallaro
- Venkateswara Rao Katta
- Veronica De Simone
- Vicent Primo Romaguera
- Vicente SimĂł
- Victor Hugo GarcĂa Orozco
- Victor Luraschi
- Victor Rachkov
- Victor Turrado-L
- Victor Visag-Castillo
- Victoria Dowling
- Victoria Graham
- Vincenzo Papagni
- Vincenzo Vigorita
- Vinicius Cordeiro Fonseca
- Virginia Jimenez Carneros
- Vittoria Bellato
- Walyson Gonçalves
- William F Powers
- William Grigg
- Wolf O Bechstein
- Ye Xin Koh
- Yu Bing Lim
- Yuksel Altinel
- Zoran GoluboviÄ
- Zutoia Balciscueta
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis.
Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic.
Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19\ub78 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6\ub76 and 2\ub74 per cent respectively before, but 23\ub77 and 5\ub73 per cent, during the pandemic (both P < 0\ub7001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe.
Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2