FOG-oriented Joint Computing and Networking: the GAUChO Project Vision

This paper presents a novel architectural principle for distributed and heterogeneous systems integrating Fog Computing and Networking approaches, which has been proposed within the “Green Adaptive Fog Computing and Networking Architecture” (GAUChO) project, funded by the MIUR Progetti di Ricerca di Rilevante Interesse Nazionale (PRIN) Bando 2015 - grant 2015YPXH4W-004. In particular a modular and flexible platform has been designed and developed, supporting low-latency and energy-efficiency applications as well as security, self-adaptation, and spectrum efficiency by means of a strict collaboration among devices. Specifically, the focus here is on the design of an integrated protocol architecture supporting mobile Fog-oriented services, and the developed Fog computing testbeds

Experimental measurements of a joint 5G-VLC communication for future vehicular networks

One of the main revolutionary features of 5G networks is the ultra-low latency that will enable new services such as those for the future smart vehicles. The 5G technology will be able to support extreme-low latency. Thanks to new technologies and the wide flexible architecture that integrates new spectra and access technologies. In particular, Visible Light Communication (VLC) is envisaged as a very promising technology for vehicular communications, since the information can flow by using the lights (as traffic-lights and car lights). This paper describes one of the first experiments on the joint use of 5G and VLC networks to provide real-time information to cars. The applications span from road safety to emergency alarm

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. We found that increased neutral essential amino acid (NEAA) uptake was a critical component of erythropoiesis. As red blood cells matured, expression of the amino acid transporter gene Lat3 increased, which increased NEAA import. Inadequate NEAA uptake by pharmacologic inhibition or RNAi-mediated knockdown of LAT3 triggered a specific reduction in hemoglobin production in zebrafish embryos and murine erythroid cells through the mTORC1 (mammalian target of rapamycin complex 1)/4E-BP (eukaryotic translation initiation factor 4E–binding protein) pathway. CRISPR-mediated deletion of members of the 4E-BP family in murine erythroid cells rendered them resistant to mTORC1 and LAT3 inhibition and restored hemoglobin production. These results identify a developmental role for LAT3 in red blood cells and demonstrate that mTORC1 serves as a homeostatic sensor that couples hemoglobin production at the translational level to sufficient uptake of NEAAs, particularly L-leucine.National Institutes of Health (U.S.) (P01 HL032262

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. We found that increased neutral essential amino acid (NEAA) uptake was a critical component of erythropoiesis. As red blood cells matured, expression of the amino acid transporter gene Lat3 increased, which increased NEAA import. Inadequate NEAA uptake by pharmacologic inhibition or RNAi-mediated knockdown of LAT3 triggered a specific reduction in hemoglobin production in zebrafish embryos and murine erythroid cells through the mTORC1 (mammalian target of rapamycin complex 1)/4E-BP (eukaryotic translation initiation factor 4E–binding protein) pathway. CRISPR-mediated deletion of members of the 4E-BP family in murine erythroid cells rendered them resistant to mTORC1 and LAT3 inhibition and restored hemoglobin production. These results identify a developmental role for LAT3 in red blood cells and demonstrate that mTORC1 serves as a homeostatic sensor that couples hemoglobin production at the translational level to sufficient uptake of NEAAs, particularly L-leucine

Neuroimaging the consciousness of self: Review, and conceptual-methodological framework

We review neuroimaging research investigating self-referential processing (SRP), that is, how we respond to stimuli that reference ourselves, prefaced by a lexical-thematic analysis of words indicative of “self-feelings”. We consider SRP as occurring verbally (V-SRP) and non-verbally (NV-SRP), both in the controlled, “top-down” form of introspective and interoceptive tasks, respectively, as well as in the “bottom-up” spontaneous or automatic form of “mind wandering” and “body wandering” that occurs during resting state. Our review leads us to outline a conceptual and methodological framework for future SRP research that we briefly apply toward understanding certain psychological and neurological disorders symptomatically associated with abnormal SRP. Our discussion is partly guided by William James’ original writings on the consciousness of self

Impianti post-estrattivi immediati in siti infetti: studio sperimentale.

Il posizionamento di impianti post-estrattivi immediati presenta molteplici vantaggi, tra cui la riduzione del numero di interventi chirurgici e la diminuzione dei tempi necessari per la riabilitazione protesica. Tuttavia la presenza di infezione nell’alveolo post-estrattivo potrebbe compromettere il successo di questa tecnica. L’obiettivo del presente studio è quello di valutare il successo clinico di 20 impianti post-estrattivi immediati posizionati in siti infetti causati da fallimenti endodontici o fratture radicolari. Un totale di 20 pazienti sono stati selezionati in questo studio. La presenza o assenza di mobilità, di dolore, di sanguinamento al sondaggio e di suppurazione, la profondità di sondaggio, l’indice di placca, il livello di attacco clinico, l’ampiezza di tessuto cheratinizzato e il livello del tessuto osseo sono stati valutati prima del posizionamento degli impianti e dopo il periodo di follow-up di 12 mesi. Il periodo di guarigione è stato asintomatico per tutti i pazienti. Tutti gli impianti si sono osteointegrati e non hanno mostrano segni di infezione. Sulla base di questo studio il posizionamento di impianti post-estrattivi immediati in siti infetti risulta essere una metodica valida in grado di indurre risultati predicibili