Optimal Panel Zone Participation in Steel Moment Frames

This work investigates the role of panel zones in the seismic response of buildings using steel moment frames. To address this debated matter requires well-developed finite element models that can accurately simulate the behavior of frame systems under a variety of ground motions. A procedure to form an optimally designed frame subassemblage is proposed to maximize its inelastic deformation energy capacity. The proposed procedure is then applied to an available steel moment frame for evaluating its overall seismic performance. A new frame finite element is developed to have a feature that is not present in available structural analysis softwares. The feature is to capture the local buckling of thin-wall structural members by using line elements. The performance of the developed theory for the new element is verified with a highly refined finite element model using shell elements. A robust analytical solution is also developed for simulating the behavior of beam-to-column connections in steel lateral force-resisting frames. The results obtained from the developed theory for the connections remarkably match available experimental results. This study proposed a procedure to maximize the inelastic deformation energy of steel moment frame subassemblages. It was found that the high ratio of the column strength to the panel zone strength has considerably positive effects on maximizing the inelastic deformation capacity. The proposed procedure can be applied to a whole frame system to increase the overall seismic performance of that frame. As a result, the safety or reliability of a steel moment frame under earthquakes can be improved while maintaining the fabrication of the structure at an effective cost

Histopathological Imaging Classification of Breast Tissue for Cancer Diagnosis Support Using Deep Learning Models

According to some medical imaging techniques, breast histopathology images called Hematoxylin and Eosin are considered as the gold standard for cancer diagnoses. Based on the idea of dividing the pathologic image (WSI) into multiple patches, we used the window [512,512] sliding from left to right and sliding from top to bottom, each sliding step overlapping by 50% to augmented data on a dataset of 400 images which were gathered from the ICIAR 2018 Grand Challenge. Then use the EffficientNet model to classify and identify the histopathological images of breast cancer into 4 types: Normal, Benign, Carcinoma, Invasive Carcinoma. The EffficientNet model is a recently developed model that uniformly scales the width, depth, and resolution of the network with a set of fixed scaling factors that are well suited for training images with high resolution. And the results of this model give a rather competitive classification efficiency, achieving 98% accuracy on the training set and 93% on the evaluation set.Comment: International Conference on Industrial Networks and Intelligent Systems (INISCOM-2022), Springer, Vol. 444, pp. 152-16

Experimental investigation of friction behavior in pre-sliding regime for pneumatic cylinder

Friction always presents in pneumatic cylinders and causes difficulties in controlling position and velocity of pneumatic systems. In order to improve the control performance of the pneumatic systems, it is necessary to fully understand behavior of friction in the pneumatic cylinders. So far, dynamic friction behavior of pneumatic cylinders has been investigated but mainly focused on the friction behavior in sliding regime. In pre-sliding regime, friction behavior has not been investigated. In this paper, experimental investigations of friction behavior of a pneumatic cylinder in pre-sliding regime are made. The friction force is calculated from the equation of motion of the piston using the measured values of pressures in the two cylinder chambers and the piston displacement. The pressures are controlled by using two proportional pressure control valve. The friction force versus piston displacement characteristics are measured and analysed under various operating conditions of the applied force and the pressures. Experimental results show that: i) the piston motion in pre-sliding regime exhibits a nonlinear spring behavior; ii) hysteretic behavior with nonlocal memory is verified; iii) the pressures have influence only on the size of the hysteretic loop. These experimental results can be applied to develop a friction model for pneumatic cylinders

Antimicrobials: A Global Alliance For Optimizing Their Rational Use In Intra-abdominal Infections (agora)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.11NIAID NIH HHS [R01 AI117211

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs

The Global Alliance for Infections in Surgery : defining a model for antimicrobial stewardship-results from an international cross-sectional survey

Background: Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-resistant organisms. However, the best strategies for an ASP are not definitively established and are likely to vary based on local culture, policy, and routine clinical practice, and probably limited resources in middle-income countries. The aim of this study is to evaluate structures and resources of antimicrobial stewardship teams (ASTs) in surgical departments from different regions of the world. Methods: A cross-sectional web-based survey was conducted in 2016 on 173 physicians who participated in the AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections) project and on 658 international experts in the fields of ASPs, infection control, and infections in surgery. Results: The response rate was 19.4%. One hundred fifty-six (98.7%) participants stated their hospital had a multidisciplinary AST. The median number of physicians working inside the team was five [interquartile range 4-6]. An infectious disease specialist, a microbiologist and an infection control specialist were, respectively, present in 80.1, 76.3, and 67.9% of the ASTs. A surgeon was a component in 59.0% of cases and was significantly more likely to be present in university hospitals (89.5%, p <0.05) compared to community teaching (83.3%) and community hospitals (66.7%). Protocols for pre-operative prophylaxis and for antimicrobial treatment of surgical infections were respectively implemented in 96.2 and 82.3% of the hospitals. The majority of the surgical departments implemented both persuasive and restrictive interventions (72.8%). The most common types of interventions in surgical departments were dissemination of educational materials (62.5%), expert approval (61.0%), audit and feedback (55.1%), educational outreach (53.7%), and compulsory order forms (51.5%). Conclusion: The survey showed a heterogeneous organization of ASPs worldwide, demonstrating the necessity of a multidisciplinary and collaborative approach in the battle against antimicrobial resistance in surgical infections, and the importance of educational efforts towards this goal.Peer reviewe

Print in 3D Web Application

The customer of the product is Origo Engineering Oy, which is an engineering company that provides mechanical engineering and 3D printing service. The mission is to develop a Web Application for this company that takes 3D printing request of quotation from the customers and sends the request information for both ends. The focus of the Web Application is to guarantee the security of the order information since 3D files and customer details are valuable, confidential and time-consuming to design. The application also needs to be user-friendly as customers are mostly non-IT-related. Finally, since the web application involves handling sizeable data, its performance speed needs to be considered. To obtain the mentioned criteria, the technology used are ReactJS for front-end development, Nodejs/PHP for backend and MySQL/MongoDB as database. The result of the thesis work contains the product design and implementation as well as test cases based on customer requirements. It is tested and performs the required features, which involve securely receiving and sending requests as a Web Application