Influence of a prudent diet on circulating cathepsin S in humans

Abstract Background: Increased circulating cathepsin S levels have been linked to increased risk of cardiometabolic diseases and cancer. However, whether cathepsin S is a modifiable risk factor is unclear. We aimed to investigate the effects of a prudent diet on plasma cathepsin S levels in healthy individuals. Findings: Explorative analyses of a randomized study were performed in 88 normal to slightly overweight and hyperlipidemic men and women (aged 25 to 65) that were randomly assigned to ad libitum prudent diet, i.e. healthy Nordic diet (ND) or a control group (habitual Western diet) for 6 weeks. Whereas all foods in the ND were provided, the control group was advised to consume their habitual diet throughout the study. The ND was in line with dietary recommendations, e.g. low in saturated fats, sugars and salt, but high in plant-based foods rich in fibre and unsaturated fats. The ND significantly decreased cathepsin S levels (from 20.1 (+/−4.0 SD) to 19.7 μg/L (+/−4.3 SD)) compared with control group (from 18.2 (+/−2.9 SD) to 19.1 μg/L (+/−3.8 SD)). This difference remained after adjusting for sex and change in insulin sensitivity (P = 0.03), and near significant after adjusting for baseline cathepsin S levels (P = 0.06), but not for change in weight or LDL-C. Changes in cathepsin S levels were directly correlated with change in LDL-C

Determination of Desert Soil Apparent Thermal Diffusivity Using a Conduction‐Convection Algorithm

Surface soil temperatures impact land‐atmosphere interactions in desert environments. Soil apparent thermal diffusivity (k) is a crucial physical parameter affecting soil temperature. Previous studies using the conduction‐convection algorithm reported k values of desert soils for only a few days. The main objective of this study is to determine the daily and monthly variations of desert k for a range of water contents over a 10 month period. The k values were estimated with a conduction‐convection algorithm using soil temperature measured at the 0.00 m and 0.20 m depths from 1 January to 11 October 2011 at the Tazhong station in the Taklimakan desert of China. Generally, the daily values of k ranged from 1.46  ×  10−7m2  s−1 to 5.88  × 10−7m2  s−1, and the 10 month average k value was 2.5(±0.8)  ×  10−7m2  s−1 for the 0.00 m to 0.20 m soil layer. The k values varied significantly with soil water content. The apparent convection parameter (W), which is the sum of the vertical gradient of k and apparent water flux density, was also determined. Comparison of the magnitudes of W and k gradients indicated that little water movement occurred during the dry months, some water infiltrated downward during the wet months, and some water moved upwards in response to evaporation following the wet months. These findings confirmed that the conduction‐convection algorithm described the general pattern of soil water movement. The presented daily and monthly values of k can be used as soil parameters when modeling land‐atmosphere interactions in the Taklimakan desert

Insulin Sensitivity Measured With Euglycemic Clamp Is Independently Associated With Glomerular Filtration Rate in a Community-Based Cohort

OBJECTIVE—To investigate the association between insulin sensitivity and glomerular filtration rate (GFR) in the community, with prespecified subgroup analyses in normoglycemic individuals with normal GFR

Comparative effectiveness of incident oral antidiabetic drugs on kidney function

Diabetes is a major cause of chronic kidney disease, and oral antidiabetic drugs are the mainstay of therapy for most patients with Type 2 diabetes. Here we evaluated their role on renal outcomes by using a national Veterans Administration database to assemble a retrospective cohort of 93,577 diabetic patients who filled an incident oral antidiabetic drug prescription for metformin, sulfonylurea, or rosiglitazone, and had an estimated glomerular filtration rate (eGFR) of 60 ml/min or better. The primary composite outcome was a persistent decline in eGFR from baseline of 25% or more (eGFR event) or a diagnosis of end-stage renal disease (ESRD). The secondary outcome was an eGFR event, ESRD, or death. Sensitivity analyses included using a more stringent definition of the eGFR event requiring an eGFR <60 ml/min per 1.73 m2 in addition to the 25% or more decline; controlling for baseline proteinuria thereby restricting data to 15,065 patients; and not requiring persistent treatment with the initial oral antidiabetic drug. Compared to patients using metformin, sulfonylurea users had an increased risk for both the primary and the secondary outcome, each with an adjusted hazard ratio of 1.20. Results of sensitivity analyses were consistent with the main findings. The risk associated with rosiglitazone was similar to metformin for both outcomes. Thus, compared to metformin, oral antidiabetic drug treatment with sulfonylureas increased the risk of a decline in eGFR, ESRD, or death

Chapter 6 Soil-Water Interaction

This chapter begins by discussing the main functional groups, the atoms and bonds, that determine the characteristic chemical reactions between molecules and hence, the accumulation, persistence, and fate of compounds in the soil-water system. It continues by providing a detailed exposition of the forces between molecules, which include intermolecular forces, inner-sphere and outer-sphere surface complexes, and the diffuse double layer of clay platelets. The theory of interaction energy based on the diffuse double layer and the Derjaguin, Landau, Verwey, and Overbeek models is presented for the three principal modes of clay particle interaction (face-to-face, edge-to-edge, and face-to-edge). Subsequently, the potential theory as it relates to subsurface water is presented, which includes a mathematical exposition of the gravitational potential, the pressure potential, and the osmotic potential. The discussion on capillary pressure, soil-moisture characteristic curve, and hysteresis provides a solid introduction in the study of flow and contaminant transport in unsaturated soils. The chapter concludes by discussing the basic unsaturated flow equations and the movement of moisture in unsaturated soils that results from thermal gradients

Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review

Background Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. Methods For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE to identify all original research articles that were published between 1 January 2003 and 1 November 2014 reporting the prevalence of CKD in the European adult general population. Data on study methodology and reporting of CKD prevalence results were independently extracted by two researchers. Results We identified 82 eligible publications and included 48 publications of individual studies for the data extraction. There was considerable variation in population sample selection. The majority of studies did not report the sampling frame used, and the response ranged from 10 to 87%. With regard to the assessment of kidney function, 67% used a Jaffe assay, whereas 13% used the enzymatic assay for creatinine determination. Isotope dilution mass spectrometry calibration was used in 29%. The CKD-EPI (52%) and MDRD (75%) equations were most often used to estimate glomerular filtration rate (GFR). CKD was defined as estimated GFR (eGFR) <60 mL/min/1.73 m2 in 92% of studies. Urinary markers of CKD were assessed in 60% of the studies. CKD prevalence was reported by sex and age strata in 54 and 50% of the studies, respectively. In publications with a primary objective of reporting CKD prevalence, 39% reported a 95% confidence interval. Conclusions The findings from this systematic review showed considerable variation in methods for sampling the general population and assessment of kidney function across studies reporting CKD prevalence. These results are utilized to provide recommendations to help optimize both the design and the reporting of future CKD prevalence studies, which will enhance comparability of study result

Chapter 14 Electrical Properties of Soils

This chapter discusses the electric and electromagnetic methods that are used to evaluate the electrical properties of soils. Electric techniques exploit the flow of a steady-state current in the subsurface, while electromagnetic methods rely on the phenomenon of electromagnetic induction and the wave character of the electromagnetic field. The electrical techniques and associated properties are: (a) spontaneous potential methods in which the formation of water resistivity is determined; (b) resistivity methods in which the apparent resistivity can be calculated using Wenner, Schlumberger, and dipole-dipole arrays; and (c) specific conductivity methods in which the soil-specific conductivity is calculated by incorporating in the analysis of soil geometric factors, such as fabric anisotropy, tortuosity, resistance to solid matrix, bulk fluid phase, and electric double layer. Various parameters that influence the measured electrical properties are also presented, such as the nature of the soil composition (particle size distribution, mineralogy), soil structure (porosity, pore size distribution, connectivity, and anisotropy), moisture content, temperature, concentration of dissolved species in the pore-solution, wet-dry cycles, age of contaminants, and mineral formation due to biodegradation. Finally, the extraction of aquifer hydraulic properties such as porosity and hydraulic conductivity, from the measured electrical properties is discussed

Проблема диагностики болезни Крона у детей

ДЕТИКРОНА БОЛЕЗНЬ /ДИАГНКИШЕЧНИКА ВОСПАЛИТЕЛЬНЫЕ БОЛЕЗНИ /ДИАГНГРАНУЛЕМАИЛЕОСКОПИЯБИОЛОГИЧЕСКИЕ МАРКЕРЫДИАГНОСТИЧЕСКИЕ МЕТОДЫ ПИЩЕВАРИТЕЛЬНЫЕ /ИСПКОЛОНОСКОПИЯКОМПЬЮТЕРНАЯ ЭНТЕРОГРАФИЯЭНТЕРОГРАФИЯ КОМПЬЮТЕРНА