ABO and Rh Blood Group Distribution Among Kunbis (Maratha) population of Amravati District, Maharashtra

The present study reports the distribution of ABO and Rh blood groups among the Kunbis (Maratha) population of Amravati district. The phenotypic frequency of blood group B is observed highest (33.06) percent, O (31.04), A (27.02) and AB is lowest (08.33) percent. The phenotypic frequency of Rh negative is (04.26) percent. TheKunbis (Maratha) population shows close genetic relationship with the Gujratis

Spiders (Araneae) from Agricultural fields near foothill of Satpura Mountain ranges of Amravati District, Maharashtra, India.

This paper deals with the study of spider distribution in agricultural fields adjoining the Satpura Mountain Ranges of the Amravati district. The total collection of spiders comprises 12 families, 37 genera and 76 species. The Araneidae and Thomisidae families were dominant, followed by Saltisidae from the selected agricultural area. Lycosidae and Tetragnathidae were also found in a decreasing number of species due to their specific habitation. The analysis of guild structure revealed six feeding guilds. Orb web weavers and Ambushers constituted the dominant feeding guild representing 33% and 22% of the total collection respectively. Stalkers and ground runners represent 20% and 17% and foliage hunters and sheet web weavers represent 5% and 3% respectively. A new species of genus Sassacus (Beetle like spider), family Saltisidae was found for the first time in the Vidarbha region. The richness of spider diversity is a sign of the overall biodiversity which is a useful indicator of the species richness of the agro-ecosystem.
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Low Prevalence of Risk Markers in Cases of Sudden Death Due to Brugada Syndrome Relevance to Risk Stratification in Brugada Syndrome

ObjectivesThe objective of this study was to determine the prevalence of conventional risk factors in sudden arrhythmic death syndrome (SADS) probands with Brugada syndrome (BrS).BackgroundPatients with BrS and previous aborted sudden cardiac death (SCD) are at high risk of recurrent events. Other universally accepted clinical features associated with higher risk include unheralded syncope and the presence of a spontaneous type 1 electrocardiogram (ECG).MethodsWe analyzed reported symptoms and reviewed ECGs from SADS probands with familial diagnoses of BrS, established by cardiological evaluation, including ECG, 2-dimensional echocardiography, Holter monitoring, exercise tolerance testing, and ajmaline provocation. These cases underwent familial evaluation between 2003 and 2010.ResultsA total of 49 consecutive families with a confirmed SADS death and a diagnosis of BrS were evaluated, comprising assessment of 202 family members in total. One family had 2 members with SADS, resulting in a total of 50 probands included. Mean age of death of probands was 29.1 ± 10.6 years, with 41 males (82%) (p < 0.05). Antemortem ECGs were available for 5 SADS probands, 1 of which demonstrated a spontaneous type 1 pattern. In 45 probands, symptoms before death were reported reliably by family members. Of these, 9 (20%) had experienced at least 1 syncopal episode before the fatal event. Importantly, 68% of probands would not have fulfilled any current criteria for consideration of implantable cardioverter-defibrillator.ConclusionsThe “low-risk” asymptomatic BrS group comprises the majority of SCD in this cohort. Current risk stratification would appear to be inadequate, and new markers of risk are vital

Antiurolithiatic activity of trans-cinnamic acid against ethylene glycol induced renal calculi in rats

Urolithiasis is a complex process characterized by supersaturation and retention of salts within the kidney and also a debilitating problem worldwide. Here, we have investigated antiurolithiatic effect of trans-cinnamic acid (t-CA) against ethylene glycol (EG) induced urolithiasis in rats. Urolithiasis was induced in Wistar albino rats using 0.75% v/v EG in drinking water for 28 days. t-CA was administered @200 and 400 mg/kg along with EG for 28 days. Biochemical, urine and histopathological analysis were performed to observe the calcium oxalate (CaC2O4) deposits and renal tissue damage. The EG group showed significant rise in urine oxalate, calcium, phosphate, and renal tissues oxalates, as compared to normal group. Serum creatinine and uric acid levels were also increased significantly in EG-treated group. Histopathological studies showed marked renal tissue damage and the presence of CaC2O4 crystals. Further, treatment of t-CA significantly ameliorated oxalate, calcium, magnesium, phosphate (urine) and creatinine, uric acid (serum) in EG-induced urolithiasis after 28 days. Moreover, t-CA-treated groups showed reversal of renal tissue damage and reduced level of CaC2O4. Interestingly, t-CA @400 mg/kg, was more effective in preventing the urolithiasis and regeneration of renal tissues in rats

Breast cancer genome heterogeneity: a challenge to personalised medicine?

Implementation of high-throughput genomics sequencing approaches into routine laboratory practice has raised the potential for the identification of multiple breast cancer targets suitable for future therapeutic intervention in order to improve cancer outcomes. Results from these studies have revealed bewildering breast cancer genome complexity with very few aberrations occurring in common between breast cancers. In addition, such complexity is compounded by evidence of genomic heterogeneity occurring within individual breast cancers. Such inter-tumoural and intratumoural heterogeneity is likely to present a challenge to personalised therapeutic approaches that might be circumvented through the definition of genome instability mechanisms governing such diversity and their exploitation using synthetic lethal approaches

The Galah survey: classification and diagnostics with t-SNE reduction of spectral information

Galah is an ongoing high-resolution spectroscopic survey with the goal of disentangling the formation history of the Milky Way, using the fossil remnants of disrupted star formation sites which are now dispersed around the Galaxy. it is targeting a randomly selected, magnitude limited (V ≤ 14) sample of stars, with the goal of observing one million objects. To date, 300,000 spectra have been obtained. Not all of them are correctly processed by parameter estimation pipelines and we need to know about them. We present a semi-automated classification scheme which identifies different types of peculiar spectral morphologies, in an effort to discover and flag potentially problematic spectra and thus help to preserve the integrity of the survey's results. To this end we employ a recently developed dimensionality reduction technique t-SNE (t-distributed Stochastic Neighbour Embedding), which enables us to represent the complex spectral morphology in a two-dimensional projection map while still preserving the properties of the local neighbourhoods of spectra. We find that the majority (178,483) of the 209,533 Galah spectra considered in this study represents normal single stars, whereas 31,050 peculiar and problematic spectra with very diverse spectral features pertaining to 28,579 stars are distributed into 10 classification categories: Hot stars, Cool metal-poor giants, Molecular absorption bands, Binary stars, Ha\Hβ emission, Ha/Hβ emission superimposed on absorption, Ha/Hβ P-Cygni, Ha/Hβ inverted P-Cygni, Lithium absorption, and Problematic. Classified spectra with supplementary information are presented in the catalogue, indicating candidates for follow-up observations and population studies of the short-lived phases of stellar evolution

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio

Transverse sphericity of primary charged particles in minimum bias proton-proton collisions at s=0.9\sqrt{s}=0.9, 2.76 and 7 TeV

Measurements of the sphericity of primary charged particles in minimum bias proton--proton collisions at $\sqrt{s}=0.9$, 2.76 and 7 TeV with the ALICE detector at the LHC are presented. The observable is linearized to be collinear safe and is measured in the plane perpendicular to the beam direction using primary charged tracks with $p_{\rm T}\geq0.5$ GeV/c in $|\eta|\leq0.8$. The mean sphericity as a function of the charged particle multiplicity at mid-rapidity ($N_{\rm ch}$) is reported for events with different $p_{\rm T}$ scales ("soft" and "hard") defined by the transverse momentum of the leading particle. In addition, the mean charged particle transverse momentum versus multiplicity is presented for the different event classes, and the sphericity distributions in bins of multiplicity are presented. The data are compared with calculations of standard Monte Carlo event generators. The transverse sphericity is found to grow with multiplicity at all collision energies, with a steeper rise at low $N_{\rm ch}$, whereas the event generators show the opposite tendency. The combined study of the sphericity and the mean $p_{\rm T}$ with multiplicity indicates that most of the tested event generators produce events with higher multiplicity by generating more back-to-back jets resulting in decreased sphericity (and isotropy). The PYTHIA6 generator with tune PERUGIA-2011 exhibits a noticeable improvement in describing the data, compared to the other tested generators.Comment: 21 pages, 9 captioned figures, 3 tables, authors from page 16, published version, figures from http://aliceinfo.cern.ch/ArtSubmission/node/308

Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

Inclusive transverse momentum spectra of primary charged particles in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}}$ = 2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross section. The measured charged particle spectra in $|\eta|<0.8$ and $0.3 < p_T < 20$ GeV/$c$ are compared to the expectation in pp collisions at the same $\sqrt{s_{\rm NN}}$, scaled by the number of underlying nucleon-nucleon collisions. The comparison is expressed in terms of the nuclear modification factor $R_{\rm AA}$. The result indicates only weak medium effects ($R_{\rm AA} \approx$ 0.7) in peripheral collisions. In central collisions, $R_{\rm AA}$ reaches a minimum of about 0.14 at $p_{\rm T}=6$-7GeV/$c$ and increases significantly at larger $p_{\rm T}$. The measured suppression of high-$p_{\rm T}$ particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb-Pb collisions at the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98