Aguas residuales y plantas acu?ticas "Berros". Un estudio de construcci?n de conceptos en el aula con estudiantes del grado cuarto y quinto de la instituci?n educativa Normal Superior Fabio Lozano Torrijos de Falan, Tolima

79 P?ginasRecurso Electr?nicoAguas Residuales y Plantas Acu?ticas ?Berros? es resultado del trabajo liderado desde el Proyecto Construcci?n conceptual en el aula de clases dentro del proyecto Aula Viva del programa de Licenciatura para la Educaci?n B?sica en Ciencias Naturales y Educaci?n Ambiental de la Universidad del Tolima. La investigaci?n es un aporte a la construcci?n conceptual en la escuela, a trav?sde la realizaci?n de las estrategias pedag?gicas y did?cticas, se construyen losconceptos de manera colaborativa o individual. El trabajo investigativo buscadar respuesta al siguiente interrogante: ?C?mo reconocer el concepto de plantas acu?ticas especialmente los berros y su utilizaci?n en la descontaminaci?n de aguas residuales con los estudiantes del grado cuarto y quinto de la sede santa filomena de la I.E. Normal superior de Falan ? Tolima? El trabajo responde a la investigaci?n de tipo formativo, centrada en el estudiantey el docente; la aprehensi?n de conceptos surge de la experimentaci?n a trav?s delas siguientes etapas: ?Las plantas acu?ticas una maravilla en el agua? resultado deuna salida pedag?gica al medio en el que viven; una segunda etapa ?El berro m?gico ?oportunidad de caracterizar, analizar, experimentar y generar conceptos con las plantas y ?El triunfo acu?tico digital? en el que se incorporan las TIC al aulade clase mediante la construcci?n de una catilla digital. El territorio de observaci?n fue en la Sede Santa Filomena de la Instituci?n Educativa Normal Superior Fabio Lozano Torrijos del municipio de Falan Tolima, con 12 estudiantes del grado cuarto y quinto de b?sica primaria, en edades que oscilan entre los 8 a 12 a?os, durante el a?o 2013.ABSTRACT. The paper residual waters and aquatic plants ?CRESS? is a partial result of the research liderated from the Project conceptual construction in the classroom in the Project living classroom in the program of Degree in Basic Education with emphasis in Natural Sciences of the Tolima?s University. The research is a contribution at the conceptual construction in the school through pedagogical and didactic strategies; the concepts are building in a collaborative and individual way. The research searches to answer the following question: How can we recognize the aquatic plants concept specially the Cress and its uses in the residual waters decontamination with the students of fourth and fifth grade in Santa Filomena?s School in the I. E. Normal Superior in Falan Tolima? The paper answers at formative research; it is centered in the student and the teacher; the conceptual apprehension are originated from the experimentation through the following steps: ?The aquatic plants a wonder in the water? that is the result of a field trip at the environment; a second step ?The magic cress? that is an opportunity for characterize, analyze, experiment and generate concepts with the water and ?The aquatic digital triumph? where we incorporated the I.C.T at the classroom through the building of a digital magazine. The observation territory was the Santa Filomena School in the I. E. Normal Superior Fabio Lozano Torrijos in de Falan Tolima, It has 12 students in fourth to fifth grade, their ages are from 8 to 12 years old, It was in the year 2013.INTRODUCCI?N 12 1. LA AVENTURA DEL CONOCIMIENTO 15 1.1 FORMULACI?N DEL PROBLEMA 15 1.2 OBJETIVOS 16 1.2.1 Objetivos Generales 16 1.2.2 Objetivos Espec?ficos 16 1.3JUSTIFICACI?N 17 2. LA ESTRATEGIA DEL SABER 19 2.1. TIPO DE INVESTIGACI?N 19 2.2. T?CNICAS PARA LA RECOLECCI?N DE INFORMACI?N 21 2.3. POBLACION Y MUESTRA 24 2.4. ETAPAS DE LA INVESTIGACI?N 27 2.4.1. Las plantas acu?ticas una maravilla 27 2.4.2. El berro m?gico 27 2.4.3. El triunfo acu?tico digital 28 3. CONSTRUCCI?N CONCEPTUAL EN EL AULA DE CLASES 29 3.1. VISI?N LEGAL SOBRE LOS PROCESOS EDUCATIVOS 29 3.2. APROXIMACI?N PSICOL?GICA 31 3.3. PROCESO DE APRENDIZAJE 33 3.4. LUGAR PARA APREHENDER 39 3.5. TIC PARA LA EDUCACI?N 43 3.6. AMBIENTE Y NATURALEZA 49 4. PUERTAS ABIERTAS AL APRENDIZAJE 51 5. CONCLUSIONES 66 RECOMENDACIONES 67 REFERENCIAS BIBLIOGR?FICAS 6

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

PMCID: PMC3544714This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

An?lisis de la influencia que tienen los estilos de ense?anza y aprendizaje frente a la comprensi?n de los procesos matem?ticos que vinculan operaciones con n?meros fraccionarios en la formaci?n t?cnica de los aprendices del Centro de Industria del Ambiente FEPMA del SENA regional Tolima

95 p. Recurso Electr?nicoEl desempe?o de los estudiantes que ingresan al SENA sobre operaciones con n?meros fraccionarios; hizo que se analizara la influencia de los estilos de ense?anza aprendizaje de los estudiantes de una instituci?n educativa p?blica del municipio de Ibagu?; se identific? las motivaciones y se describi? el desarrollo de los procesos de ense?anza aprendizaje. Se dise?? una estrategia did?ctica para mejorar el desempe?o de los estudiantes; se recab? informaci?n sobre trabajos realizados anteriormente sobre fraccionarios, se analiz? autores como Maslow (1991) para analizar las motivaciones; con Weber (2007) se estudi? los interrogantes sobre el quehacer del docente y la teor?a del aprendizaje experiencial de Kolb (1984) para los estilos de aprendizaje. La investigaci?n tuvo enfoque cualitativo y el m?todo fue el estudio de caso se utiliz? como t?cnicas la entrevista con grupos focales, testimonio focalizado y se apoy? con encuestas para recabar informaci?n m?s exacta del objeto de estudio. El an?lisis de los datos se hizo con programas de an?lisis cualitativo como el ATLAS TI y estad?stico como el SPSS para los datos cuantitativos; es aqu? donde encontramos que los estudiantes tienen motivaciones negativas sobre el aprendizaje de los n?meros fraccionarios, las estrategias de ense?anza aprendizaje utilizadas por el docente estimulan pero no lo suficiente a los estudiantes en el aprendizaje de fraccionarios; los estudiantes en si no tienen definido un estilo de aprendizaje perfilado en su inter?s por el aprendizaje de operaciones con n?meros fraccionarios. Esta investigaci?n deja evidente que en los procesos de ense?anza aprendizaje de operaciones con n?meros fraccionarios tienen que tener en cuenta los intereses del c?mo quieren ellos aprender para que su aprendizaje sea m?s significativo. Es por esto que se dise?? una estrategia did?ctica mediante una secuencia did?ctica que tiene inmerso el proceso de aprendizaje de metrolog?a dimensional enfocada en las operaciones con n?meros fraccionarios.The performance of students entering SENA on operations with fractional numbers; He made the influence of the styles of learning of students in a public school in the municipality of Ibagu? be analyzed ; motivations were identified and the development of teaching and learning processes described . a teaching strategy was designed to improve student performance ; information on previous work on fractions were collected , authors as Maslow (1991 ) was analyzed to analyze the motivations ; Weber (2007 ) questions about the task of teaching and experiential learning theory of Kolb (1984) for learning styles was studied. The research was qualitative approach and method was the case study was used as interview techniques with focus groups, and leaned testimony focused surveys to gather more accurate information of the object of study. The data analysis was done with qualitative analysis programs such as IT and statistical ATLAS as SPSS for quantitative data; Here we find that students have a negative impact on learning motivations fractional numbers, teaching and learning strategies used by teachers stimulate but not enough students in learning fractions; students if they have defined a learning style profiled interest in learning operations with fractional numbers . This research makes clear that in the process of learning of operations with fractional numbers have to take into account the interests of how they want to learn to make your learning more meaningful. That is why a teaching strategy designed by a teaching sequence that has immersed the learning process focused on dimensional metrology operations with fractional numbers. Keywords: motivation, strategy, teaching style

Non-cell-autonomous regulation of interneuron specification mediated by extracellular vesicles

Disruption in neurogenesis and neuronal migration can influence the assembly of cortical circuits, affecting the excitatory-inhibitory balance and resulting in neurodevelopmental and neuropsychiatric disorders. Using ventral cerebral organoids and dorsoventral cerebral assembloids with mutations in the extracellular matrix gene LGALS3BP, we show that extracellular vesicles released into the extracellular environment regulate the molecular differentiation of neurons, resulting in alterations in migratory dynamics. To investigate how extracellular vesicles affect neuronal specification and migration dynamics, we collected extracellular vesicles from ventral cerebral organoids carrying a mutation in LGALS3BP, previously identified in individuals with cortical malformations and neuropsychiatric disorders. These results revealed differences in protein composition and changes in dorsoventral patterning. Proteins associated with cell fate decision, neuronal migration, and extracellular matrix composition were altered in mutant extracellular vesicles. Moreover, we show that treatment with extracellular vesicles changes the transcriptomic profile in neural progenitor cells. Our results indicate that neuronal molecular differentiation can be influenced by extracellular vesicles

Transforming growth factor-β1 impairs neuropathic pain through pleiotropic effects

<p>Abstract</p> <p>Background</p> <p>Understanding the underlying mechanisms of neuropathic pain caused by damage to the peripheral nervous system remains challenging and could lead to significantly improved therapies. Disturbance of homeostasis not only occurs at the site of injury but also extends to the spinal cord and brain involving various types of cells. Emerging data implicate neuroimmune interaction in the initiation and maintenance of chronic pain hypersensitivity.</p> <p>Results</p> <p>In this study, we sought to investigate the effects of TGF-β1, a potent anti-inflammatory cytokine, in alleviating nerve injury-induced neuropathic pain in rats. By using a well established neuropathic pain animal model (partial ligation of the sciatic nerve), we demonstrated that intrathecal infusion of recombinant TGF-β1 significantly attenuated nerve injury-induced neuropathic pain. TGF-β1 treatment not only prevents development of neuropathic pain following nerve injury, but also reverses previously established neuropathic pain conditions. The biological outcomes of TGF-β1 in this context are attributed to its pleiotropic effects. It inhibits peripheral nerve injury-induced spinal microgliosis, spinal microglial and astrocytic activation, and exhibits a powerful neuroprotective effect by preventing the induction of ATF3⁺neurons following nerve ligation, consequently reducing the expression of chemokine MCP-1 in damaged neurons. TGF-β1 treatment also suppresses nerve injury-induced inflammatory response in the spinal cord, as revealed by a reduction in cytokine expression.</p> <p>Conclusion</p> <p>Our findings revealed that TGF-β1 is effective in the treatment of neuropathic by targeting both neurons and glial cells. We suggest that therapeutic agents such as TGF-β1 having multipotent effects on different types of cells could work in synergy to regain homeostasis in local spinal cord microenvironments, therefore contributing to attenuate neuropathic pain.</p

Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome

We examined adenomas and cancers from hereditary non-polyposis colorectal cancer (HNPCC) syndrome patients for the presence of frameshift mutations in the smooth-muscle myosin gene, MYH11. Our results show that mutations in MYH11 occur more frequently in cancers than adenomas (P=0.008) and are dependent on microsatellite instability (MSI+)

Prevalence of gastrointestinal nematodes in sheep and goat production systems under confinement, semi-confinement and grazing in municipalities of Antioquia, Colombia

El objetivo del estudio fue determinar la prevalencia de nematodos gastrointestinales en sistemas de producción de ganado ovino y caprino en el trópico de Antioquia, Colombia, mediante un estudio descriptivo transversal. Se incluyeron 17 apriscos de 9 municipios y 302 animales (ovejas y cabras). Se evaluó la frecuencia de parasitismo gastrointestinal y carga parasitaria de especies y géneros determinados a través de la caracterización taxonómica por identificación de las larvas (L3), considerando variables clínico-epidemiológicas. El 76% de los animales se encontraba infectado, donde el 69.5% presentó cargas parasitarias bajas (menos de 200 hpg de heces). Se concluyó que los apriscos de Antioquia presentan alta prevalencia de infección por Tricostrongilidos, siendo Haemonchus contortus (61.3%), Teladorsagia (Ostertagia) circumcincta (25.5%) y Trichostrongylus sp (21.5%) los parásitos más frecuentes.The aim of this study was to determine the prevalence of gastrointestinal nematodes in sheep and goat production systems in the tropics of Antioquia, Colombia through a cross-sectional study. Faecal samples were collected from 302 sheep and goats from 17 farms in 9 municipalities. The prevalence of nematode infection and the parasite burden based on species and genus identified through taxonomic characterization of infective third-stage larvae (L3) and considering clinical and epidemiological variables were evaluated. The prevalence of infected ruminants was 76%, where 69.5% showed low parasite burden (less than 200 epg of faeces). It is concluded that ovine and caprine farms in Antioquia had high prevalence of Trichostrongylids infection, where Haemonchus contortus (61.3%), Teladorsagia (Ostertagia) circumcincta (25.5%) and Trichostrongylus sp (21.5%) were the most common parasites

Phylogenetic relationships of cone snails endemic to Cabo Verde based on mitochondrial genomes

Background: Due to their great species and ecological diversity as well as their capacity to produce hundreds of different toxins, cone snails are of interest to evolutionary biologists, pharmacologists and amateur naturalists alike. Taxonomic identification of cone snails still relies mostly on the shape, color, and banding patterns of the shell. However, these phenotypic traits are prone to homoplasy. Therefore, the consistent use of genetic data for species delimitation and phylogenetic inference in this apparently hyperdiverse group is largely wanting. Here, we reconstruct the phylogeny of the cones endemic to Cabo Verde archipelago, a well-known radiation of the group, using mitochondrial (mt) genomes. Results: The reconstructed phylogeny grouped the analyzed species into two main clades, one including Kalloconus from West Africa sister to Trovaoconus from Cabo Verde and the other with a paraphyletic Lautoconus due to the sister group relationship of Africonus from Cabo Verde and Lautoconus ventricosus from Mediterranean Sea and neighboring Atlantic Ocean to the exclusion of Lautoconus endemic to Senegal (plus Lautoconus guanche from Mauritania, Morocco, and Canary Islands). Within Trovaoconus, up to three main lineages could be distinguished. The clade of Africonus included four main lineages (named I to IV), each further subdivided into two monophyletic groups. The reconstructed phylogeny allowed inferring the evolution of the radula in the studied lineages as well as biogeographic patterns. The number of cone species endemic to Cabo Verde was revised under the light of sequence divergence data and the inferred phylogenetic relationships. Conclusions: The sequence divergence between continental members of the genus Kalloconus and island endemics ascribed to the genus Trovaoconus is low, prompting for synonymization of the latter. The genus Lautoconus is paraphyletic. Lautoconus ventricosus is the closest living sister group of genus Africonus. Diversification of Africonus was in allopatry due to the direct development nature of their larvae and mainly triggered by eustatic sea level changes during the Miocene-Pliocene. Our study confirms the diversity of cone endemic to Cabo Verde but significantly reduces the number of valid species. Applying a sequence divergence threshold, the number of valid species within the sampled Africonus is reduced to half.Spanish Ministry of Science and Innovation [CGL2013-45211-C2-2-P, CGL2016-75255-C2-1-P, BES-2011-051469, BES-2014-069575, Doctorado Nacional-567]info:eu-repo/semantics/publishedVersio

Diagnóstico tecnológico agropecuario

La mayoría del área del CREECED Piedemonte forma parte del Departamento del Meta, cuya conquista se remonta a 1531 y cuya División Política y Administrativa forma 24 municipios de los cuales 10 están incluidos en nuestro CRECED(mas 2 de Cundinamarca y 1 de Casanare).Equinos-Caballo - caballo

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genotyped and imputed SNPs in 6608 Caucasian cases and 37 925 controls, and 895 Asian cases and 1968 controls, revealed the best signal of association for SNP rs11263763 (P = 8.4 × 10(-14), odds ratio = 0.86, 95% confidence interval = 0.82-0.89), located within HNF1B intron 1. Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus. SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs. Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region. Reporter assays demonstrated that this extended region reduces activity in combination with the minimal HNF1B promoter, and that the minor alleles of rs11263763 or rs8064454 are associated with decreased HNF1B promoter activity. Our findings provide evidence for a single signal associated with endometrial cancer risk at the HNF1B locus, and that risk is likely mediated via altered HNF1B gene expression