Time-Bin-Based Neighbourhood Algorithm for Temporal Effects in Recommendation Systems

Recommender systems are used in various applications to boost the prediction accuracy of user preferences. The recent developments in recommendation frameworks support precise user decisions on any item depending on the actions of logged users. Although the existing algorithms exhibit good performance, some temporal aspects of user data require attention. This study introduces a new algorithm that utilises the users\u27 temporal effects by extracting time-bins as recent rating timelines. After error-function-based analyses for the optimal time-bins, the time-bin-based algorithm is employed to filter the best neighbours. Analyses show that the optimal time-bin size is 41 for the MovieLens dataset while 48 for the Netflix Prize dataset. Therefore, considering the cold start problem, a flexible time-bin approach is also proposed. The time-bin-based algorithm offers improvements of 7,44% (MovieLens) and 5,36% (Netflix) for the Matthews correlation coefficient and increases the balanced accuracy by 3,78% (MovieLens) and 2,06% (Netflix). Negative predictive value and specificity reveal high percentages for most rating classes, similar to the state-of-the-art approach. Finally, the standard accuracy metric demonstrates an improvement of 1,86% for MovieLens and 2,36% for the Netflix dataset

Evaluation of the Contralateral Acoustic Stimulation Test After Audiological Examination of the Central Auditory System in Individuals with Normal Hearing

The aim of our study was to evaluate the contralateral acoustic stimulation tests of central auditory system after audiological examination of individuals with normal hearing. In this context, a number of criteria were considered for the determination of individuals with normal hearing. Normal hearing provides the ability to live independently in the social environment of an individual, and the level of hearing is considered necessary for enabling communication with the environment. A total of 15 individuals were included in our study. In all individuals, five different frequencies were obtained compared to the threshold for both ears. The frequencies were 1000 Hz, 1414 Hz, 2000 Hz, 2828 Hz and 4000 Hz; and the suppression thresholds were also measured. After audiological tests were performed for our study, the same measurements were repeated. Looking at the results of the study, a statistically significant difference was found between the measurement results for right and left ears in individuals with normal hearing (P<0.05). Result: In order to see the suppressive effect, the integrity of the neural structures must be preserved starting from the medial nucleus of the superior olivary complex and reaching the OHCs. According to the results obtained in our study, we can conclude that MOCR is active, and the central nervous system is not impaired after the audiological evaluation. However, it is thought that a further study should be conducted with a larger sample group in order to obtain more specific results. Keywords: Contralateral suppression, normal hearing, otoacoustic emissions DOI: 10.7176/JHMN/87-06 Publication date:March 31st 202

Rare etiological causes of iliofemoral deep venous thrombosis: Reports of 2 cases

AbstractDeep venous thrombosis is frequently seen in lower extremities. However, when seen in the iliac level, mass effect of an underlying pathology must be considered. In this report, we present two cases with upper region deep venous thrombosis, which had underlying pathologies of appendicitis and non-Hodgkin lymphoma

The Effects of <i>Tobacco mosaic virus</i> Infection on Growth and Physiological Parameters in Some Pepper Varieties (<i>Capsicum annuum</i> L.)

Changes in some growth (plant leaf number and area, plant biomass, plant height, root length, and plant stem diameter) and physiological (photosynthetic pigments, relative water content (RWC) and proline content) parameters of pepper (Capsicum annuum L.) varieties were studied as they were affected by Tobacco mosaic virus (TMV) infection. The greenhouse pepper cvs ‘Ergenekon F1’, ‘Kumsal F1’, and one candidate variety (‘497 F1’) were used as material to compare infected versus non-infected control plants. Infected plants showed various degrees of stunting; necrosis on stems, leaves and fruits; mosaic symptoms on leaves; deformations, defoliation of leaves, and reduction in fruit size. Besides these, TMV infection resulted in reduction of vegetative growth parameters, RWC, chlorophyll a and b, plant fresh and dry production in different parts of the plants, but increase of proline content in leaves. The level of response differed depending on varieties

Geology, Alteration and Geochemical Characteristics of Inlice (Konya-Turkey) High Sulphidation Epithermal Gold Deposit

Inlice high sulphidation epithermal gold deposit is located in the Erenlerdag-Alacadag Volcanic Complex (EAVC), approximately 40 km southwest of Konya city centre. The volcanic and volcano-sedimentary rocks seen in the study area are andesite, block and ash flow, basaltic andesite lava flow and andesite lava flow, from oldest to youngest. The youngest units unconformably covering the volcanic and volcano-sedimentary rocks are talus and alluvium. Four different alteration zones in the andesites moving from the centre of the alteration toward fresh rock are i) silicified zones (consisting of vuggy-sugary and chalcedonic/opaline quartz veins), ii) advanced argillic alteration, iii) intermediate argillic and iv) propylitic alteration. In addition, a potassic alteration zone consisting of magnetite, quartz, biotite and anhydrite was identified in the deep part of the Merkez Zone. The mineralisation is commonly represented by pyrite, and to a lesser extent enargite, chalcopyrite, covellite, chalcocite, sphalerite and marcasite. Petrographically, the fine-grained gold grains (between 2-6 mu m) are only observed in areas where sulphide minerals are oxidised. The degree of geochemical variation in the alteration zones decreases from silicified zones to propylitic alteration, and this variation is largely consistent with the mineralogies observed in these zones. Moreover, enrichment in As, Sb, Bi, Ag and Au, and depletion in Zn and Ni are especially notable from fresh/least altered andesites towards advanced argillic alteration and silicified zones. In addition, studies showed that the high Pb value in chalcedonic/opaline textured quartz veins and low Rb/Sr value in advanced argillic alteration and silicified zones can be used as a geochemical guide, at least for the Inlice region.İnlice yüksek sülfidasyon epitermal altın yatağı, Erenlerdağ-Alacadağ Volkanik Kompleksi (EAVK) içerisinde ve Konya ilinin yaklaşık 40 km güneybatısında yer almaktadır. Çalışma alanında stratigrafik konumlarına göre alttan üste doğru andezit, blok ve kül akıntısı, bazaltik andezit lav akıntısı ve andezit lav akıntısı olmak üzere dört birime ayrılan volkanik ve volkano-sedimanter kayaçlar, yamaç molozu ve alüvyonlar tarafından uyumsuz olarak örtülürler. Andezitler içerisinde gözlenen alterasyonların merkezinden dışa doğru sırasıyla kovuklu-şeker ve kalsedonik/ opalin dokulu kuvars damarlarından oluşan silisleşmeler, ileri arjilik, ortaç arjilik ve piropilitik alterasyon zonları tanımlanmıştır. Bu alterasyon topluluklarına ek olarak sadece Merkez Zonun derin kesimlerinde gözlenen manyetit, kuvars, biyotit ve anhidrit içerikli potasik bir alterasyon zonu da tanımlanmıştır. Cevherleşmeler, yaygın olarak pirit daha az oranda enarjit, kalkopirit, kalkosin, kovellin, sfalerit ve markazit gibi sülfid mineralleri ile temsil edilmektedir. Petrografik olarak altın taneleri özellikle sülfid minerallerinin oksidasyona maruz kaldığı kesimlerde saçınımlı olarak 2 ile 6 µm arası boyutlarda gözlenmektedir. Alterasyon zonlarındaki jeokimyasal değişimin derecesi silisleşmelerden piropilitik alterasyona doğru azalmakta olup, bu değişim, alterasyon zonlarında gözlenen mineralojik değişimle uyumludur. Bununla birlikte taze andezitlerden ileri arjilik alterasyon ve silisleşmelere doğru özellikle As, Sb, Bi, Ag ve Au gibi elementler zenginleşme gösterirken, Zn ve Ni’deki fakirleşmeler belirginleşmektedir. Ayrıca yapılan çalışmalar kalsedonik/ opalin dokulu kuvars damarlarındaki Pb ile ileri arjilik alterasyon ve silisleşmelerdeki düşük Rb/Sr değerlerinin en azından İnlice bölgesi için jeokimyasal bir kılavuz olarak kullanılabileceğini göstermektedir

Acil Servise Başvuran Onkolojik Tanılı Hastaların Demografik İncelenmesi

Amaç: Hasta bakımındaki iyileşmeler sayesinde kanser hastalarının yaşam süresindeki uzamalar tüm dünyada kanserli hasta sayısının giderek artmasına neden olmaktadır. Bununla beraber acil servise başvuran onkolojik hastaların sayısı da gün geçtikçe artmaktadır. Bu çalışma ile kanserli hastaların acil servise başvuru nedenleri ve prognozu etkileyen faktörleri demografik olarak incelenmiştir. Gereç ve Yöntem: Çalışmaya Tekirdağ Namık Kemal Üniversitesi Hastanesi Acil Servisi’ne 1 Mart 2018 tarihi ile 31 Ağustos 2018 tarihi arasında başvuran ve klinik/patolojik/onkolojik tanısı olan 18 yaş ve üzeri hastalar dahil edildi. Çalışma prospektif olup, başlamadan önce etik kurul onayı alındı. Bulgular: Çalışmaya onkoloji tanısı patoloji raporları ile kesinleşmiş 265 hasta dahil edildi. Olguların yaş ortalaması 60±12 yıl olup, kadınlardaki yaş ortalamasının 58±13 yıl olduğu görüldü. En sık başvuru şikayeti %13,6 (n=36) ile “ağrı” oldu. Kliniklere ve yoğun bakım ünitelerine en sık yatış nedeninin %6,8 (n=18) ile gastrointestinal sistem patolojileri ve respiratuvar patolojiler olduğu görüldü. Yatışı yapılan 90 hastadan %63,3’ünün (n=57) hastaneden taburcu edildiği ve %33,3 (n=30) hastanın ise yatırıldığı kliniklerde vefat ettiği saptandı. Sonuç: Onkolojik hasta gruplarının yaş ortalaması yüksek olduğu için morbiditesi ve mortalitesi diğer hasta gruplarına göre daha yüksektir. Bu sebeple bu hasta grupları acil servise diğer hasta gruplarına göre farklı şikayetlerle gelebilmektedirler. Onkolojik hastaların tetkik ve tedavilerinin daha dikkatli düzenlenmesi gerekmektedir

The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio