Effects of non-steroidal growth implant and dietary zilpaterol hydrochloride on growth and carcass characteristics of feedlot lambs

The effects of steroidal growth implants alone or in combination with β-adrenergic agonist feed additives have not been studied thoroughly in mutton sheep in South African feedlot conditions. This study investigated the effects of a non-steroidal growth implant zeranol (Ralgro®), alone or in combination with zilpaterol hydrochloride (Zilmax®), on growth performance, carcass characteristics, and selected meat quality traits in 160 SA Mutton Merino ram lambs fed in a commercial feedlot. The experimental design consisted of two Ralgro treatment groups x two Zilmax treatments x two Zilmax feeding periods x 20 animals per treatment group. Lambs were randomly allocated to eight treatment groups, of which one half were implanted with Ralgro after arrival, followed by feed supplementation with Zilmax at two Zilmax feeding periods during the finisher phase, compared with negative control treatments (e.g. no Ralgro or Zilmax; Ralgro + no Zilmax; or no Ralgro + Zilmax). All lambs were fed the grower ration traditionally used by the commercial feedlot, which contained 16.89% crude protein (CP) and 2.94 Mcal/kg dry matter (DM). Zilmax was supplemented in the feed at 40 mg per animal per day and fed for 18 days or 25 days, plus three days withdrawal. Lambs that did not receive the Zilmax treatment were fed the basal diet without Zilmax feed supplementation. Ralgro significantly increased average daily gains (ADG) and cold carcass mass (CCM) of lambs. Lambs supplemented with Zilmax during the finisher phase had higher ADG, greater CCM and increased dressing percentage by ca.1.1% compared with those in the control group. Lambs fed Zilmax for 25 days had higher CCM than those fed for 18 days. The duration of the Zilmax treatment also decreased hide weight, fat thickness and shear force values (tenderness). Zilmax increased ADG and CCM in lambs, particularly if combined with Ralgro implants during the growing phase. The results from this study indicate that the combination of Ralgro implants with Zilmax feed supplementation during the finisher phase had additive effects and increased ADG and CCM of feedlot lambs.Keywords: Growth performance, meat quality, South African Mutton Merino, sheep, Ralgro®, Zilmax

Exact Renormalization Group for O(4) Gauged Supergravity

We study exact renormalization group (RG) in O(4) gauged supergravity using the effective average action formalism. The nonperturbative RG equations for cosmological and newtonian coupling constants are found. It is shown the existence of (nonstable) fixed point of these equations. The solution of RG equation for newtonian coupling constant is qualitatively the same as in Einstein gravity(i.e. it is growing at large distances).Comment: Latex file, 11 page

Factors affecting success of conservation translocations of terrestrial vertebrates: a global systematic review

Translocation—moving individuals for release in different locations—is among the most important conservation interventions for increasing or re-establishing populations of threatened species. However, translocations often fail. To improve their effectiveness, we need to understand the features that distinguish successful from failed translocations. We assembled and analysed a global database of translocations of terrestrial vertebrates (n = 514) to assess the effects of various design features and extrinsic factors on success. We analysed outcomes using standardised metrics: a categorical success/failure classification; and population growth rate. Probability of categorical success and population growth rate increased with the total number of individuals released but with diminishing returns above about 20–50 individuals. Positive outcomes—categorical success and high population growth—were less likely for translocations in Oceania, possibly because invasive species are a major threat in this region and are difficult to control at translocation sites. Rates of categorical success and population growth were higher in Europe and North America than elsewhere, suggesting the key role of context in positive translocation outcomes. Categorical success has increased throughout the 20th century, but that increase may have plateaued at about 75% since about 1990. Our results suggest there is potential for further increase in the success of conservation translocations. This could be best achieved by greater investment in individual projects, as indicated by total number of animals released, which has not increased over time.Shane D. Morris, Barry W. Brook, Katherine E. Moseby, Christopher N. Johnso

Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer

<b>Background</b>: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer. <b>Methods</b>: Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jass’ and Klintrup’s criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time. <b>Results</b>: Low-grade inflammatory infiltrate assessed using Klintrup’s criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n = 179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin. <b>Conclusion</b>: Assessment of inflammatory infiltrate using Klintrup’s criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth

A Compact Beam Stop for a Rare Kaon Decay Experiment

We describe the development and testing of a novel beam stop for use in a rare kaon decay experiment at the Brookhaven AGS. The beam stop is located inside a dipole spectrometer magnet in close proximity to straw drift chambers and intercepts a high-intensity neutral hadron beam. The design process, involving both Monte Carlo simulations and beam tests of alternative beam-stop shielding arrangements, had the goal of minimizing the leakage of particles from the beam stop and the resulting hit rates in detectors, while preserving maximum acceptance for events of interest. The beam tests consisted of measurements of rates in drift chambers, scintilation counter hodoscopes, a gas threshold Cherenkov counter, and a lead glass array. Measurements were also made with a set of specialized detectors which were sensitive to low-energy neutrons, photons, and charged particles. Comparisons are made between these measurements and a detailed Monte Carlo simulation.Comment: 39 pages, 14 figures, submitted to Nuclear Instruments and Method

Anion exchange membrane soil nitrate predicts turfgrass color and yield.

Desirable nitrogen (N) management practices for turfgrass supply sufficient N for high quality turf while limiting excess soil N. Previous studies suggested the potential of anion exchange membranes (AEMs) for predicting turfgrass color, quality, or yield. However, these studies suggested a wide range of critical soil nitrate-nitrogen (NO3-N) values across sample dates. A field experiment, in randomized complete block design with treatments consisting of nine N application rates, was conducted on a mixed species cool-season turfgrass lawn across two growing seasons. Every 2 wk from May to October, turfgrass color was assessed with three different reflectance meters, and soil NO3-N was measured with in situ AEMs. Cate-Nelson models were developed comparing relative reflectance value and yield to AEM desorbed soil NO3-N pooled across all sample dates. These models predicted critical AEM soil NO3-N values from 0. 45 to 1.4 micro g cm-2 d-1. Turf had a low probability of further positive response to AEM soil NO3-N greater than these critical values. These results suggest that soil NO3-N critical values from AEMs may be applicable across sample dates and years and may serve to guide N fertilization to limit excess soil NO3-N

On the Progenitors of Core-Collapse Supernovae

Theory holds that a star born with an initial mass between about 8 and 140 times the mass of the Sun will end its life through the catastrophic gravitational collapse of its iron core to a neutron star or black hole. This core collapse process is thought to usually be accompanied by the ejection of the star's envelope as a supernova. This established theory is now being tested observationally, with over three dozen core-collapse supernovae having had the properties of their progenitor stars directly measured through the examination of high-resolution images taken prior to the explosion. Here I review what has been learned from these studies and briefly examine the potential impact on stellar evolution theory, the existence of "failed supernovae", and our understanding of the core-collapse explosion mechanism.Comment: 7 Pages, invited review accepted for publication by Astrophysics and Space Science (special HEDLA 2010 issue

Simulating MOS science on the ELT: Lyα forest tomography

Mapping the large-scale structure through cosmic time has numerous applications in studies of cosmology and galaxy evolution. At z ≳ 2, the structure can be traced by the neutral intergalactic medium (IGM) by way of observing the Lyα forest towards densely sampled lines of sight of bright background sources, such as quasars and star-forming galaxies. We investigate the scientific potential of MOSAIC, a planned multi-object spectrograph on the European Extremely Large Telescope (ELT), for the 3D mapping of the IGM at z ≳ 3. We simulated a survey of 3 ≲ z ≲ 4 galaxies down to a limiting magnitude of mr ∼ 25.5 mag in an area of 1 degree2 in the sky. Galaxies and their spectra (including the line-of-sight Lyα absorption) were taken from the lightcone extracted from the Horizon-AGN cosmological hydrodynamical simulation. The quality of the reconstruction of the original density field was studied for different spectral resolutions (R = 1000 and R = 2000, corresponding to the transverse typical scales of 2.5 and 4 Mpc) and signal-to-noise ratios (S/N) of the spectra. We demonstrate that the minimum S/N (per resolution element) of the faintest galaxies that a survey like this has to reach is S/N = 4. We show that a survey with this sensitivity enables a robust extraction of cosmic filaments and the detection of the theoretically predicted galaxy stellar mass and star-formation rate gradients towards filaments. By simulating the realistic performance of MOSAIC, we obtain S/N(Tobs, R, mr) scaling relations. We estimate that ≲35 (65) nights of observation time are required to carry out the survey with the instrument’s high multiplex mode and with a spectral resolution of R = 1000 (2000). A survey with a MOSAIC-concept instrument on the ELT is found to enable the mapping of the IGM at z >  3 on Mpc scales, and as such will be complementary to and competitive with other planned IGM tomography surveys

Electroweak instantons as a solution to the ultrahigh energy cosmic ray puzzle

We propose a scenario in which a simple power-like primary spectrum for protons with sources at cosmological distances leads to a quantitative description of all the details of the observed cosmic ray spectrum for energies from 10^{17} eV to 10^{21} eV. As usual, the ultrahigh energy protons with energies above E_{GZK} ~ 4 x 10^{19} eV loose a large fraction of their energies by the photoproduction of pions on the cosmic microwave background, which finally decay mainly into neutrinos. In our scenario, these so-called cosmogenic neutrinos interact with nucleons in the atmosphere through Standard Model electroweak instanton-induced processes and produce air showers which are hardly distinguishable from ordinary hadron-initiated air showers. In this way, they give rise to a second contribution to the observed cosmic ray spectrum -- in addition to the one from above mentioned protons -- which reaches beyond E_{GZK}. Since the whole observed spectrum is uniquely determined by a single primary injection spectrum, no fine tuning is needed to fix the ratio of the spectra below and above E_{GZK}. The statistical analysis shows an excellent goodness of this scenario. Possible tests of it range from observations at cosmic ray facilities and neutrino telescopes to searches for QCD instanton-induced processes at HERA.Comment: 14 pages, 7 figure

A community jury study exploring the public acceptability of using risk stratification to determine eligibility for cancer screening

Introduction Using risk stratification to determine eligibility for cancer screening is likely to improve the efficiency of screening programmes by targeting resources towards those most likely to benefit. We aimed to explore the implications of this approach from a societal perspective by understanding public views on the most acceptable stratification strategies. Methods We conducted three online community juries with 9 or 10 participants in each. Participants were purposefully sampled by age (40–79 years), sex, ethnicity, social grade and English region. On the first day, participants were informed of the potential benefits and harms of cancer screening and the implications of different ways of introducing stratification using scenarios based on phenotypic and genetic risk scores. On the second day, participants deliberated to reach a verdict on the research question, ‘Which approach(es) to inviting people to screening are acceptable, and under what circumstances?’ Deliberations and feedback were recorded and analysed using thematic analysis. Results Across the juries, the principle of risk stratification was generally considered to be an acceptable approach for determining eligibility for screening. Disregarding increasing capacity, the participants considered it to enable efficient resource allocation to high-risk individuals and could see how it might help to save lives. However, there were concerns regarding fair implementation, particularly how the risk assessment would be performed at scale and how people at low risk would be managed. Some favoured using the most accurate risk prediction model whereas others thought that certain risk factors should be prioritized (particularly factors considered as non-modifiable and relatively stable, such as genetics and family history). Transparently justifying the programme and public education about cancer risk emerged as important contributors to acceptability. Conclusion Using risk stratification to determine eligibility for cancer screening was acceptable to informed members of the public, particularly if it included risk factors they considered fair and when communicated transparently. Patient or Public Contribution Two patient and public involvement representatives were involved throughout this study. They were not involved in synthesizing the results but contributed to producing study materials, co-facilitated the community juries and commented on the interpretation of the findings and final report