299 research outputs found
A new model for QPOs in accreting black holes: application to the microquasar GRS 1915+105
(abridged) In this paper we extend the idea suggested previously by Petri
(2005a,b) that the high frequency quasi-periodic oscillations observed in
low-mass X-ray binaries may be explained as a resonant oscillation of the
accretion disk with a rotating asymmetric background (gravitational or
magnetic) field imposed by the compact object. Here, we apply this general idea
to black hole binaries. It is assumed that a test particle experiences a
similar parametric resonance mechanism such as the one described in paper I and
II but now the resonance is induced by the interaction between a spiral density
wave in the accretion disk, excited close to the innermost stable circular
orbit, and vertical epicyclic oscillations. We use the Kerr spacetime geometry
to deduce the characteristic frequencies of this test particle. The response of
the test particle is maximal when the frequency ratio of the two strongest
resonances is equal to 3:2 as observed in black hole candidates. Finally,
applying our model to the microquasar GRS 1915+105, we reproduce the correct
value of several HF-QPOs. Indeed the presence of the 168/113/56/42/28 Hz
features in the power spectrum time analysis is predicted. Moreover, based only
on the two HF-QPO frequencies, our model is able to constrain the mass and angular momentum of the accreting black hole.Comment: Accepted for publication in Astrophysics & Space Scienc
History of clinical transplantation
How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York
Electron-hadron shower discrimination in a liquid argon time projection chamber
By exploiting structural differences between electromagnetic and hadronic showers in a multivariate analysis we present an efficient Electron-Hadron discrimination algorithm for liquid argon time projection chambers, validated using Geant4 simulated data
Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models
Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's disease (AD). Neurodegenerative effects of particulate air pollutants were examined in a US-wide cohort of older women from the Women's Health Initiative Memory Study (WHIMS) and in experimental mouse models. Residing in places with fine PM exceeding EPA standards increased the risks for global cognitive decline and all-cause dementia respectively by 81 and 92%, with stronger adverse effects in APOE É4/4 carriers. Female EFAD transgenic mice (5xFAD+/â/human APOE É3 or É4+/+) with 225 h exposure to urban nanosized PM (nPM) over 15 weeks showed increased cerebral ÎČ-amyloid by thioflavin S for fibrillary amyloid and by immunocytochemistry for AÎČ deposits, both exacerbated by APOE É4. Moreover, nPM exposure increased AÎČ oligomers, caused selective atrophy of hippocampal CA1 neurites, and decreased the glutamate GluR1 subunit. Wildtype C57BL/6 female mice also showed nPM-induced CA1 atrophy and GluR1 decrease. In vitro nPM exposure of neuroblastoma cells (N2a-APP/swe) increased the pro-amyloidogenic processing of the amyloid precursor protein (APP). We suggest that airborne PM exposure promotes pathological brain aging in older women, with potentially a greater impact in É4 carriers. The underlying mechanisms may involve increased cerebral AÎČ production and selective changes in hippocampal CA1 neurons and glutamate receptor subunits
Fast variability from black-hole binaries
Currently available information on fast variability of the X-ray emission
from accreting collapsed objects constitutes a complex phenomenology which is
difficult to interpret. We review the current observational standpoint for
black-hole binaries and survey models that have been proposed to interpret it.
Despite the complex structure of the accretion flow, key observational
diagnostics have been identified which can provide direct access to the
dynamics of matter motions in the close vicinity of black holes and thus to the
some of fundamental properties of curved spacetimes, where strong-field general
relativistic effects can be observed.Comment: 20 pages, 11 figures. Accepted for publication in Space Science
Reviews. Also to appear in hard cover in the Space Sciences Series of ISSI
"The Physics of Accretion onto Black Holes" (Springer Publisher
Cosmological distance indicators
We review three distance measurement techniques beyond the local universe:
(1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and
(3) HI intensity mapping. We describe the principles and theory behind each
method, the ingredients needed for measuring such distances, the current
observational results, and future prospects. Time delays from strongly lensed
quasars currently provide constraints on with < 4% uncertainty, and with
1% within reach from ongoing surveys and efforts. Recent exciting discoveries
of strongly lensed supernovae hold great promise for time-delay cosmography.
BAO features have been detected in redshift surveys up to z <~ 0.8 with
galaxies and z ~ 2 with Ly- forest, providing precise distance
measurements and with < 2% uncertainty in flat CDM. Future BAO
surveys will probe the distance scale with percent-level precision. HI
intensity mapping has great potential to map BAO distances at z ~ 0.8 and
beyond with precisions of a few percent. The next years ahead will be exciting
as various cosmological probes reach 1% uncertainty in determining , to
assess the current tension in measurements that could indicate new
physics.Comment: Review article accepted for publication in Space Science Reviews
(Springer), 45 pages, 10 figures. Chapter of a special collection resulting
from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in
the Space Ag
Origins of the Ambient Solar Wind: Implications for Space Weather
The Sun's outer atmosphere is heated to temperatures of millions of degrees,
and solar plasma flows out into interplanetary space at supersonic speeds. This
paper reviews our current understanding of these interrelated problems: coronal
heating and the acceleration of the ambient solar wind. We also discuss where
the community stands in its ability to forecast how variations in the solar
wind (i.e., fast and slow wind streams) impact the Earth. Although the last few
decades have seen significant progress in observations and modeling, we still
do not have a complete understanding of the relevant physical processes, nor do
we have a quantitatively precise census of which coronal structures contribute
to specific types of solar wind. Fast streams are known to be connected to the
central regions of large coronal holes. Slow streams, however, appear to come
from a wide range of sources, including streamers, pseudostreamers, coronal
loops, active regions, and coronal hole boundaries. Complicating our
understanding even more is the fact that processes such as turbulence,
stream-stream interactions, and Coulomb collisions can make it difficult to
unambiguously map a parcel measured at 1 AU back down to its coronal source. We
also review recent progress -- in theoretical modeling, observational data
analysis, and forecasting techniques that sit at the interface between data and
theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue
connected with a 2016 ISSI workshop on "The Scientific Foundations of Space
Weather." 44 pages, 9 figure
Heavy quarkonium: progress, puzzles, and opportunities
A golden age for heavy quarkonium physics dawned a decade ago, initiated by
the confluence of exciting advances in quantum chromodynamics (QCD) and an
explosion of related experimental activity. The early years of this period were
chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in
2004, which presented a comprehensive review of the status of the field at that
time and provided specific recommendations for further progress. However, the
broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles
could only be partially anticipated. Since the release of the YR, the BESII
program concluded only to give birth to BESIII; the -factories and CLEO-c
flourished; quarkonium production and polarization measurements at HERA and the
Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the
deconfinement regime. All these experiments leave legacies of quality,
precision, and unsolved mysteries for quarkonium physics, and therefore beg for
continuing investigations. The plethora of newly-found quarkonium-like states
unleashed a flood of theoretical investigations into new forms of matter such
as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the
spectroscopy, decays, production, and in-medium behavior of c\bar{c}, b\bar{b},
and b\bar{c} bound states have been shown to validate some theoretical
approaches to QCD and highlight lack of quantitative success for others. The
intriguing details of quarkonium suppression in heavy-ion collisions that have
emerged from RHIC have elevated the importance of separating hot- and
cold-nuclear-matter effects in quark-gluon plasma studies. This review
systematically addresses all these matters and concludes by prioritizing
directions for ongoing and future efforts.Comment: 182 pages, 112 figures. Editors: N. Brambilla, S. Eidelman, B. K.
Heltsley, R. Vogt. Section Coordinators: G. T. Bodwin, E. Eichten, A. D.
Frawley, A. B. Meyer, R. E. Mitchell, V. Papadimitriou, P. Petreczky, A. A.
Petrov, P. Robbe, A. Vair
Differences in treatment and survival of older patients with operable breast cancer between the United Kingdom and the Netherlands â A comparison of two national prospective longitudinal multi-centre cohort studies
Background
Previous studies have shown that survival outcomes for older patients with breast cancer vary substantially across Europe, with worse survival reported in the United Kingdom. It has been hypothesised that these differences in survival outcomes could be related to treatment variation.
Objectives
We aimed to compare patient and tumour characteristics, treatment selection and survival outcomes between two large prospective cohorts of older patients with operable breast cancer from the United Kingdom (UK) and The Netherlands.
Methods
Women diagnosed with operable breast cancer aged â„70 years were included. A baseline comprehensive geriatric assessment was performed in both cohorts, with data collected on age, comorbidities, cognition, nutritional and functional status. Baseline tumour characteristics and treatment type were collected. Univariable and multivariable Cox regression models were used to compare overall survival between the cohorts.
Results
3262 patients from the UK Age Gap cohort and 618 patients from the Dutch Climb cohort were included, with median ages of 77.0 (IQR: 72.0â81.0) and 75.0 (IQR: 72.0â81.0) years, respectively. The cohorts were generally comparable, with slight differences in rates of comorbidity and frailty. Median follow-up for overall survival was 4.1 years (IQR 2.9â5.4) in Age Gap and 4.3 years (IQR 2.9â5.5) in Climb. In Age Gap, both the rates of primary endocrine therapy and adjuvant hormonal therapy after surgery were approximately twice those in Climb (16.6% versus 7.3%, p < 0.001 for primary endocrine therapy, and 62.2% versus 38.8%, p < 0.001 for adjuvant hormonal therapy). There was no evidence of a difference in overall survival between the cohorts (adjusted HR 0.94, 95% CI 0.74â1.17, p = 0.568).
Conclusions
In contrast to previous studies, this comparison of two large national prospective longitudinal multi-centre cohort studies demonstrated comparable survival outcomes between older patients with breast cancer treated in the UK and The Netherlands, despite differences in treatment allocation
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