Vertical Transmission of Pneumocystis jirovecii in Humans

This study is part of the project “Pneumocystis Pathogenomics: Unravelling the Colonization-to-Disease Shift,” a Coordination Action supported by the European Commission (ERANET PathoGenoMics). This study was partially supported by the Spanish Ministry of Health (FIS 03/1743). M.A.M.-C. and C.d.l.H. were supported by the Spanish Ministry of Health (FIS CP-04/217 and FIS CM-04/146).Ye

Contribución al conocimiento de la flora briofítica de la comarca de la Axarquía y la ZEC Sierra de Camarolos (Málaga, España)

Through the collection of samples and study of 61 localities, the bryophytic flora of the Axarquía region and the ZEC Sierra de Camarolos is studied. The bryophyte diversity is estimated at 140 species, of which 124 are mosses and 16 liverworts. Husnotiella sinuosa (Mitt.) J.A. Jiménez & M.J. Cano is recorded for the first time from Andalusia, Orthotrichum macrocephalum F. Lara, Garilleti & Mazimpaka, O. schimperi Hammar, and Tortella inflexa (Bruch) Broth. are reported for the first time from Malaga province. Most of the species in the catalogue (about 85%) are new for the studied territory.Resumen Mediante las recolecciones en un total de 61 localidades muestreadas, se lleva a cabo un estudio de la flora briofítica de la comarca de la Axarquía (Málaga) y la ZEC Sierra de Camarolos (Málaga). La diversidad briofítica se estima en 140 especies, de ellas 124 son musgos y 16 hepáticas. Husnotiella sinuosa (Mitt.) J.A. Jiménez & M.J. Cano se cita por vez primera de Andalucía, Orthotrichum macrocephalum F. Lara, Garilleti & Mazimpaka, O. schimperi Hammar y Tortella inflexa (Bruch) Broth. son novedades para la brioflora malacitana. La mayoría de las especies del catálogo (alrededor del 85%) son novedades para el territorio estudiado

Pneumocystis jirovecii Transmission from Immunocompetent Carriers to Infant

We report a case of Pneumocystis jirovecii transmission from colonized grandparents to their infant granddaughter. Genotyping of P. jirovecii showed the same genotypes in samples from the infant and her grandparents. These findings support P. jirovecii transmission from immunocompetent carrier adults to a susceptible child

The rest-frame ultraviolet properties of radio-loud broad absorption line quasars

We recently presented radio observations of a large sample of radio-loud broad absorption line (BAL) quasars from the SDSS and FIRST surveys, as well as a well matched sample of unabsorbed quasars, primarily to measure their radio spectral indices and estimate ensemble orientations. Here, we analyze the SDSS spectra of these samples and compare the rest-frame ultraviolet properties of radio-loud BAL and non-BAL quasars. Ultraviolet properties include the continuum shape, emission-line measurements of C IV, Al III, C III], Fe II, and Mg II, and BAL properties including the balnicity index (BI), absorption index (AI), and minimum and maximum outflow velocities. We find that radio-loud BAL quasars have similar ultraviolet properties compared to radio-loud non-BAL sources, though they do appear to have redder continua and stronger Fe II emission, which is consistent with what is found for radio-quiet BAL sources. No correlations exist between outflow properties and orientation (radio spectral index), suggesting that BAL winds along any line of sight are driven by the same mechanisms. There are also few correlations between spectral index and other properties. We conclude that BAL outflows occur along all lines of sight with similar strengths and velocities.Comment: Accepted for publication in MNRAS. Tables 1 and 2 will be published in full with the final online publicatio

Hypothetical Pneumocystis jirovecii Transmission from Immunocompetent Carriers to Infant

Revue en accès libre via : http://www.cdc.gov/ncidod/eid/index.htmInternational audienc

Nomogram-based prediction of survival in patients with advanced oesophagogastric adenocarcinoma receiving first-line chemotherapy: a multicenter prospective study in the era of trastuzumab

Background: To develop and validate a nomogram and web-based calculator to predict overall survival (OS) in Caucasian-advanced oesophagogastric adenocarcinoma (AOA) patients undergoing first-line combination chemotherapy. Methods: Nine hundred twenty-four AOA patients treated at 28 Spanish teaching hospitals from January 2008 to September 2014 were used as derivation cohort. The result of an adjusted-Cox proportional hazards regression was represented as a nomogram and web-based calculator. The model was validated in 502 prospectively recruited patients treated between October 2014 and December 2016. Harrell's c-index was used to evaluate discrimination. Results: The nomogram includes seven predictors associated with OS: HER2-positive tumours treated with trastuzumab, Eastern Cooperative Oncology Group performance status, number of metastatic sites, bone metastases, ascites, histological grade, and neutrophil-to-lymphocyte ratio. Median OS was 5.8 (95% confidence interval (CI), 4.5–6.6), 9.4 (95% CI, 8.5–10.6), and 14 months (95% CI, 11.8–16) for high-, intermediate-, and low-risk groups, respectively (P<0.001), in the derivation set and 4.6 (95% CI, 3.3–8.1), 12.7 (95% CI, 11.3–14.3), and 18.3 months (95% CI, 14.6–24.2) for high-, intermediate-, and low-risk groups, respectively (P<0.001), in the validation set. The nomogram is well-calibrated and reveals acceptable discriminatory capacity, with optimism-corrected c-indices of 0.618 (95% CI, 0.591–0.631) and 0.673 (95% CI, 0.636–0.709) in derivation and validation groups, respectively. The AGAMENON nomogram outperformed the Royal Marsden Hospital (c-index=0.583; P=0.00046) and Japan Clinical Oncology Group prognostic indices (c-index=0.611; P=0.03351). Conclusions: We developed and validated a straightforward model to predict survival in Caucasian AOA patients initiating first-line polychemotherapy. This model can contribute to inform clinical decision-making and optimise clinical trial design

Second-line treatment in advanced gastric cancer : Data from the Spanish AGAMENON registry

Second-line treatments boost overall survival in advanced gastric cancer (AGC). However, there is a paucity of information as to patterns of use and the results achieved in actual clinical practice. The study population comprised patients with AGC in the AGAMENON registry who had received second-line. The objective was to describe the pattern of second-line therapies administered, progression-free survival following second-line (PFS-2), and post-progression survival since first-line (PPS). 2311 cases with 2066 progression events since first-line (89.3%) were recorded; 245 (10.6%) patients died during first-line treatment and 1326/2066 (64.1%) received a second-line. Median PFS-2 and PPS were 3.1 (95% CI, 2.9-3.3) and 5.8 months (5.5-6.3), respectively. The most widely used strategies were monoCT (56.9%), polyCT (15.0%), ramucirumab+CT (12.6%), platinum-reintroduction (8.3%), trastuzumab+CT (6.1%), and ramucirumab (1.1%). PFS-2/PPS medians gradually increased in monoCT, 2.6/5.1 months; polyCT 3.4/6.3 months; ramucirumab+CT, 4.1/6.5 months; platinum-reintroduction, 4.2/6.7 months, and for the HER2+ subgroup in particular, trastuzumab+CT, 5.2/11.7 months. Correlation between PFS since first-line and OS was moderate in the series as a whole (Kendall's τ = 0.613), lower in those subjects who received second-line (Kendall's τ = 0.539), especially with ramucirumab+CT (Kendall's τ = 0.413). This analysis reveals the diversity in second-line treatment for AGC, highlighting the effectiveness of paclitaxel-ramucirumab and, for a selected subgroup of patients, platinum reintroduction; both strategies endorsed by recent clinical guidelines

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns