12 research outputs found
Analyse des délivrances pharmaceutiques au cours de traitements chroniques par des médicaments substituables dispensés aux assurés de la CPAM [Caisse Primaire d'Assurance Maladie] d'Angers
ANGERS-BU MĂ©decine-Pharmacie (490072105) / SudocSudocFranceF
Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies
Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal