Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Measurement of the W gamma Production Cross Section in Proton-Proton Collisions at root s=13 TeV and Constraints on Effective Field Theory Coefficients

A fiducial cross section for W gamma production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137 fb(-1) of data collected using the CMS detector at the LHC. The W -> e nu and mu nu decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.Peer reviewe

Performance of the CMS muon trigger system in proton-proton collisions at √s = 13 TeV

The muon trigger system of the CMS experiment uses a combination of hardware and software to identify events containing a muon. During Run 2 (covering 2015-2018) the LHC achieved instantaneous luminosities as high as 2 × 10 cm s while delivering proton-proton collisions at √s = 13 TeV. The challenge for the trigger system of the CMS experiment is to reduce the registered event rate from about 40 MHz to about 1 kHz. Significant improvements important for the success of the CMS physics program have been made to the muon trigger system via improved muon reconstruction and identification algorithms since the end of Run 1 and throughout the Run 2 data-taking period. The new algorithms maintain the acceptance of the muon triggers at the same or even lower rate throughout the data-taking period despite the increasing number of additional proton-proton interactions in each LHC bunch crossing. In this paper, the algorithms used in 2015 and 2016 and their improvements throughout 2017 and 2018 are described. Measurements of the CMS muon trigger performance for this data-taking period are presented, including efficiencies, transverse momentum resolution, trigger rates, and the purity of the selected muon sample. This paper focuses on the single- and double-muon triggers with the lowest sustainable transverse momentum thresholds used by CMS. The efficiency is measured in a transverse momentum range from 8 to several hundred GeV

Search for long-lived particles decaying to jets with displaced vertices in proton-proton collisions at root s=13 Te V

A search is presented for long-lived particles produced in pairs in proton-proton collisions at the LHC operating at a center-of-mass energy of 13 TeV. The data were collected with the CMS detector during the period from 2015 through 2018, and correspond to a total integrated luminosity of 140 fb(-1). This search targets pairs of long-lived particles with mean proper decay lengths between 0.1 and 100 mm, each of which decays into at least two quarks that hadronize to jets, resulting in a final state with two displaced vertices. No significant excess of events with two displaced vertices is observed. In the context of R-parity violating supersymmetry models, the pair production of long-lived neutralinos, gluinos, and top squarks is excluded at 95% confidence level for cross sections larger than 0.08 fb, masses between 800 and 3000 GeV, and mean proper decay lengths between 1 and 25 mm.Peer reviewe

Search for top squark production in fully hadronic final states in proton-proton collisions at root s=13 TeV

A search for production of the supersymmetric partners of the top quark, top squarks, is presented. The search is based on proton-proton collision events containing multiple jets, no leptons, and large transverse momentum imbalance. The data were collected with the CMS detector at the CERN LHC at a center-of-mass energy of 13 TeV, and correspond to an integrated luminosity of 137 fb(-1). The targeted signal production scenarios are direct and gluino-mediated top squark production, including scenarios in which the top squark and neutralino masses are nearly degenerate. The search utilizes novel algorithms based on deep neural networks that identify hadronically decaying top quarks and W bosons, which are expected in many of the targeted signal models. No statistically significant excess of events is observed relative to the expectation from the standard model, and limits on the top squark production cross section are obtained in the context of simplified supersymmetric models for various production and decay modes. Exclusion limits as high as 1310 GeVare established at the 95% confidence level on the mass of the top squark for direct top squark production models, and as high as 2260 GeV on the mass of the gluino for gluino-mediated top squark production models. These results represent a significant improvement over the results of previous searches for supersymmetry by CMS in the same final state.Peer reviewe

Search for a heavy resonance decaying to a top quark and a w boson at √s = 13 tev in the fully hadronic final state

A search for a heavy resonance decaying to a top quark and a W boson in the fully hadronic final state is presented. The analysis is performed using data from proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 137 fb−1 recorded by the CMS experiment at the LHC. The search is focused on heavy resonances, where the decay products of each top quark or W boson are expected to be reconstructed as a single, large-radius jet with a distinct substructure. The production of an excited bottom quark, b*, is used as a benchmark when setting limits on the cross section for a heavy resonance decaying to a top quark and a W boson. The hypotheses of b* quarks with left-handed, right-handed, and vector-like chiralities are excluded at 95% confidence level for masses below 2.6, 2.8, and 3.1 TeV, respectively. These are the most stringent limits on the b* quark mass to date, extending the previous best limits by almost a factor of two

Measurements of production cross sections of the Higgs boson in the four-lepton final state in proton–proton collisions at √s=13Te

Production cross sections of the Higgs boson are measured in the H → Z Z → 4 ℓ (ℓ=e,μ) decay channel. A data sample of proton–proton collisions at a center-of-mass energy of 13Te, collected by the CMS detector at the LHC and corresponding to an integrated luminosity of 137fb-1 is used. The signal strength modifier μ, defined as the ratio of the Higgs boson production rate in the 4 ℓ channel to the standard model (SM) expectation, is measured to be μ=0.94±0.07(stat)-0.08+0.09(syst) at a fixed value of mH=125.38Ge. The signal strength modifiers for the individual Higgs boson production modes are also reported. The inclusive fiducial cross section for the H → 4 ℓ process is measured to be 2.84-0.22+0.23(stat)-0.21+0.26(syst)fb, which is compatible with the SM prediction of 2.84±0.15fb for the same fiducial region. Differential cross sections as a function of the transverse momentum and rapidity of the Higgs boson, the number of associated jets, and the transverse momentum of the leading associated jet are measured. A new set of cross section measurements in mutually exclusive categories targeted to identify production mechanisms and kinematical features of the events is presented. The results are in agreement with the SM predictions.STFC, Marie-Curie program and the European Research Council and Horizon 2020 Gran

Enseñanza virtual: Déficit de aprendizaje en niños de Educación Básica, sector rural del Cantón Babahoyo.

Virtual teaching has become in the last two years of the pandemic (covid19), a modality available to students at different levels of the educational system; however, not everyone had the opportunity to learn through this modality, parents with limited economic resources did not have technological tools such as: Computer, Cell Phone, Tablet; as well as the availability of Internet, to be able to respond to the requirements and demands of virtual teaching, where students have access to use and manage these resources, to acquire meaningful learning, affecting the acquisition of knowledge in students, who live in rural and vulnerable sectors that did not have the opportunity to acquire these resources; For this reason, the learning deficit at the entrance of face-to-face classes is notorious, from an observable diagnosis, for this it is important to apply didactic strategies such as playful activities that allow knowledge to be developed in a fun way of learning through motivation. The main objective is to develop recreational activities that allow dynamic, motivating and creative learning to reduce the learning deficit in school-age children. The methodology that was applied for the development of this article was the surveys applied to the parents based on the results obtained where they are evidenced. In conclusion, the use of technological tools provides educational environments allowing the student to develop teaching-learning dynamics for teacher-student interaction.La enseñanza virtual, se ha convertido en los dos últimos años de pandemia (covid19), una modalidad al alcance de los estudiantes en los diferentes  niveles del sistema educativo;  sin embargo, no todos tuvieron la  oportunidad  de aprender mediante esta modalidad, los padres de familia de escasos recursos económicos no contaron con las herramientas tecnológicas como: Computadora, Celular, Tablet; así como la disponibilidad de  Internet, para poder responder a los requerimientos y exigencias de la enseñanza virtual, donde  los estudiantes tuvieran acceso a utilizar y  manejar estos recursos, para adquirir los aprendizaje significativo, afectando la adquisición de conocimientos en los educandos, que viven en los sectores rurales y en condiciones de vulnerabilidad que no tuvieron la oportunidad de adquirir estos recursos; por tal razón, es notorio el déficit de aprendizaje al ingreso de las clases presenciales, desde un diagnóstico observable, para ello es importante, aplicar estrategias didácticas como los actividades lúdicas que se permite desarrollar los conocimientos de una forma divertida de aprender mediante la motivación. El objetivo principal, desarrollar actividades lúdicas que permitan obtener un aprendizaje dinámico, motivador y creativo, para disminuir el déficit de aprendizajes en los niños de edad escolar. La metodología que se aplicó para el desarrollo de este artículo, fue las encuetas aplicadas a los padres de familia en base a los resultados obtenidos donde se evidencia los mismos. Como conclusión, el uso de las herramientas tecnológicas proporciona ambientes educativos permitiendo al estudiante el desarrollo de la dinámica de enseñanza-aprendizaje para la interacción docente estudiante

Search for top squarks in final states with two top quarks and several light-flavor jets in proton-proton collisions at root s=13 TeV

Many new physics models, including versions of supersymmetry characterized by R-parity violation (RPV), compressed mass spectra, long decay chains, or additional hidden sectors, predict the production of events with top quarks, low missing transverse momentum, and many additional quarks or gluons. The results of a search for new physics in events with two top quarks and additional jets are reported. The search is performed using events with at least seven jets and exactly one electron or muon. No requirement on missing transverse momentum is imposed. The study is based on a sample of proton-proton collisions at root s = 13TeV corresponding to 137 fb(-1) of integrated luminosity collected with the CMS detector at the LHC in 2016-2018. The data are used to determine best fit values and upper limits on the cross section for pair production of top squarks in scenarios of RPV and stealth supersymmetry. Top squark masses up to 670 (870) GeV are excluded at 95% confidence level for the RPV (stealth) scenario, and the maximum observed local signal significance is 2.8 standard deviations for the RPV scenario with top squark mass of 400 GeV.Peer reviewe

Libro de Proyectos Finales 2021 primer semestre

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