The associations of immigrants: integration and funding

As associações de imigrantes desempenham um papel fundamental na recepção e integração dos imigrantes. Esta associação surge da necessidade de conhecer, diferenciar e representar. Este artigo analisa os diferentes tipos de organizações de imigrantes e de apoio a imigrantes, enfatizando a relação entre eles e as autoridades. A forte submissão das associações ao financiamento público e a dificuldade ou facilidade de acesso ao circuito subvencional são cruciais no desenvolvimento da sua própria gestão e sobrevivência das organizações. Por último, apresentamos um caso real em que se analisa o nível de reconhecimento e limites para a concessão de auxílios ou subsídios. Os resultados obtidos permitem concluir que a dependência é condição estrutural dessas entidades e tornou-se parte integrante do seu funcionamento. Immigrant associations play a fundamental role in the reception and integration of immigrants. This association arises because of the need to meet, to differentiate and represent. This paper analyzes the different types of organizations to support immigrants and migrants, stressing the relationship between them and public authorities. The strong submission to public funding and the difficulty or ease of access subsidies are crucial elements in developing their own management and survival. Finally, we present a real case study which allows the assessment of the level of recognition and limits for grants and subsidies. These results lead to the conclusion that the dependence is a structural condition of these institutions and has become an integral part of its operation

La identidad religiosa de la inmigración en España: el caso de Castilla y León

Una revisión más profunda de la realidad sociológica de las religiones sumergidas en una globalización nos obliga a redirigir nuestros planteamientos y nuestras formas de pensar. La “imagen del otro” no es algo estático, inmutable. No podemos hablar de forma genérica de minorías religiosas. Cada grupo posee características diferentes y como se describe a continuación, estos grupos ya no sólo compiten entre ellos o con el grupo mayoritario, sino que deben posicionarse en un mercado en el que todos comparten medios globales de comunicación con movimientos, productos y servicios de consumo también no religiosos. Un elemento clava, ha sido la inmigración, que ha afectado tanto en el incremento de la población de las comunidades como en los retos y problemáticas a los que tienen que hacer frente

Principios básicos para el diseño de guías docentes de asignaturas en el marco del EEES

La Universidad de Valladolid ha elaborado, bajo los auspicios de la Agencia para la Calidad del Sistema Universitario de Castilla y León, un modelo para la elaboración de las guías docentes de las asignaturas que se imparten en la Universidad de Valladolid. La finalidad que persigue esta guía de guías, basada en los principios que inspiran la creación del Espacio Europeo de Educación Superior, no es otra que facilitar al profesor el diseño de su programación docente y la planificación de su actividad a lo largo del curso académico, pues la adecuada planificación de la formación es herramienta fundamental para el aprendizaje del alumno y constituye una exigencia básica de la docencia de calidad. La presente publicación trata, en definitiva, de ofrecer a la comunidad universitaria un modelo homogéneo en el que se incluyen, junto a elementos tradicionales de la docencia universitaria, aspectos novedosos anudados al nuevo sistema de créditos (volumen de trabajo del estudiante, definición de destrezas, conocimientos previos) y a la renovación de las metodologías docentes (trabajo colaborativo, tutorías, aprendizaje virtual…)Proyecto para la Renovación de las Metodologías docentes en el marco de la Convergencia Europea hacia el EEES, concedido a la Universidad de Valladolid por la Agencia para la Calidad del Sistema Universitario de Castilla y León

Evidence of association of the NLRP1 gene with giant cell arteritis

Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation

Narrativas audiovisuales emergentes: creaciones didácticas multimedia realizadas por alumnos para enseñanza y aprendizaje en campus virtuales

Diseño, escritura y realización de contenidos videográficos y multimedia para la enseñanza virtual. El alumnado de Ciencias de la Información analiza, crea y difunde materiales narrativos creados para campus virtuales y cursos online innovadores

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus

A genome-wide association study identifies risk alleles in plasminogen and P4HA2 associated with giant cell arteritis

Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analysed in 2,134 cases and 9,125 unaffected controls from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, P = 1.94E-54, per-allele OR = 1.79; and rs9275592, P = 1.14E-40, OR = 2.08). Additionally, PLG and P4HA2 were identified as GCA risk genes at the genome-wide level of significance (rs4252134, P = 1.23E-10, OR = 1.28; and rs128738, P = 4.60E-09, OR = 1.32, respectively). Interestingly, we observed that the association peaks overlapped with different regulatory elements related to cell types and tissues involved in the pathophysiology of GCA. PLG and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Carta abierta condenando la crisis en curso y abordando los impactos ambientales y humanitarios en Palestina

Nosotres, biólogues, ecologistas y otres profesionales dedicados a proteger la vida, les escribimos con una solicitud urgente. Les pedimos muy comedidamente que su organización o institución emita un comunicado oficial condenando la crisis en curso y abordando los impactos ambientales y humanitarios en Palestina