519 research outputs found
Softly Broken A_4 Symmetry for Nearly Degenerate Neutrino Masses
The leptonic Higgs doublet model of neutrino masses is implemented with an
A_4 discrete symmetry (the even permutation of 4 objects or equivalently the
symmetry of the tetrahedron) which has 4 irreducible representations: 1, 1',
1'', and 3. The resulting spontaneous and soft breaking of A_4 provides a
realistic model of charged-lepton masses as well as a nearly degenerate
neutrino mass matrix. Phenomenological consequences at and below the TeV scale
are discussed.Comment: 11 pages, no figur
Prognostic relevance of acquired uniparental disomy in serous ovarian cancer
BACKGROUND: Acquired uniparental disomy (aUPD) can lead to homozygosity for tumor suppressor genes or oncogenes. Our purpose is to determine the frequency and profile aUPD regions in serous ovarian cancer (SOC) and investigated the association of aUPD with clinical features and patient outcomes.METHODS: We analyzed single nucleotide polymorphism (SNP) array-based genotyping data on 532 SOC specimens from The Cancer Genome Atlas database to identify aUPD regions. Cox univariate regression and Cox multivariate proportional hazards analyses were performed for survival analysis.RESULTS: We found that 94.7% of SOC samples harbored aUPD; the most common aUPD regions were in chromosomes 17q (76.7%), 17p (39.7%), and 13q (38.3%). In Cox univariate regression analysis, two independent regions of aUPD on chromosome 17q (A and C), and whole-chromosome aUPD were associated with shorter overall survival (OS), and five regions on chromosome 17q (A, D-G) and BRCA1 were associated with recurrence-free survival time. In Cox multivariable proportional hazards analysis, whole-chromosome aUPD was associated with shorter OS. One region of aUPD on chromosome 22q (B) was associated with unilateral disease. A statistically significant association was found between aUPD at TP53 loci and homozygous mutation of TP53 (p < 0.0001).CONCLUSIONS: aUPD is a common event and some recurrent loci are associated with a poor outcome for patients with serous ovarian cancer
Light Unstable Sterile Neutrino
The three massless active (doublet) neutrinos may mix with two heavy and one
\underline {light} sterile (singlet) neutrinos so that the induced masses and
mixings among the former are able to explain the present data on atmospheric
and solar neutrino oscillations. If the LSND result is also to be explained,
one active neutrino mass eigenstate must mix with the light sterile neutrino. A
specific model is proposed with the spontaneous and soft explicit breaking of a
new global symmetry so that a sterile neutrino will decay into an
active antineutrino and a nearly massless pseudo-Majoron.Comment: Discussion and references adde
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Neutrino Physics at Fermilab
The Liquid Scintillator Neutrino Detector (LSND), located at the LANSCE (formerly LAMPF) linear accelerator at Los Alamos National Laboratory, has seen evidence for the oscillation of neutrinos, and hence neutrino mass. That discovery was the impetus for this LDRD project, begun in 1996. The goal of this project was to define the appropriate technologies to use in a follow up experiment and to set in place the requirements for such an experiment
In silico Analysis of Combinatorial microRNA Activity Reveals Target Genes and Pathways Associated with Breast Cancer Metastasis
This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited
Tests of CPT Invariance at Neutrino Factories
We investigate possible tests of CPT invariance on the level of event rates
at neutrino factories. We do not assume any specific model but phenomenological
differences in the neutrino-antineutrino masses and mixing angles in a Lorentz
invariance preserving context, such as it could be induced by physics beyond
the Standard Model. We especially focus on the muon neutrino and antineutrino
disappearance channels in order to obtain constraints on the
neutrino-antineutrino mass and mixing angle differences; we found, for example,
that the sensitivity
could be achieved.Comment: 6 pages, 1 figure, RevTeX4. Final version to be published in Phys.
Rev.
First Observation of Coherent Production in Neutrino Nucleus Interactions with 2 GeV
The MiniBooNE experiment at Fermilab has amassed the largest sample to date
of s produced in neutral current (NC) neutrino-nucleus interactions at
low energy. This paper reports a measurement of the momentum distribution of
s produced in mineral oil (CH) and the first observation of coherent
production below 2 GeV. In the forward direction, the yield of events
observed above the expectation for resonant production is attributed primarily
to coherent production off carbon, but may also include a small contribution
from diffractive production on hydrogen. Integrated over the MiniBooNE neutrino
flux, the sum of the NC coherent and diffractive modes is found to be (19.5
1.1 (stat) 2.5 (sys))% of all exclusive NC production at
MiniBooNE. These measurements are of immediate utility because they quantify an
important background to MiniBooNE's search for
oscillations.Comment: Submitted to Phys. Lett.
Forward production of charged pions with incident on nuclear targets measured at the CERN PS
Measurements of the double-differential production cross-section
in the range of momentum 0.5 \GeVc \leq p \le 8.0 \GeVc and angle 0.025 \rad
\leq \theta \le 0.25 \rad in interactions of charged pions on beryllium,
carbon, aluminium, copper, tin, tantalum and lead are presented. These data
represent the first experimental campaign to systematically measure forward
pion hadroproduction. The data were taken with the large acceptance HARP
detector in the T9 beam line of the CERN PS. Incident particles, impinging on a
5% nuclear interaction length target, were identified by an elaborate system of
beam detectors. The tracking and identification of the produced particles was
performed using the forward spectrometer of the HARP detector. Results are
obtained for the double-differential cross-sections mainly at four incident pion beam
momenta (3 \GeVc, 5 \GeVc, 8 \GeVc and 12 \GeVc). The measurements are compared
with the GEANT4 and MARS Monte Carlo simulationComment: to be published on Nuclear Physics
Large-angle production of charged pions by 3 GeV/c - 12 GeV/c protons on carbon, copper and tin targets
A measurement of the double-differential production cross-section
in proton--carbon, proton--copper and proton--tin collisions in the range of
pion momentum 100 \MeVc \leq p < 800 \MeVc and angle 0.35 \rad \le \theta
<2.15 \rad is presented. The data were taken with the HARP detector in the T9
beam line of the CERN PS. The pions were produced by proton beams in a momentum
range from 3 \GeVc to 12 \GeVc hitting a target with a thickness of 5% of a
nuclear interaction length. The tracking and identification of the produced
particles was done using a small-radius cylindrical time projection chamber
(TPC) placed in a solenoidal magnet. An elaborate system of detectors in the
beam line ensured the identification of the incident particles. Results are
shown for the double-differential cross-sections at four incident proton beam
momenta (3 \GeVc, 5 \GeVc, 8 \GeVc and 12 \GeVc)
Large-angle production of charged pions by 3 GeV/c - 12.9 GeV/c protons on beryllium, aluminium and lead targets
Measurements of the double-differential production cross-section
in the range of momentum 100 \MeVc \leq p < 800 \MeVc and angle 0.35 \rad
\leq \theta < 2.15 \rad in proton--beryllium, proton--aluminium and
proton--lead collisions are presented. The data were taken with the HARP
detector in the T9 beam line of the CERN PS. The pions were produced by proton
beams in a momentum range from 3 \GeVc to 12.9 \GeVc hitting a target with a
thickness of 5% of a nuclear interaction length. The tracking and
identification of the produced particles was performed using a small-radius
cylindrical time projection chamber (TPC) placed inside a solenoidal magnet.
Incident particles were identified by an elaborate system of beam detectors.
Results are obtained for the double-differential cross-sections at six incident
proton beam momenta (3 \GeVc, 5 \GeVc, 8 \GeVc, 8.9 \GeVc (Be only), 12 \GeVc
and 12.9 \GeVc (Al only)) and compared to previously available data
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