Improvement of corrosion protection of steel by incorporation of a new phosphonated fatty acid in a phosphorus-containing polymer coating obtained by UV curing

tSix formulations containing diacrylate monomers (from 89 to 92.5% (w/w)) as well as a phosphonatedmethacrylate monomer (from 1 to 10% (w/w)) were prepared. All formulations were UV-cured and thecorrosion performance of the resulting coatings applied onto a steel substrate was assessed by elec-trochemical impedance spectroscopy (EIS). It was first shown that the coatings containing phosphonicacid methacrylate (MAPC1(OH)2) instead of methacrylate phosphonic dimethyl ester (MAPC1) presentedhigher corrosion protection related to the strong adhesive properties of phosphonic acid on the metalsubstrate. A minimum MAPC1(OH)2content of 2.5% was determined to provide the highest impedancevalues (best efficiency). Then, a new bio-based compound, i.e. phosphonic acid-bearing oleic acid (phos-phonated fatty acid), was synthesized and added as an inhibitor to the formulations. In the presence ofthis compound, the corrosion protection was notably improved. The beneficial effect of phosphonatedfatty acid was explained by its inhibitive action at the steel/coating interface and by the improvement ofthe barrier properties

Aircraft Electrical Wiring Monitoring System

International audienceThe cumulated lengths of electrical cables continuously increases in aircrafts and trucks: now up to 10kilometers in a modern truck, 40 km in a helicopter or in a fighter aircraft and 500 km in a modern civiltransport aircraft such as A380. Electrical wiring is a critical part in the nominal operation of a system. Theimportance of the wired network has thus grown to the same level as the systems it is connected to [1].Regarding the increasing complexity of the electric system (increase in the number of electric loads, in thesupply voltages), the regulation authorities (FAA, Federal Aviation Administration and EASA, European AviationSafety Agency ) now require to consider aircrafts’ electrical wiring as a system on its own, named EWIS(Electrical Wiring Interconnection System)

An Automated SeaFAST ICP-DRC-MS Method for the Determination of 90Sr in Spent Nuclear Fuel Leachates

To reduce uncertainties in determining the source term and evolving condition of spent nuclear fuel is fundamental to the safety assessment. ß-emitting nuclides pose a challenging task for reliable, quantitative determination because both radiometric and mass spectrometric methodologies require prior chemical purification for the removal of interfering activity and isobars, respectively. A method for the determination of 90Sr at trace levels in nuclear spent fuel leachate samples without sophisticated and time-consuming procedures has been established. The analytical approach uses a commercially available automated pre-concentration device (SeaFAST) coupled to an ICP-DRC-MS. The method shows good performances with regard to reproducibility, precision, and LOD reducing the total time of analysis for each sample to 12.5 min. The comparison between the developed method and the classical radiochemical method shows a good agreement when taking into account the associated uncertaintie

The Euratom Safeguards On-site Laboratories at the Reprocessing Plants of La Hague and Sellafield

In the European Union, nuclear material is reprocessed from irradiated power reactor fuel at two sites ¿ La Hague in France and Sellafield in the United Kingdom. These are the largest nuclear sites within the EU, processing many hundreds of tons of nuclear material in a year. Under the Euratom Treaty, the European Commission has the duty to assure that the nuclear material is only used for declared purposes. The Directorate General for Energy (DG ENER), acting for the Commission, assures itself that the terms of Article 77 of Chapter VII of the Treaty have been complied with. In contrast to the Non Proliferation Treaty, the Euratom Treaty requires to safeguard all civil nuclear material in all EU member states ¿ including the nuclear weapons states. The considerable amount of fissile material separated per year (several tonnes) calls for a stringent system of safeguards measures. The aim of safeguards is to deter diversion of nuclear material from peaceful use by maximizing the chance of early detection. At a broader level, it provides assurance to the public that the European nuclear industry, the EU member states and the European Union honour their legal duties under the Euratom Treaty and their commitments to the Non-Proliferation Treaty. Efficient and effective safeguards measures are essential for the public acceptance of nuclear activities.JRC.E.7-Nuclear Safeguards and Forensic

Therapeutic targeting of cathepsin C::from pathophysiology to treatment

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the activation of pro-inflammatory granule-associated serine proteases. These proteases are synthesized as inactive zymogens containing an N-terminal pro-dipeptide, which maintains the zymogen in its inactive conformation and prevents premature activation, which is potentially toxic to the cell. The activation of serine protease zymogens occurs through cleavage of the N-terminal dipeptide by CatC during cell maturation in the bone marrow. In vivo data suggest that pharmacological inhibition of pro-inflammatory serine proteases would suppress or attenuate deleterious effects of inflammatory/auto-immune disorders mediated by these proteases. The pathological deficiency in CatC is associated with Papillon-Lefèvre syndrome. The patients however do not present marked immunodeficiency despite the absence of active serine proteases in immune defense cells. Hence, the transitory pharmacological blockade of CatC activity in the precursor cells of the bone marrow may represent an attractive therapeutic strategy to regulate activity of serine proteases in inflammatory and immunologic conditions. A variety of CatC inhibitors have been developed both by pharmaceutical companies and academic investigators, some of which are currently being employed and evaluated in preclinical/clinical trials

The Comet Interceptor Mission

Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESA’s F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum ΔV capability of 600 ms−1. Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes – B1, provided by the Japanese space agency, JAXA, and B2 – that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the mission’s science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule

Mise en place d une exigence de la norme NF EN ISO 15189 (indicateurs qualité et gestion des non-conformités sur la Plateforme Commune de Biologie du CHU de Grenoble)

L accréditation des laboratoires de biologie médicale selon la norme NF EN ISO 15189 est obligatoire en France depuis la parution de l ordonnance n2010-49 du 13 janvier 2010. Nous avons poursuivi la mise en place du système de gestion des non-conformités pré-analytiques et des indicateurs qualité sur la Plateforme Commune de Biologie du laboratoire de biologie médicale du CHU de Grenoble. L exploitation de ces enregistrements alimentera des indicateurs qualité qui permettront d évaluer les actions mises en place et proposer de nouveaux axes d amélioration.The clinical laboratory accreditation according to NF EN ISO 15189 is compulsory since the publication of the ordinance n2010-49 the 13th January of 2010. We purchase the management of the preanalytical non conformities and the development of quality indicators on the Plateforme Commune de Biologie of the clinical laboratory of Grenoble university hospital. The traceability of the non conformities will feed the quality indicators AND will enable the evaluation of corrective action and the development of new axis for improvement.GRENOBLE1-BU Médecine pharm. (385162101) / SudocSudocFranceF

Correction to Degradation and Transport of the Chiral Herbicide S -Metolachlor at the Catchment Scale: Combining Observation Scales and Analytical Approaches

International audienceEvaluating pesticide degradation and transport in the soil-surface water continuum remains challenging at the catchment scale. Here we investigated the dissipation of the chiral herbicide S-metolachlor (SM) in soil in relation to its transport in runoff. Analyses of SM, transformation products (TPs, i.e., MESA and MOXA), and enantiomers were combined to determine SM degradation at plot and catchment scales. Assisted by modeling, we found that the main dissipation pathways of SM at the plot scale were degradation (71%), volatilization (5%), leaching (8%) and runoff (3%), while 13% of SM persisted in topsoil. This highlights the relevance of degradation processes. TPs could trace the different discharge contributions: MOXA prevailed in runoff water, whereas MESA was associated with slower flowpaths. At the catchment outlet, 11% of SM applied was exported in dissolved or particulate phases or as TPs (in SM mass equivalent). A single event 1 week after application exported 96% of SM, which underlined the potential importance of severe rainfall on seasonal SM export. Enantioselective degradation enriched SM in the R-enantiomer over longer periods and may be associated with slower flowpaths. Altogether, combining observation scales and analytical approaches enabled to quantify SM degradation and to identify how degradation controls SM export at the catchment scale

Self-aggregation of oxidized procyanidins contributes to the formation of heat-reversible haze in apple-based liqueur wine

International audienc