X-ray and Radio Monitoring of GX 339-4 and Cyg X-1

Previous work by Motch et al. (1985) suggested that in the low/hard state of GX339-4, the soft X-ray power-law extrapolated backward in energy agrees with the IR flux level. Corbel and Fender (2002) later showed that the typical hard state radio power-law extrapolated forward in energy meets the backward extrapolated X-ray power-law at an IR spectral break, which was explicitly observed twice in GX339-4. This has been cited as further evidence that jet synchrotron radiation might make a significant contribution to the observed X-rays in the hard state. We explore this hypothesis with a series of simultaneous radio/X-ray hard state observations of GX339-4. We fit these spectra with a simple, but remarkably successful, doubly broken power-law model that indeed requires a spectral break in the IR. For most of these observations, the break position as a function of X-ray flux agrees with the jet model predictions. We then examine the radio flux/X-ray flux correlation in Cyg X-1 through the use of 15 GHz radio data, obtained with the Ryle radio telescope, and Rossi X-ray Timing Explorer data, from the All Sky Monitor and pointed observations. We find evidence of `parallel tracks' in the radio/X-ray correlation which are associated with `failed transitions' to, or the beginning of a transition to, the soft state. We also find that for Cyg X-1 the radio flux is more fundamentally correlated with the hard, rather than the soft, X-ray flux.Comment: To Appear in the Proceedings of "From X-ray Binaries to Quasars: Black Hole Accretion on All Mass Scales" (Amsterdam, July 2004). Eds. T Maccarone, R. Fender, L. H

Determination of Serum Antibody to Bordetella pertussis Adenylate Cyclase Toxin in Vaccinated and Unvaccinated Children and in Children and Adults with Pertussis

Presence of antibody to adenylate cyclase toxin (ACT) has been noted following Bordetella pertussis infection. Because ACT is not presently in any acellular pertussis vaccines, it has been considered as a possible antigen to use in B. pertussis diagnostic enzyme-linked immunosorbent assay (ELISA) studies. We determined antibody to B. pertussis ACT by ELISA and Western blot tests in serum samples obtained from unvaccinated children, from children vaccinated with several diphtheria and tetanus toxoid vaccines (DTP vaccines), from children vaccinated with vaccines containing acellular pertussis components in combination with diphtheria and tetanus toxoids (DTaP vaccines), and from children and adults with pertussis. Primary infections with either B. pertussis or Bordetella parapertussis stimulated a vigorous antibody response to ACT. In contrast, patients in whom DTP and DTaP vaccines failed had minimal ACT antibody responses. The lack of a significant ACT antibody response in children in whom the vaccine failed is of interest but would seem to preclude the use of ACT in diagnostic test

Chandra Observations of the Interacting NGC 4410 Galaxy Group

We present high resolution X-ray imaging data from the ACIS-S instrument on the Chandra telescope of the nearby interacting galaxy group NGC 4410. Four galaxies in the inner portion of this group are clearly detected by Chandra, including the peculiar low luminosity radio galaxy NGC 4410A. In addition to a nuclear point source, NGC 4410A contains diffuse X-ray emission, including an X-ray ridge extending out to about 12" (6 kpc) to the northwest of the nucleus. This ridge is coincident with an arc of optical emission-line gas, which has previously been shown to have optical line ratios consistent with shock ionization. This structure may be due to an expanding superbubble of hot gas caused by supernovae and stellar winds or by the active nucleus. The Chandra observations also show four or five possible compact ultra-luminous X-ray (ULX) sources (L(x) >= 10^39 erg/s) associated with NGC 4410A. At least one of these candidate ULXs appears to have a radio counterpart, suggesting that it may be due to an X-ray binary with a stellar-mass black hole, rather than an intermediate mass black hole. In addition, a faint diffuse intragroup X-ray component has been detected between the galaxies (L(x) ~ 10^41 erg/s). This supports the hypothesis that the NGC 4410 group is in the process of evolving via mergers from a spiral-dominated group (which typically have no X-ray-emitting intragroup gas) to an elliptical-dominated group (which often have a substantial intragroup medium).Comment: 27 pages, 14 figures; Accepted by Astronomical Journal; color images at http://www.etsu.edu/physics/bsmith/research/n4410.htm

Going with the flow: can the base of jets subsume the role of compact accretion disk coronae?

The hard state of X-ray binaries (XRBs) is characterized by a power law spectrum in the X-ray band, and a flat/inverted radio/IR spectrum associated with occasionally imaged compact jets. It has generally been thought that the hard X-rays result from Compton upscattering of thermal accretion disk photons by a hot, coronal plasma whose properties are inferred via spectral fitting. Interestingly, these properties-especially those from certain magnetized corona models-are very similar to the derived plasma conditions at the jet footpoints. Here we explore the question of whether the `corona' and `jet base' are in fact related, starting by testing the strongest premise that they are synonymous. In such models, the radio through the soft X-rays are dominated by synchrotron emission, while the hard X-rays are dominated by inverse Compton at the jet base - with both disk and synchrotron photons acting as seed photons. The conditions at the jet base fix the conditions along the rest of the jet, thus creating a direct link between the X-ray and radio emission. We also add to this model a simple iron line and convolve the spectrum with neutral reflection. After forward-folding the predicted spectra through the detector response functions, we compare the results to simultaneous radio/X-ray data obtained from the hard states of the Galactic XRBs GX339-4 and Cygnus X-1. Results from simple Compton corona model fits are also presented for comparison. We demonstrate that the jet model fits are statistically as good as the single-component corona model X-ray fits, yet are also able to address the simultaneous radio data.Comment: Accepted to the Astrophysical Journal. 14 pages, emulateapj.st

Chandra Detections of Two Quiescent Black Hole X-Ray Transients

Using the Chandra X-ray Observatory, we have detected the black hole transients V4641 Sgr and XTE J1859+226 in their low luminosity, quiescent states. The 0.3-8 keV luminosities are (4.0^(+3.3)_(-2.4))E31 (d/7 kpc)^2 erg/s and (4.2^(+4.8)_(-2.2))E31 (d/11 kpc)^2 erg/s for V4641 Sgr and XTE J1859+226, respectively. With the addition of these 2 systems, 14 out of the 15 transients with confirmed black holes (via compact object mass measurements) now have measured quiescent luminosities or sensitive upper limits. The only exception is GRS 1915+105, which has not been in quiescence since its discovery in 1992. The luminosities for V4641 Sgr and XTE J1859+226 are consistent with the median luminosity of 2E31 erg/s for the systems with previous detections. Our analysis suggests that the quiescent X-ray spectrum of V4641 Sgr is harder than for the other systems in this group, but, due to the low statistical quality of the spectrum, it is not clear if V4641 Sgr is intrinsically hard or if the column density is higher than the interstellar value. Focusing on V4641 Sgr, we compare our results to theoretical models for X-ray emission from black holes in quiescence. Also, we obtain precise X-ray positions for V4641 Sgr and XTE J1859+226 via cross-correlation of the X-ray sources detected near our targets with IR sources in the 2 Micron All-Sky Survey catalog.Comment: 4 pages, Accepted by ApJ Letter

Assessing dengue transmission risk and a vector control intervention using entomological and immunological indices in Thailand: study protocol for a cluster-randomized controlled trial.

BACKGROUND: Dengue fever is the most common and widespread mosquito-borne arboviral disease in the world. There is a compelling need for cost-effective approaches and practical tools that can reliably measure real-time dengue transmission dynamics that enable more accurate and useful predictions of incidence and outbreaks. Sensitive surveillance tools do not exist today, and only a small handful of new control strategies are available. Vector control remains at the forefront for combating dengue transmission. However, the effectiveness of many current vector control interventions is fraught with inherent weaknesses. No single vector control method is effective enough to control both vector populations and disease transmission. Evaluations of novel larval and adult control interventions are needed. METHODS/DESIGN: A cluster-randomized controlled trial will be carried out between 2017 and 2019 in urban community clusters in Khon Kaen and Roi Et cities, northeastern Thailand. The effectiveness of a pyriproxyfen/spinosad combination treatment of permanent water storage containers will be evaluated on epidemiological and entomological outcomes, including dengue incidence, number of female adult dengue vectors infected or not infected with dengue virus (DENV), human exposure to Aedes mosquito bites, and several other indices. These indices will also be used to develop predictive models for dengue transmission and impending outbreaks. Epidemiological and entomological data will be collected continuously for 2 years, with the intervention implemented after 1 year. DISCUSSION: The aims of the trial are to simultaneously evaluate the efficacy of an innovative dengue vector control intervention and developing predictive dengue models. Assessment of human exposure to mosquito bites by detecting antibodies generated against Aedes saliva proteins in human blood samples has, so far, not been applied in dengue epidemiological risk assessment and disease surveillance methodologies. Likewise, DENV detection in mosquitoes (adult and immature stages) has not been used in any practical way for routine disease surveillance strategies. The integration of multiple outcome measures will assist health authorities to better predict outbreaks for planning and applying focal and timely interventions. The trial outcomes will not only be important for Thailand, but also for the entire Southeast Asian region and further afield. TRIAL REGISTRATION: ISRCTN, ISRCTN73606171 . Registered on 23 June 2017

The LOFAR Transients Pipeline

Current and future astronomical survey facilities provide a remarkably rich opportunity for transient astronomy, combining unprecedented fields of view with high sensitivity and the ability to access previously unexplored wavelength regimes. This is particularly true of LOFAR, a recently-commissioned, low-frequency radio interferometer, based in the Netherlands and with stations across Europe. The identification of and response to transients is one of LOFAR's key science goals. However, the large data volumes which LOFAR produces, combined with the scientific requirement for rapid response, make automation essential. To support this, we have developed the LOFAR Transients Pipeline, or TraP. The TraP ingests multi-frequency image data from LOFAR or other instruments and searches it for transients and variables, providing automatic alerts of significant detections and populating a lightcurve database for further analysis by astronomers. Here, we discuss the scientific goals of the TraP and how it has been designed to meet them. We describe its implementation, including both the algorithms adopted to maximize performance as well as the development methodology used to ensure it is robust and reliable, particularly in the presence of artefacts typical of radio astronomy imaging. Finally, we report on a series of tests of the pipeline carried out using simulated LOFAR observations with a known population of transients.Comment: 30 pages, 11 figures; Accepted for publication in Astronomy & Computing; Code at https://github.com/transientskp/tk

Is the plateau state in GRS 1915+105 equivalent to canonical hard states?

GRS1915+105 is a very peculiar black hole binary that exhibits accretion-related states that are not observed in any other stellar-mass black hole system. One of these states, however -- referred to as the plateau state -- may be related to the canonical hard state of black hole X-ray binaries. Both the plateau and hard state are associated with steady, relatively lower X-ray emission and flat/inverted radio emission, that is sometimes resolved into compact, self-absorbed jets. However, while generally black hole binaries quench their jets when the luminosity becomes too high, GRS1915+105 seems to sustain them despite the fact that it accretes at near- or super-Eddington rates. In order to investigate the relationship between the plateau and the hard state, we fit two multi-wavelength observations using a steady-state outflow-dominated model, developed for hard state black hole binaries. The data sets consist of quasi-simultaneous observations in radio, near-infrared and X-ray bands. Interestingly, we find both significant differences between the two plateau states, as well as between the best-fit model parameters and those representative of the hard state. We discuss our interpretation of these results, and the possible implications for GRS 1915+105's relationship to canonical black hole candidates.Comment: accepted for publication in MNRA

Opacity effects and shock-in-jet modelling of low-level activity in Cygnus X-3

We present simultaneous dual-frequency radio observations of Cygnus X-3 during a phase of low-level activity. We constrain the minimum variability timescale to be 20 minutes at 43 GHz and 30 minutes at 15 GHz, implying source sizes of 2 to 4 AU. We detect polarized emission at a level of a few per cent at 43 GHz which varies with the total intensity. The delay of approximately 10 minutes between the peaks of the flares at the two frequencies is seen to decrease with time, and we find that synchrotron self-absorption and free-free absorption by entrained thermal material play a larger role in determining the opacity than absorption in the stellar wind of the companion. A shock-in-jet model gives a good fit to the lightcurves at all frequencies, demonstrating that this mechanism, which has previously been used to explain the brighter, longer-lived giant outbursts in this source, is also applicable to these low-level flaring events. Assembling the data from outbursts spanning over two orders of magnitude in flux density shows evidence for a strong correlation between the peak brightness of an event, and the timescale and frequency at which this is attained. Brighter flares evolve on longer timescales and peak at lower frequencies. Analysis of the fitted model parameters suggests that brighter outbursts are due to shocks forming further downstream in the jet, with an increased electron normalisation and magnetic field strength both playing a role in setting the strength of the outburst.Comment: Accepted for publication in MNRAS. 15 pages, 9 figure

Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand.

BACKGROUND/OBJECTIVES: Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vector abundance and dengue transmission risk. This study aims to identify entomological and immunological indices capable of discriminating between dengue case and control (non-case) houses, based on the assessment of candidate indices, as well as individual and household characteristics, as potential risk factors for acquiring dengue infection. METHODS: This prospective, hospital-based, case-control study was conducted in northeastern Thailand between June 2016 and August 2019. Immature and adult stage Aedes were collected at the houses of case and control patients, recruited from district hospitals, and at patients' neighboring houses. Blood samples were tested by RDT and PCR to detect dengue cases, and were processed with the Nterm-34 kDa salivary peptide to measure the human immune response to Aedes bites. Socioeconomic status, and other individual and household characteristics were analyzed as potential risk factors for dengue. RESULTS: Study findings showed complex relationships between entomological indices and dengue risk. The presence of DENV-infected Aedes at the patient house was associated with 4.2-fold higher odds of dengue. On the other hand, Aedes presence (irrespective of infectious status) in the patient's house was negatively associated with dengue. In addition, the human immune response to Aedes bites, was higher in control than in case patients and Aedes adult abundance and immature indices were higher in control than in case houses at the household and the neighboring level. Multivariable analysis showed that children aged 10-14 years old and those aged 15-25 years old had respectively 4.5-fold and 2.9-fold higher odds of dengue infection than those older than 25 years. CONCLUSION: DENV infection in female Aedes at the house level was positively associated with dengue infection, while adult Aedes presence in the household was negatively associated. This study highlights the potential benefit of monitoring dengue viruses in Aedes vectors. Our findings suggest that monitoring the presence of DENV-infected Aedes mosquitoes could be a better indicator of dengue risk than the traditional immature entomological indices