Topographia Metrica Misniae Compendiosae, Lipsiae, emporii qua magnificentissimi qua opulentissimi Viris Magnificis, Nobilissimis, Excellentissimis Iuxta Et Consultissimis Dn. Christophoro Pinckero, ... Dn. Friderico Kuhlewein ... Tum Etiam Magnificentia ... Dn. Johanni Philippi ... Dn. Paulo Wagnero ... Dn. Philippo Jacobo Lindnero ... et ... Dn. Quirino Schachero ... Dn. Jacobo Meuero ... Dn. Sebastiano Oheim ... Dn. Marco Scipioni ... Dn. Wolffgango Peilickio ... Dn. Johanni Seidelio ... Dn. Sigismundo Finckelthusio ... Dn. Heinrico Gramano ... dedicata a Jeremia Wittichio ...

TOPOGRAPHIA METRICA MISNIAE COMPENDIOSAE, LIPSIAE, EMPORII QUA MAGNIFICENTISSIMI QUA OPULENTISSIMI VIRIS MAGNIFICIS, NOBILISSIMIS, EXCELLENTISSIMIS IUXTA ET CONSULTISSIMIS DN. CHRISTOPHORO PINCKERO, ... DN. FRIDERICO KUHLEWEIN ... TUM ETIAM MAGNIFICENTIA ... DN. JOHANNI PHILIPPI ... DN. PAULO WAGNERO ... DN. PHILIPPO JACOBO LINDNERO ... ET ... DN. QUIRINO SCHACHERO ... DN. JACOBO MEUERO ... DN. SEBASTIANO OHEIM ... DN. MARCO SCIPIONI ... DN. WOLFFGANGO PEILICKIO ... DN. JOHANNI SEIDELIO ... DN. SIGISMUNDO FINCKELTHUSIO ... DN. HEINRICO GRAMANO ... DEDICATA A JEREMIA WITTICHIO ... Topographia Metrica Misniae Compendiosae, Lipsiae, emporii qua magnificentissimi qua opulentissimi Viris Magnificis, Nobilissimis, Excellentissimis Iuxta Et Consultissimis Dn. Christophoro Pinckero, ... Dn. Friderico Kuhlewein ... Tum Etiam Magnificentia ... Dn. Johanni Philippi ... Dn. Paulo Wagnero ... Dn. Philippo Jacobo Lindnero ... et ... Dn. Quirino Schachero ... Dn. Jacobo Meuero ... Dn. Sebastiano Oheim ... Dn. Marco Scipioni ... Dn. Wolffgango Peilickio ... Dn. Johanni Seidelio ... Dn. Sigismundo Finckelthusio ... Dn. Heinrico Gramano ... dedicata a Jeremia Wittichio ... ([1]) Titelseite ([1]) Text ([2]

High-speed quantum dot lasers and amplifiers for optical data communication

Quantum dot based 1.3 m fiber-coupled laser and amplifier modules show 10 Gb/s and 40 Gb/s operation, respectively, with bit error rates below 10 -11. Amplifier chip gain up to 26 dB has been demonstrated. Mode-locked quantum dot lasers show optical pulses with widths below 1 ps and repetition frequencies up to 80 GHz. 710 fs pulses were amplified with 10 dB net gain and without pulse broadening

Retina

PURPOSE: The aim of this study was to investigate the prevalence of vitreomacular interface abnormalities (VMIAs) and to identify associated factors in an elderly population in Europe. METHODS: The MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) Study is a population-based study, conducted in subjects older than 75 years. Vitreomacular adhesions, vitreomacular tractions, macular holes, epiretinal membranes, and macular cysts were assessed on spectral-domain optical coherence tomography examinations. The prevalence of VMIAs was estimated. We studied the association of demographic and clinical factors with VMIAs. RESULTS: The mean age of the participants was 82.3 (SD, 3.8) years, and 37.3% were men. The prevalence rates of VMIAs were vitreomacular adhesions (17.7%), vitreomacular tractions (1.4%), lamellar macular holes (1.0%), full-thickness macular holes (0.2%), macular pseudoholes (0.4%), epiretinal membranes (38.9%), and macular cysts (5.8%). In multivariate analysis, vitreomacular adhesions were positively associated with male sex (P < 0.001) and negatively associated with older age (P < 0.001) and cataract extraction (P < 0.001). Epiretinal membranes were positively associated with older age (P < 0.001) and cataract extraction (P < 0.001). CONCLUSION: The prevalence of VMIAs based on spectral-domain optical coherence tomography analysis was high in subjects older than 75 years

T cell receptor ζ reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor α

Expression and function of the antigen T cell receptor (TCR) play a central role in regulating immune responsiveness. Accordingly, targeting the expression of TCRαβ or its associated CD3 subunits profoundly influences T cell development and adaptive immunity. Down-regulation of the invariant TCRζ chain has been documented in a wide variety of chronic inflammatory and infectious diseases, and is thought to contribute to the paradoxical immune suppression observed in these diseases. Previously, we reported that prolonged exposure of T cell hybridoma clones to tumor necrosis factor α (TNF) induces nondeletional and reversible hyporesponsiveness to TCR engagement, associated with down-regulation of TCRζ chain expression, impaired TCR/CD3 complex assembly, and attenuation of TCR-induced membrane proximal tyrosine phosphorylation. Here, we have tested whether receptor specific T cell responses are rescued in TNF-treated T cell hybridomas by retroviral-mediated expression of ζ-chimeric (C2ζ) receptors or wild-type TCRζ. Expression of C2ζ receptors at the cell surface is relatively refractory to chronic TNF stimulation. However, C2ζ receptor function depends on association with endogenous TCRζ chains, whose expression is down-regulated by TNF, and so C2 receptor specific responses are attenuated in TNF-treated T cells. Unexpectedly, overexpression of wild-type TCRζ maintains cell surface TCR/CD3 complex expression but fails to rescue receptor proximal signaling in TNF-treated T cells, suggesting the existence of hitherto unrecognized mechanisms through which TNF regulates T cell responsiveness. We provide additional evidence that TNF also uncouples distal TCR signaling pathways independently of its effects on TCRζ expression