The Grizzly, March 26, 1991

First Dance Marathon for Leukemia a Success • U.S.G.A. Proposes S.A.C. Reorganization • Student Debate on Use of Force Held • College Fax for Official College Use • Residential Village Centralized • New Materials to Recycle • Financial Aid Update • The Soviets: An Inside Portrait • Communication Arts Career Night • Lange Promoted to Assistant Dean of Continuing Education • 1990 Fall Dean\u27s List • Symposium at Berman • Men\u27s Track Runs Well Despite Conditions • Women\u27s Track Makes a Splash at Greyhound Invitational • Women Win ECAC Title • Men\u27s Lacrosse Upsets Penn State Del. Co. • Women\u27s Lacrosse Hopes for Third NCAA Title • Golf Opens With a Win • Derstine First Swimming All-American • Softball Swings into Season • Men\u27s Tennis Nets Good Results • Letter: Student Apathy, Who Cares! • The New Drugstore: Nature\u27s Pharma-Sea • Don\u27t Can Your Aluminumhttps://digitalcommons.ursinus.edu/grizzlynews/1274/thumbnail.jp

Acquisition and presentation of follicular dendritic cell–bound antigen by lymph node–resident dendritic cells

Lymph node–resident dendritic cells sample antigen from follicular dendritic cells for presentation to CD8+ T cells

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Activating and Guiding the Engagement of Seniors with online social networking: Experimental findings from the AGES 2.0 project

Objectives: Guided by theoretical and empirical work attesting to the health benefits of social connections, we tested whether internet connectivity, and training in its use for social purposes, can support the well-being of older adults receiving care. Methods: Participants (N = 76) were randomly assigned to receive 3 months training versus care-as-usual. Cognitive and mental health were assessed before and after the intervention. Results: Results show significant cognitive improvements across time in the training, but not control, group. This effect was mediated through a combination of increased social activity, improved self-competence, and maintained personal identity strength. Indirect effects on mental health outcomes via these processes were also observed. Discussion: These findings suggest that internet access and training can support the self and social connectedness of vulnerable older adults and to contribute positively to well-being