Fast Neutron Spectroscopy with a High-pressure Nitrogen-filled Large Volume Spherical Proportional Counter

We present a fast neutron spectroscopy system based on a nitrogen-filled, large volume gaseous detector, the Spherical Proportional Counter. The system has been successfully operated up to gas pressure of 1.5 bar. Neutron energy is estimated through measurement of the 14N(n,a)11B and 14N(n,p)14C reaction products. These reactions have comparable cross sections and Q-values with the 3He(n,p)3H reaction making nitrogen a good alternative to 3He use for fast neutron detection. Two detectors were built at the University of Birmingham and are currently used for the measurement of fast and thermal neutrons in the University of Birmingham and the Boulby underground laboratory, respectively.Comment: 3 pages, 6 Figure

Early clinical assessment of response to treatment of skin and soft-tissue infections:How can it help clinicians? Perspectives from Europe

AbstractSkin and soft-tissue infections (SSTIs) are a common indication for antibiotic use in Europe and are associated with considerable morbidity. Treatment of SSTIs, occasionally complicated by infection with meticillin-resistant Staphylococcus aureus, can be resource intensive and lead to high healthcare costs. For patients treated in an inpatient setting, once the acute infection has been controlled, a patient may be discharged on suitable oral antibiotic therapy or outpatient parenteral antibiotic therapy. The recently confirmed efficacy of single-dose (e.g. oritavancin) and two-dose (e.g. dalbavancin) infusion therapies as well as tedizolid phosphate, a short-duration therapy available both for intravenous (i.v.) and oral use, for treating SSTIs has highlighted the need for clinicians to re-evaluate their current treatment paradigms. In addition, recent clinical trial data reporting a novel endpoint of early clinical response, defined as change in lesion size at 48–72 h, may be of value in determining which patients are most suitable for early de-escalation of therapy, including switch from i.v. to oral antibiotics, and subsequent early hospital discharge. The aim of this paper is to review the potential impact of assessing clinical response on clinical decision-making in the management of SSTIs in Europe, with a focus on emerging therapies

Vegetation Type Dominates the Spatial Variability in CH<inf>4</inf> Emissions Across Multiple Arctic Tundra Landscapes

Methane (CH4) emissions from Arctic tundra are an important feedback to global climate. Currently, modelling and predicting CH4 fluxes at broader scales are limited by the challenge of upscaling plot-scale measurements in spatially heterogeneous landscapes, and by uncertainties regarding key controls of CH4 emissions. In this study, CH4 and CO2 fluxes were measured together with a range of environmental variables and detailed vegetation analysis at four sites spanning 300 km latitude from Barrow to Ivotuk (Alaska). We used multiple regression modelling to identify drivers of CH4 flux, and to examine relationships between gross primary productivity (GPP), dissolved organic carbon (DOC) and CH4 fluxes. We found that a highly simplified vegetation classification consisting of just three vegetation types (wet sedge, tussock sedge and other) explained 54% of the variation in CH4 fluxes across the entire transect, performing almost as well as a more complex model including water table, sedge height and soil moisture (explaining 58% of the variation in CH4 fluxes). Substantial CH4 emissions were recorded from tussock sedges in locations even when the water table was lower than 40 cm below the surface, demonstrating the importance of plant-mediated transport. We also found no relationship between instantaneous GPP and CH4 fluxes, suggesting that models should be cautious in assuming a direct relationship between primary production and CH4 emissions. Our findings demonstrate the importance of vegetation as an integrator of processes controlling CH4 emissions in Arctic ecosystems, and provide a simplified framework for upscaling plot scale CH4 flux measurements from Arctic ecosystems

A review of the impacts of degradation threats on soil properties in the UK

National governments are becoming increasingly aware of the importance of their soil resources and are shaping strategies accordingly. Implicit in any such strategy is that degradation threats and their potential effect on important soil properties and functions are defined and understood. In this paper, we aimed to review the principal degradation threats on important soil properties in the UK, seeking quantitative data where possible. Soil erosion results in the removal of important topsoil and, with it, nutrients, C and porosity. A decline in soil organic matter principally affects soil biological and microbiological properties, but also impacts on soil physical properties because of the link with soil structure. Soil contamination affects soil chemical properties, affecting nutrient availability and degrading microbial properties, whilst soil compaction degrades the soil pore network. Soil sealing removes the link between the soil and most of the ‘spheres’, significantly affecting hydrological and microbial functions, and soils on re-developed brownfield sites are typically degraded in most soil properties. Having synthesized the literature on the impact on soil properties, we discuss potential subsequent impacts on the important soil functions, including food and fibre production, storage of water and C, support for biodiversity, and protection of cultural and archaeological heritage. Looking forward, we suggest a twin approach of field-based monitoring supported by controlled laboratory experimentation to improve our mechanistic understanding of soils. This would enable us to better predict future impacts of degradation processes, including climate change, on soil properties and functions so that we may manage soil resources sustainably

Inside to Outside: A Collaborative Effort to Address Cancer Disparities among Incarcerated and Formerly Incarcerated Populations

Inmates experience higher rates of serious and chronic illness. Among the chronic illnesses experienced by this population is the diagnosis of cancer. During the past decade the incidence of cancer has slowly but steadily increased. One explanation for this increase in cancer diagnosis in correctional populations is the aging of the population. However, cancer diagnosis is not only evident in the aging inmate population (65 or older) but there is evidence of a younger population (30-45) presenting with cancer at intake or receiving a cancer diagnosis within months of admission to our jails and prisons. The consistent increase in patients with or diagnosis with cancer suggest a need to explore strategies to successfully manage and provide care meeting best practice standards for this special population. The increase in patients with a diagnosis of cancer further suggests a need to develop policies that decrease the risk of cancer disparities in the inmate population and among formerly incarcerated persons. Ensuring access to quality of care and continuity of care for patients with cancer requires health professionals to be vigilant in screening, health promotion, prevention and treatment. Presenters will discuss approaches to care and treatment and policy implications for this population

Impact of the GUIDE Project on Faculty Scholarship at GSU

A high priority for addressing cancer health disparities is to increase the representativeness of the research workforce. A large number of potential investigators from groups underrepresented in cancer research are employed in minority-serving institutions that are teaching-intensive. A high teaching intensity with a comparatively low level of campus-wide research activity can make scholarly productivity challenging. In the GSU-UICC Disparities Education Cancer Research Training and Education Project (The GUIDE Project) our aim was to develop a cohort of early stage cancer health disparities researchers by putting in place supportive practices that were highly sustainable and cost-effective. In this poster, we examine the impact of planned mentoring and faculty development activities on faculty perceptions of productivity, overall scholarly productivity, and proportion of cancer /health disparities related work products over the four-year period of the grant. The experiences of these 7 researchers from underrepresented groups can inform best practices in training researchers at teaching-intensive institutions

Differences in childhood body mass index between lesbian/gay and bisexual and heterosexual female adolescents: A follow-back study.

OBJECTIVE:To determine whether childhood body mass index (BMI), assessed in childhood, differs between lesbian/gay and bisexual (LGB) and heterosexual late adolescents, and whether childhood social stressors impact the association between sexual orientation and childhood BMI. METHODS:Participants included 2,070 late adolescents from the Pittsburgh Girls Study, of whom 233 (11.2%) identified as lesbian or bisexual and 1,837 (88.8%) as heterosexual at ages 17-20 years. Weight and height were used to calculate body mass index (BMI) at ages 10 through 14 years. Data were collected on child reported loneliness at ages 8 to 10 and peer victimization from 10 to 14 years. RESULTS:LGB females had higher BMIs and greater increases in BMI from ages 10-14 years compared to heterosexual females and reported higher levels of loneliness and peer victimization in childhood. Loneliness moderated the association between sexual identity and changes in BMI; for participants with loneliness scores in the upper quartile, the increase in BMI over time was approximately 30% higher for LGB females compared to heterosexual females. Child report of peer victimization mediated the association between sexual identity and changes in BMI, with nearly 18% of the total effect of sexual identity on BMI over time accounted for by peer victimization. CONCLUSIONS:Lesbian and bisexual adolescents report greater loneliness and peer victimization as children than heterosexual adolescents; these stressors confer risk for higher BMI among LGB females. These data underscore the importance of research on the social determinants of health. The hypothesis that the social stressors may partially account for differences in BMI and other cardiometabolic risk factors between LGB and heterosexual females should be addressed in future research

Test of mediation of peer victimization on the association between sexual identity and change in BMI from ages 10–14 years.

<p>Test of mediation of peer victimization on the association between sexual identity and change in BMI from ages 10–14 years.</p