A Harmonic-based Fault detection algorithm for Microgrids

The trend toward Microgrids (MGs) is significantly increasing by employing Distributed Generators (DGs) which leads to new challenges, especially in the fault detection. This paper proposes an algorithm based on the Total Harmonic Distortion (THD) of the grid voltages to detect the events of faults in MGs. The algorithm uses the THD together with the estimate amplitude voltages and the zero-sequence component for the detection and identification of the faults. The performance is evaluated by using MATLAB/Simulink simulations to validate the capability for detecting different fault types in the least possible time.Comment: Proc. of the Interdisciplinary Conference on Mechanics, Computers and Electrics (ICMECE 2022) 6-7 October 2022, Barcelona, Spai

A comparative study of smart THD-based fault protection techniques for distribution networks

The integration of Distributed Generators (DGs) into distribution systems (DSs) leads to more reliable and efficient power delivery for customers. However, the possibility of bi-directional power flow creates new technical problems for protection schemes. This poses a threat to conventional strategies because the relay settings have to be adjusted depending on the network topology and operational mode. As a solution, it is important to develop novel fault protection techniques to ensure reliable protection and avoid unnecessary tripping. In this regard, Total Harmonic Distortion (THD) can be used as a key parameter for evaluating the grid’s waveform quality during fault events. This paper presents a comparison between two DS protection strategies that employ THD levels, estimated amplitude voltages, and zero-sequence components as instantaneous indicators during the faults that function as a kind of fault sensor to detect, identify, and isolate faults. The first method uses a Multiple Second Order Generalized Integrator (MSOGI) to obtain the estimated variables, whereas the second method uses a single SOGI for the same purpose (SOGI-THD). Both methods rely on communication lines between protective devices (PDs) to facilitate coordinated protection. The effectiveness of these methods is assessed by using simulations in MATLAB/Simulink considering various factors such as different types of faults and DG penetrations, different fault resistances and fault locations in the proposed network. Moreover, the performance of these methods is compared with conventional overcurrent and differential protections. The results show that the SOGI-THD method is highly effective in detecting and isolating faults with a time interval of 6–8.5 ms using only three SOGIs while requiring only 447 processor cycles for execution. In comparison to other protection methods, the SOGI-THD method exhibits a faster response time and a lower computational burden. Furthermore, the SOGI-THD method is robust to harmonic distortion, as it considers pre-existing harmonic content before the fault and avoids interference with the fault detection process.Peer ReviewedPostprint (published version

Power calculation algorithm for single-phase droop-operated inverters considering nonlinear loads and unsing n-order SOGI filtering

The average active and reactive powers, P and Q, are crucial parameters that have to be calculated when sharing common loads between parallelized droop-operated single-phase inverters. However, the droop method algorithm should employ low-pass filters (LPF) with very low cut-off frequency to minimize the distortion impact in the provide droop amplitude and frequency references. This situation forces the droop control to operate at a very low dynamic velocity, degrading the stability of the parallelized system. For this reason, different solutions had been proposed in literature to increase the droop velocity, but the issues derived from the sharing of nonlinear loads had not been properly considered. This work proposes a novel method to calculate P and Q based on the fundamental components of the inverter's output voltage and current and using the measured phase angle between the output voltage and current. The method is used under normal and highly distorting conditions due to the sharing non-linear loads. The fundamental components are obtained by means of the highly filtering capability provided by norder cascaded second order generalized integrators (nSOGI). The proposed method leads to faster and more accurate P and Q calculations that enhances the droop-method dynamic performance. Simulations are provided to validate the proposal.Peer ReviewedPostprint (published version

A new LPF-based grid frequency estimation for the SOGI filter with improved harmonic rejection

This paper proposes a new method for the estimation of the grid voltage frequency using a low-pass filter (LPF) approach. The estimated frequency is used to tune a second order generalized integrator (SOGI) filter commonly used for grid monitoring purposes and applications requiring parameter estimation from the grid. A first-order LPF is used first for the estimation that behaves identically to the reported normalized SOGI-FLL. A second-order LPF is proposed instead to overcome this circumstance. The behavior of this approach is dynamically analyzed and a linearized model useful for design purposes is derived. The behavior of the proposed system is checked with simulations, showing that the model matches well with the real system and has a smoother transient response to step frequency perturbations and also a better rejection to harmonic distortion than previous approaches.Peer ReviewedPostprint (published version

Control strategy to maximize the power capability of PV three-phase inverters during voltage sags

Under voltage sags, grid-tied photovoltaic inverters should remain connected to the grid according to low-voltage ride-through requirements. During such perturbations, it is interesting to exploit completely the distributed power provisions to contribute to the stability and reliability of the grid. In this sense, this paper proposes a low-voltage ride-through control strategy that maximizes the inverter power capability by injecting the maximum-rated current during the sag. To achieve this objective, two possible active power situations have been considered, i.e., high- and low-power production scenarios. In the first case, if the source is unable to deliver the whole generated power to the grid, the controller applies active power curtailment to guarantee that the maximum rated current is not surpassed. In the second case, the maximum allowed current is not reached, thus, the control strategy determined the amount of reactive power that can be injected up to reach it. The control objective can be fulfilled by means of a flexible current injection strategy that combines a proper balance between positive- and negative-current sequences, which limits the inverter output current to the maximum rated value and avoid active power oscillations. Selected experimental and simulation results are reported in order to validate the effectiveness of the proposed control strategy.Peer ReviewedPostprint (author's final draft

p53 Amino-Terminus Region (1–125) Stabilizes and Restores Heat Denatured p53 Wild Phenotype

BACKGROUND:The intrinsically disordered N-ter domain (NTD) of p53 encompasses approximately hundred amino acids that contain a transactivation domain (1-73) and a proline-rich domain (64-92) and is responsible for transactivation function and apoptosis. It also possesses an auto-inhibitory function as its removal results in remarkable reduction in dissociation of p53 from DNA. PRINCIPAL FINDINGS/METHODOLOGY:In this report, we have discovered that p53-NTD spanning amino acid residues 1-125 (NTD125) interacted with WT p53 and stabilized its wild type conformation under physiological and elevated temperatures, both in vitro and in cellular systems. NTD125 prevented irreversible thermal aggregation of heat denatured p53, enhanced p21-5'-DBS binding and further restored DBS binding activity of heat-denatured p53, in vitro, in a dose-dependent manner. In vivo ELISA and immunoprecipitation analysis of NTD125-transfected cells revealed that NTD125 shifted equilibrium from p53 mutant to wild type under heat stress conditions. Further, NTD125 initiated nuclear translocation of cytoplasmic p53 in transcriptionally active state in order to activate p53 downstream genes such as p21, Bax, PUMA, Noxa and SUMO. CONCLUSION/SIGNIFICANCE:Here, we showed that a novel chaperone-like activity resides in p53-N-ter region. This study might have significance in understanding the role of p53-NTD in p53 stabilization, conformational activation and apoptosis under heat-stress conditions

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK

The GTPases belonging to the Rho family control the actin cytoskeleton rearrangements needed for particle internalization during phagocytosis. ROCK and mDia1 are downstream effectors of RhoA, a GTPase involved in that process. Coxiella burnetii, the etiologic agent of Q fever, is internalized by the host´s cells in an actin-dependent manner. Nevertheless, the molecular mechanism involved in this process has been poorly characterized. This work analyzes the role of different GTPases of the Rho family and some downstream effectors in the internalization of C. burnetii by phagocytic and non-phagocytic cells. The internalization of C. burnetii into HeLa and RAW cells was significantly inhibited when the cells were treated with Clostridium difficile Toxin B which irreversibly inactivates members of the Rho family. In addition, the internalization was reduced in HeLa cells that overexpressed the dominant negative mutants of RhoA, Rac1 or Cdc42 or that were knocked down for the Rho GTPases. The pharmacological inhibition or the knocking down of ROCK diminished bacterium internalization. Moreover, C. burnetii was less efficiently internalized in HeLa cells overexpressing mDia1-N1, a dominant negative mutant of mDia1, while the overexpression of the constitutively active mutant mDia1-ΔN3 increased bacteria uptake. Interestingly, when HeLa and RAW cells were infected, RhoA, Rac1 and mDia1 were recruited to membrane cell fractions. Our results suggest that the GTPases of the Rho family play an important role in C. burnetii phagocytosis in both HeLa and RAW cells. Additionally, we present evidence that ROCK and mDia1, which are downstream effectors of RhoA, are involved in that processFil: Salinas Ojeda, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Ortiz Flores, Rodolfo Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Distel, Jesús Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Aguilera, Milton Osmar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Beron, Walter. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentin

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London