718 research outputs found
Complex epilepsy: it's all in the history
- Author
- Publication venue
- Publication date
- 17/10/2020
- Field of study
Late diagnoses of Dravet syndrome: How many individuals are we missing?
- Author
- Publication venue
- Publication date
- 16/07/2021
- Field of study
We report new genetic diagnoses of Dravet syndrome in a group of adults with complex epilepsy of unknown cause, under follow up at a tertiary epilepsy centre. Individuals with epilepsy and other features of unknown cause from our unit underwent whole genome sequencing through the 100,000 Genomes Project. Virtual gene panels were applied to frequency-filtered variants based on phenotype summary. Of 1078 individuals recruited, 8 (0.74%) were identified to have a pathogenic or likely pathogenic variant in SCN1A. Variant types were: nonsense (stopgain) in five (62.5%) and missense in three (37.5%). Detailed review of childhood history confirmed a phenotype compatible with Dravet syndrome. Median age at genetic diagnosis was 44.5 years (range 28-52 years). Tonic-clonic seizures were ongoing in all despite polytherapy including valproate. All had a history of fever sensitivity and myoclonic seizures, which were ongoing in two (25%) and three (37.5%) individuals, respectively. Salient features of Dravet syndrome may be less apparent in adulthood, making clinical diagnosis difficult. Regardless of age, benefits of a genetic diagnosis include access to syndrome-specific treatment options, avoidance of harmful drugs, and monitoring for common complications
Postictal Psychosis in Epilepsy: A Clinicogenetic Study
- Author
- Publication venue
- Publication date
- 03/08/2021
- Field of study
OBJECTIVE: Psychoses affecting people with epilepsy increase disease burden and diminish quality of life. We characterised post-ictal psychosis, which comprises about one-quarter of epilepsy-related psychoses, and has unknown causation. METHODS: We conducted a case-control cohort study including patients diagnosed with post-ictal psychosis, confirmed by psychiatric assessment, with available data regarding epilepsy, treatment, psychiatric history, psychosis profile and outcomes. After screening 3,288 epilepsy patients, we identified 83 with psychosis: 49 had post-ictal psychosis. Controls were 98 adults, matched by age and epilepsy type, with no history of psychosis. Logistic regression was used to investigate clinical factors associated with post-ictal psychosis; univariate associations with a P-value<0.20 were used to build a multivariate model. Polygenic risk scores for schizophrenia were calculated. RESULTS: Cases were more likely to have seizure clustering (OR 7.59, P<0.001), seizures with a recollected aura (OR 2.49, P=0.013) and a family history of psychiatric disease (OR 5.17, P=0.022). Cases showed predominance of right temporal epileptiform discharges (OR 4.87, P=0.007). There was no difference in epilepsy duration, neuroimaging findings or anti-seizure treatment between cases and controls. Polygenic risk scores for schizophrenia in an extended cohort of post-ictal psychosis cases (58) were significantly higher than in 1,366 epilepsy controls (R2 =3%, P=6x10-3 ), but not significantly different from 945 independent patients with schizophrenia (R2 =0.1%, P=0.775). INTERPRETATION: Post-ictal psychosis occurs under particular circumstances in people with epilepsy with a heightened genetic predisposition to schizophrenia, illustrating how disease biology (seizures) and trait susceptibility (schizophrenia) may interact to produce particular outcomes (post-ictal psychosis) in a common disease
Measurement of the t(t)over-bar production cross section in the dilepton channel in pp collisions at âs=8 TeV
- Author
- Abdelalim AA
- Adam W
- Adler Volker
- Alda WL
- Alderweireldt S
- Alves GA
- Antunovic Z
- Asawatangtrakuldee C
- Assran Y
- Attikis A
- Avila C
- Ban Y
- Bansal M
- Bansal S
- Basegmez S
- Beernaert Kelly
- Beliy N
- Beluffi C
- Benucci Leonardo
- Bergauer T
- Bernardes CA
- Besancon M
- Bian JG
- Blekman F
- Blyweert S
- Brigljevic V
- Bruno G
- Caebergs T
- Caillol C
- Carvalho W
- Castello R
- Caudron A
- Ceard L
- Chatrchyan S
- Chen GM
- Chen HS
- Chen M
- Chinellato J
- Cimmino Anna
- Clerbaux B
- Cornelis T
- Costantini Silvia
- Couderc F
- Custodio A
- D'Hondt J
- Da Costa EM
- Da Silva WLP
- Da Silveira GG
- Damiao DD
- Daubie E
- De Lentdecker G
- De Souza SF
- De Wolf EA
- Delaere C
- Dias FA
- Diblen SS
- Dildick Sven
- Dimitrov A
- Dragicevic M
- du Pree T
- Du R
- Eerola P
- Elgammal S
- Ero J
- Fabjan C
- Favart D
- Favart L
- Fedi G
- Figueiredo DM
- Finger M
- Finger M
- Florez C
- Forthomme L
- Friedl M
- Fruhwirth R
- Garcia Guillaume
- Garcia JMV
- Gay APR
- Genchev V
- Ghete VM
- Giammanco A
- Glushkov I
- Godinovic N
- Gomez JP
- Gonzalez JS
- Gregores EM
- Guo Y
- Hadjiiska R
- Hammad GH
- Harkonen J
- Hartl C
- Heracleous N
- Hollar J
- Hormann N
- Hrubec J
- Iaydjiev P
- Janssen X
- Jeitler M
- Jez P
- Jiang CH
- Kadastik M
- Kadija K
- Kalogeropoulos A
- Kamel AE
- Karimaki V
- Keaveney J
- Khachatryan V
- Kiesenhofer W
- Kim TJ
- Kinnunen R
- Klein Benjamin
- Knunz V
- Knutsson A
- Komm M
- Kortelainen MJ
- Kovac M
- Kozhuharov V
- Krammer M
- Kratschmer I
- Lampen T
- Lassila-Perini K
- Lehti S
- Lelas D
- Lellouch Jeremie
- Lemaitre V
- Leonard A
- Li Q
- Li W
- Liang D
- Liang S
- Liao J
- Liko D
- Linden T
- Litov L
- Liu S
- Lowette S
- Luetic J
- Luukka P
- Luyckx S
- Maenpaa T
- Maes M
- Mahmoud MA
- Malbouisson H
- Malek M
- Manganote EJT
- Mao Y
- Marage PE
- Marinov A
- Marono MV
- Martins CD
- Martins MC
- Martins T
- Mavromanolakis G
- McCartin Joseph
- Mekterovic D
- Meng X
- Mercadante PG
- Mikulec I
- Militaru O
- Mohammadi A
- Montoya CAC
- Moreno BG
- Morovic S
- Mossolov V
- Mousa J
- Mucibello L
- Mundim L
- Muntel M
- Murumaa M
- Nicolaou C
- Nogima H
- Novaes SF
- Nuttens C
- Ocampo Rios Alberto Andres
- Ochesanu S
- Olbrechts A
- Padula SS
- Pagano D
- Pavlov B
- Peltola T
- Pereira AV
- Pernie L
- Petkov P
- Pin A
- Piotrzkowski K
- Piperov S
- Plestina R
- Pol ME
- Polic D
- Popov A
- Ptochos F
- Puljak I
- Qian SJ
- Quertenmont L
- Rabady D
- Radi A
- Rahbaran B
- Raidal M
- Razis PA
- Rebane L
- Reis T
- Rodozov M
- Rohringer H
- Roland B
- Rougny R
- Ryckbosch Dirk
- Sanabria JC
- Santaolalla J
- Santoro A
- Schofbeck R
- Selvaggi M
- Seva T
- Shumeiko N
- Sierra LFC
- Sigamani Michael
- Sirunyan AM
- Souza MHG
- Strauss J
- Strobbe Nadja
- Strom D
- Sultanov G
- Sznajder A
- Tao J
- Taurok A
- Tavernier S
- Thomas L
- Thyssen Filip
- Tiko A
- Tikvica L
- Tomei TRFP
- Treberer-Treberspurg W
- Tumasyan A
- Tuominen E
- Tuominiemi J
- Tuovinen E
- Tuuva T
- Tytgat Michael
- Van Doninck W
- Van Haevermaet H
- Van Mechelen P
- Van Mulders P
- Van Onsem GP
- Van Remortel N
- Van Spilbeeck A
- Vander Velde C
- Vanlaer P
- Villella I
- Voutilainen M
- Vutova M
- Walsh SinĂŠad Mary
- Waltenberger W
- Wang D
- Wang J
- Wang X
- Wang Z
- Wendland L
- Wulz CE
- Yazgan Efe
- Zaganidis Nikolaos
- Zhang L
- Zou W
- Publication venue
- Publication date
- 01/01/2014
- Field of study
The top-antitop quark (t (t) over bar) production cross section is measured in proton-proton collisions at root s = 8 TeV with the CMS experiment at the LHC, using a data sample corresponding to an integrated luminosity of 5.3 fb(-1). The measurement is performed by analysing events with a pair of electrons or muons, or one electron and one muon, and at least two jets, one of which is identified as originating from hadronisation of a bottom quark. The measured cross section is 239 +/- 2 (stat.) +/- 11 (syst.) +/- 6 (lum.) pb, for an assumed top-quark mass of 172.5 GeV, in agreement with the prediction of the standard model
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
- Author
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdullin S.
- Acosta D.
- Acosta J. G.
- Acosta M. Vazquez
- Adair A.
- Adam N.
- Adam W.
- Adams M. R.
- Adams T.
- Adiguzel A.
- Adler V.
- Adzic P.
- Afanasiev S.
- Agostino L.
- Agram J-L
- Aguilar-Benitez M.
- Aguilo E.
- Ahmad M.
- Ahmad W. Haj
- Ahuja S.
- Akchurin N.
- Akgun B.
- Akgun U.
- Akin I. V.
- Alagoz E.
- Albajar C.
- Albayrak E. A.
- Albergo S.
- Albrow M.
- Alcaraz Maestre J.
- Alda Junior W. L.
- Alexander J.
- Aliev T.
- Almeida N.
- Alver B.
- Alverson G.
- Alves G. A.
- Amapane N.
- Amsler C.
- Anagnostou G.
- Anastassov A.
- Anderson J.
- Anderson M.
- Andrea J.
- Andreev V.
- Andreev V.
- Andreev Yu.
- Andrews W.
- Anghel I. M.
- Anjos T. S.
- Antonelli L.
- Antunes J. Rodrigues
- Antunovic Z.
- Apanasevich L.
- Apollinari G.
- Appelt E.
- Apresyan A.
- Aranyi A.
- Arce P.
- Arcidiacono R.
- Arenton M. W.
- Arfaei H.
- Argiro S.
- Arisaka K.
- Arneodo M.
- Arora S.
- Asawatangtrakuldee C.
- Asghar M. I.
- Askew A.
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- Attikis A.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
The production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
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- Zarubin A
- Zatserklyaniy A
- Zeinali M
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- Zeuner WD
- Zeyrek M
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- Zhukov V
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
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- Cipriano PMR
- Cirino G
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- Cockerill DJA
- Codispoti G
- Colafranceschi S
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- Contardo D
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- Cortezon EP
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- Cutajar M
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- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
- Zabel J
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
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- Zeinali M
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Compressed representation of a partially defined integer function over multiple arguments
- Author
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- Abbiendi G
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
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- Abbiendi G
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- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
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- Sfiligoi I
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- Sheldon P
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- Wissing C
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- Won S
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- Xiao H
- Xie S
- Xu M
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- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
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- Zhukova V
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
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