Juan Ramón Jiménez: Lírica de una Atlántida

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Redensificación y cooperativismo como instrumentos para la regeneración urbana sostenible de barrios vulnerables en Madrid

Hasta la crisis financiera de 2008, la regeneración urbana en barrios vulnerables de Madrid se basaba en la inversión pública, que asumía entre el 60 y el 70 % de los costes de rehabilitación de las viviendas. A partir de 2008, esta inversión pública se retrae y la población se empobrece. En estas circunstancias, un modo de hacer viable estas intervenciones es utilizar recursos económicos locales, implícitos en el propio proceso de regeneración. Entre estos recursos se encuentra el aumento de edificabilidad, tradicionalmente asociado a modos de producción expansiva de la ciudad y a su planificación. Ahora bien, la redensificación ha de ser utilizada respondiendo a nuevos criterios: ¿cuál es el crecimiento mínimo necesario para hacer viable la regeneración urbana sostenible?, ¿cómo evaluar que estemos ante un proceso desarrollado con criterios de sostenibilidad?, y, por último, ¿cómo asegurar que la plusvalía generada se utiliza en la rehabilitación de las viviendas existentes? Este artículo presenta los resultados de una investigación que pretende responder a estas cuestiones, tomando como caso el barrio del Aeropuerto en Madrid. Se han propuesto tres escenarios de intervención que implican incrementos de la edificabilidad, considerando las necesidades de rehabilitación energética de las viviendas existentes, y se han evaluado con indicadores de sostenibilidad urbana, fácilmente aplicables desde la administración local. De todo ello se deduce que la redensificación puede ser parte de una estrategia sostenible. Por último, se discute la necesidad de gestión público-privada considerando las cooperativas vecinales de regeneración urbana para redistribuir los beneficios producto de la redensificación.González González, FJ.; Moreno Soriano, S.; Márquez Martinón, JM. (2020). Redensificación y cooperativismo como instrumentos para la regeneración urbana sostenible de barrios vulnerables en Madrid. En III Congreso Internacional ISUF-H. CIUDAD COMPACTA VS. CIUDAD DIFUSA. Editorial Universitat Politècnica de València. (20-05-2020):385-396. https://doi.org/10.4995/ISUFh2019.2019.9650OCS38539620-05-202

Captación y selección de materias primas en la primera metalurgia del Sureste de la península ibérica

The authors are grateful for the technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). We are also in debt with Eduardo Galán, Ruth Maicas and Carmen Cacho, curators of the Museo Arqueológico Nacional (Madrid) for facilitating the sampling and study of metal objects as well as with Ignacio Soriano Llopis for his help on the selection and sampling of the Palmela points, with Massimo Chiaradia who performed the analyses of the Palmela points at the Department of Earth Sciences (University of Geneva, Switzerland) and with Óscar García Vuelta for his pictures of some assemblages. We also appreciate and the careful work of editing and style of the TP editorial team.The role of metallurgy in the Copper Age communities of the Iberian Southeast is a recurrent question of archaeological research in western Europe. Based on lead isotope and trace element analyses of archaeometallurgical remains, this paper addresses the territorial organisation of metallurgical production during the Copper Age (3100-2200 cal BC) in the Vera Basin (Almería, Spain), the region with the earliest metallurgical evidence in western Europe. This paper comprises the study of materials from the three main settlements with metallurgical activity in the area (Las Pilas, Santa Bárbara and Almizaraque), as well as some metal objects from these and other sites (La Encantada I, Loma de Belmonte and Las Churuletas 1). The results support a model of small-scale regional production whereby settlements exploited the resources of their nearby surroundings (up to 30 km as the crow flies). However, metallurgical exploitation prioritised mineralisations rich in arsenic and other elements, even when other sources were more readily accessible: for the case of Las Pilas, the exploitation of Pinar de Bédar sources instead of Sierra Cabrera, closer to the site; for the cases of Santa Bárbara and Almizaraque, the sources of Cerro Minado. The possibility that Almizaraque and Las Pilas also exploited the minerals of Herrerías, although to a lesser extent, remains open. Broader exchange networks are indicated by the data from finished objects, from which greater mobility can be inferred.El papel de la metalurgia en las comunidades de la Edad del Cobre del Sureste de la península ibérica es una cuestión recurrente en la investigación arqueológica en Europa occidental. A partir del análisis de isótopos de plomo y elementos traza de restos arqueometalúrgicos, este artículo aborda la organización territorial de la producción metalúrgica durante la Edad del Cobre (3100-2200 cal aC) en la cuenca de Vera (Almería, España); la región con las primeras evidencias metalúrgicas en Europa Occidental. Este artículo incluye el estudio de materiales de los tres principales asentamientos con actividad metalúrgica en la zona (Las Pilas, Santa Bárbara y Almizaraque), así como algunos objetos metálicos de estos y otros sitios (La Encantada I, Loma de Belmonte y Las Churuletas 1). Los resultados sustentan un modelo de producción regional a pequeña escala mediante el cual los asentamientos explotaron varios de los recursos de su entorno cercanos (hasta 30 km en línea recta). Se priorizaron las mineralizaciones ricas en arsénico y otros elementos, incluso cuando otras fuentes eran más accesibles: para el caso de Las Pilas, la explotación de las fuentes de Pinar de Bédar en lugar de las de Sierra Cabrera, más cercanas al yacimiento; y para los casos de Santa Bárbara y Almizaraque, las fuentes de Cerro Minado. La posibilidad de que tanto Almizaraque como Las Pilas también explotaran los minerales de Herrerías, aunque en menor medida, permanece abierta. La existencia de redes de intercambio más amplias queda reflejada por los datos de los objetos, a partir de los cuales se puede inferir una mayor movilidad.European funding (ERDF)European funding (ESF)This study was suported by the following sources of funding: a Marie Curie Intra European Fellowship (PN623183) funded within the 7th European Community Framework Programme; two Research and Development (R&D) projects funded by the Spanish Ministry of Science, Innovation and Universities: “Metal and amber: Models of raw materials circulation in Iberian Recent Prehistory” (HAR2017-82685-R) and “Tecnología y Sociedad. Las primeras artesanías de las comunidades neolíticas en Andalucía oriental entre el VI y el III milenio a.n.e” (HAR 2016-78197-P); and a Research Excellence Chair 2011-2016 “Activités minières et métallurgiques: anthropisation des milieux et productions matérielles”, funded by the Centre National de la Recherche Scientifique (CNRS)

Excess hospitalizations and mortality associated with seasonal influenza in Spain, 2008-2018

Influenza may trigger complications, particularly in at-risk groups, potentially leading to hospitalization or death. However, due to lack of routine testing, influenza cases are infrequently coded with influenza-specific diagnosis. Statistical models using influenza activity as an explanatory variable can be used to estimate annual hospitalizations and deaths associated with influenza. Our study aimed to estimate the clinical and economic burden of severe influenza in Spain, considering such models. The study comprised ten epidemic seasons (2008/2009-2017/2018) and used two approaches: (i) a direct method of estimating the seasonal influenza hospitalization, based on the number of National Health Service hospitalizations with influenza-specific International Classification of Diseases (ICD) codes (ICD-9: 487-488; ICD-10: J09-J11), as primary or secondary diagnosis; (ii) an indirect method of estimating excess hospitalizations and deaths using broader groups of ICD codes in time-series models, computed for six age groups and four groups of diagnoses: pneumonia or influenza (ICD-9: 480-488, 517.1; ICD-10: J09-J18), respiratory (ICD-9: 460-519; ICD-10: J00-J99), respiratory or cardiovascular (C&R, ICD-9: 390-459, 460-519; ICD-10: I00-I99, J00-J99), and all-cause. Means, excluding the H1N1pdm09 pandemic (2009/2010), are reported in this study. The mean number of hospitalizations with a diagnosis of influenza per season was 13,063, corresponding to 28.1 cases per 100,000 people. The mean direct annual cost of these hospitalizations was €45.7 million, of which 65.7% was generated by patients with comorbidities. Mean annual influenza-associated C&R hospitalizations were estimated at 34,894 (min: 16,546; max: 52,861), corresponding to 75.0 cases per 100,000 (95% confidence interval [CI]: 63.3-86.3) for all ages and 335.3 (95% CI: 293.2-377.5) in patients aged ≥ 65 years. We estimate 3.8 influenza-associated excess C&R hospitalizations for each hospitalization coded with an influenza-specific diagnosis in patients aged ≥ 65 years. The mean direct annual cost of the estimated excess C&R hospitalizations was €142.9 million for all ages and €115.9 million for patients aged ≥ 65 years. Mean annual influenza-associated all-cause mortality per 100,000 people was estimated at 27.7 for all ages. Results suggest a relevant under-detected burden of influenza mostly in the elderly population, but not neglectable in younger people. The online version contains supplementary material available at 10.1186/s12879-023-08015-3

Immunogenicity, transplacental transfer of pertussis antibodies and safety following pertussis immunization during pregnancy: Evidence from a randomized, placebo-controlled trial.

Background: Pertussis immunization during pregnancy is recommended in many countries. Data from large randomized controlled trials are needed to assess the immunogenicity, reactogenicity and safety of this approach. Methods: This phase IV, observer-blind, randomized, placebo-controlled, multicenter trial assessed immunogenicity, transplacental transfer of maternal pertussis antibodies, reactogenicity and safety of a reduced-antigen-content diphtheria-tetanus-three-component acellular pertussis vaccine (Tdap) during pregnancy. Women received Tdap or placebo at 27–36 weeks’ gestation with crossover 72-hourpostpartum immunization. Immune responses were assessed before the pregnancy dose and 1 month after, and from the umbilical cord at delivery. Superiority (primary objective) was reached if the lower limits of the 95% confidence intervals (CIs) of the pertussis geometric mean concentration (GMC) ratios (Tdap/control) in cord blood were 1.5. Solicited and unsolicited adverse events (AEs) and pregnancy-/ neonate-related AEs of interest were recorded. Results: 687 pregnant women were vaccinated (Tdap: N = 341 control: N = 346). Superiority of the pertussis immune response (maternally transferred pertussis antibodies in cord blood) was demonstrated by the GMC ratios (Tdap/control): 16.1 (95% CI: 13.5–19.2) for anti-filamentous hemagglutinin, 20.7 (15.9–26.9) for anti-pertactin and 8.5 (7.0–10.2) for anti-pertussis toxoid. Rates of pregnancy-/ neonate-related AEs of interest, solicited general and unsolicited AEs were similar between groups. None of the serious AEs reported throughout the study were considered related to maternal Tdap vaccination. Conclusions: Tdap vaccination during pregnancy resulted in high levels of pertussis antibodies in cord blood, was well tolerated and had an acceptable safety profile. This supports the recommendation of Tdap vaccination during pregnancy to prevent early-infant pertussis disease.post-print502 K

Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

<p>Abstract</p> <p>Background</p> <p>Rotavirus is the most common cause of gastroenteritis in young children worldwide. The aim of the study was to assess the health outcomes and the economic impact of a universal rotavirus vaccination programme with RotaTeq, the pentavalent rotavirus vaccine, versus no vaccination programme in Spain.</p> <p>Methods</p> <p>A birth cohort was followed up to the age of 5 using a cohort model. Epidemiological parameters were taken from the REVEAL study (a prospective epidemiological study conducted in Spain, 2004-2005) and from the literature. Direct and indirect costs were assessed from the national healthcare payer and societal perspectives by combining health care resource utilisation collected in REVEAL study and unit costs from official sources. RotaTeq per protocol efficacy data was taken from a large worldwide rotavirus clinical trial (70,000 children). Health outcomes included home care cases, General Practioner (GP)/Paediatrician, emergency department visits, hospitalisations and nosocomial infections.</p> <p>Results</p> <p>The model estimates that the introduction of a universal rotavirus vaccination programme with RotaTeq (90% coverage rate) would reduce the rotavirus gastroenteritis (RVGE) burden by 75% in Spain; 53,692 home care cases, 35,187 GP/Paediatrician visits, 34,287 emergency department visits, 10,987 hospitalisations and 2,053 nosocomial infections would be avoided. The introduction of RotaTeq would avoid about 76% of RVGE-related costs from both perspectives: €22 million from the national health system perspective and €38 million from the societal perspective.</p> <p>Conclusions</p> <p>A rotavirus vaccination programme with RotaTeq would reduce significantly the important medical and economic burden of RVGE in Spain.</p

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

Background: Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD). Variants in the PRNP gene that encodes prion protein are strong risk factors for sCJD but, although the condition has similar heritability to other neurodegenerative disorders, no other genetic risk loci have been confirmed. We aimed to discover new genetic risk factors for sCJD, and their causal mechanisms. Methods: We did a genome-wide association study of sCJD in European ancestry populations (patients diagnosed with probable or definite sCJD identified at national CJD referral centres) with a two-stage study design using genotyping arrays and exome sequencing. Conditional, transcriptional, and histological analyses of implicated genes and proteins in brain tissues, and tests of the effects of risk variants on clinical phenotypes, were done using deep longitudinal clinical cohort data. Control data from healthy individuals were obtained from publicly available datasets matched for country. Findings: Samples from 5208 cases were obtained between 1990 and 2014. We found 41 genome-wide significant single nucleotide polymorphisms (SNPs) and independently replicated findings at three loci associated with sCJD risk; within PRNP (rs1799990; additive model odds ratio [OR] 1·23 [95% CI 1·17-1·30], p=2·68 × 10-15; heterozygous model p=1·01 × 10-135), STX6 (rs3747957; OR 1·16 [1·10-1·22], p=9·74 × 10-9), and GAL3ST1 (rs2267161; OR 1·18 [1·12-1·25], p=8·60 × 10-10). Follow-up analyses showed that associations at PRNP and GAL3ST1 are likely to be caused by common variants that alter the protein sequence, whereas risk variants in STX6 are associated with increased expression of the major transcripts in disease-relevant brain regions. Interpretation: We present, to our knowledge, the first evidence of statistically robust genetic associations in sporadic human prion disease that implicate intracellular trafficking and sphingolipid metabolism as molecular causal mechanisms. Risk SNPs in STX6 are shared with progressive supranuclear palsy, a neurodegenerative disease associated with misfolding of protein tau, indicating that sCJD might share the same causal mechanisms as prion-like disorders. Funding: Medical Research Council and the UK National Institute of Health Research in part through the Biomedical Research Centre at University College London Hospitals National Health Service Foundation Trust

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection