Design of a large scale flow-meter test and calibration facility

The design and set up of a large-scale flowmeter calibration and test facility is presented. The facility was designed to handle flowmeters with diameters between 6” and 14”, flow rates up to 0.3 m3/s and to give results less than 1% accurate. The calibration methodology consisted firstly in calibrating the pattern flowmeters, using volume and time primary measurements, and secondly, comparing the pattern to the flowmeters needing calibration. The design and calculation of the primary calibration device is addressed, including numerical simulations of the outflow manifold and the comparison to experimental data. The calibration facility proved to be accurate and reliable in producing renewed calibration data for various tested flowmeter

Design of a flow deflector for an accurate flow meter calibration facility

The design and test of a flow deflector gate used for controlling the flow deviation toward the primary tank in a flow-meter calibration facility is presented. The deflector gate is pneumatically controlled and permits the flow conduction to either the suction tank or to the primary tank. The deflector is designed to approximately compensate the flow deficit towards the primary tank during the opening, with the flow excess while in the shutting process. Numerical simulations are performed to study the flow hydrodynamics during the deflector operation. Results are compared to experimental data, and used to improve the gate design. The enhanced design proved to guarantee the uniformity of the flow through the calibration section and the dramatic reduction of the error in volume measurement during calibration

Design of the distribution manifold for a large-scale flowmeter calibration facility

The design and test of the distribution manifold for a large-scale flowmeter calibration facility is presented. The design was intended to have an air-free flow operation and a free-surface flow-like towards the downstream half-body discharge. Back of the envelope calculations are presented for the estimation of the preliminary dimensions. Numerical simulations of the flow during manifold steady state operation are utilized to refine the manifold design. No air entrapment is noticed in the flow simulatio

Design of a large scale flow-meter test and calibration facility

The design and set up of a large-scale flowmeter calibration and test facility is presented. The facility was designed to handle flowmeters with diameters between 6” and 14”, flow rates up to 0.3 m3/s and to give results less than 1% accurate. The calibration methodology consisted firstly in calibrating the pattern flowmeters, using volume and time primary measurements, and secondly, comparing the pattern to the flowmeters needing calibration. The design and calculation of the primary calibration device is addressed, including numerical simulations of the outflow manifold and the comparison to experimental data. The calibration facility proved to be accurate and reliable in producing renewed calibration data for various tested flowmeter

Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool

Cancer is one of the most prevalent diseases in the world and requires new therapies for its treatment. In this context, the biosynthesis of silver nanoparticles (AgNPs) has been developed to treat different types of tumors. The Annona muricata plant is known for having anticancer activity. Its main compounds present in the leaves, stems and skin, allowing for its use as reducing agents. In this manuscript, AgNPs with leaf extract (AgNPs-LE) and fruit peel extract (AgNPs-PE) of A. muricata were biosynthesized obtaining an average nanoparticle diameter sizes smaller than 50 nm, being 19.63 ± 3.7 nm and 16.56 ± 4.1 nm, and with a surface plasmonic resonance (SPR) at 447 and 448 nm, respectively. The lactone functional group present in the LE and PE extracts was identified by the FTIR technique. The behavior and antiproliferation activity of AgNPs-LE and AgNPs-PE were evaluated in breast, colon and melanoma cancer cell lines. Our results showed that Annona muricata fruit peel, which is a waste product, has an antitumor effect more potent than leaf extract. This difference is maintained with AgNPs where the destruction of cancer cells was, for the first time, achieved using concentrations that do not exceed 3 μg/mL with a better therapeutic index in the different tumor strains. In conclusion, we present a low-cost one-step experimental setup to generate AgNPs-PE whose in-vitro biocompatibility and powerful therapeutic effect make it a very attractive tool worth exploiting.Fundacion Empresa Universidad de Granada (Project PR/18/001)Fundación Mutua Madrileña (Project FMM-AP16683-2017)Consejería de Salud Junta de Andalucía (PI-0089-2017)Instituto de Salud Carlos III (RTI2018-101309-B-C22

Partial inhibition of RNA polymerase I promotes animal health and longevity

Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, age-related impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality

DEFICIENCIA DE AZUFRE EN SUELOS CULTIVABLES Y SU EFECTO EN LA PRODUCTIVIDAD

En décadas pasadas el azufre fue considerado como un elemento contaminante del ambiente, esto generó que se crearan legislaciones para reducir las emisiones del elemento a la atmósfera, lo cual ocasionó un desbalance en el ciclo global de azufre, llegando a ser insuficiente en suelos donde se practica la agricultura intensiva. China fue el primer país en reconocer el problema y creó un programa de fertilización con azufre. El resultado fue un incremento en la productividad agrícola. La deficiencia de azufre en suelos está relacionada a baja productividad, mayor susceptibilidad a plagas, menor resistencia a sequía, frío y salinidad. Es necesario que cada región agrícola determine los niveles de azufre en suelos de cultivo, donde las medidas correctivas mejorarían la productividad. Según datos de la FAO se necesita incrementar la producción de alimentos en un 60% en las próximas 4 décadas; la fertilización con azufre podría ser un factor a considerar para lograrlo. La tecnología de fertilizantes ha generado una variedad de productos azufrados cuya selección estará en función de las condiciones edafoclimáticas, entre otros factores. Para los suelos deficientes de azufre, es necesario tomar medidas correctivas, dado que la demanda de alimentos es cada vez más grande

Hematite photoelectrodes grown on porous CuO–Sb₂O₅–SnO₂ ceramics for photoelectrochemical water splitting

Photoelectrodes capable of cost-effective hydrogen production on a large scale, via photoelectrochemical water splitting under solar light, could offer an elegant solution to many current problems of humankind caused by over-reliance on fossil fuels and the resulting environmental pollution. The search and design of low-cost photoelectrode materials and substrates for practical applications are required. In this work, unmodified hematite photoanodes grown by metal-organic chemical vapor deposition (MO-CVD) onto CuO–Sb2O5–SnO2 ceramic substrates are reported. The deposition time of hematite precursor varied between 10 min, 60 min, and 90 min. The photoanode grown for 60 min exhibits the highest photocurrent density recorded at 1.23 V vs RHE (reversible hydrogen electrode): 4.79 mA/cm2 under blue light of Thorlabs LED M455L2 (455 nm), 0.41 mA/cm2 under the radiation of the real sun in Mexico, and 0.38 mA/cm2 under AM1.5G solar simulator conditions. The high porosity of CuO–Sb2O5–SnO2 ceramics permits the permeation of the hematite precursor into the substrate bulk, which results in 3D-growth of a thin Fe2O3-coating (50 nm or less) on conductive SnO2-grains in the ceramics to a depth of ca. 5 μm. The thick photocatalytic layer (SnO2-grains coated by hematite) of several micrometers assures a good light harvesting by the photoelectrode, while the nano-sized Fe2O3-films on conductive SnO2-grains is favorable for charge diffusion. This architecture of the photoelectrode results in good photoelectrochemical characteristics and is promising for further development.</p

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio