77 research outputs found
Skeletal Ring Contractions via I(I)/I(III) Catalysis: Stereoselective Synthesis of cis-α,α-Difluorocyclopropanes
The clinical success of α,α-difluorocyclopropanes, combined with limitations in the existing synthesis portfolio, inspired the development of an operationally simple, organocatalysis-based strategy to access cis-configured derivatives with high levels of stereoselectivity (up to >20:1 cis:trans). Leveraging an I(I)/I(III)-catalysis platform in the presence of an inexpensive HF source, it has been possible to exploit disubstituted bicyclobutanes (BCBs) as masked cyclobutene equivalents for this purpose. In situ generation of this strained alkene, enabled by BrĂžnsted acid activation, facilitates an unprecedented 4 â 3 fluorinative ring contraction, to furnish cis-α,α-difluorinated cyclopropanes in a highly stereoselective manner (up to 88% yield). Mechanistic studies are disclosed together with conformational analysis (X-ray crystallography and NMR) to validate cis-α,α-difluorocyclopropanes as isosteres of the 1,4-dicarbonyl moiety. Given the importance of this unit in biology and the foundational no â Ï* interactions that manifest themselves in this conformation (e.g., collagen), it is envisaged that the title motif will find application in focused molecular design
Trece años de evaluaciĂłn compartida en EducaciĂłn FĂsica
En este trabajo realizamos una revisiĂłn de trece años de experiencia docente e investigaciĂłn educativa sobre la AutoevaluaciĂłn y la EvaluaciĂłn Compartida en EducaciĂłn FĂsica. En una primera parte llevamos a cabo una revisiĂłn del estado de la cuestiĂłn, describimos el objeto de estudio y la metodologĂa utilizada, para pasar posteriormente a analizar los resultados generales de estos trece años de experimentaciĂłn. Los resultados los hemos organizado en dos grandes apartados: a-ventajas y posibilidades y b- inconvenientes, dificultades y posibles soluciones, de modo que puedan ser de utilidad para el profesorado interesado en el estudio y la puesta en prĂĄctica de este tipo de sistemas de evaluaciĂłn
Incorporating temporal-bounded CBR techniques in real-time agents
Nowadays, MAS paradigm tries to move Computation to a new level of abstraction: Computation as interaction,
where large complex systems are seen in terms of the services they offer, and consequently in
terms of the entities or agents providing or consuming services. However, MAS technology is found to
be lacking in some critical environments as real-time environments. An interaction-based vision of a
real-time system involves the purchase of a responsibility by any entity or agent for the accomplishment
of a required service under possibly hard or soft temporal conditions. This vision notably increases the
complexity of these kinds of systems. The main problem in the architecture development of agents in
real-time environments is with the deliberation process where it is difficult to integrate complex
bounded deliberative processes for decision-making in a simple and efficient way. According to this, this
work presents a temporal-bounded deliberative case-based behaviour as an anytime solution. More specifically,
the work proposes a new temporal-bounded CBR algorithm which facilitates deliberative processes
for agents in real-time environments, which need both real-time and deliberative capabilities.
The paper presents too an application example for the automated management simulation of internal
and external mail in a department plant. This example has allowed to evaluate the proposal investigating
the performance of the system and the temporal-bounded deliberative case-based behaviour.
2010 Elsevier Ltd. All rights reserved.This work is supported by TIN2006-14630-C03-01 projects of the Spanish government, GVPRE/2008/070 project, FEDER funds and CONSOLIDER-INGENIO 2010 under Grant CSD2007-00022.Navarro LlĂĄcer, M.; Heras BarberĂĄ, SM.; Julian Inglada, VJ.; Botti Navarro, VJ. (2011). Incorporating temporal-bounded CBR techniques in real-time agents. Expert Systems with Applications. 38(3):2783-2796. https://doi.org/10.1016/j.eswa.2010.08.070S2783279638
Visor de escenarios de cambio climĂĄtico de adapteCCa: consulta interactiva y acceso a escenarios-PNACC 2017
Ponencia presentada en: XI Congreso de la AsociaciĂłn Española de ClimatologĂa celebrado en Cartagena entre el 17 y el 19 de octubre de 2018.[ES]Las proyecciones regionales de cambio climĂĄtico son una informaciĂłn bĂĄsica para realizar estudios de impacto y adaptaciĂłn en distintos sectores socio-econĂłmicos. La recopilaciĂłn y producciĂłn de estas proyecciones a nivel nacional es una tarea bĂĄsica del Plan Nacional de AdaptaciĂłn al Cambio ClimĂĄtico (PNACC), a travĂ©s de Escenarios-PNACC. La primera versiĂłn (2012) se basĂł en la informaciĂłn del IPCCAR4 y en dos acciones estratĂ©gicas nacionales (ESCENA y ESTCENA). Recientemente, se ha llevado a cabo una actualizaciĂłn de estos escenarios regionales a partir de IPCC-AR5 y de los proyectos CORDEX y VALUE (con la participaciĂłn de AEMET y CSIC-UC), que proporciona series diarias en rejilla y puntuales de distintas variables e Ăndices para mĂșltiples escenarios y modelos. En este trabajo se presenta la actualizaciĂłn Escenarios-PNACC 2017, asĂ como el visor de escenarios de cambio climĂĄtico desarrollado en el marco de la plataforma AdapteCCa para facilitar a los usuarios el anĂĄlisis interactivo y el acceso a esta informaciĂłn (http://escenarios.adaptecca.es).[EN]Regional projections of climate change are key information to carry out impact and adaptation studies in different socio-economic sectors. The compilation and production of these projections at the national level is a basic task of the National Plan of Adaptation to Climate Change (PNACC), through Escenarios-PNACC. The first version (2012) was based on IPCC-AR3 information and two national strategic actions (ESCENA and ESTCENA). Recently, an update of these regional scenarios has been carried out from IPCC-AR5 and from the CORDEX and VALUE projects (with the participation of AEMET and CSIC-UC), providing daily gridded and point series of different variables and indices for multiple scenarios and models. This paper describes the update Escenarios-PNACC 2017, as well as the "viewer of climate change scenarios" developed within the framework of the AdapteCCa platform to provide users with interactive analysis and access to this information (http://escenarios.adaptecca.es)
How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?
Background and Aims. To control the COVID-19 spread, in March 2020, a forced home lockdown was established in Spain. In the present study, we aimed to assess the effect of mobility and social COVID-19-established restrictions on depressive symptomatology in older adults with metabolic syndrome. We hypothesize that severe restrictions might have resulted in detrimental changes in depressive symptomatology. Methods. 2,312 PREDIMED-Plus study participants (men = 53:9%; mean age = 64:9±4:8 years) who completed a COVID-19 lockdown questionnaire to assess the severity of restrictions/lockdown and the validated Spanish version of the Beck Depression Inventory-II (BDI-II) during the three established phases concerning the COVID-19 lockdown in Spain (prelockdown, lockdown, and postlockdown) were included in this longitudinal analysis. Participants were categorized according to high or low lockdown severity. Analyses of covariance were performed to assess changes in depressive symptomatology across lockdown phases. Results. No significant differences in participant depression symptomatology changes were observed between lockdown severity categories (low/high) at the studied phases. During the lockdown phase, participants showed a decrease in BDI-II score compared to the prelockdown phase (mean (95% CI), -0.48 (-0.24, -0.72), P < 0:001); a nonsignificantly larger decrease was observed in participants allocated in the low-lockdown category (low: -0.59 (-0.95, -0.23), high: -0.43 (-0.67, -0.19)). Similar decreases in depression symptomatology were found for the physical environment dimension. The post- and prelockdown phase BDI-II scores were roughly similar. Conclusions. The COVID-19 pandemic lockdown was associated with a decrease in depressive symptomatology that returned to prelockdown levels after the lockdown. The degree of lockdown was not associated with depressive symptomatology. The potential preventive role of the physical environment and social interactions on mental disorders during forced home lockdown should be further studie
Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimerâs Disease Aetiopathogenesis in Men
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimerâs disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the moment of DNA sampling. Therefore, mLOY phenotype associations with AD can be severely age-confounded in the context of genome-wide association studies. Here, we applied Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) using 114 autosomal variants. The mloy-PRS instrument was associated with an 80% increase in mLOY risk per standard deviation unit (p = 4.22 Ă 10â20) and was orthogonal with age. We found that a higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment (hazard ratio (HR) = 1.23, p = 0.01). Importantly, mloy-PRS had no effect on AD conversion or risk in the female group, suggesting that these associations are caused by the inherent loss of the Y chromosome. Additionally, the blood mLOY phenotype in men was associated with increased cerebrospinal fluid levels of total tau and phosphorylated tau181 in subjects with mild cognitive impairment and dementia. Our results strongly suggest that mLOY is involved in AD pathogenesis.P.G.-G. (Pablo GarcĂa-GonzĂĄlez) is supported by CIBERNED employment plan CNV-304-PRF-866. CIBERNED is integrated into ISCIII (Instituto de Salud Carlos III). I.d.R is supported by a national grant from the Instituto de Salud Carlos III FI20/00215. A.C. (Amanda Cano) acknowledges the support of the Spanish Ministry of Science, Innovation, and Universities under the grant Juan de la Cierva (FJC2018-036012-I). M.B. (MercĂ© Boada) and A.R. (AgustĂn Ruiz) are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240, and PI19/01301. The Genome Research @ FundaciĂł ACE project (GR@ACE) is supported by Grifols SA, FundaciĂłn bancaria âLa Caixaâ, FundaciĂł ACE, and CIBERNED. AcciĂłn EstratĂ©gica en Salud is integrated into the Spanish National Râ+âDâ+âI Plan and funded by ISCIII (Instituto de Salud Carlos III)âSubdirecciĂłn General de EvaluaciĂłnâand the Fondo Europeo de Desarrollo Regional (FEDERââUna manera de hacer Europaâ). Genotyping of the ACE MCI-EADB samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). This work was supported by a grant (European Alzheimer DNA BioBank, EADB) from the EU Joint ProgramâNeurodegenerative Disease Research (JPND). Partial funding for open access charge: Universidad de MĂĄlag
Relationship of Weather Types on the Seasonal and Spatial Variability of Rainfall, Runoff, and Sediment Yield in the Western Mediterranean Basin
Rainfall is the key factor to understand soil erosion processes, mechanisms, and rates. Most research was conducted to determine rainfall characteristics and their relationship with soil erosion (erosivity) but there is little information about how atmospheric patterns control soil losses, and this is important to enable sustainable environmental planning and risk prevention. We investigated the temporal and spatial variability of the relationships of rainfall, runoff, and sediment yield with atmospheric patterns (weather types, WTs) in the western Mediterranean basin. For this purpose, we analyzed a large database of rainfall events collected between 1985 and 2015 in 46 experimental plots and catchments with the aim to: (i) evaluate seasonal differences in the contribution of rainfall, runoff, and sediment yield produced by the WTs; and (ii) to analyze the seasonal efficiency of the different WTs (relation frequency and magnitude) related to rainfall, runoff, and sediment yield. The results indicate two different temporal patterns: the first weather type exhibits (during the cold period: autumn and winter) westerly flows that produce the highest rainfall, runoff, and sediment yield values throughout the territory; the second weather type exhibits easterly flows that predominate during the warm period (spring and summer) and it is located on the Mediterranean coast of the Iberian Peninsula. However, the cyclonic situations present high frequency throughout the whole year with a large influence extended around the western Mediterranean basin. Contrary, the anticyclonic situations, despite of its high frequency, do not contribute significantly to the total rainfall, runoff, and sediment (showing the lowest efficiency) because of atmospheric stability that currently characterize this atmospheric pattern. Our approach helps to better understand the relationship of WTs on the seasonal and spatial variability of rainfall, runoff and sediment yield with a regional scale based on the large dataset and number of soil erosion experimental stations.Spanish Government (Ministry of Economy and Competitiveness, MINECO) and FEDER Projects: CGL2014 52135-C3-3-R, ESP2017-89463-C3-3-R, CGL2014-59946-R, CGL2015-65569-R, CGL2015-64284-C2-2-R, CGL2015-64284-C2-1-R, CGL2016-78075-P, GL2008-02879/BTE, LEDDRA 243857, RECARE-FP7, CGL2017-83866-C3-1-R, and PCIN-2017-061/AEI. Dhais Peña-Angulo received a âJuan de la Ciervaâ postdoctoral contract (FJCI-2017-33652 Spanish Ministry of Economy and Competitiveness, MEC). Ana Lucia acknowledge the "Brigitte-Schlieben-Lange-Programm". The âGeoenvironmental Processes and Global Changeâ (E02_17R) was financed by the AragĂłn Government and the European Social Fund. JosĂ© AndrĂ©s LĂłpez-TarazĂłn acknowledges the Secretariat for Universities and Research of the Department of the Economy and Knowledge of the Autonomous Government of Catalonia for supporting the Consolidated Research Group 2014 SGR 645 (RIUS- Fluvial Dynamics Research Group). Artemi CerdĂ thank the funding of the OCDE TAD/CRP JA00088807. JosĂ© MartĂnez-Fernandez acknowledges the project Unidad de Excelencia CLU-2018-04 co-funded by FEDER and Castilla y LeĂłn Government. Ane Zabaleta is supported by the Hydro-Environmental Processes consolidated research group (IT1029-16, Basque Government). This paper has the benefit of the Lab and Field Data Pool created within the framework of the COST action CONNECTEUR (ES1306)
Associations between eating speed, diet quality, adiposity, and cardiometabolic risk factors
Objective: To assess the associations between eating speed, adiposity, cardiometabolic risk factors, and diet quality in a cohort of Spanish preschool-children. Study design: A cross-sectional study in 1371 preschool age children (49% girls; mean age, 4.8 ± 1.0 years) from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS) cohort was conducted. After exclusions, 956 participants were included in the analyses. The eating speed was estimated by summing the total minutes used in each of the 3 main meals and then categorized into slow, moderate, or fast. Multiple linear and logistic regression models were fitted to assess the ÎČ-coefficient, or OR and 95% CI, between eating speed and body mass index, waist circumference, fat mass index (FMI), blood pressure, fasting plasma glucose, and lipid profile. Results: Compared with participants in the slow-eating category, those in the fast-eating category had a higher prevalence risk of overweight/obesity (OR, 2.9; 95% CI, 1.8-4.4; P < .01); larger waist circumference (ÎČ, 2.6 cm; 95% CI, 1.5-3.8 cm); and greater FMI (ÎČ, 0.3 kg/m2; 95% CI, 0.1-0.5 kg/m2), systolic blood pressure (ÎČ, 2.8 mmHg; 95% CI, 0.6-4.9 mmHg), and fasting plasma glucose levels (ÎČ, 2.7 mg/dL, 95% CI, 1.2-4.2 mg/dL) but lower adherence to the Mediterranean diet (ÎČ, â0.5 points; 95% CI, â0.9 to â0.1 points). Conclusions: Eating fast is associated with higher adiposity, certain cardiometabolic risk factors, and lower adherence to a Mediterranean diet. Further long-term and interventional studies are warranted to confirm these associations
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
- âŠ